AU2018309049A1 - Use of gaboxadol in the treatment of diabetes and related conditions - Google Patents
Use of gaboxadol in the treatment of diabetes and related conditions Download PDFInfo
- Publication number
- AU2018309049A1 AU2018309049A1 AU2018309049A AU2018309049A AU2018309049A1 AU 2018309049 A1 AU2018309049 A1 AU 2018309049A1 AU 2018309049 A AU2018309049 A AU 2018309049A AU 2018309049 A AU2018309049 A AU 2018309049A AU 2018309049 A1 AU2018309049 A1 AU 2018309049A1
- Authority
- AU
- Australia
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- administered
- diabetes
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- ZXRVKCBLGJOCEE-UHFFFAOYSA-N Gaboxadol Chemical compound C1NCCC2=C1ONC2=O ZXRVKCBLGJOCEE-UHFFFAOYSA-N 0.000 title claims abstract description 244
- 229950004346 gaboxadol Drugs 0.000 title claims abstract description 238
- 206010012601 diabetes mellitus Diseases 0.000 title claims description 42
- 238000011282 treatment Methods 0.000 title description 49
- 150000003839 salts Chemical class 0.000 claims abstract description 1172
- 208000030159 metabolic disease Diseases 0.000 claims abstract description 214
- 238000000034 method Methods 0.000 claims abstract description 204
- 208000016097 disease of metabolism Diseases 0.000 claims abstract description 60
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 53
- 239000008103 glucose Substances 0.000 claims abstract description 53
- 239000003472 antidiabetic agent Substances 0.000 claims abstract description 29
- 229940126904 hypoglycaemic agent Drugs 0.000 claims abstract description 28
- 238000007410 oral glucose tolerance test Methods 0.000 claims abstract description 15
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 154
- 201000009104 prediabetes syndrome Diseases 0.000 claims description 144
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims description 136
- 208000001280 Prediabetic State Diseases 0.000 claims description 136
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 135
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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| US201762541260P | 2017-08-04 | 2017-08-04 | |
| US62/541,260 | 2017-08-04 | ||
| PCT/US2018/044973 WO2019028234A1 (en) | 2017-08-04 | 2018-08-02 | USE OF GABOXADOL IN THE TREATMENT OF DIABETES AND RELATED CONDITIONS |
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| AU2018309049A1 true AU2018309049A1 (en) | 2020-02-27 |
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| EP (1) | EP3648762A4 (https=) |
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| IL (1) | IL272414A (https=) |
| MX (1) | MX2020001342A (https=) |
| WO (1) | WO2019028234A1 (https=) |
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| JP2020529440A (ja) | 2017-08-04 | 2020-10-08 | オービッド・セラピューティクス・インコーポレイテッドＯｖｉｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 糖尿病および関連する状態の処置におけるガボキサドールの使用 |
| JP7148605B2 (ja) | 2017-10-12 | 2022-10-05 | ノヴォ ノルディスク アー／エス | 医学療法におけるセマグルチド |
| US11123332B2 (en) | 2018-11-21 | 2021-09-21 | Certego Therapeutics Inc. | Gaboxadol for reducing risk of suicide and rapid relief of depression |
| EP4051272A4 (en) | 2019-12-18 | 2023-01-04 | Ovid Therapeutics Inc. | GABOXADOL FOR THE THERAPEUTIC TREATMENT OF 1P36 DELETION SYNDROME |
| MX2022014599A (es) | 2020-05-20 | 2022-12-16 | Certego Therapeutics Inc | Gaboxadol deuterado en anillo y su uso para el tratamiento de trastornos psiquiatricos. |
| JP2025516137A (ja) * | 2022-04-20 | 2025-05-27 | アクリプス ツー インコーポレイテッド | 胃腸疾患の処置 |
| WO2025049710A1 (en) * | 2023-08-29 | 2025-03-06 | Aclipse Two Inc. | Pharmaceutical composition for use in the disease treatments |
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| DK270278A (da) | 1977-06-20 | 1978-12-21 | Krogsgaard Larsen P | Cycliske aminosyrer |
| US4362731A (en) | 1980-09-01 | 1982-12-07 | Sandoz Ltd. | Myotonolytic use of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridin-3-ol and derivatives thereof |
| US4353910A (en) | 1981-11-27 | 1982-10-12 | Kefalas A/S | Derivatives of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-one, pharmaceutical compositions and methods of treatment |
| DE19525598C2 (de) | 1995-07-13 | 1997-09-25 | Max Planck Gesellschaft | Schlafmittel |
| GB0402118D0 (en) | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
| EA200601853A1 (ru) * | 2004-04-02 | 2007-02-27 | Х. Лундбекк А/С | Лечение нарушенной дыхательной функции |
| JP2007530604A (ja) * | 2004-04-02 | 2007-11-01 | ハー・ルンドベック・アクチエゼルスカベット | 呼吸機能障害の治療 |
