AU2019101308A4 - Analyzing apparatus for after cataract in rabbit eyes based on image gray calculation and analysis, and evaluation method of after cataract severity - Google Patents

Analyzing apparatus for after cataract in rabbit eyes based on image gray calculation and analysis, and evaluation method of after cataract severity Download PDF

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AU2019101308A4
AU2019101308A4 AU2019101308A AU2019101308A AU2019101308A4 AU 2019101308 A4 AU2019101308 A4 AU 2019101308A4 AU 2019101308 A AU2019101308 A AU 2019101308A AU 2019101308 A AU2019101308 A AU 2019101308A AU 2019101308 A4 AU2019101308 A4 AU 2019101308A4
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Yuemei HAN
Quankui LIN
Junmei TANG
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Wenzhou Medical University
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Abstract

The present invention provides an analyzing apparatus for an after cataract in rabbit eyes based on image gray calculation and analysis, and an evaluation method for the severity of an after cataract in rabbit eyes; the present invention performs a grey level analysis on an obtained picture of the capsule containing intraocular lens by image processing to obtain grey level of each zone, thus objectively evaluating the severity of the after cataract and avoiding individual difference and subjective factors caused by artificial grading; the method of the present invention is a convenient, feasible, objective and rigorous method to study the evaluation of the severity of the after cataract after artificial lens implantation.

Description

ANALYZING APPARATUS FOR AFTER CATARACT IN RABBIT EYES BASED ON IMAGE GRAY CALCULATION AND ANALYSIS, AND EVALUATION METHOD OF AFTER CATARACT SEVERITY
TECHNICAL FIELD
The present invention relates to the technical field of the evaluation on the severity of complications after ophthalmic intraocular lens implantation, and in particular to an analyzing apparatus for an after cataract in rabbit eyes based on image gray calculation and analysis, and an evaluation method for after cataract severity.
BACKGROUND
Cataract is a most common blindness-leading eye disease. The combination of ultrasonic emulsification and intraocular lens implantation is an effective method in the clinic treatment of cataract. The various existing intraocular lenses, including hydrophilic and hydrophobic one, usually cause foreign body reaction after implanted into human eyes for a long time, thus greatly decreasing visual quality. An after cataract refers that lens capsule encounters turbid once again after intraocular lens is implanted, and it is a major complication to seriously affect patients’ vision recovery after receiving the intraocular lens implantation. Generally, for adult, the incidence of an after cataract within 5 years after receiving cataract surgery may be up to nearly 30%; while for children, the incidence is higher.
Researches indicate that: the main reason of an after cataract lies in that lens epithelial cells are broken, stimulated and incompletely removed in surgery, and finally adhered on the surface of the intraocular lens material for hyperplasia after surgery. In existing studies, the incidence of the after cataract after intraocular lens implantation is reduced by new shape design of intraocular lens or material surface modification: such as a Chinese patent CN103948965B “Surface modified intraocular lens and surface modification method, a Chinese patent CN103405807B Surface comblike polymer hydrophilic modified intraocular lens and preparation method thereof', a Chinese patent CN100344269C surface phospholipid-modified flexible intraocular lens and manufacturing method thereof', a Chinese patent CN1665553A Surface-modified intraocular lenses, a Chinese patent CN1219497C hydrophobic intraocular lens treated by front surface hydrophilization and manufacturing method thereof', a Chinese patent CN1200739C Alpha-allyl glucoside surface-modified intraocular lens and manufacturing method thereof', a Chinese patent CN106362205A Zwitterionic surface-modified intraocular lens and preparation method thereof', a Chinese patent CN101053680A intraocular lens with anti-proliferous medicine coating for preventing after cataract forming, a Chinese patent CN101036804A
2019101308 29 Oct 2019
Nanometer fluorouracil coat intraocular lens and preparation method thereof, a Chinese patent CN200973766Y intraocular lens for preventing after cataract, a Chinese patent CN2531755Y Slow-releasing agent carried intraocular lens and a Chinese patent CN200810061511 surface anti-TGF (transforming growth factor) β2 antibody membrane intraocular lens, etc. So, the evaluation on the severity of the intraocular lens an after cataract appears to be particularly important during study process, and it is a key indicator to evaluate whether the improved intraocular lens has the effect of lowering the incidence of an after cataract. One of the conventional methods is to observe eyes of a living animal by a slit lamp, but the method is limited to the observation range of the capsule (generally, 6 mm optical zone may be observed, but periphery of the capsule may be not observed); in addition, the most common conventional method is to carry out subjective scoring to the obtained pictures of the capsule containing intraocular lens respectively by two experienced clinicians, then to obtain the mean value. Specific scoring criteria: no posterior capsule opacification: 0; mild posterior capsule opacification: 1; moderate posterior capsule opacification: 2; severe posterior capsule opacification: 3. The concepts no, mild, moderate and severe considerably vary from individual subjective consciousness, causing that the obtained results may not always reflect the real severity of the after cataract. Therefore, the scoring method is not enough scientific and rigorous. In specific study process, it is observed that the more severe the posterior capsule opacification is (namely, the higher the incidence of an after cataract is), the less the light penetrating the capsule tissue is, and it shows the difference varying from colorlessness and transparency, gray to black under stereoscopic microscope. With the increase of the severity of an after cataract, tissue density increases and it turns to black more.
SUMMARY
To overcome the insufficiency of the method for evaluating an after cataract after implanting intraocular lens in existing studies, an objective of the present invention is to provide an analyzing apparatus for an after cataract in rabbit eyes based on image gray calculation and analysis, and an objective evaluation method for the severity of an after cataract in rabbit's eyes, and software is used to analyze the grey level of capsule to reflect the severity of an after cataract, free from the interference of human subjective factors, therefore, the method is more rigorous.
The technical solution of the present invention: an analyzing apparatus for an after cataract in rabbit eyes based on image gray calculation and analysis, where, the analyzing apparatus includes a capturing unit for capturing a microscopic image of completely separating a dead rabbit's eye capsule containing intraocular lens, an image processing unit for performing image gray
2019101308 29 Oct 2019 treatment to the captured microscopic image of completely separating dead rabbit's eye capsule containing intraocular lens, a calculation model for calculating the grey level of a central optical zone, a peripheral optical zone and capsule periphery beyond the optical zone of the microscopic image, and an evaluation model for evaluating the severity of the after cataract after intraocular lens implantation, the capturing unit is used for capturing to obtain a picture of the rabbit's eye capsule containing intraocular lens by a stereomicroscope;
the image processing unit is used for selecting a scope of the central optical zone with 3 mm center diameter of the intraocular lens on the picture according to a picture box of intraocular lens, selecting a scope of the whole optical zone with 6 mm center diameter of the intraocular lens on the picture according to the picture box of intraocular lens, and selecting a scope of the whole capsule on the picture according to a capsule form box, performing image processing to obtain gray level images of the above central optical zone, whole optical zone and the whole capsule zone, and to obtain the accumulative density and area respectively of the central optical zone, whole optical zone and the whole capsule zone;
the calculation model is used for calculating the grey level of the central optical zone, peripheral optical zone and capsule periphery beyond the optical zone according to the accumulative density and area of the central optical zone, whole optical zone and the whole capsule zone, where grey level of the central optical zone=accumulative density of the central optical zone/area of the central optical zone;
grey level of the peripheral optical zone=(accumulative density of the whole optical zone accumulative density of the central optical zone)/(area of the whole optical zone - area of the central optical zone);
grey level of the capsule periphery beyond the optical zone=(accumulative density of the whole capsule zone - accumulative density of the whole optical zone)/(area of the whole capsule zone - area of the whole optical zone);
the evaluation model is used for evaluating the obtained grey level of the central optical zone, the peripheral optical zone and the capsule periphery beyond the optical zone, where a larger number indicates a severer after cataract.
Illumination intensity is 0-1000Lx; exposure time is 1 ms-10 s; resolution is 1280χ960,
2019101308 29 Oct 2019
2><2Bining; amplification times is 0.75 when the stereomicroscope of the capturing unit works.
The grey level of the central optical zone, the peripheral optical zone and the capsule periphery beyond the optical zone ranges from 0 to 255, 0 denotes absolute black and 255 denotes pure white.
An objective evaluation method for severity of an after cataract in rabbit's eyes based on image gray calculation and analysis, including the following steps:
(1) completely separating a dead rabbit's eye capsule containing intraocular lens, and capturing to obtain a picture of the rabbit's eye capsule containing intraocular lens by a stereomicroscope;
(2) processing the rabbit's eye capsule containing intraocular lens by the image processing unit, selecting a scope of the central optical zone with 3 mm center diameter of the intraocular lens on the picture according to the picture box of intraocular lens, selecting a scope of the whole optical zone with 6 mm center diameter of the intraocular lens on the picture according to the picture box of intraocular lens, and selecting a scope of the whole capsule on the picture according to a capsule form box, performing image processing to obtain gray level images of the above central optical zone, whole optical zone and the whole capsule zone, and to obtain the accumulative density and area respectively of the central optical zone, whole optical zone and the whole capsule zone;
(3) calculating to obtain the grey level of the central optical zone, peripheral optical zone and capsule periphery beyond the optical zone according to the accumulative density and area of the central optical zone, whole optical zone and the whole capsule zone, grey level of the central optical zone=accumulative density of the central optical zone/area of the central optical zone;
grey level of the peripheral optical zone=(accumulative density of the whole optical zoneaccumulative density of the central optical zone)/(area of the whole optical zone - area of the central optical zone);
grey level of the capsule periphery beyond the optical zone=(accumulative density of the whole capsule zone - accumulative density of the whole optical zone)/(area of the whole capsule zone - area of the whole optical zone);
(4) evaluating the obtained grey level of the central optical zone, the peripheral optical zone and the capsule periphery beyond the optical zone, where a larger number indicates a severer
2019101308 29 Oct 2019 after cataract.
Illumination intensity is 0-1000Lx; exposure time is 1 ms-10 s; resolution is 1280χ960, 2x2Bining; amplification times is 0.75 when the stereomicroscope works.
The grey level of the central optical zone, the peripheral optical zone and the capsule periphery beyond the optical zone ranges from 0 to 255, 0 denotes absolute black and 255 denotes pure white.
Beneficial effects of the present invention: the present invention provides an analyzing apparatus for an after cataract in rabbit eyes based on image gray calculation and analysis and an objective evaluation method for the severity of an after cataract in rabbit's eyes; the present invention performs a grey level analysis on an obtained picture of the capsule containing intraocular lens by image processing to obtain the grey level of each zone, thus objectively evaluating the severity of the after cataract and avoiding individual difference and subjective factors caused by artificial grading; it is a convenient, feasible, objective and rigorous method to study the evaluation of the severity of the after cataract after artificial lens implantation.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a schematic diagram showing a gradual change of grey level from small to large.
FIG. 2 is a picture showing rabbit's eye capsule containing intraocular lens.
FIG. 3 shows 3 zones (A: central optical zone; B: peripheral optical zone; C: capsule periphery beyond the optical zone) for scoring the severity of an after cataract of the rabbit's eye capsule containing intraocular lens.
FIG. 4: a scope of the central optical zone (center diameter: 3 mm) of the intraocular lens, and area, average gray level and accumulated area calculated by Photoshop.
FIG. 5: a scope of the whole optical zone (center diameter: 6 mm) of the intraocular lens, and area, average gray level and accumulated area calculated by Photoshop.
FIG. 6: a scope of the whole capsule, and area, average gray level and accumulated area calculated by Photoshop.
DETAILED DESCRIPTION
To describe the content of the present invention more clearly, detailed embodiments are employed for description below and are not considered to limit the scope of the present invention.
2019101308 29 Oct 2019
Embodiment 1: Acquisition of the picture of the rabbit's eye capsule containing intraocular lens
A dead rabbit's eye capsule containing intraocular lens was separated completely, and the obtained rabbit's eye capsule containing intraocular lens was put onto an objective table right above a stereomicroscope for capturing a picture of the rabbit's eye capsule containing intraocular lens in the conditions of 500 Lx illumination intensity, 3 ms exposure time, 1280χ96 and 2><2Bining resolution and 0.75 amplification times, as shown in FIG. 2.
Embodiment 2: Division of different zones of the rabbit's eye capsule containing intraocular lens
Based upon functional zones of the intraocular lens and evaluation division of the whole capsule an after cataract, the acquired picture of the rabbit's eye capsule containing intraocular lens (as shown in FIG. 2) was partitioned into a central optical zone, a peripheral optical zone and capsule periphery beyond the optical zone of intraocular lens, respectively corresponding to a central optical zone (FIG. 3-yellow zone A) with 3 mm center diameter in intraocular lens, a circular peripheral optical zone (FIG. 3-purple zone B) with 1.5 mm ring width in the intraocular lens optical zone after removing the 3 mm-diameter central optical zone and a capsule periphery (FIG. 3-red zone C) in the capsule after removing the intraocular lens optical zone.
Embodiment 3: Analysis calculation of the grey level in each zone of the rabbit's eye capsule containing intraocular lens
Photoshop software was used to open the picture of the rabbit's eye capsule containing intraocular lens, and to select a scope of the artificial lens central optical zone with 3 mm center diameter (as shown in FIG. 4-zone 4) according to a picture box of artificial lens; a command of image-reverse phase-analysis measurement was used to obtain the average gray level, accumulative density and area (Table 1) of the intraocular lens central optical zone;
then a scope of the intraocular lens whole optical zone with 6 mm center diameter (FIG. 5-zone E) was selected according to the picture box of artificial lens; a command of image-reverse phase-analysis measurement was used to obtain the average gray level, accumulative density and area (Table 1) of the intraocular lens whole optical zone;
afterwards, a scope of the whole capsule (FIG. 6-zone F) according to the capsule form box; a command of image-reverse phase-analysis measurement was used to obtain the average gray level, accumulative density and area (Table 1) of the intraocular lens whole capsule zone.
2019101308 29 Oct 2019
The grey level in different zones was calculated by the following method:
average gray level of zone A=grey level measured directly average gray level of zone B=(E accumulative density - D accumulative density )/(E area D area) average gray level of zone C=(F accumulative density - E accumulative density )/(F area - E area) then the average gray level of zones A, B and C (Table 2) were calculated to respectively denote the grey level of the central optical zone, peripheral optical zone and Sommering’s ring zone for evaluating the severity of the intraocular lens an after cataract.
Table 1: Original data measured by Photoshop
Area Gray level (average value) Accumulative density
Central optical zone (D) of crystalline lens 319712 79.212254 25325108
Optical zone (E) of crystalline lens 1278916 58.635383 74989730
Whole capsule (F) 3392006 54.402332 184533035
Table 2: Data obtained by calculation
Grey level (average value)
Central optical zone (A) of intraocular lens 79.212254
Peripheral optical zone (B) of intraocular lens 51.77691294
Capsule periphery (C) beyond the optical zone 51.84034045
It should be understood by those skilled in the art that although the present invention has been described in terms of the above specific embodiments, however, the inventive concept of the present invention is not limited thereto.
The embodiments described above are only preferred embodiments of the present invention, and are not intended to limit the scope of the present invention. Various modifications and improvements performed on the technical solution of the present invention by those skilled in the art without departing from the design spirit of the present invention shall fall within the protection scope as defined by the claims of the present invention. It should be pointed out that for a person of ordinary skilled in the art, several improvements and modifications may further be made without departing from the principle of the present invention, and the improvements and
2019101308 29 Oct 2019 modifications should also be considered to fall within the protection scope of the present invention.

Claims (5)

  1. (1) completely separating a dead rabbit's eye capsule containing intraocular lens, and capturing to obtain a picture of the rabbit's eye capsule containing intraocular lens by a stereomicroscope;
    1. An analyzing apparatus for an after cataract in rabbit eyes based on image gray calculation and analysis, wherein, the analyzing apparatus comprises a capturing unit for capturing a microscopic image of completely separating a dead rabbit's eye capsule containing intraocular lens, an image processing unit for performing image gray processing on the captured microscopic image of completely separating dead rabbit's eye capsule containing intraocular lens, a calculation model for calculating the grey level of a central optical zone, a peripheral optical zone and capsule periphery beyond the optical zone of the microscopic image, and an evaluation model for evaluating the severity of the after cataract after intraocular lens implantation, wherein the capturing unit is used for capturing to obtain a picture of the rabbit's eye capsule containing intraocular lens by a stereomicroscope;
    the image processing unit is used for selecting a scope of the central optical zone with 3 mm center diameter of the intraocular lens on the picture according to a picture box of intraocular lens, selecting a scope of the whole optical zone with 6 mm center diameter of the intraocular lens on the picture according to the picture box of intraocular lens, and selecting a scope of the whole capsule on the picture according to a capsule form box, performing image processing to obtain gray level images of the above central optical zone, whole optical zone and the whole capsule zone, and to obtain the accumulative density and area respectively of the central optical zone, whole optical zone and the whole capsule zone;
    the calculation model is used for calculating the grey level of the central optical zone, peripheral optical zone and capsule periphery beyond the optical zone according to the accumulative density and area of the central optical zone, whole optical zone and the whole capsule zone, grey level of the central optical zone=accumulative density of the central optical zone/area of the central optical zone;
    grey level of the peripheral optical zone=(accumulative density of the whole optical zone accumulative density of the central optical zone)/(area of the whole optical zone - area of the central optical zone);
    grey level of the capsule periphery beyond the optical zone=(accumulative density of the whole capsule zone - accumulative density of the whole optical zone)/(area of the whole capsule zone - area of the whole optical zone);
    2019101308 29 Oct 2019 the evaluation model is used for evaluating the obtained grey level of the central optical zone, the peripheral optical zone and the capsule periphery beyond the optical zone, wherein a larger number indicates a severer after cataract.
  2. (2) processing the rabbit's eye capsule containing intraocular lens by the image processing unit, selecting a scope of the central optical zone with 3 mm center diameter of the intraocular lens on the picture according to the picture box of intraocular lens, selecting a scope of the whole optical zone with 6 mm center diameter of the intraocular lens on the picture according to the picture box of intraocular lens, and selecting a scope of the whole capsule on the picture according to a capsule form box, performing image processing to obtain gray level images of the above central optical zone, whole optical zone and the whole capsule zone, and to obtain the accumulative density and area respectively of the central optical zone, whole optical zone and the whole capsule zone;
    2. The analyzing apparatus for an after cataract in rabbit eyes based on image gray calculation and analysis according to claim 1, wherein illumination intensity is 0-1000 Lx; exposure time is 1 ms-10 s; resolution is 1280χ960, 2><2Bining; amplification times is 0.75 when a stereomicroscope of the capturing unit works.
  3. (3) calculating to obtain the grey level of the central optical zone, peripheral optical zone and capsule periphery beyond the optical zone according to the accumulative density and area of the central optical zone, whole optical zone and the whole capsule zone, wherein grey level of the central optical zone=accumulative density of the central optical zone/area of the central optical zone;
    grey level of the peripheral optical zone=(accumulative density of the whole optical zone 11
    2019101308 29 Oct 2019 accumulative density of the central optical zone)/(area of the whole optical zone - area of the central optical zone);
    grey level of the capsule periphery beyond the optical zone=(accumulative density of the whole capsule zone - accumulative density of the whole optical zone)/(area of the whole capsule zone - area of the whole optical zone);
    3. The analyzing apparatus for an after cataract in rabbit eyes based on image gray calculation and analysis according to claim 2, wherein the grey level of the central optical zone, the peripheral optical zone and the capsule periphery beyond the optical zone ranges from 0 to 255, 0 denotes absolute black and 255 denotes pure white.
  4. (4) evaluating the obtained grey level of the central optical zone, the peripheral optical zone and the capsule periphery beyond the optical zone, wherein a larger number indicates a severer an after cataract.
    4. An objective evaluation method for the severity of an after cataract in rabbit eyes based on image gray calculation and analysis, comprising the following steps:
  5. 5. The objective evaluation method for the severity of an after cataract in rabbit eyes based on image gray calculation and analysis according to claim 4, wherein illumination intensity is 0-1000 Lx; exposure time is 1 ms-10 s; resolution is 1280χ960, 2><2Bining; amplification times is 0.75 when the stereomicroscope works, preferably, wherein the grey level of the central optical zone, the peripheral optical zone and the capsule periphery beyond the optical zone ranges from 0 to 255, 0 denotes absolute black and 255 denotes pure white.
AU2019101308A 2018-10-31 2019-10-29 Analyzing apparatus for after cataract in rabbit eyes based on image gray calculation and analysis, and evaluation method of after cataract severity Ceased AU2019101308A4 (en)

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