AU2017248353A1 - TDP-43 mitochondrial localization inhibitor for the treatment of neurodegenerative disease - Google Patents
TDP-43 mitochondrial localization inhibitor for the treatment of neurodegenerative disease Download PDFInfo
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- AU2017248353A1 AU2017248353A1 AU2017248353A AU2017248353A AU2017248353A1 AU 2017248353 A1 AU2017248353 A1 AU 2017248353A1 AU 2017248353 A AU2017248353 A AU 2017248353A AU 2017248353 A AU2017248353 A AU 2017248353A AU 2017248353 A1 AU2017248353 A1 AU 2017248353A1
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- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rehabilitation Therapy (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662319580P | 2016-04-07 | 2016-04-07 | |
| US62/319,580 | 2016-04-07 | ||
| US201662328484P | 2016-04-27 | 2016-04-27 | |
| US62/328,484 | 2016-04-27 | ||
| PCT/US2017/026675 WO2017177178A1 (en) | 2016-04-07 | 2017-04-07 | Tdp-43 mitochondrial localization inhibitor for the treatment of neurodegenerative disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2017248353A1 true AU2017248353A1 (en) | 2018-10-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017248353A Abandoned AU2017248353A1 (en) | 2016-04-07 | 2017-04-07 | TDP-43 mitochondrial localization inhibitor for the treatment of neurodegenerative disease |
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| Country | Link |
|---|---|
| US (2) | US11124553B2 (enExample) |
| EP (1) | EP3440094B1 (enExample) |
| JP (1) | JP2019513752A (enExample) |
| KR (1) | KR20180132807A (enExample) |
| CN (1) | CN109563130A (enExample) |
| AU (1) | AU2017248353A1 (enExample) |
| CA (1) | CA3020344A1 (enExample) |
| SG (1) | SG11201808829VA (enExample) |
| WO (1) | WO2017177178A1 (enExample) |
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| EP3645557B1 (en) | 2017-06-28 | 2024-10-23 | The Cleveland Clinic Foundation | Treatment of nervous system injury and neurodegenerative disorders and related conditions |
| CN113683703B (zh) * | 2020-05-18 | 2023-08-15 | 中国人民解放军陆军军医大学第二附属医院 | 一种hTERT靶向物及其用途 |
| WO2021247893A1 (en) * | 2020-06-03 | 2021-12-09 | Yumanity Therapeutics, Inc. | Bicyclic heteroaromatic amide compounds and uses thereof |
| CN114057858B (zh) | 2020-08-10 | 2023-03-21 | 上海瑞吉康生物医药有限公司 | 对引起神经变性和神经退行性疾病的蛋白聚集具有解聚作用的多肽 |
| KR102488166B1 (ko) | 2020-09-24 | 2023-01-13 | 재단법인대구경북과학기술원 | Ｈｄａｃ６의 ｔｄｐ－４３ 단백질병증 예방 또는 치료제로서의 용도 |
| JP6961278B1 (ja) * | 2021-03-10 | 2021-11-05 | 国立研究開発法人量子科学技術研究開発機構 | 生体試料中のｔｄｐ−４３を測定する方法及び装置 |
| CN113450336B (zh) * | 2021-07-01 | 2022-10-25 | 维柯基科技(上海)有限公司 | 一种多孔荧光微阵列图像的处理方法、装置、计算机设备及计算机可读存储介质 |
| KR20240133923A (ko) * | 2023-02-28 | 2024-09-05 | (주)케어젠 | 펩타이드 복합체를 유효성분으로 포함하는 항노화용 조성물 |
| KR102859015B1 (ko) | 2023-07-20 | 2025-09-12 | 충북대학교 산학협력단 | ｃＡｂｌ에 의한 ＴＤＰ４３의 특이적 인산화 분석을 통한 신경퇴행성 질환을 진단하는 방법 및 이를 이용한 신경퇴행성 질환의 치료제 스크리닝 방법 |
| WO2025152803A1 (zh) * | 2024-01-17 | 2025-07-24 | 四川大学 | 一种靶向traf6的多肽及其用途 |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US5670617A (en) | 1989-12-21 | 1997-09-23 | Biogen Inc | Nucleic acid conjugates of tat-derived transport polypeptides |
| US5804604A (en) | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
| CA2096222C (en) | 1990-11-13 | 1998-12-29 | Stephen D. Lupton | Bifunctional selectable fusion genes |
| AU6953394A (en) | 1993-05-21 | 1994-12-20 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| US5858683A (en) * | 1996-08-30 | 1999-01-12 | Matritech, Inc. | Methods and compositions for the detection of cervical cancer |
| GB9718609D0 (en) | 1997-09-02 | 1997-11-05 | Imp College Innovations Ltd | Fusion protein |
| GB9723824D0 (en) * | 1997-11-11 | 1998-01-07 | Actinova Ltd | Cytostatic agents |
| EP1305333A4 (en) | 2000-07-31 | 2006-04-12 | Active Motif | PEPTIDE-MEDIATED DELIVERY OF MOLECULES IN CELLS |
| US20040229837A1 (en) * | 2003-05-15 | 2004-11-18 | Yijuang Chern | Treatment of neurodegenerative diseases |
| EP1915621A2 (en) * | 2005-07-01 | 2008-04-30 | Arbor Vita Corporation | Methods and compositions for diagnosis and treatment of viral and bacterial infections |
| JP5519291B2 (ja) | 2006-12-06 | 2014-06-11 | トーマス・ジェファーソン・ユニバーシティ | Ｈｉｖ−１感染症のためのペプチド及び治療法 |
| CA2713871C (en) | 2008-02-01 | 2018-05-22 | Washington University In St. Louis | Sequences associated with tdp-43 proteinopathies and methods of using the same |
| WO2010072228A1 (en) * | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
| US9926353B2 (en) * | 2011-07-19 | 2018-03-27 | New York University | Immunotherapeutic modulation of amyloidogenic disease using non-fibrillogenic, non-amyloidogenic polymerized proteins and peptides |
| CN104520439A (zh) * | 2012-02-28 | 2015-04-15 | 国立大学法人东京农工大学 | Tdp-43细胞内存在量关联疾患的认定方法 |
| US9017672B2 (en) * | 2012-05-11 | 2015-04-28 | Immunicum Aktiebolag | Hexon Tat-PTD modified adenovirus and uses thereof |
| WO2013192298A1 (en) * | 2012-06-22 | 2013-12-27 | The Scripps Research Institute | Apoptosis biomarkers |
| GB201408255D0 (en) * | 2014-05-09 | 2014-06-25 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML) |
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- 2017-04-07 CN CN201780028382.0A patent/CN109563130A/zh active Pending
- 2017-04-07 JP JP2018552826A patent/JP2019513752A/ja active Pending
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- 2017-04-07 US US16/090,786 patent/US11124553B2/en active Active
- 2017-04-07 AU AU2017248353A patent/AU2017248353A1/en not_active Abandoned
- 2017-04-07 SG SG11201808829VA patent/SG11201808829VA/en unknown
- 2017-04-07 CA CA3020344A patent/CA3020344A1/en not_active Abandoned
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2021
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20180132807A (ko) | 2018-12-12 |
| CA3020344A1 (en) | 2017-10-12 |
| JP2019513752A (ja) | 2019-05-30 |
| WO2017177178A1 (en) | 2017-10-12 |
| EP3440094A4 (en) | 2019-03-20 |
| EP3440094A1 (en) | 2019-02-13 |
| US11124553B2 (en) | 2021-09-21 |
| EP3440094B1 (en) | 2021-02-17 |
| SG11201808829VA (en) | 2018-11-29 |
| CN109563130A (zh) | 2019-04-02 |
| US20220220173A1 (en) | 2022-07-14 |
| US20190211070A1 (en) | 2019-07-11 |
| US12129285B2 (en) | 2024-10-29 |
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Legal Events
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| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |