AU2016323017B2 - T cell receptors recognizing HLA-Cw8 restricted mutated KRAS - Google Patents

T cell receptors recognizing HLA-Cw8 restricted mutated KRAS Download PDF

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Publication number
AU2016323017B2
AU2016323017B2 AU2016323017A AU2016323017A AU2016323017B2 AU 2016323017 B2 AU2016323017 B2 AU 2016323017B2 AU 2016323017 A AU2016323017 A AU 2016323017A AU 2016323017 A AU2016323017 A AU 2016323017A AU 2016323017 B2 AU2016323017 B2 AU 2016323017B2
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val
ser
ala
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AU2016323017A1 (en
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Yong-Chen LU
Steven A. Rosenberg
Eric TRAN
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US Department of Health and Human Services
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Government of the United States of America
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Priority to AU2021200833A priority Critical patent/AU2021200833B2/en
Priority to AU2022209229A priority patent/AU2022209229B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/82—Translation products from oncogenes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
AU2016323017A 2015-09-15 2016-09-09 T cell receptors recognizing HLA-Cw8 restricted mutated KRAS Active AU2016323017B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021200833A AU2021200833B2 (en) 2015-09-15 2021-02-10 T Cell receptors recognizing HLA-Cw8 restricted mutated KRAS
AU2022209229A AU2022209229B2 (en) 2015-09-15 2022-07-26 T Cell receptors recognizing HLA-Cw8 restricted mutated KRAS

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562218688P 2015-09-15 2015-09-15
US62/218,688 2015-09-15
PCT/US2016/050875 WO2017048593A1 (en) 2015-09-15 2016-09-09 T cell receptors recognizing hla-cw8 restricted mutated kras

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021200833A Division AU2021200833B2 (en) 2015-09-15 2021-02-10 T Cell receptors recognizing HLA-Cw8 restricted mutated KRAS

Publications (2)

Publication Number Publication Date
AU2016323017A1 AU2016323017A1 (en) 2018-04-05
AU2016323017B2 true AU2016323017B2 (en) 2020-11-12

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AU2016323017A Active AU2016323017B2 (en) 2015-09-15 2016-09-09 T cell receptors recognizing HLA-Cw8 restricted mutated KRAS
AU2021200833A Active AU2021200833B2 (en) 2015-09-15 2021-02-10 T Cell receptors recognizing HLA-Cw8 restricted mutated KRAS
AU2022209229A Active AU2022209229B2 (en) 2015-09-15 2022-07-26 T Cell receptors recognizing HLA-Cw8 restricted mutated KRAS

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AU2021200833A Active AU2021200833B2 (en) 2015-09-15 2021-02-10 T Cell receptors recognizing HLA-Cw8 restricted mutated KRAS
AU2022209229A Active AU2022209229B2 (en) 2015-09-15 2022-07-26 T Cell receptors recognizing HLA-Cw8 restricted mutated KRAS

Country Status (14)

Country Link
US (3) US10556940B2 (enExample)
EP (2) EP3901169A1 (enExample)
JP (2) JP7185524B2 (enExample)
KR (2) KR20250117744A (enExample)
CN (2) CN115073583A (enExample)
AU (3) AU2016323017B2 (enExample)
CA (1) CA2998869A1 (enExample)
DK (1) DK3350213T3 (enExample)
ES (1) ES2879287T3 (enExample)
IL (1) IL257840B2 (enExample)
MX (1) MX2018003062A (enExample)
SA (1) SA518391109B1 (enExample)
SG (1) SG10201913868XA (enExample)
WO (1) WO2017048593A1 (enExample)

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GB2557123B (en) 2015-07-31 2021-11-03 Univ Minnesota Modified cells and methods of therapy
LT3494133T (lt) * 2016-08-02 2022-12-12 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Anti-kras-g12d t ląstelės receptoriai
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
EP3602053B1 (en) * 2017-03-31 2023-06-28 The United States of America, as represented by The Secretary, Department of Health and Human Services Methods of isolating neoantigen-specific t cell receptor sequences
EP3635000A4 (en) * 2017-05-16 2021-04-14 The Johns Hopkins University Manabodies and methods of using
WO2019006418A2 (en) 2017-06-30 2019-01-03 Intima Bioscience, Inc. ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
SG11202002425PA (en) * 2017-09-20 2020-04-29 The United States Of America As Represented By The Secretary Hla class ii-restricted t cell receptors against mutated ras
AU2018345400B2 (en) 2017-10-05 2024-06-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for selectively expanding cells expressing a TCR with a murine constant region
CN111836638B (zh) * 2017-12-04 2024-10-29 美国卫生和人力服务部 针对突变的ras的hla i类限制性t细胞受体
CA3103983A1 (en) 2018-06-19 2019-12-26 Biontech Us Inc. Neoantigens and uses thereof
US12331097B2 (en) * 2018-08-16 2025-06-17 Biontech Us Inc. T cell receptor constructs and uses thereof
CN113412277B (zh) * 2019-01-22 2025-07-18 美国卫生和人力服务部 针对含有g12r突变的ras的hla第ii类限制性t细胞受体
GB2596461B (en) 2019-02-20 2023-09-27 Fred Hutchinson Cancer Center Binding proteins specific for RAS neoantigens and uses thereof
US20220175899A1 (en) * 2019-04-11 2022-06-09 The Board Of Trustees Of The Leland Stanford Junior University Cytotoxic t lymphocytes specific for mutated forms of epidermal growth factor receptor for use in treating cancer
CN110172089B (zh) * 2019-06-11 2020-01-07 北京鼎成肽源生物技术有限公司 一种kras突变多抗原组合、靶向kras突变肿瘤ctl及其应用
CN112110995A (zh) * 2019-06-19 2020-12-22 上海交通大学医学院 肿瘤新抗原多肽及其用途
US20210342750A1 (en) * 2019-08-14 2021-11-04 Nec Corporation Information processing apparatus, information processing method, and storage medium
CN112759641B (zh) * 2019-11-01 2023-01-20 香雪生命科学技术（广东）有限公司 一种识别Kras G12V的高亲和力TCR
WO2021123832A1 (en) 2019-12-20 2021-06-24 Instil Bio (Uk) Limited Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof
WO2021163477A1 (en) * 2020-02-14 2021-08-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class i-restricted t cell receptors against ras with g12v mutation
CN111574616B (zh) * 2020-06-17 2021-02-02 深圳豪石生物科技有限公司 分离的t细胞受体和应用
EP4182029A1 (en) * 2020-07-16 2023-05-24 The United States of America, as represented by the Secretary, Department of Health and Human Services Hla class ii-restricted drb t cell receptors against ras with g12v mutation
AU2021351710A1 (en) * 2020-10-02 2023-06-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class ii-restricted dq t cell receptors against ras with g13d mutation
US20240175047A1 (en) 2021-02-25 2024-05-30 Alaunos Therapeutics, Inc. Recombinant Vectors Comprising Polycistronic Expression Cassettes and Methods of Use Thereof
US20250145950A1 (en) 2022-02-01 2025-05-08 Alaunos Therapeutics, Inc. Methods for Activation and Expansion of T Cells
CN114920824B (zh) * 2022-05-27 2023-12-05 重庆医科大学 Tcr或其抗原结合片段及其应用

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Also Published As

Publication number Publication date
JP7185524B2 (ja) 2022-12-07
MX2018003062A (es) 2018-09-11
KR20250117744A (ko) 2025-08-05
AU2021200833B2 (en) 2022-04-28
JP2023025108A (ja) 2023-02-21
CN108350059B (zh) 2021-10-08
KR20180044428A (ko) 2018-05-02
US20200148739A1 (en) 2020-05-14
US20190040111A1 (en) 2019-02-07
EP3901169A1 (en) 2021-10-27
JP7461445B2 (ja) 2024-04-03
ES2879287T3 (es) 2021-11-22
EP3350213A1 (en) 2018-07-25
IL257840A (en) 2018-04-30
US11667692B2 (en) 2023-06-06
IL257840B1 (en) 2023-06-01
WO2017048593A1 (en) 2017-03-23
US20230406904A1 (en) 2023-12-21
JP2018535647A (ja) 2018-12-06
CA2998869A1 (en) 2017-03-23
SA518391109B1 (ar) 2022-02-14
AU2021200833A1 (en) 2021-03-04
KR102841067B1 (ko) 2025-08-01
US10556940B2 (en) 2020-02-11
CN108350059A (zh) 2018-07-31
AU2022209229A1 (en) 2022-09-15
SG10201913868XA (en) 2020-03-30
IL257840B2 (en) 2023-10-01
CN115073583A (zh) 2022-09-20
AU2022209229B2 (en) 2024-05-23
EP3350213B1 (en) 2021-03-31
AU2016323017A1 (en) 2018-04-05
DK3350213T3 (da) 2021-06-21
HK1257902A1 (en) 2019-11-01

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