AU2019201117B1 - Self-shielding cyclotron system - Google Patents
Self-shielding cyclotron system Download PDFInfo
- Publication number
- AU2019201117B1 AU2019201117B1 AU2019201117A AU2019201117A AU2019201117B1 AU 2019201117 B1 AU2019201117 B1 AU 2019201117B1 AU 2019201117 A AU2019201117 A AU 2019201117A AU 2019201117 A AU2019201117 A AU 2019201117A AU 2019201117 B1 AU2019201117 B1 AU 2019201117B1
- Authority
- AU
- Australia
- Prior art keywords
- unit
- target
- self
- cyclotron
- shielding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000032258 transport Effects 0.000 claims abstract description 78
- 238000004090 dissolution Methods 0.000 claims abstract description 43
- 239000002245 particle Substances 0.000 claims abstract description 40
- 230000002285 radioactive effect Effects 0.000 claims abstract description 10
- 239000002184 metal Substances 0.000 claims description 34
- 229910052751 metal Inorganic materials 0.000 claims description 34
- 230000004308 accommodation Effects 0.000 claims description 10
- 230000001678 irradiating effect Effects 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 description 16
- 238000000034 method Methods 0.000 description 11
- 230000002093 peripheral effect Effects 0.000 description 11
- 230000008569 process Effects 0.000 description 11
- 239000007789 gas Substances 0.000 description 9
- 238000007789 sealing Methods 0.000 description 8
- 239000000758 substrate Substances 0.000 description 7
- 239000011888 foil Substances 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 5
- 239000002826 coolant Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 238000003892 spreading Methods 0.000 description 4
- 230000007480 spreading Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000002600 positron emission tomography Methods 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 239000000498 cooling water Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229940121896 radiopharmaceutical Drugs 0.000 description 2
- 239000012217 radiopharmaceutical Substances 0.000 description 2
- 230000002799 radiopharmaceutical effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- MKXBOPXRKXGSTI-PJKMHFRUSA-N 1-[(2s,4s,5r)-2-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1[C@]1(F)O[C@H](CO)[C@@H](O)C1 MKXBOPXRKXGSTI-PJKMHFRUSA-N 0.000 description 1
- HIIJZYSUEJYLMX-UHFFFAOYSA-N 1-fluoro-3-(2-nitroimidazol-1-yl)propan-2-ol Chemical compound FCC(O)CN1C=CN=C1[N+]([O-])=O HIIJZYSUEJYLMX-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000011133 lead Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229950001518 raclopride Drugs 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000013077 target material Substances 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H13/00—Magnetic resonance accelerators; Cyclotrons
- H05H13/005—Cyclotrons
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
- G21F7/00—Shielded cells or rooms
- G21F7/06—Structural combination with remotely-controlled apparatus, e.g. with manipulators
- G21F7/067—Transferring devices within cells or boxes
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H2277/00—Applications of particle accelerators
- H05H2277/10—Medical devices
- H05H2277/11—Radiotherapy
- H05H2277/116—Isotope production
Abstract
There is provided a self-shielding cyclotron system (100)
which can further improve safety against radiation exposure when
5 a radioisotope is obtained. A transport unit (22) transports
a target (10) from a target holding unit (20) where the target
(10) is irradiated with a charged particle beam (B), to a
dissolution unit (21) for recovering a radioisotope. Here, the
target holding unit (20), the dissolution unit (21), and the
10 transport unit (22) are arranged inside a self-shielding member
(4). Therefore, a step of irradiating the target (10) with the
charged particle beam (B), a step of dissolving and recovering
the radioisotope, and a step of transporting the target (10)
betweenboththestepsareallperformedinside the self-shielding
15 member (4) . Therefore, in each step, the self-shielding member
(4) shields the units from a radioactive ray emitted from the
target (10) after the target (10) is irradiated with the charged
particle beam (B).
20
Description
Field of the Invention
[0001]
Certain embodiments of the present invention relate to a
self-shielding cyclotron system.
Description of Related Art
[00021
As disclosedin Japanese Unexamined Patent PublicationNo.
2000-105293, a self-shielding cyclotron system is known which
includes a self-shielding member accommodating a cyclotron and
preventing a radioactive ray emitted from the cyclotron from
being emitted outward. In recent years, a device has been
developedwhich obtains a solid radioisotope (RI) byirradiating
a target having ametallayer with achargedparticle beam. This
radioisotope is used for manufacturing a radiopharmaceutical
to be used for a positron emission tomography (PET) inspection
in a hospital. For example, according to Japanese Unexamined
Patent Publication No. 2014-115229, the target having the solid
radioisotope attached thereto is transported to a dissolution
device, and the radioisotopeis dissolvedinside the dissolution
device, thereby recovering the RI.
1003104705 2
[0002A]
Reference to any prior art in the specification is not an
acknowledgement or suggestion that this prior art forms part
of the common general knowledge in any jurisdiction or that this
prior art could reasonably be expected to be combined with any
other piece of prior art by a skilled person in the art.
[00031
Here, a target is subjected to radioactivation after the
target is irradiated with a charged particle beam. Therefore,
it is necessary to further improve safety against radiation
exposure when the target is attached to a dissolution device
by removing the target from an irradiation device.
[0004]
The present invention aims to provide a self-shielding
cyclotron system which can further improve safety against
radiation exposure when a radioisotope is obtained.
[00051
According to the present invention, there is provided a
self-shieldingcyclotron systemincludingacyclotron thatemits
a charged particle beam, and a self-shielding member that is
located inside a building, and that internally accommodates the
cyclotron so as to prevent a radioactive ray emitted from the
cyclotron from being emitted outward. The self-shielding
1003104705 2A
cyclotron system includes a target holding unit that holds a
target having a metal layer at an irradiation position of the
charged particle beam, a dissolution unit that dissolves the
metal layer containing a radioisotope in the target, and a
transportunit that transports the target from the targetholding
unit to the dissolution unit. The target holding unit, the dissolution unit, and the transport unit are arranged inside the self-shielding member.
[0006]
In the self-shielding cyclotron system according to the
present invention, the target holding unit holds the target having
themetallayerattheirradiationpositionofthechargedparticle
beam. Therefore, the target held by the target holding unit is
irradiated with the charged particle beam. In this manner, the
radioisotope is formed in a location irradiated with the charged
particle beam, in the metal layer of the target. In addition,
the dissolution unit dissolves the metal layer containing the
radioisotope in the target. In this manner, since a solution
is recovered, the radioisotope can be recovered. The transport
unit transports the target from the target holding unit where
the target is irradiated with the charged particle beam, to the
dissolution unit for recovering the radioisotope. Here, the
target holding unit, the dissolution unit, and the transport
unit are arranged inside the self-shielding member. Therefore,
a step of irradiating the target with the charged particle beam,
a step of dissolving and recovering the radioisotope, and a step
oftransportingthetargetbetweenboththestepsareallperformed
inside the self-shielding member. Therefore, in each step, the
self-shielding member shields the units from a radioactive ray
emitted from the target after the target is irradiated with the
charged particle beam. According to the above-described configuration, it is possible to further improve safety against radiation exposure when the radioisotope is obtained.
[00071
The self-shielding cyclotron system may further include
a control unit. After the metal layer is irradiated with the
chargedparticlebeam, the controlunitmay controlthe transport
unit so as to transport the target held by the target holding
unit to the dissolution unit. In this manner, transporting the
target transported by the transport unit is automatically
controlled by the control unit. In this manner, it is possible
to further prevent a worker from being exposed to radiation.
In addition, since the control unit automatically transports
the target, it is possible to shorten working hours.
[0008]
According to the present invention, it is possible to
provide a self-shielding cyclotron system which can further
improve safety against radiation exposure when a radioisotope
is obtained.
[0009]
Fig. 1 is a schematic configuration view illustrating a
self-shielding cyclotron system according to an embodiment of
the present invention.
Fig. 2 is a perspective view of a target.
Fig. 3 is an enlarged view ofa radioisotope manufacturing
unit.
Fig. 4 is a flowchart illustrating a process content of
a control unit.
Fig. 5 is an enlarged view illustrating an operation of
the radioisotope manufacturing unit.
Fig. 6 is an enlarged view illustrating an operation of
the radioisotope manufacturing unit.
Fig. 7 is an enlarged view illustrating an operation of
the radioisotope manufacturing unit.
Fig. 8 is an enlarged view illustrating an operation of
the radioisotope manufacturing unit.
Fig. 9 is an enlarged view illustrating an operation of
the radioisotope manufacturing unit.
Fig. 10 is an enlarged view illustrating a self-shielding
cyclotron system according to a modification example.
[00103
Hereinafter, preferred embodiments according to the
present invention will be described in detail with reference
to the drawings. In each figure, the same reference numerals
will be given to the same or equivalent elements, and repeated
description will be omitted.
[0011]
AsillustratedinFig.1, aself-shieldingcyclotronsystem
100 is a system disposed inside a building 150. The
self-shielding cyclotron system 100 according to the present
embodiment is a system for manufacturing a radioisotope
(hereinafter, referred to as an RI in some cases) by using a
charged particle beam. For example, the self-shielding
cyclotron system 100 can be used as a cyclotron for PET. For
example, theRImanufacturedinthesystemisusedinmanufacturing
a radiopharmaceutical (including a radioactive medicine) which
is a radioisotope-labeled compound (RI compound). As the
radioisotope-labeled compound used for a positron emission
tomography (PET) inspection in a hospital, the examples include
18 i 8 F-FLT (fluorothymidine), F-FMISO (fluoromisonidazole), and
IC-raclopride.
[0012]
The self-shielding cyclotron system 100 includes a
cyclotron 2, a radioisotope manufacturing unit 3, and a
self-shielding member 4. The self-shielding cyclotron system
100 is installed on a building floor surface 151 in a cyclotron
room 152 inside a building 150. The cyclotron room152 is a room
covered with concrete (shielding wall). Therefore, a user can
acquire a radioisotope on the spot inside the building by using
the self-shielding cyclotron system 100.
[0013]
The cyclotron 2 is an accelerator which emits a charged particlebeam. Thecyclotron2isaverticallyinstalledcircular accelerator which supplies the charged particle into an acceleration space fromanion source andaccelerates the charged particleinside the accelerationspace soas tooutput thecharged particle beam. The cyclotron 2 has a pair of magnetic poles, avacuumbox, and anannular yoke surrounding the pair ofmagnetic poles and the vacuumbox. In some of the pair of magnetic poles, main surfaces inside the vacuum box face each other with a predetermined space therebetween. Inside a gapbetween the pair ofmagnetic poles, the charged particle is accelerated multiple times. Examples of the charged particle include protons and heavy particles (heavy ions) . In the present embodiment, the cyclotron
2includesapluralityofports2aforemittingthechargedparticle
beam. One of the plurality of ports 2a has a target holding unit
20 (to be described later). The cyclotron 2 adjusts a trajectory
of the charged particle beam inside the acceleration space, and
extracts the charged particle beam from the desired port 2a.
[0014]
The self-shielding member 4 is located inside the building,
and internally accommodates the cyclotron 2 so as to prevent
theradioactiverayemittedfromthecyclotron2frombeingemitted
to the cyclotron room152. The self-shielding member 4 can shield
the cyclotron room 152 from the radioactive ray by covering the
cyclotron 2 in all directions. In the present embodiment, the
self-shielding member 4 has a hexahedral box-shaped structure, but the shape is not particularly limited. The self-shielding member 4 partitions an internal space (cyclotron room 152) of the building 150 and an internal space 120 of the self-shielding cyclotron system 100. The internal space of the building 150 may be configured to serve as a space in which other devices can be installed or through which a worker can pass. Therefore, the self-shielding cyclotron system100 according to the present embodiment is different from those in which the cyclotron 2 is simply located inside the room of the building. Surrounding walls configuring the room of the building do not correspond to the self-shielding member 4. The walls of the self-shielding member
4 are formed of a material such as polyethylene, iron, lead,
heavy concrete, for example. Inside the self-shielding member
4, in addition to the cyclotron 2, a vacuum pump and wires for
operating the cyclotron 2 are also arranged. Inside the
self-shielding member 4, configuration elements of the
radioisotope manufacturing unit 3 are also arranged.
[0015]
Theradioisotopemanufacturingunit3irradiatesthetarget
10 with the charged particle beam, and dissolves and recovers
the radioisotope generated by the irradiation. Theradioisotope
manufacturing unit 3 is formed near an outer peripheral part
of the cyclotron 2, and is located inside the self-shielding
member 4. A solution containing the radioisotope obtained by
the radioisotope manufacturingunit 3 is fed through a transport pipe 161 to a purifier for purifying the radioisotope in the solution or a device 160 such as a synthesizer for synthesizing a drug.
[0016]
Referring to Fig. 2, the target 10 will be described. The
target 10 includes a target substrate 13 and a metal layer 11.
Specifically, as illustrated in Fig. 2, in the target 10, the
metal layer 11 serving as a target material is formed on the
target substrate 13 made of a metal plate. The metal layer 11
is not limited to a metal layer with high purity, and may be
ametaloxidelayer. The target substrate13is setinthedevice,
and the metal layer 11 is irradiated with a charged particle
beam B, thereby generating a minute amount of a radioisotope
12 in the irradiated portion. In this manner, the radioisotope
12is containedin themetallayer11. As amaterialofthe target
substrate 13, a material which does not dissolve in the solution
isadopted. For example, Auor Pt is adopted. Although the target
substrate 13 illustrated in Fig. 2 is formed in a disk shape,
the shape or the thickness is not particularly limited. Examples
ofthematerialofthemetallayer11servingasthetargetmaterial
include 64Ni, 89Y, 10OMo, and 68Zn. As the radioisotope 12
generated corresponding to the metal layer 11, it is possible
to use 64Cu, 89Zr, 99mTc, and 68Ga. The metal layer 11is formed
byplatingafrontsurface10aofthetargetsubstrate13. Without
being limited to the plating process, a plate-shaped metal layer may be attached to the target substrate 13. The metal layer 11 illustrated in Fig. 2 is formed in a circular shape at the center positionofthe targetsubstrate13, butthe shape or the position is not particularly limited. Cooling water is supplied to a rear surface 10b of the target substrate 13 when the metal layer 11 is irradiated with the charged particle beam B. In this manner, heat generation of the metal layer 11 (and the target substrate
13) caused by irradiation of the charged particle beam B can
be absorbed by the cooling water.
[0017]
Next, referring to Fig. 3, a configuration of the
radioisotope manufacturing unit 3 will be described in detail.
The radioisotope manufacturing unit 3 includes a target holding
unit 20, a dissolutionunit 21, a transportunit 22, and a control
unit 50.
[00181
The target holding unit 20 holds the target 10 with the
metallayer 11at an irradiation position of the charged particle
beam B. In addition, the target holding unit 20 releases the
holding of the target 10 after the target 10 is completely
irradiated with the charged particle beam B. Specifically, the
targetholdingunit 20 includes a stationaryunit 23 andamovable
unit 24. The target holding unit 20 holds the target 10 at an
irradiation position RP by interposing the target 10 between
the stationary unit 23 and the movable unit 24. Both the stationary unit 23 and the movable unit 24 are accommodated inside the self-shielding member 4.
[0019]
The stationaryunit23is a tubularmember fixedto anouter
peripheral part of the cyclotron 2. The stationary unit 23 is
disposedsoas toprotrude fromtheouterperipheryofthecyclotron
2 in a state of extending along an irradiation axis BL of the
charged particle beam B emitted from the cyclotron 2. The
stationary unit 23 includes an internal space 26 for passing
the charged particle beam B at a position corresponding to the
irradiation axis BL of the charged particle beam B. The internal
space 26 is formed so as to extend along the irradiation axis
BL by setting the irradiation axis BL as a center line. The
stationary unit 23 and the internal space 26 are arranged so
as to be inclineddownwardwithrespect to ahorizontaldirection.
[00201
A lower end side of the stationary unit 23 has a surface
spreading in the horizontal direction, as a facing surface 23a
facing an upper surface of the movable unit 24. The stationary
unit 23 holds the target 10 at a position of the facing surface
23a. A sealing member such as an O-ring is disposed on the facing
surface 23a. The facing surface 23a comes into contact with the
target 10 via the sealing member, thereby functioning as a sealing
surface for the target 10. In the present embodiment, a location
where the internal space 26 is open on the facing surface 23a
(position of the irradiation axis BL in the opening) corresponds
to the irradiation position RP. Therefore, when the target
holding unit 20 holds the target 10, the target holding unit
20 holds the target 10 so that the metal layer 11 of the target
10 is located in the opening of the internal space 26.
[0021]
The stationary unit 23 includes a vacuum foil 25 at an
intermediate position of the internal space 26. The vacuum foil
25 maintains a vacuum state of an upstream side region of the
vacuum foil 25 in the internal space 26.
[00223
The stationary unit 23 has a flow path 27 which blows gas
such as helium to the charged particle beam B and the vacuum
foil 25 which are arranged at the irradiation position. Theflow
path 27 has a main flow path 27a and branch flow paths 27b and
27c branched from the main flow path 27a. The branch flow path
27b extends towards the vacuum foil 25, and blows the gas to
the vacuum foil 25. The branch flow path 27 c extends towards
the irradiation position RP of the target 10, and blows the gas
to the held target 10.
