AU2016353150A1 - Laser assisted wound healing protocol and system - Google Patents
Laser assisted wound healing protocol and system Download PDFInfo
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- AU2016353150A1 AU2016353150A1 AU2016353150A AU2016353150A AU2016353150A1 AU 2016353150 A1 AU2016353150 A1 AU 2016353150A1 AU 2016353150 A AU2016353150 A AU 2016353150A AU 2016353150 A AU2016353150 A AU 2016353150A AU 2016353150 A1 AU2016353150 A1 AU 2016353150A1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0616—Skin treatment other than tanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0468—Specially adapted for promoting wound healing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0644—Handheld applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
- A61N2005/0663—Coloured light
Landscapes
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
A method of treating diseased tissue while healing the wound using a diode laser which generates a beam of light having a wavelength in the visible portion of the electromagnetic spectrum (400nm-700nm) at a laser power of 0.001 to 1.2 watts, used with intermittent stops to control tissue temperature and biostimulate epithelial regeneration when used with or without substrates. A method of treating diseased tissue using a laser light in the green wavelength range (520-570 nm) at a laser power of 0.001W to 5W. A method of treating diseased tissue using a laser light in the IR wavelength range (700-1400 nm) at a laser power of 0.001W to 5W.
Description
The present invention relates generally to a method of treating gum diseases using a diode laser which produces a beam of light having a wavelength in the visible portion of the electromagnetic spectrum (400am - 700nm). Optionally, the laser light utilizes green wavelength range (520 - 570 nm) at a laser power 0.001 W to 5W to treat wounds. It is also contemplated that described is a method of treating diseased tissue rising a diode laser. Optionally, the laser light utilizes the IR wavelength range (700nm - 1400nm) at a laser power of .0G1W to 5W to treat wounds. Optionally, an LED light utilizes the IR wavelength range to treat wounds.
BACKGROUND OF THE INVENTION
Laser Assisted Periodontium and Osseous Regeneration (LABOR) is a protocol which is laser assisted with the use of a substrate such as but not limited the LAPOR periodontal solution, fee LAPOR periodontal gel and the LABOR substrate and thus causes an increase in cell attachment of epithelial cells, gingival fibroblasts, PDL fibroblasts and adhesion of osteogenic cells. Enhanced cell migration and proliferation appears to lead to accelerated wound fill rates in vitro using PDL fibroblasts, gingival fibroblasts and osteoblast-like cells.
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A substrate such as the LAPOR periodontal solution, the LABOR periodontal gel and the LAPOR substrate, used in the LAPOR protocol, stimulates total protein synthesis and the synthesis of specific extracellular matrix molecules. Studies that evaluate the bone remodeling regulation system indicate that proteins influence this regulation system, thus indicating an indirect involvement in the bone remodeling process. When used in conjunction with three specially formulated periodontal and wound healing substrates, and LAPOR gel root conditioner, LAPOR has shown to stimulate total tissue and bone synthesis, increase gingival attachment, gingival height, bone density, bone height thereby showing accelerated wound fill rates in vivo.
The diode laser used produces a beam of light having a wavelength in the visible portion of the electromagnetic spectrum (400nm - 70Gmn), Optionally, a beam of light having a wavelength in the green wavelength range (520 - 570 nm) at a laser power of 0,5 to 1,2W is used in the LAPOR protocol. It has been shown by the LAPOR protocol to biostimulate the healing and regenerative processes of the periodontium, including the biostimulation of new bone and its supporting elements. The diode laser used in the LAPOR protocol, biostimulates the healing response of the periodontium nonsurgically, and biostimulates the tissue regeneration of the periodontium, nonsurgically, and prevents long junctional epithelium from migrating downwards into the sulcus (a biomechanical aspect of tissue healing), thereby preserving the tissue height, A diode laser used in the LAPOR protocol helps a substrate such as but not limited to proteins to stimulate total protein synthesis and the synthesis of extracellular matrix molecules, nonsurgically.
Alternatively, the LAPOR protocol may use a beam of light having a wavelength in the green wavelength range (520-570 nm), red wavelength range (620-750 nm), or yellow wavelength range (570-590 nm) having an alternative wattage of 0.001W to 5W, preferably O.002W to 4W, more preferably 0.003W to 4W, and most preferably 0.005W to 2W, The diode laser used helps die substrates stimulate total tissue and hone synthesis by biostimulating the healing response and hone/tissue regeneration and its supporting elements of the wound.
It is further contemplated that the invention may be used to treat tissue damage and wounds,
i.e. Laser Assisted Tissue and Osseous Regeneration (LATOR) using a solution, LATOR gel and
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LATOR substrate to enhance cell migration end proliferation leading to accelerated wound Sil rates. The protocol is used in conjunction with six specially formulated tissue and wound healing substrates and a gel conditioner to stimulate total tissue and bone synthesis, increase tissue attachment, tissue height, bone density and bone height thereby showing accelerated would fill rates like the LAPOR protocol.
SUMMARY OF THF INVENTION
In an exemplary embodiment of the present invention, there is disclosed a method of treating wounds, including gum disease and gingival tissues post sealing/root planning, using a diode laser which generates a beam of light having a wavelength in the visible portion of the electromagnetic spectrum (400nm - 700nm), Optionally, a beam of light having a wavelength in the green range (520 - 570 nm) at a laser power of 0.5 to 1.2 watts is used to decontaminate the gum tissue and to biostimulate healing and regenerate the periodontium (including cementum of the root surface), thus preventing long junctional epithelium from migrating downwards into the sulcus and thereby presenting the tissue height. Alternatively, a beam of light having a wavelength in the green wavelength range (520-570 nm), red wavelength range (620-750 nm), or yellow1' wavelength range (570-590 nm) having an alternative wattage of 0.001W to 5W may be used to biostimulate healing and regenerate foe wound site, its tissue and bone, in a preferred embodiment, the wattage is in the range of0.002W to 4W, more preferred in the range of 0.003 to 3WS and most preferred in the range of 0.005W to 2W. A diode laser also biostimulates the healing and regenerative response induced by a substrate, i.e, the LAPOR periodontal and wound healing solution, foe LAPOR periodontal gel and the LAPOR periodontal and wound healing substrates, the method comprising: 1) placing the laser inside foe sulcus; 2) penetrating foe entire sulcus by moving the laser light intermittently vertically and horizontally throughout the sulcus; and 3) placing the substrate in foe sulcus prior to a blood clot forming (which then increases cell attachment, adhesion, migration and proliferation). In a preferred embodiment, the LATOR protocol may use a diode laser per the above parameters to treat general wound sites. Optionally, foe laser light, utilizes the IR wavelength range (700nm - 1400nm) at a laser power of .001W to 5W to treat wounds.
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In an alternative embodiment, the LAPOR protocol may use an LED light to hiostimulate healing and regenerate periodontium and general wound tissue (LATGR protocol). The LED light is used at 10W or lower on wounds to assist in new cell organization and hence tissue regeneration. Optionally, an LED light utilizes the IR wavelength range to treat wounds. Optionally, the laser light utilizes the IR wavelength range (70Onm - 1400nm) at a laser power of .001W to 5W to treat wounds.
In an alternative embodiment, the LAPOR and LATGR protocols may use a radiofrequency (RF) wave to decontaminate the gum tissue and biostimulate healing and regenerate the periodontium. The RF beam is used at 10W or lower on wounds to assist in new cell organization and hence tissue regeneration, A carrier wave (sine wave) transports a nonsinusoidal waveform to the treatment location. The carrier wave frequency may be in the range of 0.1MHz to 20MHz while the non-sinusoidal waveform may be in the range of 0 to 40 KHz or alternatively 0 - 24 GHz, In a preferred embodiment, the carrier wave frequency is in the range of 0.2MHz to 10MHz, preferably 0,3MHz to 5MHz. Optionally the 0,001 W to 10 watt range, preferably a 0.001 W to 3W range, is utilized in the hertz range of 40 Hz to 24 GHz. In a further alternative embodiment, the RF’ wave is a single sine wave, In a further alternative embodiment, the RF wave is more than one sine wave wherein the more than one demonstrates a harmonics pattern. In a preferred embodiment, the LATOR protocol may use an RF wave per the above parameters to treat general wound sites. Optionally, the non-sinusoidal waveform may be in the range of the above parameters in the absence of a carrier wave.
In another embodiment of the present invention, there is disclosed a rootZbone/cartilage conditioner comprised of EDTA 15%, calcium gluconate 20%, methylparaben, propylparaben, Ethanolamine as a buffering agent, carboxymethylcellulose, and green food coloring and sterile water.
In still another embodiment of the present invention, there is disclosed a first substrate comprised of: a combination of mono or disodium phosphate and sodium hydroxide in solution with a sodium content of 1 Img/lOGg; 60% water; 9% Lysine; 9% Proline; 9% all other essential
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PCT/US2016/061423 amino acids wherein hie amino acids are chosen from the group consisting of Isoleueine, Leucine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, Histadine, Asparagine and Selenocysteine; 2% of all other non-essential amino acids wherein the amino acids are chosen from the group consisting of Alanine, Arginine, Aspartate, Cysteine, Glutamate, Glutamine, Glycine, Serine, Tyrosine and Pyrrolsine; 6.9% free bases wherein the free bases are chosen from the group consisting of adenosine, uridine, gnanosine, iridin and cytidine; 2% phosphates wherein the phosphates are chosen from the group consisting of ADP, ATP and acetycholine; and 1% benzoic acid.
In still another embodiment of the present invention, there is disclosed a second substrate comprised of; tricalcium phosphate wherein the tricalcium phosphate is precipitated with calcium hydroxide/Claw oil; and hydroxyapatite crystals.
In yet another embodiment of the present invention, there is disclosed a third substrate comprised of: 5 J % hyaluronic acid; 8% fatty' acids wherein the fatty acids are chosen from the group consisting of Linoleic acid (LA), alpha-linolenic acid (ALA), 4.4% sugars wherein the sugars are chosen from the group consisting of mannose, galactose. N-acetylglactosamine, Nacetyiglucosamine, N-acetylneuraminie acid, foeose (L configuration minus a carboxyl group at the 6 position), and xylose: 2,2% mixture of glucose and fucose (L configuration minus a carboxyl group at the 6 position); 3% lipids wherein the lipids are chosen from the group consisting of vitamin A, vitamin D2, D3, vitamin E, vitamin ΚΙ, K2, vitamin B12 (methyleobalamin, hydroxoeofealamin), cholesterol, and diaglyeerol; 2„?% vitamins wherein the vitamins are chosen from the group consisting of vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin B9, vitamin C and pantothenic acid; 4.5% electrolyte sources: wherein the electrolyte sources are chosen from the group consisting of Calcium Chloride, Choline Chloride, Magnesium Sulfate, Potassium Chloride, Potassium Phosphate (monobasic), Sodium Bicarbonate, Sodium Chloride, and Sodium Iodide; 6% metals wherein the metals are chosen from the group consisting of Ag nanoparticles and Au nanoparticles; 3.9% ionic metals wherein the ionic metals are chosen from the group consisting of copper, zinc, selenium, iron, manganese, cobalt, chromium, boron, and molybdenum; and 4% other ionic metals wherein the other ionic metals are chosen from the group consisting of boron, silicon, nickel and vanadium.
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In another embodiment of the present invention, there is disclosed a fourth substrate comprised of carbarn er, potassium chloride, chloride, sodium, potassium, manganese, calcium triphosphate, sulfate, carbonate, snail serum, snail secretion filtrate, HA, Au. Ag, Cu, Fe, Pt, collagen, glyceine HCI and iueose.
In another embodiment of the present invention, there is disclosed as fifth substrate comprised of a tricalcium phosphate and/or collagen limed and/or collagen unlimed.
Is another embodiment of the present invention, there is disclosed a sixth substrate comprised of tricalcium phosphate and/or collagen limed and/or collagen unlimed and/or HCI and/or NaCl. and/or metals wherein the metals arc chosen from the group consisting of copper, Au, Ag, iron and platinum or any combination thereof
The more important features of the Invention have thus been outlined in order that the more detailed description that follows may be better understood and in order that the present contribution to fee art may better be appreciated. Additional features of the invention will be described hereinafter and will form the subject matter of the claims that follow.
Before explaining at least one emhadiment of the Invention in detail, it Is to be understood that the invention is not limited in its application to the details of construction and the arrangements of the components set forth in fee following description or illustrated In fee drawings. The invention is capable of other embodiments and of being practiced and carried out in various ways. Also, it is to he understood that the phraseology and terminology employed herein are for the purpose of description and should not be regarded as lim iting.
As such, those skilled in the art will appreciate that fee conception, upon which feis disclosure is based, may readily he utilized as a basis for the designing of other structures, methods and systems for carrying out the several purposes of the present invention. It Is Important, therefore, that the claims be regarded as including such equivalent constructions insofar as they do not depart from the spirit and scope of fee present invention.
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The foregoing has outlined, rather broadly, the preferred feature of the present invention so feat those skilled in fee art may better understand fee detailed description of fee invention that follows. Additional features of the invention will be described hereinafter that form the subject of the claims of fee invention. Those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiment as a basis for designing or modifying ofeer structures for carrying out the same purposes of fee present invention and that such other structures do not depart from the spirit and scope of the invention in its broadest form.
BRIEF DESCRIPTION OF THE DRAWINGS
Other aspects, features, and advantages of fee present invention will become more felly apparent ft'om the following detailed description, the appended claim, and fee accompanying drawings in which similar elements are given similar reference numerals.
Fig. 1 shows an X-Ray view of a patient's teeth before treatment wife a diode laser before a substrate has been applied.
Fig, 2-7 show X-Ray views of fee lower teeth of Fig. 1 after treatment with a diode laser after treatment wife a substrate.
Fig. 8 shows an X-Ray view of fee upper teeth before treatment with a diode laser after treatment with a substrate.
Fig, 9 show's an X-ray view of the upper teeth of Fig. 8 after treatment wife a diode laser after treatment with a substrate.
Fig. 10 shows a flow diagram of a method of using a diode laser to treat gum disease in accordance wife the principles of fee invention.
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Fig. J1 shows bone density measurements for tooth 15 of a patient al 12 loci on the tooth following treatment with a diode laser and a substrate over time.
Fig, 12 shows bone density measurements for tooth 28 of a patient at 17 loci on the tooth following treatment with a diode laser and a substrate over time.
Fig. 13 shows hone density measurements for tooth 2, tooth 3 and tooth 15 of a patient at 3 loci per tooth following treatment with a diode laser and a substrate over time.
Fig, 14a and 14b show X-rays of tooth 15 of a patient from which measurements shown in Fig. 1.1 were collected, (a) shows tooth 15 before treatment, (b) shows tooth 15 at the October 2011 measurement following three treatments.
Fig. 15a and 15b show X-rays of tooth 28 of a patient from which measurements shown in Fig, 12 were collected, (a) shows tooth 28 before treatment, (b) shows tooth 28 at the January 2011 measurement following four treatments.
Fig. 16a and 16b show a panoramic X~ray of tooth 2, tooth 3 and tooth 15 of a patient from which measurements shown in Fig. 13 were collected, (a) shows the teeth before treatment, (b) shows the teeth at the July 2011 measurement.
Fig. 17a-17f show various view’s of a first embodiment of a diode laser of the present invention, (a) shows a right side view, (b) show's a hack side view, (c) show's a left side view', (d) shows a front side view, (e) shows a top view, (f) shows a bottom view.
Fig, 18a-18c show an exploded view of the diode laser of Fig, 17. (a) shows an exploded view, (b) shows an assembled view, (c) show's a close-up of the laser housing.
Fig. 19a-19g shows various views of a second embodiment of a diode laser of the present invention, (a) shows a top perspective view, (b) shows a back view', (c) shows a left side view.
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PCT/US2016/061423 (d) shows a top view, (e) shows a front perspective view, (f) shows a right side view, (g) shows a bottom view.
Fig. 20a and 20b an exploded view of the diode laser of Kg. 19. (a) shows an exploded vi ew, (b) shows a close-up of the laser housing.
Fig. 21a-21e show' various view of a third embodiment of the diode laser of the present invention, (a) shows a side perspective view, (b) shows an exploded view, (c) shows a close-up view of the laser housing.
Fig. 22&~2.2c shows a fiber optic laser of the present invention, (a) sho ws an assembled view, (b) shows an exploded view, (c) shows a fully assembled laser.
Fig, 23 shows a flow chart of the protocol for using a laser of the present invention.
Fig. 24 shows chin profile measurements before and after treatment.
Fig. 25 shows toe crease length measurements before and after treatment,
Fig. 26a-26c show gingival wound healing and tissue regeneration measurements before and after treatment, (a) show's wounds before treatment, (b) shows tissue regeneration after treatment, (e) shows tissue height measurements before and after treatment.
Fig. 27 shows hand crease length measurements before and after treatment.
Fig, 28 shows wound new skin growth measurements before and after treatment.
Fig. 29 shows (anal) sear width reduction measurements before and after treatment.
Fig, 30 shows (anal) scar length reduction measurements before and after treatment.
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Fig, 31 shows swallowing strength measurements before and after treatment,
Fig, 32 shows breast firmness measurements before and after treatment.
Fig, 33a~33e show various views of an RF hand piece of the present invention, (a) shows a top view, (b) shows a side view, (c) shows a perspective view of the RF tips, (d) shows an exploded side perspective view’, (e) shows an alternative side perspective view.
Fig. 34a-34f show various views of a fourth alternative diode laser of the present invention, (a) shows a right side view, (b) show's a front view, (c) shows a left side view, (d) shows a left side perspective view, (e) shows a top view, (f) shows a rigid side perspective view.
Fig. 35a-35f show various views of a laser power source for the fiber optic hand piece and interchangeable tips,
Fig, 36a-36f shows various views of a portable RF transmitter of the present invention, (a) shows a top view, (b) shows a front view, (c) shows a bottom view, (d) shows a left side view, (e) shows a left front perspective view, (f) shows a right front perspective view.
Fig, 37a-37b show alternative fiber optic lasers of the present invention, (a) shows a flat tip. (b) shows a glass dispersion tip.
Fig. 38 shows epithelial wound regeneration before and after treatment,
Fig. 39 shows cancaeal tendon wound regeneration before and after treatment.
Fig, 40 shows ankle epithelial wound regeneration before and after treatment.
Fig. 41 shows ankle wound size reduction before and after treatment.
Fig. 42 shows oral cavity wound regeneration before and after treatment.
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Fig. 43 a-b shows (a) vein wound regeneration before and after treatment and (b) a flashlight style infrared laser.
DETAILED DESCRIPTION OF THE INVENTION
Definitions
As used herein, the term “gum disease” means periodontal disease which can lead to tooth loss and/or other health problems. Examples of periodontal disease include Gingivitis, aggressive periodontitis, chronic periodontitis, periodontitis as a manifestation of systemic diseases, and necrotizing periodontal disease.
As used herein, die term Tissue disease” means tissue and/or epithelial loss due to injury and/or wounds which can lead to other health problems such as amputation of limbs.
As used herein, the term “patient” means any individual suffering from a disease of the gums and in need of treatment for said gum disease.
As used herein, the term “locus” means an exact point of measurement within the sulcus
As used herein, the term “substrate mixtare” means foe mixture of the first substrate and/or the second substrate and/or the third substrate and/or the fourth substrate and/or foe 'fifth substrate and/or sixth substrate disclosed herein for treatment of gum disease and/or tissue disease and/or wounds.
As used herein, the term “bone regeneration” means increasing the density of calcium at specific loci in or around the sulcus.
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As used herein, the term “calcium density” means the measurement of calcium mass around a given loci.
As used herein the term “wound” means any area that has lost any original tissue or bone or any other structure not named that lost a healthy non-wounded, undamaged and imaged term.
The LAPOR. protocol can be used lu the treatment of gum disease and wounds by combining the most effective methods of treatment, with the use of a special laser. Approximately 66% of fee United States population has some form of gum disease. But many avoid seeking treatment because ofthe discomfort that often results from gum surgery. LAPOR provides a new choice. The LAPOR protocol is a treatment that is more effective as traditional periodontal surgery, and it is much more beneficial to the patient both in the short term and in the long run. The LATOR protocol can similarly be used for treatment of tissue disease and wounds.
The LAPOR protocol takes only about an hour and only two short follow-up visits. Patients enjoy no downtime with recovery taking only 24 hours. This makes immediate return to work both possible and comfortable.
After having the LAPOR protocol performed, gum recession is zero when compared to that which most often fellows normal periodontal surgery. This, combined with new cementum formation on the roots, bone formation in previous defects, periodontal ligament formation and no tooth loss. After having the LATOR protocol performed, wound fibrosis is zero compared to that which most often, follow's normal treatment, new tissue formation occurs multi directionally arid the wound closes without grafting.
The LAPOR protocols of the present invention can be used to heal wound sites by combining or using separately the most effective methods of treatment with the laser, LED, radiofrequ ency energy? and substrates. Following performance of treatment protocols, no receding of tissue from the wound site was observed. In a preferred embodiment, the RF energy waves may be up to 10W. The carrier wave frequency may be in the range of 0.1 MHz to 2GMHz while the non-sinusoidal waveform may be in fhe range of 0 to 40 KHz or from 0 to
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24GHz. In a preferred embodiment, the carrier wave frequency is in the range of 0.2MHz to 10MHz, preferably 0.3MHz to 5MHz. Optionally a 0.001 W to 10W range RF energy, preferably a 0.001 W to 3W range, is utilized in the hertz range of 40 Hz to 24 GHz, In a farther alternative embodiment, the RF wave is more than one sine wave wherein fee more than one demonstrates a harmonics pattern.
The special type of laser used in the LAPOR protocol and the LATOR protocol is the diode, a semiconductor coherent light beam used on s. The laser light used has a wavelength in the visible portion of the electromagnetic spectrum, between 400nm - 700nm wavelength. Optionally, fee green range (520 — 570 nm) of the visible spectrum is utilized at a laser power of 0.5 to 1.2 watts, which disinfects fee site, leaving the gum tissue bacteria free, and biostirnnlates healing; in conjunction wife treatment wife a substrate, the laser biostimulates regeneration of the periodontium. Traditional periodontal therapy removes tissue height of a tooth to reduce fee pocket depths. The LAPOR protocol is a regenerative procedure. The patient does not lose tissue volume. Tissue volume is increased and bone is regenerated. For general tissue disease, fee laser bioslimulates regeneration of tissue where traditional therapy removes tissue height to reduce fee disease. Optionally, the laser light utilizes fee IR wavelength range (700nm - 140Onm) at a laser power of .001W to 5 W to treat wounds. Optionally, LED light is used at 10W or lower.
The use of the diode laser in conjunction with routine sealing and root planning is more effective than sealing and root planning alone. It enhances fee speed and extent of the patients gingival healing and postoperative comfort. This is accomplished through laser bacterial reduction and biostimulation wife a laser light having a wavelength in the visible portion of the electromagnetic spectrum, between 400nm — 700nm wavelength. Optionally, the green range (520 - 570 nm) of fee visible spectrum is utilized at a laser power of 0.5 to 1.2 watts. Alternatively, the laser power wattage may be in fee range of 0.001W to 5W, preferably 0.002W to 4W, more preferably 0.003W to 3W, and most preferably 0.005W to 2W.
Referring to Fig. 10, there is disclosed a method 10 of using a diode laser which produces a beam of light, used intermittently, having a wavelength in fee visible portion of the electromagnetic spectrum, between 4G0nm - 70Qnm wavelength. Optionally, the green range (520
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- 570 mn) of the visible spectrum is utilized at a laser power of 0.5 to 1.2 watts to treat gum disease. Starting at block 12, a perio probe determines the degree of excessive pocket depth and thus helps the dentist better identify diseased tissue and areas of bacterial infection. The dentist removes calculus from the root surface using an ultrasonic scaler and hand instruments, block 14. This action by the dentist helps stimulate a healing response in the sulcus by opening the capillaries upon scaling. Going to block 18, the laser tip is placed inside the sulcus and a continuous light beam with intermittent stops for tissue temperature control is allowed to penetrate the entire sulcus by moving the tip vertically and horizontally throughout the sulcus. The laser tip is cut at a 45 degree angle during the first pass. The laser is cut at the opposite 45 degree angle during the second pass. This allows for the laser beam to penetrate tire existing periodontium to decontaminate tire tissue, as the heat of the targeted laser light kills the bacteria. This also allows for biostknulation of the suleular contents. At block 20, the dentist scales the suleular area and root surfaces once again to induce a healing response through renewed blood flow. Going to block 22, at least one substrate, such as but not limited to matrix proteins, is then placed in the sulcus of the tooth prior to the blood clot forming arid at block 24, a blood clot is carefully allowed to form by gently helping patient keep their mouth open for 5 minutes, to keep the substrate intact. Optionally, tire laser light utilizes tire IR wavelength range (700nm - 1400nm) at a laser power of ,001W to 5W to treat wounds.
Alternatively, the laser tip is a specially designed tip that disperses light energy throughout the wounded sulcus which allows the laser beam to penetrate the existing tissues to decontaminate the tissue, as the heat of the targeted laser light kills the bacteria and as a result block 20 may he eliminated going directly to block 22
The LAPOR protocol is much less invasive than traditional surgery and offers advantages and benefits over its counterpart. Recovery time is much faster because most, if not all, damage to healthy tissue is avoided through the use of more advanced technology. Because the LAPOR protocol leaves healthy tissue intact, the height of the gums themselves increases around the teeth and is better preserved, The LAPOR protocol prevents long junctional epithelium from migrating downwards into the sulcus, thus preserving the tissue height and allowing for the regeneration of the periodontium.
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Referring to Fig. 17a~17f, shown are various angles of the first embodiment of a device 100 for use in conjunction wi th the substrates and methods of the present invention. Fig. 18a and 18b show perspective views of the device 100 in the first embodiment Specifically, Fig. 18a illustrates as exploded view of the device 100 comprised of cord 101 integrally connected to handle 109, handle 109 further connected to heat sink 102. Housing 103 securely connects to heat sink 102 thereby creating a cavity between the housing 1.03 and heat sink 102. Laser 104 is positioned within the cavity between housing 103 and heat sink 102. Male connectors 105 connect RF source 108 to housing 103 wherein threaded inserts 106 cover the connection therebetween. Cap 107 is positioned over housing 103 and secures to handle 109. FIG 18c shows a detailed view' of heat sink 102, laser 104, housing 103 and male connectors 105 in relation to each other. In a preferred embodiment, the device 100 may have a plurality of RF sources 108 wherein a plurality is defined as at least two tips (i.e. dipole). Housing 103 is capable of movement such that RF source 108 may be adj usted 45c up or do wn relative to the xaxis for ease of use depending upon the location of the wound receiving treatment.
The laser energy may have wavelength in the green wavelength range (520-570 nm), red wavelength range (620-750 nm), or yellow wavelength range (570-590 nm) having a wattage of 0.001 W to 5W. In a preferred embodiment, laser energy has a wattage of .001W to 5W. The wattage is in the range of 0.001 W to 4W, more preferred in the range of 0.003 to 3W, and most preferred in the range of 0.005W to 2W, Tire RF energy may have a power of 10 watts or lower. The carrier wave frequency may be in the range of 0.1 MHz to 20MHz while the non~sinusoidal waveform may be in the range of 0 to 40 KHz or from 0 to 24GHz. In a preferred embodiment, the carrier wave frequency is in the range of 0.2MHz to 10MHz, preferably 0,3 MHz to 5MHz. Optionally a 0.001W to 10W range RF energy, preferably a 0.GG1W to 3W range, is utilized in the hertz range of 40 Hz to 24 GHz. In a further alternative embodiment, the RF wave is more than one sine wave wherein the more than one demonstrates a harmonics pattern. Optionally, the non-sinusoidal waveform may be in the range of the above parameters in the absence of a carrier wave.
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Referring to Fig, 19a-19g, shown are various angles of a second embodiment of a device 200 for use in conjunction with the substrates and methods of the present invention. Fig, 20a shows a perspective view of the device 200 of the second embodiment. Specifically, Fig. 20a illustrates an exploded view of the device 200 comprised of wire grommet 201 integrally connected to handle 209, handle 209 further comprised of heat sink 202. Housing 203 securely connects to heat sink 202 thereby creating a cavity between the housing 203 and heat sink 202, Laser 204 is positioned within the cavity between housing 203 and heat, sink 202. Male connectors 205 connect RF source 208 to housing .203 wherein threaded inserts 206 cover the connection there between, Fig, 20b shows a detailed view of laser 204 and housing 203 in relation to each other.
Referring to Fig, 21a-21c, shown is a third embodiment of a device 300 for use in conjunction with the substrates and methods of the present invention. Fig. 21 a shows a perspective view of the device 300 of the second embodiment, Specifically, Fig, 21b illustrates an exploded view of the device 300 comprised of wire grommet 301 integrally connected to housing 303, housing 303 further comprised of heat sink 302. Housing 303 securely connects to heat sink 302 thereby creating a cavity between the housing 303 and heat sink 302. Laser 304 is positioned within the cavity between housing 303 and heat sink 302, Male connectors 305 connect RF source 308 to housing 303 wherein threaded inserts 306 cover the connection there between. Fig, 21c shows a detailed view of laser 304 and housing 303 in relation to each other. By way of example only, the device may have five or six tips.
Referring to Fig. 22a and 22b, shown is a fiber optic device 400 for use in conjunction with the substrates and methods of the present invention. Fiber optic device 400 is comprised of hand grip assembly 401 disposed between a first end and a second end. The first end is further comprised of nose insert 402 positioned between hand grip assembly 401 and removable nose assembly 404, Bent fiber tube 405 extends from removable nose assembly 405, The second end is further comprised of base insert 406 positioned between hand grip assembly 401 and rubber boot 407, Extending from rubber boot 407 is sheathed fiber 408 having a SMA connector 409 at the end opposite rubber boot 407. Fig, 22c show's a fully assembled fiber optic device 400 further comprising a body for housing the laser source.
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Firstly, the conditioner is applied to the root or bone surface. The root conditioner comprises the following at Table 1;
Component | |
EDTA | 20-25 g. |
Calcium gluconate | 10-20 g. |
Methyl para ben | .1-.9 g, |
Propylparaben | .01-.1 g. |
Etharsolamine | 2-S mb. |
Carboxymethylcellulose | 2-10 g. |
Green food coloring | 1-2 drops |
Sterile water | 100 mis. |
The conditioner is optionally rinsed out prior to application of additional substrates or laser light. Alternatively, the conditioner is left on the root or bone surface with the laser light being applied prior to application of any substrate. In an alternative embodiment, fee conditioner is left in with only one substrate applied prior to application of the laser light. Optionally, the conditioner is left in the sulcus and substrate is added prior to any application of laser light.
The placement of the substrate into the sulcus containing luminesced blood enables the luminesced blood to coagulate upon the substrate.
Optionally, the liquid substrate or substrate 1 is comprised of fee following, per ί L of solution, at Table 2:
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Table 2
Amino Adds | % |
Isoleucine | 1,1 25 |
Leucine | 1.125 |
Methionine | 1.125 |
Plienyialanine | 1,125 |
Threonine | 1,125 |
Tryptophan | 1.125 |
Valine | 1.125 |
Histidine | 1.125 |
lysine | 9 |
Aw | |
j&S’OTS&i | % |
Alanine | 0.25 |
Arginine | 0,25 |
Aspartate | 0,75 |
Glutamate | 0.25 |
Glycine | 0.25 |
Serine | 0,25 |
Proline | 9 |
% | |
ADP | 0.667 |
ATP | 0.667 |
Acetylcholine | 0.667 |
Jhssw | % |
Adenosine | 1.725 |
Uridine | 1,725 |
Gu&uosine | 1,725 |
Cytidine | 1,725 |
Benzoic Acid | 1 |
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Sodium
Chloride
Toto/; 100
Optionally, the total sterile water component is adjusted 20% up or down, depending on the desired viscosity to be achieved,
In an alternative embodiment, the liquid substrate or substrate 1 is comprised of the following, at Table 3;
Table 3
JSssoiriW isoteueine
Leucine £7ra/w
ΪΤ25
11.25
Methionine 11.25
Phenylalanine Threonine Tryptophan Valine Histidine Lysine | 11.25 11.25 11.25 11.25 11.25 90 |
Mm- JEssmfcW Amo zridsfe | Gr«?ns |
Arginine | 2.5 |
Aspartate | 7.5 |
Glutamate | 2.5 |
Giycsne | 2.5 |
Serine | 2.5 |
Proline | 90 |
C&w | |
ADP | 7-8 |
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ATP 7-8
Acetylcholine 6-7
Grams TmT 13-14 13-14 13-14 13-14
Benzoic Acid 20
Sodium
Chloride '
Sterile water .9-1,2L
Adenosine
Uridine
Guanosine
Cytidine
Iridine
In an alternative embodiment, an additional substrate may be applied, the additional substrate, substrate 2, comprised of; tricalcium phosphate wherein the tricaleium phosphate is precipitated with calcium hydroxide/Claw oil; and hydroxyapatite crystals.
In an alternative embodiment, an additional substrate may be applied, the additional substrate, substrate 3, is comprised of the following at Table 4;
Table 4
Hyaluronic acid
200mg
Fatty «rids
Alpha-iinolenic add (ALA)
Grams
Grams
0,6
Galactose
0.6
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N- acetylga lactosa m ine N- acgtylglucosamine | 0.6 0.6 |
N-scetyfeeuramfeic | 0.6 |
add Fncose (L config. | |
and no carboxyl at 6 position) | 0.6 |
Xylose | 0.6 4.2 |
Glucose Fucose (L config. | 1.1 |
and no carboxyl at 6 position) | 1.1 |
Gram |
A | |
02 | 03 |
D3 | 03 |
E | 0,3 |
K1 | 0.3 |
K2 | 0.3 |
012 | 0.3 |
(Methylcobalamin) | |
B12 | 03 |
(Nydroxocobalamin) | |
Cholesterol | 03 |
Diaglycerol | 0.3 |
3.0 |
0.3
0.3
0.3
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Pantothenic add | 03 2.7 | |
bledbwxte Smmvss | Grams | |
Choline Chloride | .5 | |
Magnesium Sulfate | 3 | |
Potassium Chloride | ,5 | |
Potassium | ||
Phosphate- | 1 | |
monobasic | ||
Sodium Bicarbonate | .5 | |
Sodium Chloride | .5 | |
Sodium iodide | .5 4.5 | |
Afeto/s | Groms | |
Ag nanopartides | 0.3 | |
Au nanopartsdes | 0.3 0.6 | |
fcgmfr merafe | Grams | |
Copper | 0.3 | |
Zinc | 03 | |
Selenium | 03 | |
Iron | 03 | |
Manganese | 03 | |
Cobalt | 0.3 | |
Chromium | 0.3 | |
Boron | 03 | |
Molybdenum | 03 2.7 |
Otter fente mettfe | Grams |
................................................................... | ................................... |
Boron | 03 |
Silicon | 03 |
Nickel | 03 |
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Vanadium | 0.3 |
1.2 |
Benzoic Acid | Up to 10.1 |
Sodium Chloride | .1-.9 |
Sterile water | 60< A* |
Optionally, the total sterile water component is adjusted 20% up or down, depending on the desired viscosity to be achieved.
