AU2018375298A1 - Methods and pharmaceutical compositions for the treatment of non-alcoholic steatohepatitis - Google Patents
Methods and pharmaceutical compositions for the treatment of non-alcoholic steatohepatitis Download PDFInfo
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- AU2018375298A1 AU2018375298A1 AU2018375298A AU2018375298A AU2018375298A1 AU 2018375298 A1 AU2018375298 A1 AU 2018375298A1 AU 2018375298 A AU2018375298 A AU 2018375298A AU 2018375298 A AU2018375298 A AU 2018375298A AU 2018375298 A1 AU2018375298 A1 AU 2018375298A1
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- Prior art keywords
- pirfenidone
- administered
- ubenimex
- nash
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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- A—HUMAN NECESSITIES
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762591667P | 2017-11-28 | 2017-11-28 | |
| US62/591,667 | 2017-11-28 | ||
| PCT/US2018/062645 WO2019108551A1 (en) | 2017-11-28 | 2018-11-27 | Methods and pharmaceutical compositions for the treatment of non-alcoholic steatohepatitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2018375298A1 true AU2018375298A1 (en) | 2020-05-28 |
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|---|---|---|---|
| AU2018375298A Abandoned AU2018375298A1 (en) | 2017-11-28 | 2018-11-27 | Methods and pharmaceutical compositions for the treatment of non-alcoholic steatohepatitis |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20210369693A1 (https=) |
| EP (1) | EP3716975A4 (https=) |
| JP (1) | JP2021504479A (https=) |
| CN (1) | CN111386115A (https=) |
| AU (1) | AU2018375298A1 (https=) |
| CA (1) | CA3082178A1 (https=) |
| WO (1) | WO2019108551A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| BE1031925B1 (de) * | 2024-06-03 | 2025-10-30 | Univ Guizhou Medical | Eine orale, leberzielgerichtete nanoemulsion zur beladung mit pirfenidon sowie deren herstellungsverfahren und anwendung |
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| EP3518918A4 (en) | 2016-09-28 | 2020-04-22 | Eiger Biopharmaceuticals, Inc. | METHOD AND PHARMACEUTICAL COMPOSITIONS FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS |
| WO2023220003A1 (en) * | 2022-05-10 | 2023-11-16 | Opko Pharmaceuticals, Llc | Topical ophthalmic pirfenidone-loaded liposomes to increase the therapeutic activity of the drug in cornea and useful for prevention or therapy of corneal haze |
Family Cites Families (9)
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| CN1098249C (zh) * | 1995-06-21 | 2003-01-08 | 国家医药管理局四川抗菌素工业研究所 | 乌比美克及含乌比美克的药物组合物治疗病毒性肝炎的用途 |
| WO2001058448A1 (fr) * | 2000-02-09 | 2001-08-16 | Shionogi & Co., Ltd. | Inhibiteur d'apoptose |
| US20080025986A1 (en) * | 2003-06-06 | 2008-01-31 | Ozes Osman N | Methods of Treating Tnf-Mediated Disorders |
| US9233089B2 (en) * | 2012-03-23 | 2016-01-12 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of pulmonary hypertension with leukotriene inhibitors |
| CA2819967C (en) * | 2012-08-31 | 2016-03-22 | Intermune, Inc. | Use of pirfenidone concomitantly with ciprofloxacin |
| AU2016348638A1 (en) * | 2015-11-06 | 2018-06-07 | Gemphire Therapeutics Inc. | Gemcabene combinations for the treatment of cardiovascular disease |
| WO2017108744A1 (de) * | 2015-12-22 | 2017-06-29 | Bayer Pharma Aktiengesellschaft | Neue substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
| EP3518918A4 (en) * | 2016-09-28 | 2020-04-22 | Eiger Biopharmaceuticals, Inc. | METHOD AND PHARMACEUTICAL COMPOSITIONS FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS |
| MX364040B (es) * | 2016-11-11 | 2019-04-11 | Cell Therapy And Tech S A De C V | Uso farmacéutico de una composición que contiene pirfenidona de liberación prolongada (pfd-lp) para la reversión y tratamiento de la esteatohepatitis humana (nafld/nash). |
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2018
- 2018-11-27 EP EP18883621.7A patent/EP3716975A4/en not_active Withdrawn
- 2018-11-27 WO PCT/US2018/062645 patent/WO2019108551A1/en not_active Ceased
- 2018-11-27 JP JP2020546307A patent/JP2021504479A/ja active Pending
- 2018-11-27 CN CN201880076561.6A patent/CN111386115A/zh active Pending
- 2018-11-27 CA CA3082178A patent/CA3082178A1/en active Pending
- 2018-11-27 US US16/768,000 patent/US20210369693A1/en not_active Abandoned
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| BE1031925B1 (de) * | 2024-06-03 | 2025-10-30 | Univ Guizhou Medical | Eine orale, leberzielgerichtete nanoemulsion zur beladung mit pirfenidon sowie deren herstellungsverfahren und anwendung |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111386115A (zh) | 2020-07-07 |
| US20210369693A1 (en) | 2021-12-02 |
| EP3716975A4 (en) | 2022-01-12 |
| JP2021504479A (ja) | 2021-02-15 |
| CA3082178A1 (en) | 2019-06-06 |
| WO2019108551A1 (en) | 2019-06-06 |
| EP3716975A1 (en) | 2020-10-07 |
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