| WO2006102093A1 (en) * | 2005-03-18 | 2006-09-28 | Transform Pharmaceuticals, Inc. | Gaboxadol forms, compositions thereof, and related methods |
| DE102005020882A1 (de) * | 2005-05-04 | 2006-11-09 | Dömling, Alexander, Dr. | Verwendung von Gaboxadol und Derivaten zur Behandlung von Kinase-induzierten Krankheiten |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20110046090A1 (en) | 2005-10-31 | 2011-02-24 | Braincells Inc. | Modulation of neurogenesis with gaba agents and gaba analogs |
| US7635710B2 (en) | 2006-02-15 | 2009-12-22 | Neurim Pharmaceuticals (1991) Ltd. | Pyrone-indole derivatives and process for their preparation |
| ES2610508T3 (es) | 2006-11-22 | 2017-04-27 | Clinical Research Associates, Llc | Métodos para tratar el síndrome de Down, el síndrome del cromosoma X frágil y el autismo |
| TW200920358A (en) * | 2007-08-13 | 2009-05-16 | Lundbeck & Co As H | Method of treating stress-mediated depression |
| US20090143335A1 (en) | 2007-10-29 | 2009-06-04 | H. Lundbeck A/S | Modified absorption formulation of gaboxadol |
| US8450286B2 (en) * | 2008-03-18 | 2013-05-28 | Bristol-Myers Squibb Company | Method for treating cancers having high glucose requirements employing an SGLT2 inhibitor and compositions thereof |
| WO2012050907A2 (en) * | 2010-09-28 | 2012-04-19 | The Regents Of The University Of California | Gaba agonists in the treatment of disorders associated with metabolic syndrome and gaba combinations in treatment or prophylaxis of type i diabetes |
| WO2013024047A1 (en) | 2011-08-12 | 2013-02-21 | Ascendis Pharma A/S | High-loading water-soluble carrier-linked prodrugs |
| DK3151832T3 (da) | 2014-06-06 | 2021-06-14 | Ovid Therapeutics Inc | Fremgangsmåder til øgning af tonisk hæmning og behandling af sekundær søvnløshed |
| EP3154979B1 (en) | 2014-06-12 | 2018-03-07 | Pfizer Limited | Imidazopyridazine derivatives as modulators of the gabaa receptor activity. |
| US10610504B2 (en) * | 2014-12-23 | 2020-04-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Alpha-cell re-generation combined with conversion to beta cells |
| US20170348232A1 (en) | 2016-06-07 | 2017-12-07 | Ovid Therapeutics Inc. | Formulations of gaboxadol for treatment of angelman syndrome, fragile x syndrome and fragile x-associated tremor/ataxia syndrome |
| IL256912B2 (en) | 2015-07-17 | 2024-01-01 | Ovid Therapeutics Inc | Methods of treating developmental disorders with gaboxadol |
| US9682069B2 (en) | 2015-07-17 | 2017-06-20 | Ovid Therapeutics Inc | Methods of treating Dravet syndrome |
| US9399034B1 (en) | 2015-08-11 | 2016-07-26 | Ovid Therapeutics Inc | Methods of sedation during critical care treatment |
| US9351968B1 (en) | 2015-09-09 | 2016-05-31 | Ovid Therapeutics Inc | Methods of treating developmental disorders using pipradrol |
| EP4233861A3 (en) | 2016-08-11 | 2023-10-11 | Ovid Therapeutics, Inc. | Compositions for treatment of essential tremor |
| JP2020529440A (ja) | 2017-08-04 | 2020-10-08 | オービッド・セラピューティクス・インコーポレイテッドＯｖｉｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 糖尿病および関連する状態の処置におけるガボキサドールの使用 |
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2018
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- 2018-08-02 AU AU2018309049A patent/AU2018309049A1/en not_active Abandoned
- 2018-08-02 EP EP18840846.2A patent/EP3648762A4/en not_active Withdrawn
- 2018-08-02 US US16/053,081 patent/US10813918B2/en not_active Expired - Fee Related
- 2018-08-02 WO PCT/US2018/044973 patent/WO2019028234A1/en not_active Ceased
- 2018-08-02 MX MX2020001342A patent/MX2020001342A/es unknown
- 2018-08-02 KR KR1020207006304A patent/KR20200047557A/ko not_active Withdrawn
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2020
- 2020-02-02 IL IL272414A patent/IL272414A/en unknown
- 2020-10-08 US US17/066,389 patent/US11291658B2/en active Active
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| CA3071939A1 (en) | 2019-02-07 |
| EP3648762A4 (en) | 2021-03-24 |
| CN111201022A (zh) | 2020-05-26 |
| WO2019028234A1 (en) | 2019-02-07 |
| US20210030728A1 (en) | 2021-02-04 |
| IL272414A (en) | 2020-03-31 |
| US20190038606A1 (en) | 2019-02-07 |
| MX2020001342A (es) | 2020-08-31 |
| KR20200047557A (ko) | 2020-05-07 |
| EP3648762A1 (en) | 2020-05-13 |
| US11291658B2 (en) | 2022-04-05 |
| US10813918B2 (en) | 2020-10-27 |
| JP2020529440A (ja) | 2020-10-08 |
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Legal Events
| Date | Code | Title | Description |
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| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |