AU2018363212A1 - Protein engineered extracellular vesicles - Google Patents
Protein engineered extracellular vesicles Download PDFInfo
- Publication number
- AU2018363212A1 AU2018363212A1 AU2018363212A AU2018363212A AU2018363212A1 AU 2018363212 A1 AU2018363212 A1 AU 2018363212A1 AU 2018363212 A AU2018363212 A AU 2018363212A AU 2018363212 A AU2018363212 A AU 2018363212A AU 2018363212 A1 AU2018363212 A1 AU 2018363212A1
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- Prior art keywords
- evs
- protein
- lysosomal
- polypeptide
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
- C12N2509/10—Mechanical dissociation
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| GB1718681.8 | 2017-11-13 | ||
| GBGB1718681.8A GB201718681D0 (en) | 2017-11-13 | 2017-11-13 | Protein engineered extracellular vesicles |
| PCT/EP2018/081122 WO2019092287A1 (en) | 2017-11-13 | 2018-11-13 | Protein engineered extracellular vesicles |
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| AU2018363212A1 true AU2018363212A1 (en) | 2020-05-28 |
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| AU2018363212A Abandoned AU2018363212A1 (en) | 2017-11-13 | 2018-11-13 | Protein engineered extracellular vesicles |
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| EP (1) | EP3710022A1 (https=) |
| JP (1) | JP2021502105A (https=) |
| KR (1) | KR20200081487A (https=) |
| CN (1) | CN111601607A (https=) |
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| SG (1) | SG11202004200PA (https=) |
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| WO2020152298A1 (en) * | 2019-01-24 | 2020-07-30 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | Method for producing enzymes |
| EP3986429A4 (en) * | 2019-06-21 | 2023-07-19 | Entelexo Biotherapeutics Inc. | PLATFORMS, COMPOSITIONS, AND METHODS OF ADMINISTRATION OF THERAPEUTICS |
| CN114616344B (zh) * | 2019-10-28 | 2026-03-31 | 普赛尔根技术股份公司 | 用于绘制滚环扩增产物图谱的方法 |
| US20210322483A1 (en) | 2020-04-16 | 2021-10-21 | Ichilov Tech Ltd. | Cell-derived particles presenting heterologous cd24 and use thereof in therapy |
| US20210324339A1 (en) | 2020-04-16 | 2021-10-21 | Ichilov Tech Ltd. | Cell-derived particles presenting heterologous cd24 and use thereof in therapy |
| JP2023535632A (ja) | 2020-07-27 | 2023-08-18 | アンジャリウム バイオサイエンシズ エージー | Ｄｎａ分子の組成物、その作製方法、及びその使用方法 |
| CN112285195B (zh) * | 2020-10-27 | 2021-08-10 | 江南大学 | 一种牛奶外泌体的特征性糖蛋白标志物和牛奶外泌体的特征性标志物分离方法 |
| AU2022315530A1 (en) | 2021-07-20 | 2024-01-18 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their preparation, and uses |
| WO2023144127A1 (en) | 2022-01-31 | 2023-08-03 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon administration, and uses |
| CN118973591A (zh) * | 2022-03-28 | 2024-11-15 | 合同会社博子科技 | 包含miR-140的药物组合物及其制备方法 |
| WO2023193665A1 (zh) * | 2022-04-07 | 2023-10-12 | 威海纽兰生物科技有限公司 | 基于细胞外囊泡酯酶响应药物递送载体及其制备方法和用途 |
| WO2023232976A1 (en) | 2022-06-03 | 2023-12-07 | Ags Therapeutics Sas | Extracellular vesicles from genetically-modified microalgae containing endogenously-loaded cargo, their preparation, and uses |
| WO2024088808A1 (en) | 2022-10-24 | 2024-05-02 | Ags Therapeutics Sas | Extracellular vesicles from microalgae, their biodistribution upon intranasal administration, and uses thereof |
| WO2024107831A1 (en) * | 2022-11-15 | 2024-05-23 | Board Of Trustees Of Michigan State University | Use of extracellular vesicles as a molecular screening platform |
| WO2025176843A1 (en) | 2024-02-21 | 2025-08-28 | Ags Therapeutics Sas | Microalgae extracellular vesicle based gene therapy vectors (mev-gtvs), their preparation, and uses thereof |
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| DK3145493T3 (da) * | 2014-05-18 | 2022-10-31 | Childrens Medical Center | Fremgangsmåder og sammensætninger vedrørende exosomer |
| WO2016044947A1 (en) * | 2014-09-26 | 2016-03-31 | Exerkine Corporation | Exosomes useful to treat lysosomal storage disease |
| WO2016057755A1 (en) * | 2014-10-09 | 2016-04-14 | Anthrogenesis Corporation | Placenta-derived adherent cell exosomes and uses thereof |
| EP3307286B1 (en) * | 2015-06-12 | 2023-01-11 | Hudson Institute of Medical Research | Allogeneic mammalian amniotic exosomes for treating a fibrotic disease |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2021502105A (ja) | 2021-01-28 |
| BR112020007327A2 (pt) | 2020-10-06 |
| SG11202004200PA (en) | 2020-06-29 |
| IL274124A (en) | 2020-06-30 |
| RU2020119155A (ru) | 2021-12-15 |
| GB201718681D0 (en) | 2017-12-27 |
| CN111601607A (zh) | 2020-08-28 |
| RU2020119155A3 (https=) | 2022-03-21 |
| KR20200081487A (ko) | 2020-07-07 |
| WO2019092287A1 (en) | 2019-05-16 |
| EP3710022A1 (en) | 2020-09-23 |
| MX2020004712A (es) | 2020-11-06 |
| US20200399591A1 (en) | 2020-12-24 |
| CA3082299A1 (en) | 2019-05-16 |
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