AU2016342420B2 - Single-chain LIGHT receptor agonist proteins - Google Patents

Single-chain LIGHT receptor agonist proteins Download PDF

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Publication number
AU2016342420B2
AU2016342420B2 AU2016342420A AU2016342420A AU2016342420B2 AU 2016342420 B2 AU2016342420 B2 AU 2016342420B2 AU 2016342420 A AU2016342420 A AU 2016342420A AU 2016342420 A AU2016342420 A AU 2016342420A AU 2016342420 B2 AU2016342420 B2 AU 2016342420B2
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AU
Australia
Prior art keywords
gly
leu
ser
val
thr
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2016342420A
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English (en)
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AU2016342420A1 (en
Inventor
Christian Gieffers
Oliver Hill
Tim SCHNYDER
Meinolf Thiemann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apogenix AG
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Apogenix AG
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Application filed by Apogenix AG filed Critical Apogenix AG
Publication of AU2016342420A1 publication Critical patent/AU2016342420A1/en
Application granted granted Critical
Publication of AU2016342420B2 publication Critical patent/AU2016342420B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2016342420A 2015-10-23 2016-10-24 Single-chain LIGHT receptor agonist proteins Ceased AU2016342420B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562245943P 2015-10-23 2015-10-23
US62/245,943 2015-10-23
PCT/EP2016/075536 WO2017068180A1 (en) 2015-10-23 2016-10-24 Single-chain light receptor agonist proteins

Publications (2)

Publication Number Publication Date
AU2016342420A1 AU2016342420A1 (en) 2018-04-26
AU2016342420B2 true AU2016342420B2 (en) 2020-10-01

Family

ID=57206257

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016342420A Ceased AU2016342420B2 (en) 2015-10-23 2016-10-24 Single-chain LIGHT receptor agonist proteins

Country Status (7)

Country Link
US (2) US10683332B2 (OSRAM)
EP (1) EP3365361A1 (OSRAM)
JP (1) JP6873119B2 (OSRAM)
CN (1) CN108699129A (OSRAM)
AU (1) AU2016342420B2 (OSRAM)
CA (1) CA3002587A1 (OSRAM)
WO (1) WO2017068180A1 (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3365448A1 (en) * 2015-10-23 2018-08-29 Apogenix AG Single-chain cd137-receptor agonist proteins
CN112955175A (zh) * 2018-10-17 2021-06-11 阿尔伯特爱因斯坦医学院 增强抗体依赖性细胞介导的细胞毒性（adcc）的方法
WO2021229103A2 (en) 2020-05-15 2021-11-18 Apogenix Ag Multi-specific immune modulators
WO2022120187A2 (en) * 2020-12-03 2022-06-09 Shattuck Labs, Inc. Method of determining resistance to checkpoint inhibitor therapies
WO2023088876A1 (en) 2021-11-16 2023-05-25 Apogenix Ag Multi-specific immune modulators
CN114632156B (zh) * 2022-05-17 2022-08-16 中国人民解放军军事科学院军事医学研究院 Tim-3在预防、治疗或减轻疼痛中的应用
CA3258663A1 (en) * 2022-06-08 2023-12-14 Gilead Sciences, Inc. MUTÉINES LIGHT AND THEIR USES

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010010051A1 (en) * 2008-07-21 2010-01-28 Apogenix Gmbh Tnfsf single chain molecules
WO2015164588A1 (en) * 2014-04-23 2015-10-29 Abbvie, Inc. Single-chain trail-receptor agonist proteins
WO2016146818A1 (en) * 2015-03-18 2016-09-22 Universität Stuttgart Single-chain tnf ligand family molecules and fusion proteins and derivatives thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1226173A1 (en) 1999-10-07 2002-07-31 Maxygen Aps Single-chain antagonist polypeptides
DE19963859A1 (de) 1999-12-30 2001-07-12 Apotech Res & Dev Ltd Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
CA2314199A1 (en) 2000-07-21 2002-01-21 Robert Simoneau C-chip
PT1606318E (pt) 2003-03-26 2009-11-10 Deutsches Krebsforsch Proteínas de fusão de fc melhoradas
DE102004014983A1 (de) 2004-03-26 2005-10-20 Univ Stuttgart Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
WO2006079176A1 (en) * 2005-01-28 2006-08-03 Apollo Life Sciences Limited Molecules and chimeric molecules thereof
CN101160322A (zh) * 2005-01-28 2008-04-09 阿波罗生命科学有限公司 分子及其嵌合分子
JP2008537941A (ja) * 2005-03-31 2008-10-02 ゼンコー・インコーポレイテッド 最適化特性を有するＦｃ変異体
WO2014202773A1 (en) * 2013-06-20 2014-12-24 Innate Pharma Enzymatic conjugation of polypeptides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010010051A1 (en) * 2008-07-21 2010-01-28 Apogenix Gmbh Tnfsf single chain molecules
WO2015164588A1 (en) * 2014-04-23 2015-10-29 Abbvie, Inc. Single-chain trail-receptor agonist proteins
WO2016146818A1 (en) * 2015-03-18 2016-09-22 Universität Stuttgart Single-chain tnf ligand family molecules and fusion proteins and derivatives thereof

Also Published As

Publication number Publication date
EP3365361A1 (en) 2018-08-29
US10683332B2 (en) 2020-06-16
JP2018533948A (ja) 2018-11-22
JP6873119B2 (ja) 2021-05-19
US20200331979A1 (en) 2020-10-22
US20180251509A1 (en) 2018-09-06
CA3002587A1 (en) 2017-04-27
WO2017068180A1 (en) 2017-04-27
AU2016342420A1 (en) 2018-04-26
CN108699129A (zh) 2018-10-23

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired