AU2016287508B2 - Methods of treating solid tumors using nanoparticle MTOR inhibitor combination therapy - Google Patents

Methods of treating solid tumors using nanoparticle MTOR inhibitor combination therapy Download PDF

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AU2016287508B2
AU2016287508B2 AU2016287508A AU2016287508A AU2016287508B2 AU 2016287508 B2 AU2016287508 B2 AU 2016287508B2 AU 2016287508 A AU2016287508 A AU 2016287508A AU 2016287508 A AU2016287508 A AU 2016287508A AU 2016287508 B2 AU2016287508 B2 AU 2016287508B2
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sirolimus
nanoparticles
individual
albumin
effective amount
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AU2016287508A1 (en
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Neil P. Desai
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Abraxis Bioscience LLC
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    • A61K38/15—Depsipeptides; Derivatives thereof
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    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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AU2016287508A 2015-06-29 2016-06-29 Methods of treating solid tumors using nanoparticle MTOR inhibitor combination therapy Active AU2016287508B2 (en)

Applications Claiming Priority (3)

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US201562186325P 2015-06-29 2015-06-29
US62/186,325 2015-06-29
PCT/US2016/040202 WO2017004267A1 (en) 2015-06-29 2016-06-29 Methods of treating solid tumors using nanoparticle mtor inhibitor combination therapy

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AU2016287508B2 true AU2016287508B2 (en) 2021-10-14

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US (2) US20180153863A1 (enExample)
EP (1) EP3313382A4 (enExample)
JP (1) JP2018521058A (enExample)
KR (2) KR20180019229A (enExample)
CN (1) CN107921006A (enExample)
AU (1) AU2016287508B2 (enExample)
CA (1) CA2990726A1 (enExample)
CL (1) CL2017003457A1 (enExample)
EA (1) EA201890146A1 (enExample)
HK (1) HK1247093A1 (enExample)
IL (1) IL256333B2 (enExample)
MX (1) MX2017016492A (enExample)
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WO (1) WO2017004267A1 (enExample)

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IL256333A (en) 2018-02-28
CN107921006A (zh) 2018-04-17
IL256333B2 (en) 2023-03-01
NZ738929A (en) 2024-01-26
EA201890146A1 (ru) 2018-06-29
US20180153863A1 (en) 2018-06-07
US20230263779A1 (en) 2023-08-24
HK1247093A1 (zh) 2018-09-21
EP3313382A1 (en) 2018-05-02
CA2990726A1 (en) 2017-01-05
AU2016287508A1 (en) 2018-02-01
KR20240090657A (ko) 2024-06-21
WO2017004267A1 (en) 2017-01-05
IL256333B (en) 2022-11-01
EP3313382A4 (en) 2019-03-06
CL2017003457A1 (es) 2018-05-11
MX2017016492A (es) 2018-08-16
KR20180019229A (ko) 2018-02-23

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