AU2018301829B2 - Methods for inhibition of HAO1 (hydroxyacid oxidase 1 (glycolate oxidase) gene expression - Google Patents

Methods for inhibition of HAO1 (hydroxyacid oxidase 1 (glycolate oxidase) gene expression Download PDF

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AU2018301829B2
AU2018301829B2 AU2018301829A AU2018301829A AU2018301829B2 AU 2018301829 B2 AU2018301829 B2 AU 2018301829B2 AU 2018301829 A AU2018301829 A AU 2018301829A AU 2018301829 A AU2018301829 A AU 2018301829A AU 2018301829 B2 AU2018301829 B2 AU 2018301829B2
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pharmaceutically acceptable
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dsrna
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AU2018301829A1 (en
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David V. Erbe
Tracey L. McGREGOR
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Alnylam Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2320/30—Special therapeutic applications
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen

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  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2018301829A 2017-07-13 2018-07-12 Methods for inhibition of HAO1 (hydroxyacid oxidase 1 (glycolate oxidase) gene expression Active AU2018301829B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024227498A AU2024227498A1 (en) 2017-07-13 2024-10-21 Methods for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase) gene expression

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762532176P 2017-07-13 2017-07-13
US62/532,176 2017-07-13
US201762581565P 2017-11-03 2017-11-03
US62/581,565 2017-11-03
US201862646285P 2018-03-21 2018-03-21
US62/646,285 2018-03-21
US201862682020P 2018-06-07 2018-06-07
US62/682,020 2018-06-07
PCT/US2018/041891 WO2019014491A1 (en) 2017-07-13 2018-07-12 METHODS OF INHIBITING GENE EXPRESSION OF HAO1 (HYDROXYACID OXIDASE 1 (GLYCOLATE OXIDASE))

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AU2018301829B2 true AU2018301829B2 (en) 2024-08-01

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AU2024227498A Pending AU2024227498A1 (en) 2017-07-13 2024-10-21 Methods for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase) gene expression

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EP (1) EP3651775A4 (enExample)
JP (2) JP7337044B2 (enExample)
AU (2) AU2018301829B2 (enExample)
CA (1) CA3069451A1 (enExample)
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JOP20200115A1 (ar) 2014-10-10 2017-06-16 Alnylam Pharmaceuticals Inc تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
WO2016205323A1 (en) 2015-06-18 2016-12-22 Alnylam Pharmaceuticals, Inc. Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
AU2018301829B2 (en) 2017-07-13 2024-08-01 Alnylam Pharmaceuticals, Inc. Methods for inhibition of HAO1 (hydroxyacid oxidase 1 (glycolate oxidase) gene expression
KR20220097442A (ko) 2019-11-01 2022-07-07 기안알엑스 사이언스 인코포레이티드 글리콜레이트 산화효소 억제제로서의 헤테로사이클릭 카르복실레이트 화합물
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AU2018301829A1 (en) 2020-02-27
EP3651775A4 (en) 2021-04-07
US11261447B2 (en) 2022-03-01
CA3069451A1 (en) 2019-01-17
WO2019014491A1 (en) 2019-01-17
EP3651775A1 (en) 2020-05-20
AU2024227498A1 (en) 2025-01-09
US20220403394A1 (en) 2022-12-22
JP7337044B2 (ja) 2023-09-01
JP2020526553A (ja) 2020-08-31
US20200165616A1 (en) 2020-05-28
JP2023179412A (ja) 2023-12-19
JP7767365B2 (ja) 2025-11-11

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