AU2016347631B2 - Methods and systems for analyzing tissue quality using mid-infrared spectroscopy - Google Patents

Methods and systems for analyzing tissue quality using mid-infrared spectroscopy Download PDF

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Publication number
AU2016347631B2
AU2016347631B2 AU2016347631A AU2016347631A AU2016347631B2 AU 2016347631 B2 AU2016347631 B2 AU 2016347631B2 AU 2016347631 A AU2016347631 A AU 2016347631A AU 2016347631 A AU2016347631 A AU 2016347631A AU 2016347631 B2 AU2016347631 B2 AU 2016347631B2
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Australia
Prior art keywords
sample
fixation
spectrum
fixed
quality
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AU2016347631A
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AU2016347631A1 (en
Inventor
Daniel Bauer
David Chafin
Niels KROEGER-LUI
Michael Otter
Wolfgang Petrich
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F Hoffmann La Roche AG
Ventana Medical Systems Inc
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F Hoffmann La Roche AG
Ventana Medical Systems Inc
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N2001/305—Fixative compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
    • G01N2021/396—Type of laser source
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N2021/757—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated using immobilised reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods

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  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2016347631A 2015-10-28 2016-10-28 Methods and systems for analyzing tissue quality using mid-infrared spectroscopy Active AU2016347631B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562247609P 2015-10-28 2015-10-28
US62/247,609 2015-10-28
PCT/EP2016/076130 WO2017072320A1 (en) 2015-10-28 2016-10-28 Methods and systems for analyzing tissue quality using mid-infrared spectroscopy

Publications (2)

Publication Number Publication Date
AU2016347631A1 AU2016347631A1 (en) 2018-04-26
AU2016347631B2 true AU2016347631B2 (en) 2019-03-28

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016347631A Active AU2016347631B2 (en) 2015-10-28 2016-10-28 Methods and systems for analyzing tissue quality using mid-infrared spectroscopy

Country Status (6)

Country Link
US (1) US20190369017A1 (enExample)
EP (1) EP3368885B1 (enExample)
JP (1) JP6676160B2 (enExample)
AU (1) AU2016347631B2 (enExample)
CA (1) CA3001763C (enExample)
WO (1) WO2017072320A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6839400B2 (ja) 2018-05-09 2021-03-10 国立研究開発法人量子科学技術研究開発機構 組織識別装置、組織識別システム、組織識別方法、組織識別プログラム、および記録媒体
WO2020022394A1 (en) * 2018-07-24 2020-01-30 Sony Corporation Information processing apparatus and microscope for separating the fluorescence of a fluorescent reageant from the autofluorescence of a specimen
WO2021037869A1 (en) * 2019-08-28 2021-03-04 Ventana Medical Systems, Inc. Assessing antigen retrieval and target retrieval progression quantitation with vibrational spectroscopy
EP4022287B1 (en) * 2019-08-28 2025-07-30 Ventana Medical Systems, Inc. Systems and methods for assessing specimen fixation duration and quality using vibrational spectroscopy
JP7652762B2 (ja) * 2019-08-28 2025-03-27 ベンタナ メディカル システムズ， インコーポレイテッド 振動分光法によるバイオマーカー発現の無標識評価
US11460400B2 (en) * 2020-07-07 2022-10-04 Sakura Finetek U.S.A., Inc. Use of IR spectroscopy to evaluate penetration of reagents into biological specimen
CN113030007B (zh) * 2021-02-10 2023-04-18 河南中烟工业有限责任公司 基于相似度学习算法快速检验烟用香精质量稳定性的方法
EP4437549A4 (en) * 2021-11-23 2025-09-24 Agilent Technologies Inc DIGITAL ANALYSIS OF PREANALYTICAL FACTORS IN TISSUES USED FOR HISTOLOGICAL STAINING
WO2025038339A1 (en) * 2023-08-16 2025-02-20 Ventana Medical Systems, Inc. Deep learning model to determine a fixation status of a morphologically stained biological specimen
CN119360129B (zh) * 2024-12-23 2025-03-21 浙江省测绘科学技术研究院 页岩油气井场分类方法和页岩油气开发活动监测方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011163624A1 (en) * 2010-06-25 2011-12-29 Cellmark Theranostics, Llc Method for analyzing biological specimens by spectral imaging
US20120270293A1 (en) * 2009-12-07 2012-10-25 Wei-Sing Chu Standardization of tissue specimen preservation by ultrasound and temperature control

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040253649A1 (en) * 1998-10-21 2004-12-16 Smith Steven J. Protein quantitation with cell imaging densitometry
US20010055799A1 (en) * 1998-12-15 2001-12-27 David Baunoch Method and apparatus for automated reprocessing of tissue samples
US20060249668A1 (en) * 2005-05-05 2006-11-09 Palo Alto Research Center Incorporated Automatic detection of quality spectra
CA2604317C (en) * 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120270293A1 (en) * 2009-12-07 2012-10-25 Wei-Sing Chu Standardization of tissue specimen preservation by ultrasound and temperature control
WO2011163624A1 (en) * 2010-06-25 2011-12-29 Cellmark Theranostics, Llc Method for analyzing biological specimens by spectral imaging

Also Published As

Publication number Publication date
US20190369017A1 (en) 2019-12-05
EP3368885B1 (en) 2020-06-03
AU2016347631A1 (en) 2018-04-26
CA3001763A1 (en) 2017-05-04
CA3001763C (en) 2020-10-27
JP2018532116A (ja) 2018-11-01
WO2017072320A1 (en) 2017-05-04
JP6676160B2 (ja) 2020-04-08
EP3368885A1 (en) 2018-09-05

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