AU2018301829B2 - Methods for inhibition of HAO1 (hydroxyacid oxidase 1 (glycolate oxidase) gene expression - Google Patents

Methods for inhibition of HAO1 (hydroxyacid oxidase 1 (glycolate oxidase) gene expression Download PDF

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AU2018301829B2
AU2018301829B2 AU2018301829A AU2018301829A AU2018301829B2 AU 2018301829 B2 AU2018301829 B2 AU 2018301829B2 AU 2018301829 A AU2018301829 A AU 2018301829A AU 2018301829 A AU2018301829 A AU 2018301829A AU 2018301829 B2 AU2018301829 B2 AU 2018301829B2
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pharmaceutically acceptable
acceptable salt
dsrna
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AU2018301829A1 (en
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David V. Erbe
Tracey L. McGREGOR
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Alnylam Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/351—Conjugate
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    • C12N2320/30—Special therapeutic applications
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen

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  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2018301829A 2017-07-13 2018-07-12 Methods for inhibition of HAO1 (hydroxyacid oxidase 1 (glycolate oxidase) gene expression Active AU2018301829B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024227498A AU2024227498A1 (en) 2017-07-13 2024-10-21 Methods for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase) gene expression

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762532176P 2017-07-13 2017-07-13
US62/532,176 2017-07-13
US201762581565P 2017-11-03 2017-11-03
US62/581,565 2017-11-03
US201862646285P 2018-03-21 2018-03-21
US62/646,285 2018-03-21
US201862682020P 2018-06-07 2018-06-07
US62/682,020 2018-06-07
PCT/US2018/041891 WO2019014491A1 (en) 2017-07-13 2018-07-12 METHODS OF INHIBITING GENE EXPRESSION OF HAO1 (HYDROXYACID OXIDASE 1 (GLYCOLATE OXIDASE))

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AU2018301829B2 true AU2018301829B2 (en) 2024-08-01

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AU2024227498A Pending AU2024227498A1 (en) 2017-07-13 2024-10-21 Methods for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase) gene expression

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US (2) US11261447B2 (https=)
EP (1) EP3651775A4 (https=)
JP (3) JP7337044B2 (https=)
AU (2) AU2018301829B2 (https=)
CA (1) CA3069451A1 (https=)
WO (1) WO2019014491A1 (https=)

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TW202503057A (zh) 2014-10-10 2025-01-16 美商艾爾妮蘭製藥公司 用於抑制hao1(羥酸氧化酶1(乙醇酸鹽氧化酶))基因表現的組合物及方法
EP3310918B1 (en) 2015-06-18 2020-08-05 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
CA3069451A1 (en) 2017-07-13 2019-01-17 Alnylam Pharmaceuticals, Inc. Methods for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
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TW202237150A (zh) * 2020-12-01 2022-10-01 美商艾拉倫製藥股份有限公司 用於抑制ｈａｏ１（羥基酸氧化酶１（乙醇酸氧化酶））基因表現的方法及組成物
EP4043018A1 (en) 2021-02-10 2022-08-17 Charité - Universitätsmedizin Berlin Composition and method for reducing oxalate levels in patients receiving maintenance dialysis
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CN118460656B (zh) * 2024-07-10 2024-12-06 凯莱英医药集团（天津）股份有限公司 一种Lumasiran的制备方法

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AU2024227498A1 (en) 2025-01-09
US20200165616A1 (en) 2020-05-28
US20220403394A1 (en) 2022-12-22
JP7767365B2 (ja) 2025-11-11
AU2018301829A1 (en) 2020-02-27
JP2023179412A (ja) 2023-12-19
WO2019014491A1 (en) 2019-01-17
EP3651775A4 (en) 2021-04-07
EP3651775A1 (en) 2020-05-20
JP2026035588A (ja) 2026-03-04
JP7337044B2 (ja) 2023-09-01
JP2020526553A (ja) 2020-08-31
CA3069451A1 (en) 2019-01-17
US11261447B2 (en) 2022-03-01

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