AU2018247958A1 - Arenavirus particles to treat solid tumors - Google Patents
Arenavirus particles to treat solid tumors Download PDFInfo
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- AU2018247958A1 AU2018247958A1 AU2018247958A AU2018247958A AU2018247958A1 AU 2018247958 A1 AU2018247958 A1 AU 2018247958A1 AU 2018247958 A AU2018247958 A AU 2018247958A AU 2018247958 A AU2018247958 A AU 2018247958A AU 2018247958 A1 AU2018247958 A1 AU 2018247958A1
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- arenavirus
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| CA3003557A1 (en) | 2015-11-04 | 2017-05-11 | Hookipa Biotech Ag | Vaccines against hepatitis b virus |
| DK3373959T3 (da) | 2015-11-12 | 2022-09-19 | Hookipa Biotech Gmbh | Arenaviruspartikler som cancervacciner |
| BR112022024404A2 (pt) * | 2020-05-29 | 2023-02-07 | Hookipa Biotech Gmbh | Método para tratar câncer, sequência de nucleotídeos, célula hospedeira, partícula de lcmv, partícula de picv, composição farmacêutica, partícula de arenavírus |
| CN117280027A (zh) | 2021-03-23 | 2023-12-22 | 霍欧奇帕生物科技有限公司 | 用于治疗前列腺癌的沙粒病毒 |
| US20240229073A1 (en) * | 2021-05-13 | 2024-07-11 | Hookipa Biotech Gmbh | Arenaviruses as vectors |
| CA3236106A1 (en) | 2021-11-08 | 2023-05-11 | Henning Lauterbach | Modified arenavirus particles expressing mutant kras, mutated cancer driver gene, or tumor-associated antigen as cancer immunotherapies |
| WO2023152116A1 (en) | 2022-02-08 | 2023-08-17 | Hookipa Biotech Gmbh | Combination therapy with arenavirus particles and immune checkpoint modulators or cytokines |
| WO2023174998A1 (en) * | 2022-03-16 | 2023-09-21 | Boehringer Ingelheim International Gmbh | Tumor antigens, compounds comprising the tumor antigens kras, tpx2 or aurka and uses thereof |
| CN115192709B (zh) * | 2022-05-12 | 2023-07-21 | 黄淮学院 | O-GlcNAc糖基转移酶抑制剂在制备抑制精子发生的药物中的用途 |
| CN116218681B (zh) * | 2022-08-02 | 2025-11-11 | 汕头大学 | 三角褐指藻钙网蛋白基因过表达突变株的构建方法 |
| WO2025101837A1 (en) * | 2023-11-10 | 2025-05-15 | Eccletech Llc | Biological devices and methods of using the same for detection of different types of cancer |
| WO2025191169A1 (en) | 2024-03-15 | 2025-09-18 | Hookipa Biotech Gmbh | Modified arenavirus particles expressing cancer testis antigens as cancer immunotherapies |
Family Cites Families (15)
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| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| EP1553966B1 (en) * | 2002-10-03 | 2012-08-01 | Wyeth Holdings Corporation | Fusion peptides comprising the human papillomavirus e7 and e6 polypeptides and immunogenic compositions thereof |
| ES2536426T3 (es) | 2006-03-23 | 2015-05-25 | Novartis Ag | Compuestos de imidazoquinoxalina como inmunomoduladores |
| US8063063B2 (en) | 2006-03-23 | 2011-11-22 | Novartis Ag | Immunopotentiating compounds |
| SI2604695T1 (sl) * | 2007-12-27 | 2023-03-31 | Universitaet Zuerich Prorektorat Forschung | Replikacijsko defektni arenavirusni vektorji |
| EP2968506B1 (en) | 2013-03-15 | 2019-07-31 | Université de Genève | Anti-mycobacterial vaccines |
| EP3110443A4 (en) * | 2014-02-27 | 2017-11-15 | Viralytics Limited | Combination method for treatment of cancer |
| SI3218504T1 (sl) * | 2014-11-13 | 2020-11-30 | Universite De Geneve | Tri-segmentirani arenavirusi kot vakcinski vektorji |
| DE102015207036A1 (de) * | 2015-04-17 | 2016-10-20 | Karl Sebastian Lang | Arenaviren zur Anwendung bei der Behandlung und/oder Vorbeugung von Tumoren sowie Verfahren zur Herstellung von Arenaviren mit (verbesserten) tumorregressiven Eigenschaften |
| CN108064176A (zh) * | 2015-04-22 | 2018-05-22 | 库瑞瓦格股份公司 | 用于治疗肿瘤疾病的含有rna的组合物 |
| AU2016274655B2 (en) * | 2015-06-10 | 2021-06-17 | NeoTrail Therapeutics, Inc. | HPV vaccines |
| DK3373959T3 (da) * | 2015-11-12 | 2022-09-19 | Hookipa Biotech Gmbh | Arenaviruspartikler som cancervacciner |
| IL262963B2 (en) * | 2016-05-18 | 2025-01-01 | Hookipa Biotech Gmbh | Trisegmented PICHINDE viruses as vaccine vectors |
| US20200206334A1 (en) * | 2016-11-04 | 2020-07-02 | Hookipa Biotech Gmbh | Replication-deficient arenavirus particles and tri-segmented arenavirus particles as cancer vaccines |
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- 2018-04-06 US US16/500,648 patent/US20200113995A1/en not_active Abandoned
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| EP3606549A1 (en) | 2020-02-12 |
| US20200113995A1 (en) | 2020-04-16 |
| CA3058539A1 (en) | 2018-10-11 |
| WO2018185307A1 (en) | 2018-10-11 |
| JP2020516601A (ja) | 2020-06-11 |
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