AU2016357460B2 - Improved serum albumin binders - Google Patents

Improved serum albumin binders Download PDF

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Publication number
AU2016357460B2
AU2016357460B2 AU2016357460A AU2016357460A AU2016357460B2 AU 2016357460 B2 AU2016357460 B2 AU 2016357460B2 AU 2016357460 A AU2016357460 A AU 2016357460A AU 2016357460 A AU2016357460 A AU 2016357460A AU 2016357460 B2 AU2016357460 B2 AU 2016357460B2
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amino acid
acid sequence
chosen
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AU2016357460A1 (en
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Marie-Ange Buyse
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Ablynx NV
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Ablynx NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2016357460A 2015-11-18 2016-11-17 Improved serum albumin binders Active AU2016357460B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2023229506A AU2023229506A1 (en) 2015-11-18 2023-09-12 Improved serum albumin binders

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562256841P 2015-11-18 2015-11-18
US62/256,841 2015-11-18
US201662335746P 2016-05-13 2016-05-13
US62/335,746 2016-05-13
US201662349294P 2016-06-13 2016-06-13
US62/349,294 2016-06-13
PCT/EP2016/077973 WO2017085172A2 (en) 2015-11-18 2016-11-17 Improved serum albumin binders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2023229506A Division AU2023229506A1 (en) 2015-11-18 2023-09-12 Improved serum albumin binders

Publications (2)

Publication Number Publication Date
AU2016357460A1 AU2016357460A1 (en) 2018-05-17
AU2016357460B2 true AU2016357460B2 (en) 2023-07-27

Family

ID=57326420

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016357460A Active AU2016357460B2 (en) 2015-11-18 2016-11-17 Improved serum albumin binders
AU2023229506A Pending AU2023229506A1 (en) 2015-11-18 2023-09-12 Improved serum albumin binders

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2023229506A Pending AU2023229506A1 (en) 2015-11-18 2023-09-12 Improved serum albumin binders

Country Status (7)

Country Link
US (2) US11332519B2 (enExample)
EP (1) EP3377525A2 (enExample)
JP (3) JP7046804B2 (enExample)
CN (3) CN108473564B (enExample)
AU (2) AU2016357460B2 (enExample)
CA (1) CA3005488A1 (enExample)
WO (1) WO2017085172A2 (enExample)

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Also Published As

Publication number Publication date
CN120535622A (zh) 2025-08-26
JP2019503990A (ja) 2019-02-14
AU2016357460A1 (en) 2018-05-17
JP7046804B2 (ja) 2022-04-04
EP3377525A2 (en) 2018-09-26
WO2017085172A2 (en) 2017-05-26
CN108473564A (zh) 2018-08-31
CN108473564B (zh) 2022-04-08
CA3005488A1 (en) 2017-05-26
US20220380445A1 (en) 2022-12-01
JP7453206B2 (ja) 2024-03-19
WO2017085172A3 (en) 2017-06-29
JP2024063213A (ja) 2024-05-10
US11332519B2 (en) 2022-05-17
CN114605530B (zh) 2025-06-10
CN114605530A (zh) 2022-06-10
AU2023229506A1 (en) 2023-09-28
US20200283509A1 (en) 2020-09-10
JP2022037133A (ja) 2022-03-08

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