In an alternative embodiment, an additional substrate may be applied, the additional substrate, substrate 4, is comprised of the following at Table 5:
Table 5
Groms | /Votes | |
carbomer | 10-40 | For acute wound (see Fig. 39) use 10-20 |
For chronic wound (see Fig. 38) use 25-40 | ||
Rfecfro/yfes | Groms | |
Potassium chloride | 0.5-3 | |
Chloride | 0.1-1 | |
Sodium | 0.1-1 | |
Potassium | 0.1-1 | |
Manganese | 0.1-1 | With one size or variety of sizes of crystals: 4-50 |
Calcium tri- | O !v-4 | pm, 50-150 pm, 100-300 gm, 500-1000 pm, 1-3 |
Phosphate | mm, and 3-5 mm; may be dense or porous. | |
Sulfate | 0.1-1 | |
Bicarbonate | 0.1-1 |
Snail serum
50-150 ml; for chronic wounds substrate 6 may be
Incorporated (see Fig. 41); decreases depending of volume of substrate 6
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Snail secretion | 50- |
filtrate | ISOrog |
HA | 3-6 |
Ao | 0.1-1 |
Ag | 0,1-1 |
Co | 0.1-1 |
Fe | 0.1-1 |
Pt | 0.1-1 |
Collagen | 50- 150 |
focose | 0.5-1 |
Glyceine HCI | 0-0,4 |
Metals may be increased 50% for chronic wounds (see Fig. 40).
Optionally, the total sterile water component is adjusted 20% up or down, depending on the desired viscosity to be achieved.
Substrates 1,2 and 3 may have different modalities of delivery, for example, drops, spray's, injections or intravenous having fee same ingredients, as well as sublingual, anal, foam and ointment formulations or drinkable liquids.
In an alternative embodiment, an additional substrate may be applied, the additional substrate 5 is comprised of the following:
1. collagen, limed and/or
2. collagen, unlimed, and/or
3. collagen, supplemented with porous triealcium phosphate crystals with one size or variety of sizes: 4-50 gm, 50-150 pm, 100-300 pm, 500-1000 pm, l-3mm and 3-6 mm. The tricalcium phosphate crystals may he dense or porous. Optionally, substrate 5 may be used in the absence of other substrates.
In an alternative embodiment, an additional substrate may be applied, the additional substrate 6 Is comprised of fee following:
1. collagen, limed and/or
2. collagen, unlnned and/or
3. HCI and/or
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4. NaCl and/or
5. Cu, Ag. Fe, Au, Pt or any combination thereof and/or
6. Collagen, supplemented with porous tricalcium phosphate crystals with one size or variety of sizes: 4-50 pm, 50-150 pm, 100-300 μηι, 500-1000 pm, l-3mm and 3~6mm. The tricaleium phosphate crystals may be dense or porous. Optionally, substrate 6 may be used in the absence of other substrates.
An additional substrate may be applied, tile additional substrate comprised of the following: a mixture of triealcium phosphate and hydroxyapatite crystals. The triealcium phosphate is precipitated with CaOH/devil’s claw oil, in a preferred embodiment Optionally, the additional substrate includes 50% tricalcium phosphate/devil’s claw oil precipitated with 50% porous hydroxyapatite crystals. The triealcium phosphate crystals used are granules in the following sizes: 4-50 pm, 50-150 pm, 100-300 pm, 500-1000 pm, l-3mm and 3-6 mm. The triealcium phosphate crystals may be dense or porous.
The additional substrate may be comprised of hydroxyapatite crystals of granules containing the following sizes: 10-50 pm, 50-150 pm, 100-300 pm, 500-1000 pm, 1 -3mm and 3~ 6 mm. The hydroxyapatite crystals may be dense or porous,
In tiie following examples, the conditioner is applied and subsequently rinsed out. Optionally, the conditioner Is left in the sulcus, as the conditioner allowed the micropores widen the tooth structures to remain open.
After the conditioner is applied, fire sulcus is biostimulated with a laser light. After this occurs, the liquid substrate is applied. Optionally, the additional substrate is applied. For cavities other than oral cavities, a diluted substrate assists treatment when ingested or taken via IV is beneficial although not required.
In an alternative embodiment, an optional spray substrate, spray 1, may be applied, the spray comprised of the following: Au, Ag, Cu, Fe, Pt, and sterile water.
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In an alternative embodiment, an. optional spray substrate, spray 2, may be applied, the spray comprised of the following: Cl, Na, K, Mg, Phosphate, Sulfate, bicarbonate and sterile water.
The fiber optic device of the present invention is the sole device placed inside the sulcus for treatment. The sulcus may also be treated with laser, RF or laser with RF. The remaining disclosed embodiments of the device may be used in wound treatment in conjunction with the substrates depending on the wound site and severity of the wound. Substrates disclosed herein may be a form including, but not limited to, liquid, tablet, enema, gel, injection or foam.
Alternative KF pti/or laser assisted wounded tissae regeMeratloa;
1. Scale/root plane;
2. Etch root of tooth;
3. Rinse with saline water;
4. Place tip of laser into the sulcular wound and turn the laser on fbr 5 seconds;
5. Repeat step 4 circumferentially vertically and horizontally around tooth until the entire sulcular wound has been saturated by laser energy;
6. Place Substrate 1, and/or 2, and/or 3, and/or 4 and/or 5 into glass dappen dishes;
7. Mix the desired amount of substrate 1, and/or 2 and/or 3 and/or 4 and/or 5 in dappers.
dish;
8. Place the desired mixture into the sulcular wound where bone/tissne loss occurred;
9. Wait a few seconds;
10. Place more of the mixture into the sulcular wound where bone/tissue damage occurred;
11. Wait a few seconds;
12. Repeat steps 8 until all defects have been filled;
13. Wait 1 minute;
14. Place hand piece with its RF tip and/or LED tip, with or without laser, perpendicular to the wound, turn on and keep in position for 1 minute;
15. Wait 10 seconds; and
16. Repeat RF step 14 until entire wound has been covered with RF energy, with or without laser.
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Alternative RF asid/or laser
1. Cleanse wound with saline;
2. Place Substrate 1 and/or 3 onto wound;
3. Direct RF/laser, RF, LED, or laser energy at wound for 1 minute;
4. Place another layer of substrate 1, and/or 2, and/or 3, and/or 4, and/or 5 or any combination thereof onto wound;
5. Wait 10 seconds;
6. Repeat steps 2-5 until wound bed is covered; and
7. Alternatively wait a week in between step 2-b and gradually cover wound bed.
Treatment of the oral cavity, head/neck, tongue, anal, vaginal region and the deeper areas reached while treating these may be performed with the RF with substrate (applied substrate or drank with water), RF without substrate, RF plus laser with substrate (applied substrate or drank with water), RF plus laser without substrate and laser with substrate (applied substrate or drank with water), laser without substrate. The treatment described may be utilized throughout tire gastrointestinal tract, head/neck and anus. The laser, RF or LED treatment applied to the oral cavity and surrounding structures, anal cavity and its surrounding structures, head and neck region and its surrounding structures has benefits in deeper areas of the structures. Those deeper areas of the corresponding structures are thus part of the treatment site. Surrounding structures include, but are not limited to, all bone, cartilage, muscles, tendons, nerves, blood vessels, epithelium and fascia.
W and/or laser gsgbtod head and neck wound tissue regain
1. Drink 4 oz. diluted Substrate 1;
2. Wait 15 minutes;
3. Drink 4 oz. diluted Substrate 3;
4. Wait 15 minutes;
5. Direct RF/laser, RF or laser energy at head and neck location and the surrounding structures where wound occurred;
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6, Keep energy in place or move over desired area until desired effect achieved; and
7. Move on to next site until desired result achieved,
Surrounding structures include, hut are not limited to, all hone, cartilage, muscles, tendons, nerves, blood vessels, and epithelium.
Head and neck includes, but is not limited to, all structures of the head and neck including esophagus and its surrounding structures, mouth including all interior mouth structures such as tongue (entire area of tongue including but not limited to anterior, posterior, dorsal, ventral, and sublingual), floor of mouth including hut not limited to arterial and nerve beds, lines alba, buccal mucosa, buccal flanges, lingual flanges, nose, interior of nose (including hut. not limited to the epithelial lining), all muscles and other structures of the tongue and surrounding the tongue, all muscles of the eye and surrounding the eye, all arterial, venous and nerve beds of Are eye and surrounding the eye. AU muscles, nerves, veins, all glands and tissue of the head and neck and any other structure of tire head and neck.
1. Drink 4 oz. diluted Substrate 1;
2. Wait 15 minutes;
3. Drink 4 oz, diluted Substrate 2;
4. Wait 15 minutes;
5. Direct RF/laser, RF or laser energy at the vagina and its surrounding structures;
6. Keep energy in place for 10-20 minutes or until desired effect achieved;
7. Rotate hand piece; and
8. Repeat steps 5-7 until desired result achieved.
Surrounding structures Include, but are not limited to, all bone, cartilage, muscles, tendons, nerves, blood vessels, and epithelium.
BF and/or laser and/or LED
1. Drink 4 oz. diluted Substrate 1, and/or 2, and/or 3, and/or 4, and/or 5;
2. Wait 15 minutes;
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3. Drink 4 oz, diluted Substrate 1, and/or 2, and/or 3, and/or 4, and/or 5;
4. Wait 15 minutes;
5. Direct RF/hser, RF or laser energy at the anus and Its surrounding structures;
6. Keep energy in place for 10-20 minutes or until desired effect achieved;
7. Rotate hand piece; and
8. Repeat steps 5-7 until desired result achieved.
Surrounding structures include, but are not limited to, all bone, cartilage, muscles, tendons, nerves, blood vessels, and epithelium and any other structures of the anal cavity.
1. Drink 4 oz. diluted Substrate 1, and/or 2, and,tor 3, and/or 4, and/or 5;
2. Wait 15 minutes;
3. Drink 4 oz. diluted Substrate 1, and/or 2, and/or 3, and/or 4, and/or 5;
4. Wait 15 minutes;
5. Direct RF/iaser, RF or laser energy at the breast end structures related to the breast;
6. Keep energy in place for 10-20 minutes or until desired effect achieved;
7. Rotate hand piece; and
8. Repeat steps 5-7 until desired result achieved.
Related structures include, but are not limited to, all bone, cartilage, muscles, tendons, nerves, blood vessels, lymph nodes and epithelium.
RF aod/or b-g assisted wound/tbsue repair.
1. Drink 4 oz, diluted Substrate 1, and/or 2, and/or 3, and/or 4, auditor 5;
2. Wait 15 minutes;
3. Drink 4 oz. diluted Substrate 1, and/or 2, and/or 3. and/or 4, and/or 5;
4. Wait 15 minutes;
5. Direct RF/laser, RF or laser energy at. tongue and its surrounding structures;
6. Keep energy in place for 10-20 minutes or until desired effect achieved;
7. Rotate hand piece if necessary, and
8. Repeat steps 5-7 until desired result achieved,
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Surrounding structures include, but are not limited to, all bone, cartilage, muscles, tendons, nerves, blood vessels, and epithelium.
RF and/or laser assisted wound regeaeratiou:
1. Drink 4 02, diluted Substrate 1, and/or 2, and/or 3, and/or 4, and/or 5 and/or 6;
2. Wait 15 minutes;
3. Drink 4 02. diluted Substrate 1, and/or 2, and/or 3, and/or 4, and/or 5 and/or 6;
4. Wait 15 minutes;
5. Direct RF/laser, RF, LED or laser energy at wound and its surrounding structures;
6. Apply Substrate 1, and/or 2, and/or 3, and/or 4, and/or 5 and/or 6;
7. Direct RF,laser, RF, LED or laser energy at wound and its surrounding structures;
8. Keep energy in place for 10-20 minutes or until desired effect achieved;
9. Rotate energy source if necessary; and
10. Repeat steps 5-9 until desired result achieved.
11. Alternatively wait a week in between steps 5-9 and gradually cover wound bed. Surrounding structures include, but are not limited to, all bone, cartilage, muscles, tendons, nerves, blood vessels, and epithelium.
RF .ggd/or laser assisted pore repair;
1. Drink 4 oz. diluted Substrate 1, and/or 2, and/or 3, and/or 4, and/or 5;
2. Wait 15 minutes;
3. Drink 4 oz. diluted Substrate 1, and/or 2, andtor 3, and/or 4, and/or 5;
4. Wait 15 minutes;
5. Direct RF/laser, RF or laser energy at pores and their surrounding structures;
6. Keep energy in place for 10-20 minutes or until desired effect achieved;
7. Rotate hand piece; and
8. Repeat steps 5-7 until desired result achieved.
Surrounding structures include, but are not limited to, all hone, cartilage, muscles, tendons, nerves, blood vessels, and epithelium.
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1. Drink 4 oz. diluted Substrate 1., and/or 2, and/or 3, and/or 4, and/or 5 and/or 6;
2. Wait 15 minutes;
3. Drink 4 oz. diluted Substrate 1, and/or 2, and/or 3, and/or 4, and/or 5 and/or 6;
4. Wait 15 minutes;
5. Direct RF/laser, RF or laser energy at oral cavity and its’ surrounding structures;
6. Apply Substrate 1, and/or 2, and/or 3, and/or 4, and/or 5 and/or 6;
7. Direct RF/laser, RF, LED or laser energy wound and its surrounding structures;
8. Keep energy in place for 10-20 minutes or until desired effect achieved;
9. Rotate energy source; and
8. Repeat steps 5-9 until desired result achieved.
Surrounding structures include, but are not limited io, all bone, cartilage, muscles, tendons, nerves, blood vessels, and epithelium.
Further still, wound treatment, may be utilized for additional conditions including, but not limited to, vaginal wound repair, breast wound repak/regeneration/generation, anal wound repair, age spot repair, pore repair, skin and tissue repair and general body wound repair.
Referring to Fig. 33a~33es shown is a fourth embodiment of a device 500 for use in conjunction with the substrates and methods of the present invention, Fig. 33 a shows a top view of the device 500 of the fourth embodiment. Fig. 33b shows a side view and Fig. 33c shows a close-up of the tip of device 500. Specifically, Fig. 33d illustrates an exploded view of foe device 500 comprised of housing 503, tips 505 and energy source 507. Energy source 507 provides RF energy to housing 503 when connected. Fig. 33e shows a side perspective view of the assembled device 500. Optionally, the device 500 may be used in the absence of substrates.
Referring to Fig. 34a~34f, shown is a fifth embodiment of a device 600 for use in conjunction with the substrates and methods of the present invention. Fig. 34d and 34f show side perspective views of device 600. Fig. 34a shows a side view of device 600 wherein device 600 has a hemispheric shape and is further comprised of a flat surface opposite the hemispheric surface. The flat surface is further comprised of a plurality of mini lasers 605 for delivery of diode laser
WO 2017/083579
PCT/US2016/061423 energy for treatment of an acute wound. The mini lasers 605 are self-contained within device 600, In a preferred embodiment, the laser power used for treatment may be approximately 6-24 mW.
Referring to Fig, 35a-35f, shown is power device 700 for a fiber optic had piece for use in conjunction with the substrates and methods of the present invention. Fig. 35a shows the components of pocket power device 700, the pocket power device 700 further comprised of a base 701, a battery mount 702, a rechargeable battery 703, a handle for a fiber optic laser 704, and a top 705. Fig. 35b-35f show various views of tire pocket power device 700. The handle 704 is a selfcontained unit having an attached fiber optic line 706 upon which a fiber optic laser head (not shown) is connected, Further, a diode laser module is housed in pocket power device 700.
Referring to Fig, 36a~36£, shown is a portable RF transmitter 800 for use in conjunction with the substrates and methods of the present invention. Fig, 36e and 36f show side perspective views of RF transmitter 800. Fig. 36a shows a top view; Fig, 36b shows front view; Fig, 36c shows a bottom view’; and Fig, 36d shows a left side view’. Optionally, the RF transmitter 800 may be used in the absence of substrates.
Referring to Fig. 37a~37b, shown are alternative embodiments of interchangeable fiber optic tips for a laser for use in conjunction with the substrates and methods of the present invention. Fig. 37a shows an interchangeable fiber optic tip for a laser having a nose piece 900 and a flat tip 901. Fig. 37b shows an interchangeable fiber optic tip for a laser having a nose piece 900 and a glass dispersion tip 902.
A patient’s pocket depths at tooth 15 were measured at 12 separate loci. The root of the tooth was then scaled and planed to remove calculus build up on the root surface, After scaling and planning, bleeding occurs in the sulcus. The sulcus was allowed to air dry and immediately thereafter the conditioner is applied to the sulcus and left for 30 seconds before being rinsed with saline. The tooth was next scaled and planed again to renew blood flow. Wife blood pooling in
WO 2017/083579
PCT/US2016/061423 the sulcus, the 45° laser tip was placed into the sulcus. The laser light used has a wavelength in the visible portion of the electromagnetic spectrum, between 400nm - 700nm wavelength. The laser wax emitted continuously with only intermittent stops for tissue temperature control. The laser was allowed to penetrate the entire sulcus by moving the tip vertically and horizontally tiiroughont the sulcus for 30 second. The laser tip was cut to 45 in the opposite angle for the second pass into the sulcus and 90° for the third pass to allow the laser bean to penetrate the existing periodontium to decontaminate and biostimulate the sulcular contents.
In the meantime, the first substrate and the second substrate were mixed in a glass dish. Some of the patient’s blood that has been treated with foe laser light in the sulcus was also mixed in the glass dish. This mixture is then placed immediately into the sulcus upon mixture, Enough of foe mixture was placed into the sulcus to fill foe sulcus while ensuring the mixture stayed 3 nun below the top of foe gingival margin and remained immersed in blood. The patient’s mouth was kept open for 5 minutes to ensure the newly formed blood clot containing the substrate mixture remained intact.
Treatment was repeated on tooth 15 on four subsequent occasions, at which time the pocket depths at each foci were measured prior to treatment. Measurements are shown in Fig. 11, The data show an increase in calcium density at the specific loci.
Π.
A patient’s pocket depths at tooth 28 were measured at 17 separate loci. The treatment disclosed herein was performed on five subsequent occasions, at which time the pocket depths at each loci were measured prior to treatment Measurements are shown in Fig, 12. The data show an increase in calcium density across all foci.
Ill,
A patient’s pocket depths at tooth 2, tooth 3 and tooth 15 were measured at three separate loci per tooth. The treatment disclosed herein was performed 3 months after the initial treatment,
WO 2017/083579
PCT/US2016/061423 at which time the pocket depths at each loci were measured prior to treatment Measurements are shown sn Fig, 13. The data show a progression of bone generation.
A patient’s chin profile was measured. The treatment disclosed herein was performed ones after the initial measurements were taken with measurements repeated following treatment. Measurements are shown in Fig. 24, The data show a general increase in chin profile following a single treatment
A patient’s toe crease length was measured. The treatment disclosed herein was performed after Initial measurements were obtained with measurements repeated following treatment, Measurements are shown in Fig. 25. The data show a 71% overall decrease in crease size following treatment.
VL Analysis of Gingival Wound Tissue
A patient’s gingival wounds were measured from the line to the top of the gingiva. The treatment disclosed herein was performed and measurements were repeated following treatment. Images of gingival wounds are shown before and after treatment in Fig. 26a and 26b. Measurements are shown in Fig. 26c. The data show a 50% or greater decrease in the wound following a single treatment.
VII, Analysis of .Hand Qgjjje
A patient’s hand crease length was measured. The treatment disclosed herein was performed after initial measurements were taken with measurements repeated following treatment. Measurements are shown in Fig, 27. The data show an overall decrease in crease length following treatment.
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VUL Analysis of New Skin Growth
A patient’s skin leg wound was measured. The treatment disclosed herein was performed after initial measurements were taken with measurements repeated following treatment. Measurements are shown in Fig. 28. The data show an overall increase in new skin growth following treatment. In a preferred embodiment, chronic wounds on limbs may be treated using a three-sided LED system wherein the treatment unit is placed around the limb on three sides and applies the LED energy to a larger surface area. T he LED system uses an energy source no greater than 60 mW.
A patient’s anal scar tissue was measured. The treatment disclosed herein was performed after initial measurements were taken with measurements repeated following treatment. Measurements are shown in Fig. 29 and Fig, 30. The data show a reduction in both length and width of scar tissue following treatment.
Tongue strength and swallowing was assessed for three patients. The treatment disclosed herein was performed after initial assessments were made and tongue strength and swallowing were reevaluated following treatment. Measurements are shown in Fig, 31. The data show each patient experiencing an increase in tongue strength following treatment.
XI, A
Breast firmness was recorded for two patients. The treatment disclosed herein was performed after initial assessments were made and breast firmness was reevaluated following treatment. Comparative firmness is shown in Fig, 32, The data show the patients experiencing an increase in firmness of 75% and 66,7% following treatment respectively.
WO 2017/083579
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The epithelial wound regeneration of a patient was assessed. The treatment disclosed herein was performed after initial wound measurement and wound size was remeasured following treatment. Comparative measurements are shown in Fig, 38, Epithelial regeneration was found to have increased in area by 170% one day following treatment
The calcaneal tendon wound regeneration of a patient was assessed, The treatment disclosed herein was performed after initial wound measurement and wound size was remeasured following trcauneut, Comparative measurements are shown in Fig. 39, Tendon shelf size increased four times from the initial measurement to fee third and final measurement, .Oil,
The ankle epithelial wound regeneration of a patient was assessed. The treatment disclosed herein was performed after initial wound measurement and wound size was remeasured following treatment Comparative measurements for two treatment areas are shown in Fig. 40. Epithelial regeneration was found to have increased in area by 264% five months following treatment.
XIV.
The ankle epithelial wound size reduction of a patient was assessed. The treatment disclosed herein was performed after initial wound measurement and wound size was remeasured following treatment Comparative measurements for two treatment areas are shown in Fig. 41.. Epithelial wound size was found to have decreased in area hy 72% five months following treatment.
WO 2017/083579
PCT/US2016/061423
The oral cavity epithelial wound regeneration of a patient was assessed. The treatment disclosed herein was performed after initial wound measurement and wound size was remeasured following treatment. Comparative measurements are shown in Fig, 42. Epithelial regeneration size increased by 1.34 cm2 from the initial measurement to the fourth and find
The vein wound regeneration of a patient was assessed. The treatment disclosed herein was performed after initial wound measurement and wound size was remeasured following treatment. Comparative measurements are shown in Fig, 43 a, Epithelial regeneration size increased by 2.9 cm2 from tire initial measurement to final measurement. Treatment was conducted using a flashlight style infrared laser as shown in Fig. 43b wherein the LED beam is a concentrated flat line of light applied to the skin and veins. The flashlight style laser is a selfcontained modular laser that allows for manipulation of skin around a wound during treatment. Alternatively, a LED panel may be used.
One embodiment of the present invention provides a device for treating a wound according to the method described herein, the devi ce emitting a laser a beam of light having a wavelength in the green wavelength range (520-570 nm), red wavelength range (620-750 nm), or yellow wavelength range (570-590 nm) having an alternative wattage of 0.001 W to 5W, preferably 0.002W to 4W, more preferably 0.003W to 3W, and most preferably 0.005W to 2W. Optionally, the laser light utilizes the IR wavelength range (700nm - 1400nm) at a laser power of .001W to 5W to treat wounds. Optionally, a LED light utilizes the IR wavelength range to treat wounds.
Another embodiment of the present invention provides a device for treating a wound according to tire method described herein, the device emitting a RF beam up to 10W comprised of a carrier wave frequency in the range of 0.1 MHz to 20MHz and a non-sinusoidal waveform in
WO 2017/083579
PCT/US2016/061423 the range of 0 to 40 KHz. In a preferred embodiment, fee carrier wave frequency is in the range of 0.2MHz to 10MHz, preferably 03MHz to 5MHz. Optionally a 0.001 W to 10W range RF energy*', preferably a 0.001W to 3W range, is utilized in the hertz range of 40 Hz to 24 GHz. In a further alternative embodiment, the RF wave is more than one sine wave wherein the more than one demonstrates a harmonics pattern. Optionally, the non-sinusoidal waveform may he in the range of the above parameters in the absence of a carrier wave.
Yet another embodiment of fee present invention provides a device for treatment of a wound according to the method described herein, the device emitting a laser beam, a RF beam or a combination thereof.
Still another embodiment of the present, invention provides a device for treatment of wounds in the oral cavity according to the method described herein, the device emitting a fiber optic laser beam. In a preferred embodiment, the fiber optic device may be used in conjunction wife fee laser and RF device for treating general wounds and wounds of the oral cavity. Optionally, fee device emits a LED light.
While there have been shown and described and pointed out the fundamental novel features of fee invention as applied to the preferred embodiments, it will be understood that the foregoing is considered as illustrative only of the principles of fee Invention and not intended to be exhaustive or to limit fee invention to fee precise forms disclosed.
Obvious modifications or variations are possible considering fee above teachings. The embodiments discussed were chosen and described to provide the best illustration of fee principles of the invention and its practical application to enable one of ordinary skill in the art to utilize the invention in various embodiments and wife various modifications as are suited to fee particular use contemplated All such modifications and variations are within the scope of the invention as determined by fee appended claims when interpreted in accordance with the breadth to which they are entitled.
WO 2017/083579
PCT/US2016/061423
Claims (33)
- What is claimed is:1. A method of treating damage to a tissue in the form of a wound, comprising:(a) providing an instrument comprising a hand piece, further comprising at least one opening through which a diode laser is positioned, the diode laser generating a beam of light having a wavelength from about 400am to about 700nm, wherein the beam of light exits the instrument through the at least one opening;(b) providing a power source to operate the instrument; and (c) positioning the at least one opening from the hand piece of the instrument directly or in close proximity to the damage to the tissue of an individual.
- 2. The method of claim 1, wherein the beam of light has a wavelength from about 520 nm to about 570 nm and the power source transmits a range of po wer from about 0.5 W to about 1.2 W to the instrument.
- 3. The method of claim 2, wherein the tissue that is damaged is gum tissue.
- 4. The method of cl aim 1, wherein the beam of light has a wavelength selected from the group consisting of from about 520 am to about 570 ran, from about 620 nm to about 750 nm and from about 570 nm to about 590 nm, further wherein the power source transmits a range of power from about .0001 W to about 5 W to the instrument
- 5. The method of claim 4, wherein the power source transmits a range of power selected from the group consisting of from about .002 W to about 4 W, from about .003 W to about 3 W and from about .005 W to about 2 W to the instrument.
- 6. A system for use in repairing soft tissue damage subsequent to an acute or chronic injury to an individual comprising:(a) providing an instrument comprising a hand piece with at least one opening, through which a light source can emit a beam of light, further wherein the instrument is connected to a power source;WO 2017/083579PCT/US2016/061423 (b) providing at least one substrate, wherein the substrate is capable of inducing a biostimulatory response when applied to the soft tissue damage;(c) applying the band piece directly or in close proximity to the soft tissue damage;(d) moving tire hand piece vertically and horizontally throughout the soft tissue; and (e) applying the at least one substrate directly on the soft tissue damage,
- 7 The system of claim 6, wherein the soft tissue damage from the acute or chronic injury is located on the skin surface of the individual.
- 8. The system of claim 6, wherein the soft tissue damage from the acute or chronic injury is located beneath the skin surface of the individual.
- 9. The system of claim 6, wherein the light source is one selected from the group consisting of a diode laser or a light emitting diode (LED).
- 10. The system of claim 9, wherein tire power source transmits 10 W or less power to the LED light, wherein the LED beam of light is at a wavelength from about 700 nm to about 1400 nm.
- 11. A system for use in decontaminating and healing soft, tissue comprising:(a) providing an instrument comprising a hand piece with at least one opening, through which a radiofrequeney (RF) wave is transmitted;(b) providing a power source to operate the instrument;(c) positioning the at least one opening from the hand piece of the instrument directly or in close proximity to the soft tissue of an individual.
- 12. The system of claim 11, wherein the power source uses 10 W or less to power the instrument.
- 13. The system of claim 11, wherein a carrier wave is used together with the RF wave.4£5WO 2017/083579PCT/US2016/061423
- 14. The system of claim 13, wherein the carrier wave is a sine wave and transports a nonsinusoidal waveform to the soft tissue of an individual.
- 15. The system of claim 14,, wherein the carrier wave frequency is from about 0.1 MHz to about 20 MHz and the non-sinusoidal waveform frequency is from about 0 KHz to about 40 KHz to about 24 GHz.
- 16. Hie system of claim 11, wherein tire RF wave is a single sine wave.
- 17. The system of claim 11, wherein the RF wave is more than one sine wave, further wherein tire more than one sine wave is transmitted hr a harmonics pattern.
- 18. A substrate for use in treating soft tissue damage, comprising;(a) an effective amount of tricalcium phosphate;(b) at least one of collagen limed and collagen unlimed;(c) an effective amount of HC1 or NaCl and at least one metal.
- 19. The substrate of claim 18, wherein the at least one metal is selected from the group consisting of copper, gold, silver, iron and platinum, or any combination thereof.WO 2017/083579PCT/US2016/0614231/33SUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/0614232/332-22-11Fig. 8SUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/0614233/33SUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/0614234/330.75 4--------Bone Density Measurement0.55 4----------0.25Tooth 150.65 4-0.45 40.35Jan. 2011 May. 2011 Jun. 2011 Jul. 2011 Oct. 2011Measurement DateLocus 1Locus 2 ''''Α?'''''' Locus 3Locus 4Locus 5Locus 6Locus 7Locus 8Locus 9Locus 10Locus 11Locus 12Fig. 11SUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/0614235/33Tooth 280.Bone Density MeasurementLocus 1Locus 2Locus 3Locus 4Locus 5Locus 6Locus 7Locus 8Locus 9Locus 10Locus 11Locus 12Locus 13Locus 14Locus 15Locus 16Locus 17Mar. 2010 May. 2010 Jun. 2010 Aug. 2010 Oct. 2010 Jan. 2011Measurement DateFig. 12SUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/0614236/33Bone Density MeasurementMeasurement LocationFig. 13SUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/0614237/33Fig. 14aFig. 14bSUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/0614238/33Fig. 15bSUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/0614239/33Fig. 16aFig. 16bSUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/06142310/33100FIG. 17BFIG. 17CFIG. 17E
-c _c FIG. 17DFIG. 17FSUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/06142311/33FIG. 18CSUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/06142312/33FIG. 19A200·FIG. 19DSUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/06142313/33200-FIG. 19E200FIG. 19GSUBSTITUTE SHEET (RULE 26)Wo 2017/083579 PCT/VS20l6/06l4232OB substitute SliEET (BVLe 26)WO 2017/083579PCT/US2016/06142315/33ΟΟCOSUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/06142316/33409SUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/06142317/33 d¢:SUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/06142318/33SUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/06142319/33 millimetersFIG. 24BEFOREAFTERPATIENT M2 TOE CREASE LENGTH BEFORE AND AFTER TREATMENT in mmFIG. 25SUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/061423 - 20/33
ε ε 5 ε ε ε £ ε co CO 'Ct o o o II II II II V— CQ o Q PATIENT H2 GINGIVAL WOUND HEALING, TISSUE REGENERATION BEFORE AFTERLULU 8 cc sCC ’DECREASE IN MM VALUE FROM LINE = INCREASE IN TISSUE HEIGHT <0 <Nε ε ε ε ε ε ε ε co co ο xt c*5 C\i C\i II II II II CQ Ο Q dECSUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/061423 - 21/33PATIENT H1 HAND CREASE LENGTH REDUCTION AFTER 1 TREATMENTPATIENT S1 NEW SKIN GROWTH WIDTH millimetersFIG. 28 *- BEFORE 4- AFTERSUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/061423
- 22/33FIG. 29-a- AFTER 4- BEFORE0.0 10.0 20.0 30.0 40.0 50.0 60.0 70.0FIG. 30SUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/061423
- 23/33LEVEL OF STRENGTH OF THEIR SWALLOWING FUNCTION ACROSS 3 PATIENTSTONGUE STRENGTH AFTER TONGUE STRENGTH BEFORELEVEL OF REPORTED STRENGTHFIG. 31BREAST FIRMNESS BEFORE AND AFTER 1 TREATMENT ACROSS 2 PATIENTSFIRMNESS BEFORE 1 TREATMENTFRIMNESS AFTER 1 TREATMENTLEVEL OF REPORTED FIRMNESSFIG. 32SUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/061423
- 24/33SUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/061423
- 25/33FIG. 33EJ—605ΛΑFIG. 34A FIG. 34BΛΑFIG. 34CSUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/061423
- 26/33I Iz-J IFIG. 34EFIG. 35ASUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/061423
- 27/33700FIG. 35B700700FIG. 35FFIG. 35D FIG. 35ESUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/061423
- 28/33FIG. 36B \_/FIG. 36DFIG. 36FSUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/061423
- 29/33900SUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/061423
- 30/33PERCENT CHANGE: 170.78651685%DATEFIG. 38 a SIZE (CM)FIG. 39SUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/061423
- 31/339.08.83PERCENT CHANGE: 264.87603305%6.03.02.421.0CM2AREA Y1FIG. 40CM §AREA OF WOUNDPERCENT CHANGE:FIG. 419.0 -p 8.83-6.0-3.02.42__1.0__CM2-72.59343148%AREA Y1
<o <o V* V* X X o CM £9 CM X X uo a AREA OF WOUNDSUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/061423 - 32/33
DATE SKIN AREA (CM2) 9/20/2016 0 9/20/2016 0.53 9/21/2016 0.72 9/23/2016 1.34 EPITHELIAL REGENERATION AREA INCREASE □ SKIN AREA (CM2)FIG. 42DATEFIG. 43ASUBSTITUTE SHEET (RULE 26)WO 2017/083579PCT/US2016/061423 - 33/33SUBSTITUTE SHEET (RULE 26)
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US11745026B2 (en) | 2011-04-01 | 2023-09-05 | The Bioregentech Institute, Inc. | Laser assisted wound healing protocol and system |
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