[0023]
The movable unit 24 moves forward to and rearward from the
stationary unit 23 in an upward-downward direction. When the
target 10 is installed in a transport tray 60, the movable unit
24is locatedatapositionseparated downwardfromthe stationary unit 23. When the target 10 is held at the irradiation position
RP, the movable unit 24 is located at a position where the target
10 is interposed between the stationary unit 23 and the movable
unit 24 (refer to Fig. 5).
[0024]
The movable unit 24 has a columnar shape extending in the
upward-downward direction. A portion of the outer peripheral
surface of the movable unit 24 is connected to a drive mechanism
28whichmovesintheupward-downwarddirection. Asmalldiameter
portion 29 projecting upward is formed in an upper end of the
movable unit 24. A diameter of the small diameter portion 29
is smaller than at least a diameter of an inner peripheral portion
ofthe transport tray 60 (tobedescribedlater). Inthismanner,
the small diameter portion 29 passes through a through-hole on
an inner peripheral side of the transport tray 60, comes into
contact with the target 10, and presses the target 10 against
the stationary unit 23 located above.
[0025]
Inthemovableunit24, anupperendsideofthesmalldiameter
portion 29 has a surface spreading in the horizontal direction,
as a facing surface 24a facing the facing surface 23a of the
stationary unit 23. The facing surface 24a has a sealing member
such as an O-ring. The facing surface 24a comes into contact
with the target 10 via the sealing member, thereby functioning
as the sealingsurface for the target10. When the targetholding unit 20 holds the target 10, the target 10 is interposed between the facing surface 23a and the facing surface 24a (refer to Fig.
5) .
[0026]
The movable unit 24 has an internal space 31 which is open
on the facing surface 24a. The internal space 31 is a space for
storing a cooling medium for cooling the target 10. A supply
pipe 32 for supplying the cooling medium and a discharge pipe
33 for discharging the cooling medium are connected to the internal
space 31.
[0027]
The dissolution unit 21 dissolves the metal layer 11
containing the radioisotope in the target 10. The dissolution
unit 21 includes a stationary unit 40 and a movable unit 41.
Thedissolutionunit21interposesandholds the target10between
the stationary unit 40 and the movable unit 41. The dissolution
unit 21 supplies a solution to at least the metal layer 11 in
a state where the target 10 is held, dissolves metal of the metal
layer11containingtheradioisotopeinthesolution, andrecovers
the solution together with the radioisotope. As the solution,
hydrochloricacidornitricacidis adopted. The stationaryunit
40 and the movable unit 41 are accommodated inside the
self-shielding member 4.
[00281
The stationary unit 40 is located at a position separated from the stationary unit 23 of the target holding unit 20 to a side opposite to the cyclotron 2. The stationary unit 40 includes a cylindrical main body portion 48 extending in the upward-downward direction and a support portion 49 supporting the main body portion 48 on the outer peripheral side. A lower end side of the main body portion 48 has a surface spreading in the horizontal direction, as a facing surface 40a facing the movable unit 41. The target 10 is held at the position of the facing surface 40a. The facing surface 40a has a sealing member such as an O-ring. The facing surface 40a comes into contact with the target 10 via the sealing member, thereby functioning as the sealing surface for the target 10. The target 10 is held at the position of the facing surface 40a.
[0029]
The main body portion 48 has an internal space 42 which
is open on the facing surface 40a. The internal space 42 is a
dissolving tank for storing the solution for dissolving themetal
layer 11 of the target 10. A supply pipe 43 for supplying the
solution and a suction pipe 44 for suctioning the solution and
suctioning the gas inside the internal space 42 are connected
to the internal space 42. The diameter of the internal space
42 which is open on the facing surface 40a is smaller than at
leastthediameterofthetarget10, andislargerthanthediameter
of the metal layer 11. The diameter of the facing surface 40a
itself is not particularly limited, but in the present embodiment, the diameter is smaller than the diameter of the target 10.
[0030]
The support portion 49 is a cylindrical member having an
end surface wall extending outward in a radial direction from
the outer peripheral surface of the main body portion 48. The
support portion 49 includes a through-hole 49a for inserting
the main body portion 48 at a centralposition. A flange portion
is formed near the upper end portion of the main body portion
48. The flange portion engages with an upper edge portion of
the through-hole 49a of the main body portion 48.
[0031]
The movable unit 41moves forward to and rearward from the
stationary unit 40 in the upward-downward direction. When the
target 10 is attached to the stationary unit 40, the movable
unit 41 is located at a position separated downward from the
stationary unit 40. When the metal layer 11 of the target 10
is dissolved by the dissolution unit 21, the movable unit 41
is located at apositionwhere the target10isinterposedbetween
the stationary unit 40 and the movable unit 41 (refer to Fig.
9).
[0032]
The movable unit 41 includes a main body portion 46 and
a plate receiving portion 47 disposed on the upper end side of
themainbodyportion 46. Themainbodyportion 46has acolumnar
shape extending in the upward-downward direction. Aportion of the outer peripheral surface of the main body portion 46 is connected to a drive mechanism (not illustrated) which moves in the upward-downward direction. The upper end of the mainbody portion 46 has a groove structure for supporting the plate receiving portion 47.
[0033]
The plate receiving portion 47 has a bottom wall portion
47a extending in the horizontal direction in the upper end of
the mainbody portion 46 and a side wallportion 47b rising upward
from the outer peripheral edge of the bottom wall portion 47a.
The bottom wall portion 47a has a surface spreading in the
horizontal direction, as a facing surface 41a facing the facing
surface 40a of the stationary unit 40. The facing surface 41a
comesintocontactwiththe target10. When the dissolutionunit
21 holds the target 10, the target 10 is interposed between the
facing surface 40a and the facing surface 41a (refer to Fig 9).
The inner diameter of the side wall portion 47b is larger than
the diameter of the target 10. In addition, when the target 10
is held, the upper end portion of the side wall portion 47b is
located at a position which is higher than that of the target
10. Therefore, in a case where the solution leaks out of the
internal space 42 when the metal layer 11 of the target 10 is
dissolved, the plate receivingportion 47 receives the solution.
A lower surface side of the bottom wallportion 47a has an uneven
structure for engaging with the groove structure of the main body portion 46.
[00341
In the dissolution unit 21, the main body portion 48 and
the plate receiving portion 47 which come into contact with the
solution are configured to serve as replaceable and disposable
components. That is, the main body portion 48 is detachably
attached to the support portion 49. The plate receiving portion
47 is detachably attached to the main body portion 46. Here,
the description of "detachable" indicates an attachment form
where the portions canbe detachedbyaworkercarryingoutnormal
maintenance work even if the portions are attached once. For
example, a detachable attachment structure includes an attachment
structure through bolt joining, and an attachment structure
through fitting or engaging with strength to such an extent that
theportionsarenotdetachedduringthedissolution. Forexample,
a fixing structure such as welding and fusing does not fall into
the detachable form. For example, as a material of the main body
portion48andtheplatereceivingportion47whicharereplaceable,
it is possible to use a material having high acid resistance,
such as Teflon (registered trademark).
[0035]
The transport unit 22 transports the target 10 from the
target holdingunit 20 to the dissolutionunit 21. Thetransport
unit 22 is located inside the self-shielding member 4. The
transport unit 22 includes a transport tray 60 for transporting the target 10 in a state where the target 10 is placed thereon, and a transport drive unit 61 for driving the transport tray
60. The transport tray 60 is an annular member having a support
portion for supporting the target 10 on the upper surface side.
The transport tray 60 has a groove portion formed over the entire
periphery in an inner peripheral side edge portion on the upper
surface, and the outer peripheral edge on the lower surface side
of the target 10 is placed on the groove portion. The transport
drive unit 61 is configured to include a combination of a drive
source andadrive force transmissionmechanism (notillustrated)
At least when the target 10 is transported to the dissolution
unit21afterthetarget10isirradiatedwiththechargedparticle
beam, the transport drive unit 61 moves the transport tray 60
inthehorizontaldirectionfromthepositionofthetargetholding
unit20, therebytransportingthe transporttray60totheposition
of the dissolution unit 21. The transport drive unit 61
transports the transport tray 60 from a region between the
stationary unit 23 and the movable unit 24 of the target holding
unit 20 to aregionbetween the stationary unit 40 and the movable
unit 41 of the dissolution unit 21. The transport drive unit
61 may be configured to adopt a known drive source such as a
rotary motor and a linear motor, and a drive force transmission
mechanism such as a gear and a rod. The transport drive unit
61 may adopt any configuration as long as the transport drive
unit 61 can avoid interference with other members andis configured to perform a desired operation. The position of the transport tray 60ateachstagewillbe describedindetailwhenanoperation thereof is described later.
[0036]
The control unit 50 controls the self-shielding cyclotron
system 100. The control unit 50 is configured to include a CPU,
a RAM, a ROM, and an input/output interface. The control unit
50 determines control content, based on a detection signal output
from each sensor inside the device and a program stored in the
ROM, and controls each configuration element inside the
self-shielding cyclotron system 100. The control unit 50 may
not be configured to include one processing device, and may be
configured to include a plurality of processing devices. The
control unit 50 may be located inside the self-shielding member
4, or may be located outside the self-shielding member 4.
[0037]
The control unit 50 includes an irradiation control unit
51, a holding control unit 52, a dissolution control unit 53,
and a transport control unit 54. The irradiation control unit
51 mainly controls the cyclotron 2, and controls an operation
relating to the irradiation of the charged particle beam B which
is performed by the cyclotron 2. The holding control unit 52
mainly controls the target holding unit 20, and controls an
operation relating to the holding of the target 10 which is
performedby the targetholdingunit20. The dissolutioncontrol unit 53 mainly controls the dissolution unit 21, and controls an operation relating to the dissolution of the metal layer 11 of the target 10. The transport control unit 54 mainly controls the transport unit 22, and controls an operation relating to the transport of the target 10. After the metal layer 11 is irradiatedwiththechargedparticlebeamB, thetransportcontrol unit 54 controls the transport unit 22 so as to transport the target 10 held by the target holding unit 20 to the dissolution unit 21.
[0038]
Next, referring to Figs. 3 to 9, an operation of the
self-shielding cyclotron system 100 will be described together
with content of a control process performed by the control unit
50. Fig.4is aflowchartillustratingthe contentofthe control
process performed by the control unit 50. Figs. 4 to 9 are views
illustrating a state of the radioisotope manufacturing unit 3
at each stage during the operation. For the sake ofdescription,
in Figs. 4 to 9, the control unit 50 and the transport drive
unit 61are omittedin the illustration. In addition, reference
numerals which are not used for the description may be
appropriately omitted in some cases.
[0039]
As illustrated in Fig. 4, the control unit 50 performs a
process for setting the target 10 in the radioisotope
manufacturing unit 3 (Step S1O). In the process in S10, the control unit 50 arranges the target holding unit 20, the dissolution unit 21, and the transport unit 22 at an initial stage position. The control unit 50 brings the radioisotope manufacturingunit 3 into a state illustratedin Fig. 3 by driving a drive unit of each configuration element. In this state, the movable unit 24 is located at a position separated downward from the stationary unit 23. The movable unit 41 is located at a position separated downward from the stationary unit 40. The transport tray 60 is located at a position separated downward from the stationary unit 23, which is a position of a reference height. Here, the "reference height" means a distance between the stationary unit 23 and the movable unit 24 in the height direction, and a predetermined height position between the stationaryunit40andthemovableunit41. Attheheightposition, the transport tray 60 does not interfere with the respective units 23, 24, 40, and 41 even if the transport tray 60 moves in the horizontal direction. The control unit 50 may cause a monitor to notify a worker that the target 10 can be set. If the worker detects that the target 10 is placed on the transport tray 60, the control unit 50 recognizes that the target 10 is completely set. The control unit 50 may detect that the target
10 is completely set, by means of sensor detection or by worker
inputting.
[0040]
Next, the control unit 50 performs a process for holding thetarget10attheirradiationpositionRPofthechargedparticle beam B (Step S20: Fig. 4). In S20, the holding control unit 52 of the control unit 50 controls the drive mechanism 28 of the movable unit 24 so as to move the movable unit 24 upward. In this manner, as illustrated in Fig. 5, the target 10 is brought into an interposed state between the stationary unit 23 and the movable unit 24 at the irradiation position RP. In a process while the movable unit 24 moves upwards, the target 10 placed on the transport tray 60 is supported by the movable unit 24 which passes through a through-hole of the transport tray 60 from below. In this case, the transport tray 60 may rise in a state ofbeing supported by the movable unit 24. Alternatively, the transport tray 60 may be driven so as to rise together with the movable unit 24.
[0041]
Next, thecontrolunit50performsaprocessforirradiating
the target 10 with the charged particle beam B (Step S30: Fig.
4). In S30, the irradiation control unit 51 of the control unit
50 irradiates the target 10 with the charged particle beam B
bycontrollingthecyclotron2. Inthiscase, theholdingcontrol
unit 52 controls a flow path system so that helium gas is blown
from the flow path 27 of the stationary unit 23 to the target
10 and the vacuum foil25. In addition, the holding controlunit
52 controls a pipeline system of the supply pipe 32 and the
discharge pipe 33 so as to coolthe target 10 by causing a cooling medium to flow into the internal space 31.
[0042]
If the process in S30 is completed, the holding control
unit 52 of the control unit 50 moves the movable unit 24 downward
by controlling the drive mechanism 28 of the movable unit 24.
In this manner, as illustrated in Fig. 6, the movable unit 24
returnstotheinitialstateposition. Inaddition, thetransport
tray 60 also return to the position of the reference height in
a state where the target 10 is placed thereon.
[00431
Next, the control unit 50 performs a process for
transporting the target 10 from the target holding unit 20 to
the dissolutionunit 21 (StepS40: Fig. 4). In S40, the transport
control unit 54 of the control unit 50 controls the transport
drive unit 61 (refer to Fig. 3) of the transport unit 22 so as
tohorizontallymove the transport tray 60fromthe targetholding
unit20tothepositionofthedissolutionunit21. Inthismanner,
asillustratedin Fig.7, the transport tray 60is locatedbetween
the stationary unit 40 and the movable unit 41while the position
of the reference height is maintained in the height direction.
In this manner, the target 10 is located at a position which
faces a lower side of the facing surface 40a having the internal
space 42 open.
[00441
Next, the control unit 50 performs a process for setting the target 10 in the dissolution unit 21 (Step 350: Fig. 4).
In S50, as illustrated in Fig. 8, the dissolution control unit
53 of the control unit 50 controls the pipeline system of the
suction pipe 44 so that the target 10 is adsorbed by the facing
surface 40a via the internal space 42. Before the target 10 is
adsorbed, the target 10 is pressed against the facing surface
40a of the main body portion 48 by raising the transport tray
60. In thismanner, theinternalspaceis sealedina statewhere
an 0-ring (not illustrated) disposed between the target 10 and
the main body portion 48 is crushed. Thereafter, the transport
control unit 54 controls the transport drive unit 61 (refer to
Fig. 3) so as to move the transport tray 60 to the position on
the target holding unit 20 side. In this manner, the transport
tray 60 is avoided from interfering with the movable unit 41.
[0045]
In 350, the dissolution controlunit 53 controls the drive
unit of the movable unit 41 so as to move the movable unit 41
upward. In this manner, as illustrated in Fig. 9, the target
10is broughtinto aninterposed state between the facing surface
40a of the stationary unit 40 and the facing surface 41a of the
movable unit 41. In this case, the target 10 is pressed against
the main body portion 48 fromabove ina state of being accommodated
in the plate receiving portion 47.
[0046]
Next, the controlunit 50performs aprocess for recovering the radioisotope contained in the metal layer 11 by causing the dissolution unit 21 to dissolve the metal layer 11 of the target
10 (Step S60: Fig. 4). In S60, the dissolution control unit 53
of the control unit 50 controls the pipeline system of the supply
pipe 43 so as to supply a solution SL from the supply pipe 43
to the internal space 42. In addition, the dissolution control
unit 53 controls the pipeline system of the suction pipe 44 so
that the suctionpipe 44 sucksandrecovers the solutionSLhaving
the radioisotope dissolved therein. According to the
above-described configuration, the controlprocess illustrated
in Fig. 4 is completed. After the radioisotope is completely
recovered, the worker removes the target 10 from each of the
main body portion 48 and the plate receiving portion 47, and
pulls out the target 10 from the self-shielding member 4.
[0047]
As illustrated in Fig. 1, the solution SL having the
radioisotope dissolved therein is discharged outward from the
self-shielding member 4, and is fed to the device 160 such as
a purifier for purifying the radioisotope contained in the
solution SL and a synthesizer for synthesizing a drug. The
purifierorthesynthesizermaybelocatedinside thesamebuilding
150, or may be located at another building. In a case of
transporting the solution SL to the synthesizer inside the same
building 150, the solution SL is fed to the synthesizer by the
transport pipe 161 connected to the suction pipe 44. Since the radioactive ray is emitted from the solution SL, the transport pipe 161 is covered with a shielding shield, or is caused to pass through a shielding wall (floor or wall) of the building
150. When the solution SL is transported to another building,
the recovered solution SL is stored in a shielding box (box which
prevents the radioactive ray from being released outward such
as aleadbox), and the shieldingbox together with the recovered
solution SL is transported using a vehicle.
[0048]
Next, an operation and an advantageous effect of the
self-shielding cyclotron system 100 according to the present
embodiment will be described.
[00491
In the self-shielding cyclotron system 100 according to
the present embodiment, the target holding unit 20 holds the
target having the metal layer 11 at the irradiation position
RP of the chargedparticle beamB. Therefore, the target10held
by the target holding unit 20 is irradiated with the charged
particle beam B. In this manner, the radioisotope 12 is formed
at the location irradiated with the charged particle beam B in
the metal layer 11 of the target 10. In addition, the dissolution
unit 21dissolves the metal layer 11 containing the radioisotope
in the target 10. In this manner, the radioisotope can be
recovered by recovering the solution. The transport unit 22
transports the target 10 from the target holding unit 20 where the target 10 is irradiated with the charged particle beam B tothedissolutionunit2lforrecoveringtheradioisotope. Here, the target holding unit 20, the dissolution unit 21, and the transport unit 22 are arranged inside the self-shielding member
4. Therefore, the step of irradiating the target 10 with the
charged particle beam B, the step of recovering the radioisotope
by means of dissolution, and the step of transporting the target
betweenboththestepsareallperformedinside theself-shielding
member 4. Therefore, in each step, the self-shielding member
4 shields the units from the radioactive ray emitted from the
target 10 after the target 10 is irradiated with the charged
particlebeam. According to the above-described configuration,
it is possible to further improve safety against radiation
exposure when the radioisotope is obtained.
[0050]
The self-shieldingcyclotronsystem100mayfurtherinclude
the controlunit 50. After the metallayer 11is irradiatedwith
the charged particle beam B, the control unit 50 may control
the transport unit 22 so as to transport the target 10 held by
the target holding unit 20 to the dissolution unit 21. In this
manner, transporting the target 10 by the transport unit 22 is
automatically controlledby the controlunit 50. Inthismanner,
it is possible to further improve the safety against the radiation
exposure. In addition, since the control unit 50 automatically
transports the target10, itispossible toshortenworkinghours.
[00511
Thepresentinventionisnotlimitedtothe above-described
embodiments, and various modifications as described below can
bemadewithin the scopenotdepartingfromthe gistofthepresent
invention.
[0052]
For example, a configuration as illustrated in Fig. 10 may
be adopted. The self-shielding cyclotron systemillustrated in
Fig. 10 may include an accommodation unit 70 for covering the
dissolution unit 21 inside the self-shielding member 4, and an
exhaust unit 71 for exhausting the gas inside the accommodation
unit 70 outward from the self-shielding member 4. The
accommodation unit 70 covers only the dissolution unit 21 without
covering the target holding unit 20. In the accommodation unit
70, an opening 70a may be formed in a location through which
the transport tray passes. The opening 70a may be closed when
the transport-tray does not pass therethrough. In addition, the
exhaust unit 71 may have an exhaust pipe communicating with the
outside of the self-shielding member 4 after passing from the
accommodation unit 70 through the self-shielding member 4. The
exhaust unit 71may include a pump disposed in the exhaust pipe.
[0053]
In this manner, in a case where the solution of the
dissolution unit 21vaporizes, the accommodation unit 70 prevents
the gas from being diffused into the self-shielding member 4.
In addition, the gas in the accommodation unit 70 is discharged
outward from the self-shielding member 4 by the exhaust unit
71. In this manner, it is possible to prevent other equipment
inside the self-shielding member 4 from being corroded by the
gas.
[0054]
In addition, the configuration of the radioisotope
manufacturing unit illustrated in each drawing of the
above-described embodiments is merely an example, and the shape
or the arrangementmay be appropriately changed within the scope
of the present invention. For example, instead of the transport
tray, the transport unit may adopt an arm-shaped gripping portion
for gripping the target.
[0055]
Transporting the target by the transport unit is
automatically controlled by the control unit. Alternatively,
the transport unit may be manually driven by the worker. Even
in this case, since the target is accommodated inside the
self-shielding member, it is possible to further improve the
safety against the radiation exposure.
Brief Description of the Reference Symbols
[0056]
2: cyclotron
4: self-shielding member
10: target
11: metal layer
20: target holding unit
21: dissolution unit
22: transport unit
50: control unit
70: accommodation unit
71: exhaust unit
100: self-shielding cyclotron system
Claims (3)
1. Aself-shielding cyclotron systemincluding acyclotron that
emits a charged particle beam, and a self-shielding member that
is located inside a building, and that internally accommodates
the cyclotron so as to prevent a radioactive ray emitted from
the cyclotron frombeingemitted outward, the systemcomprising:
a target holding unit that holds a target having a metal
layer at an irradiation position of the charged particle beam;
adissolutionunitthatdissolvesthemetallayercontaining
a radioisotope in the target; and
a transportunit that transports the target from the target
holding unit to the dissolution unit,
wherein the target holdingunit, the dissolution unit, and
the transportunitare arrangedinside the self-shieldingmember.
2. The self-shielding cyclotron system according to claim 1,
further comprising:
a control unit,
whereinafter themetallayerisirradiatedwiththe charged
particle beam, the control unit controls the transport unit so
as to transport the target held by the target holding unit to
the dissolution unit.
3. The self-shielding cyclotron system according to claim 1 or
1003104705 33
2, further comprising:
an accommodation unit that covers the dissolution unit
inside the self-shielding member; and
an exhaust unit that causes gas inside the accommodation
unit to be exhausted outward from the self-shielding member.
1 / 10
2 / 10
3 / 10
4 / 10
5 / 10
6 / 10
7 / 10
8 / 10
9 / 10
10 / 10
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2019201117A AU2019201117B1 (en) | 2019-02-18 | 2019-02-18 | Self-shielding cyclotron system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2019201117A AU2019201117B1 (en) | 2019-02-18 | 2019-02-18 | Self-shielding cyclotron system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2019201117B1 true AU2019201117B1 (en) | 2020-09-03 |
Family
ID=72235090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2019201117A Active AU2019201117B1 (en) | 2019-02-18 | 2019-02-18 | Self-shielding cyclotron system |
Country Status (1)
| Country | Link |
|---|---|
| AU (1) | AU2019201117B1 (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000019450A1 (en) * | 1998-09-29 | 2000-04-06 | Gems Pet Systems Ab | Integrated radiation shied |
| JP2007248309A (en) * | 2006-03-16 | 2007-09-27 | Sumitomo Heavy Ind Ltd | Radiopharmaceutical manufacturing system |
| JP2009085970A (en) * | 2008-12-15 | 2009-04-23 | Sumitomo Heavy Ind Ltd | Self-shielding particle accelerator system |
| US20090194713A1 (en) * | 2006-06-02 | 2009-08-06 | Frederic Stichelbaut | Shielding for ionizing radiation |
| US20120223254A1 (en) * | 2011-03-02 | 2012-09-06 | Sumitomo Heavy Industries, Ltd. | Ri manufacturing apparatus |
| JP2012207966A (en) * | 2011-03-29 | 2012-10-25 | Jfe Technos Corp | Radiation shield member of cyclotron for pet diagnosis and construction method therefor |
| JP2014115229A (en) * | 2012-12-11 | 2014-06-26 | Sumitomo Heavy Ind Ltd | Radioisotope refiner |
| US20170345523A1 (en) * | 2016-05-25 | 2017-11-30 | Ion Beam Applications, S.A. | Isotope production apparatus |
| WO2019023787A1 (en) * | 2017-07-31 | 2019-02-07 | Stefan Zeisler | System, apparatus and method for producing gallium radioisotopes on particle accelerators using solid targets and ga-68 composition produced by same |
-
2019
- 2019-02-18 AU AU2019201117A patent/AU2019201117B1/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000019450A1 (en) * | 1998-09-29 | 2000-04-06 | Gems Pet Systems Ab | Integrated radiation shied |
| JP2007248309A (en) * | 2006-03-16 | 2007-09-27 | Sumitomo Heavy Ind Ltd | Radiopharmaceutical manufacturing system |
| US20090194713A1 (en) * | 2006-06-02 | 2009-08-06 | Frederic Stichelbaut | Shielding for ionizing radiation |
| JP2009085970A (en) * | 2008-12-15 | 2009-04-23 | Sumitomo Heavy Ind Ltd | Self-shielding particle accelerator system |
| US20120223254A1 (en) * | 2011-03-02 | 2012-09-06 | Sumitomo Heavy Industries, Ltd. | Ri manufacturing apparatus |
| JP2012207966A (en) * | 2011-03-29 | 2012-10-25 | Jfe Technos Corp | Radiation shield member of cyclotron for pet diagnosis and construction method therefor |
| JP2014115229A (en) * | 2012-12-11 | 2014-06-26 | Sumitomo Heavy Ind Ltd | Radioisotope refiner |
| US20170345523A1 (en) * | 2016-05-25 | 2017-11-30 | Ion Beam Applications, S.A. | Isotope production apparatus |
| WO2019023787A1 (en) * | 2017-07-31 | 2019-02-07 | Stefan Zeisler | System, apparatus and method for producing gallium radioisotopes on particle accelerators using solid targets and ga-68 composition produced by same |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101788675B1 (en) | Neutron capture therapy system | |
| JP4130680B2 (en) | Treatment apparatus and bed positioning apparatus using ion beam | |
| US5917874A (en) | Accelerator target | |
| JP6152341B2 (en) | Self-shielding targets for isotope production systems | |
| KR101731436B1 (en) | Neutron capture therapy system | |
| CN107736081B (en) | Target assembly isotope production system with vibrating device and target assembly | |
| JP2018190711A (en) | System and method for making solid target within production chamber of target assembly | |
| JP5875135B2 (en) | RI manufacturing equipment | |
| JP2016080574A (en) | Radioactive medicine production system, radioactive medicine production device, and method for producing radioactive medicine | |
| JP6914870B2 (en) | Radioisotope production equipment | |
| KR102362279B1 (en) | System for the irradiation of a target material | |
| JP5968804B2 (en) | Neutron capture therapy system and mounting table for neutron capture therapy | |
| JP6979334B2 (en) | Self-shielding cyclotron system | |
| AU2019201117B1 (en) | Self-shielding cyclotron system | |
| JP6591318B2 (en) | Neutron capture therapy system | |
| KR102625405B1 (en) | Self-shielding cyclotron system | |
| JPWO2003081604A1 (en) | Mobile accelerator system and radionuclide production method | |
| JP7084446B2 (en) | Nuclide production equipment using liquid target | |
| TWI684184B (en) | Self-shielding cyclotron system | |
| WO2020196793A1 (en) | Target irradiation system, and recovery method for radioactive isotope from solid target | |
| US20220254537A1 (en) | Method And Apparatus For Production Of Radiometals And Other Radioisotopes Using A Particle Accelerator | |
| JP6741556B2 (en) | Target container and method for manufacturing target container | |
| CN111465165A (en) | Self-shielded cyclotron system | |
| JP6450211B2 (en) | Mobile radionuclide production irradiation equipment | |
| JP2013055989A (en) | Charged particle radiation irradiation apparatus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |