AU2018101773A4 - Polyoxypropylene glyceryl ether production plant - Google Patents
Polyoxypropylene glyceryl ether production plant Download PDFInfo
- Publication number
- AU2018101773A4 AU2018101773A4 AU2018101773A AU2018101773A AU2018101773A4 AU 2018101773 A4 AU2018101773 A4 AU 2018101773A4 AU 2018101773 A AU2018101773 A AU 2018101773A AU 2018101773 A AU2018101773 A AU 2018101773A AU 2018101773 A4 AU2018101773 A4 AU 2018101773A4
- Authority
- AU
- Australia
- Prior art keywords
- tank
- pump
- store
- feedstock
- polymerizer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2696—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds characterised by the process or apparatus used
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
- C08G65/2606—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups
- C08G65/2609—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups containing aliphatic hydroxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polyethers (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Polyoxypropylene polyoxyethylene glyceryl ether production plant Abstract 5 Polyoxypropylene polyoxyethylene glyceryl ether production plant, including: tank (F101), tank (F102), tank (F103), feedstock pump (JI01), feedstock pump (J102), feedstock pump (J103), feedstock pump (J108), feedstock pump (J109), polymerizer (DI01), polymerizer (D102), neutralization tank (D103), transfer pump (J104), transfer pump (JI05), transfer pump (J106), transfer pump (J107), water knockout 10 (D104), pressure filter (LIO), tank (F104), tank (F105); among them, tank (FlOl) is used to store glycerol, tank (F102) is used to store propylene oxide, tank (F103) is used to store ethylene oxide, tank (F104) is used to store phosphoric acid, tank (F105) is used to store sulfuric acid; among them, cylinder diameter of tank (F103) is 470-490 mm. Figure 1 r -I> -*---------* v-f t -~ V t F 2 _ ;j<-tT I Figure
Description
FIELD OF THE INVENTION
The present invention relates to a kind of pharmaceutical synthesis plant, more particularly, relates to Polyoxypropylene glyceryl ether production plant
GENERAL BACKGROUND
Polyoxypropylene glyceryl ether is mainly used as defoaming agent in the pharmaceutical industry. It is widely used in the production of oxytetracycline, tetracycline and other antibiotics to replace soybean oil defoaming. Its defoaming 10 efficiency is 25-30 times higher than soybean oil, and can reduce the loss of stock solution. Most of the existing production plant processes are complex. Thus, as a defoamer, the advantages and disadvantages of production equipment of Polyoxypropylene glyceryl ether have a great economic significant for improving product quality and reducing the by-product contents.
SUMMARY
The purpose of the present invention is to provide Polyoxypropylene glyceryl ether production plant, including: tank (Fl01), tank (Fl02), tank (Fl03), feedstock pump (J101), feedstock pump (J102), feedstock pump (J103), feedstock pump (J108), feedstock pump (JI09), polymerizer (DI01), polymerizer (DI02), neutralization tank 20 (DI03), transfer pump (JI04), transfer pump (JI05), transfer pump (JI06), transfer pump (JI07), water knockout (DI04), pressure filter (LI01), tank (Fl04), tank (Fl05); among them, tank (Fl01) is used to store glycerol, tank (Fl02) is used to store propylene oxide, tank (Fl03) is used to store ethylene oxide, tank (Fl04) is used to store phosphoric acid, tank (Fl05) is used to store sulfuric acid; among them, cylinder 25 diameter of tank (F103) is 470-490 mm, impeller diameter of feedstock pump (J108) is 130-135 mm, nominal volume of polymerizer (D102) is 700-730 L.
Polyoxypropylene glyceryl ether production plant, the production process is:
added propylene oxide and glycerol into polymerizer D101, addition reacted for 1-2 h under heating and the catalysis of potassium hydroxide. After reaction, pumped into
2018101773 18 Nov 2018 polymerizer DI02, then added ethylene oxide to polymerization react for 2-3h. After the polymerization reaction, reduced the temperature to 50-56 °C, pressed the materials into neutralization tank DI03, added a certain amount of water and phosphoric acid under stirring to dissolve the excess alkali of the materials. Pumped 5 into DI04, added sulfuric acid for neutralization and dehydration. Finally filtered by
LI01 and got the finished product. The advantages of this invention are that the reaction time is reduced and the reaction rate is improved.
DESCRIPTION OF THE DRAWINGS
Figure 1 Polyoxypropylene glyceryl ether production plant.
Include: tank (Fl01), tank (Fl02), tank (Fl03), feedstock pump (JI01), feedstock pump (JI02), feedstock pump (JI03), feedstock pump (JI08), feedstock pump (JI09), polymerizer (DI01), polymerizer (DI02), neutralization tank (DI03), transfer pump (JI04), transfer pump (JI05), transfer pump (JI06), transfer pump (JI07), water knockout (DI04), pressure filter (LI01), tank (Fl04), tank (Fl05);
DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
The following examples with reference to specific embodiments of the present invention are further illustrated:
Embodiment 1
Raw materials and dosages
| Glycerin | Reagent grade | 30 kg | Ethylene oxide | Industrial grade | 520 kg |
| Propylene oxide | Industrial grade | 1500 kg | Potassium hydroxide | Industrial grade | 10 kg |
Polyoxypropylene glyceryl ether production plant, including: tank (F101), tank (Fl02), tank (Fl03), feedstock pump (JI01), feedstock pump (JI02), feedstock pump (JI03), feedstock pump (JI08), feedstock pump (JI09), polymerizer (DI01), polymerizer (DI02), neutralization tank (DI03), transfer pump (JI04), transfer pump (JI05), transfer pump (JI06), transfer pump (JI07), water knockout (DI04), pressure filter (LI01), tank (Fl04), tank (Fl05); among them, tank (Fl01) is used to store
2018101773 18 Nov 2018 glycerol, tank (F102) is used to store propylene oxide, tank (F103) is used to store ethylene oxide, tank (Fl04) is used to store phosphoric acid, tank (Fl05) is used to store sulfuric acid; among them, cylinder diameter of tank (F103) is 470 mm, impeller diameter of feedstock pump (JI08) is 130 mm, nominal volume of polymerizer (DI02) 5 is 700 L.
Polyoxypropylene glyceryl ether production plant, the production process is: added propylene oxide and glycerol into polymerizer D101, addition reacted for 1 h under heating and the catalysis of potassium hydroxide. After reaction, pumped into polymerizer DI02, then added ethylene oxide to polymerization react for 2h. After the 10 polymerization reaction, reduced the temperature to 50 °C, pressed the materials into neutralization tank DI03, added a certain amount of water and phosphoric acid under stirring to dissolve the excess alkali of the materials. Pumped into DI04, added sulfuric acid for neutralization and dehydration. Finally filtered by LI01 and got the finished product.
The qualities of the product are as follows:
| Exterior | Colorless transparent liquid |
| Cloud point | 18 °C |
| Acid value | <0.3 mg KOH/g |
| Hydroxyl value | 49mg KOH/g |
Embodiment 2
Raw materials and dosages
| Glycerin | Reagent grade | 40 kg | Ethylene oxide | Industrial grade | 540 kg |
| Propylene oxide | Industrial grade | 1600 kg | Potassium hydroxide | Industrial grade | 13 kg |
Polyoxypropylene glyceryl ether production plant, including: tank (Fl01), tank (Fl02), tank (Fl03), feedstock pump (JI01), feedstock pump (JI02), feedstock pump (JI03), feedstock pump (JI08), feedstock pump (JI09), polymerizer (DI01), polymerizer (DI02), neutralization tank (DI03), transfer pump (JI04), transfer pump
2018101773 18 Nov 2018 (JI05), transfer pump (JI06), transfer pump (JI07), water knockout (DI04), pressure filter (LI01), tank (Fl04), tank (Fl05); among them, tank (Fl01) is used to store glycerol, tank (F102) is used to store propylene oxide, tank (F103) is used to store ethylene oxide, tank (Fl04) is used to store phosphoric acid, tank (Fl05) is used to 5 store sulfuric acid; among them, cylinder diameter of tank (Fl 03) is 490 mm, impeller diameter of feedstock pump (JI08) is 135 mm, nominal volume of polymerizer (DI02) is 730 L.
Polyoxypropylene glyceryl ether production plant, the production process is: added propylene oxide and glycerol into polymerizer D101, addition reacted for 2 h 10 under heating and the catalysis of potassium hydroxide. After reaction, pumped into polymerizer DI02, then added ethylene oxide to polymerization react for 3h. After the polymerization reaction, reduced the temperature to 56 °C, pressed the materials into neutralization tank DI03, added a certain amount of water and phosphoric acid under stirring to dissolve the excess alkali of the materials. Pumped into DI04, added 15 sulfuric acid for neutralization and dehydration. Finally filtered by LI01 and got the finished product.
The qualities of the product are as follows:
| Exterior | Colorless transparent liquid |
| Cloud point | 19 °C |
| Acid value | <0.4 mg KOH/g |
| Hydroxyl value | 51mgKOH/g |
The embodiments of the present invention are merely preferred embodiments of the present invention, but the range of the present invention is not limited this, and any person who is familiar with those skilled in the arts, within the technical range of the present invention. It is intended that the technical solution and its inventive concept be replaced or modified equivalently with reference to the range of the invention.
Claims (3)
- Claims1. Polyoxypropylene glyceryl ether production plant, including: tank (F101), tank (Fl02), tank (Fl03), feedstock pump (JI01), feedstock pump (JI02), feedstock5 pump (JI03), feedstock pump (JI08), feedstock pump (JI09), polymerizer (DI01), polymerizer (DI02), neutralization tank (DI03), transfer pump (JI04), transfer pump (JI05), transfer pump (JI06), transfer pump (JI07), water knockout (DI04), pressure filter (LI01), tank (Fl04), tank (Fl05); among them, tank (Fl01) is used to store glycerol, tank (F102) is used to store propylene oxide, tank (F103) is used to store 10 ethylene oxide, tank (Fl04) is used to store phosphoric acid, tank (Fl05) is used to store sulfuric acid; among them, cylinder diameter of tank (F103) is 470-490 mm.
- 2. Polyoxypropylene glyceryl ether production plant according to claim 1 wherein impeller diameter of feedstock pump (JI 08) is 130-135 mm.
- 3. Polyoxypropylene glyceryl ether production plant according to claim 1 wherein15 nominal volume of polymerizer (DI02) is 700-730 L.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017112533814 | 2017-12-02 | ||
| CN201711253381.4A CN108239276A (en) | 2017-12-02 | 2017-12-02 | The process units of polyoxyethylene polyoxypropylene glycerin ether |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2018101773A4 true AU2018101773A4 (en) | 2019-01-03 |
Family
ID=61157917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018101773A Ceased AU2018101773A4 (en) | 2017-12-02 | 2018-11-18 | Polyoxypropylene glyceryl ether production plant |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN108239276A (en) |
| AU (1) | AU2018101773A4 (en) |
| GB (2) | GB201721999D0 (en) |
-
2017
- 2017-12-02 CN CN201711253381.4A patent/CN108239276A/en not_active Withdrawn
- 2017-12-28 GB GBGB1721999.9A patent/GB201721999D0/en not_active Ceased
- 2017-12-29 GB GBGB1722264.7A patent/GB201722264D0/en not_active Ceased
-
2018
- 2018-11-18 AU AU2018101773A patent/AU2018101773A4/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| GB201721999D0 (en) | 2018-02-14 |
| GB201722264D0 (en) | 2018-02-14 |
| CN108239276A (en) | 2018-07-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2018101773A4 (en) | Polyoxypropylene glyceryl ether production plant | |
| IE20180440U1 (en) | Polyoxypropylene glyceryl ether production plant | |
| CN204841666U (en) | Modified silicon oil reation kettle | |
| IES20180440A2 (en) | Polyoxypropylene glyceryl ether production plant | |
| AU2018101767A4 (en) | Emulsifier triisopropylamine polyoxyethylene ether production plant | |
| AU2018101877A4 (en) | Neuritis treatment drug thiamine hydrochloride production plant | |
| AU2018101985A4 (en) | Dye dispersant sodium cellulose sulfate production plant | |
| CN111187164B (en) | 6-carbonyl-8-chloro ethyl caprylate synthesis device and method for synthesizing 6-carbonyl-8-chloro ethyl caprylate by using same | |
| CN109021222B (en) | Preparation method of high-collapse-resistance polyether monomer | |
| AU2018101968A4 (en) | 2-hydroxy-3-sulfopropyl propyl starch ether production plant | |
| CN103087206B (en) | Hetastarch 200/0.5 that can be used as plasma substitute and preparation method thereof | |
| CN112920019A (en) | Novel process for preparing high-purity sodium tert-butoxide | |
| AU2018101971A4 (en) | CT1-6 acid gelling agent production plant | |
| CN104844435A (en) | System and technology for producing benzaldehyde by utilizing benzyl chloride and benzyl alcohol waste materials | |
| AU2018101774A4 (en) | Alkyl glucoside production plant | |
| AU2018101980A4 (en) | N, N'-salicyl-1,2-propionamide production plant | |
| AU2018101811A4 (en) | Polyvinyl formal production plant | |
| IE20180404U1 (en) | Modified sunflower oil phosphate ester production | |
| AU2018101397A4 (en) | Crosslinking agent benzoyl peroxide production plant | |
| AU2018101771A4 (en) | Polyvinyl alcohol modified starch production plant | |
| AU2018101929A4 (en) | PVC stabilizer dibutyltin dilaurate production plant | |
| AU2018101920A4 (en) | Polyoxyethylene cinnamate production plant | |
| AU2018101734A4 (en) | Modified asphalt emulsion waterproof coating production plant | |
| AU2018101923A4 (en) | Epoxy soybean octyl oleate production plant | |
| AU2018101815A4 (en) | Underwater adhesive epoxy resin production plant |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGI | Letters patent sealed or granted (innovation patent) | ||
| MK22 | Patent ceased section 143a(d), or expired - non payment of renewal fee or expiry |