AU2015346527A1 - Instrument and cartridge for performing assays in a closed sample preparation and reaction system - Google Patents
Instrument and cartridge for performing assays in a closed sample preparation and reaction system Download PDFInfo
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- AU2015346527A1 AU2015346527A1 AU2015346527A AU2015346527A AU2015346527A1 AU 2015346527 A1 AU2015346527 A1 AU 2015346527A1 AU 2015346527 A AU2015346527 A AU 2015346527A AU 2015346527 A AU2015346527 A AU 2015346527A AU 2015346527 A1 AU2015346527 A1 AU 2015346527A1
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- fluid
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- cam
- chamber
- assembly
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- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
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- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/538,533 US9598722B2 (en) | 2014-11-11 | 2014-11-11 | Cartridge for performing assays in a closed sample preparation and reaction system |
| US14/538,565 US9498778B2 (en) | 2014-11-11 | 2014-11-11 | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
| US14/538,533 | 2014-11-11 | ||
| US14/538,565 | 2014-11-11 | ||
| PCT/US2015/059978 WO2016077364A2 (en) | 2014-11-11 | 2015-11-10 | Instrument and cartridge for performing assays in a closed sample preparation and reaction system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2015346527A1 true AU2015346527A1 (en) | 2017-06-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015346527A Abandoned AU2015346527A1 (en) | 2014-11-11 | 2015-11-10 | Instrument and cartridge for performing assays in a closed sample preparation and reaction system |
Country Status (4)
| Country | Link |
|---|---|
| EP (3) | EP4578539A2 (enrdf_load_stackoverflow) |
| JP (1) | JP2018502309A (enrdf_load_stackoverflow) |
| AU (1) | AU2015346527A1 (enrdf_load_stackoverflow) |
| WO (1) | WO2016077364A2 (enrdf_load_stackoverflow) |
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| JP1628116S (enrdf_load_stackoverflow) | 2012-10-24 | 2019-04-01 | ||
| US20210016281A1 (en) * | 2018-03-22 | 2021-01-21 | Nikon Corporation | Fluid device |
| CA3182396C (en) * | 2018-07-10 | 2024-06-11 | Precision Planting Llc | Agricultural sampling system and related methods |
| GB201818412D0 (en) * | 2018-11-12 | 2018-12-26 | Lumiradx Tech Ltd | A magnetic assembly for use in a device for conducting assays |
| JP7285746B2 (ja) * | 2019-09-20 | 2023-06-02 | ニデックプレシジョン株式会社 | 搬送装置 |
| TWI742905B (zh) * | 2019-12-10 | 2021-10-11 | 財團法人工業技術研究院 | 核酸萃取裝置 |
| CN112940061B (zh) | 2019-12-10 | 2024-05-03 | 财团法人工业技术研究院 | 核酸萃取装置 |
| US11859734B2 (en) | 2020-11-16 | 2024-01-02 | Siemens Healthcare Diagnostics Inc. | Valve for microfluidic device |
| WO2022139820A1 (en) * | 2020-12-22 | 2022-06-30 | Hp Health Solutions Inc. | Devices to control magnetizing microparticles in fluid density columns |
| WO2023272800A1 (zh) * | 2021-07-02 | 2023-01-05 | 北京乐普智慧医疗科技有限公司 | 一种包含提取扩增检测全流程的分子诊断卡及其使用工艺方法 |
| CN113786795B (zh) * | 2021-10-21 | 2022-12-30 | 广州卡洛莱化妆品有限公司 | 一种具有滋润皮肤修饰肤色效果的组合物的生产系统 |
| CN113877645A (zh) * | 2021-10-29 | 2022-01-04 | 深圳迈瑞动物医疗科技有限公司 | 微流控芯片 |
| US20230181809A1 (en) * | 2021-12-13 | 2023-06-15 | Medtronic Xomed, Inc. | Surgical devices, systems, and methods facilitating multiple flow path fluid management |
| WO2024059707A2 (en) * | 2022-09-16 | 2024-03-21 | Siemens Healthcare Diagnostics Inc. | Improving signal to noise in immunoassays |
| EP4344776A1 (en) * | 2022-09-28 | 2024-04-03 | Gerresheimer Regensburg GmbH | Test cartridges and systems |
| DE102024103863B3 (de) | 2024-02-12 | 2025-01-02 | Friz Biochem Gmbh | Probenanalysegerät |
Family Cites Families (150)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| JPS63121024A (ja) * | 1986-11-10 | 1988-05-25 | Hitachi Ltd | 液晶表示装置 |
| GB8708201D0 (en) | 1987-04-06 | 1987-05-13 | Cogent Ltd | Gas sensor |
| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5386023A (en) | 1990-07-27 | 1995-01-31 | Isis Pharmaceuticals | Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling |
| US5644048A (en) | 1992-01-10 | 1997-07-01 | Isis Pharmaceuticals, Inc. | Process for preparing phosphorothioate oligonucleotides |
| US5591578A (en) | 1993-12-10 | 1997-01-07 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5824473A (en) | 1993-12-10 | 1998-10-20 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5637684A (en) | 1994-02-23 | 1997-06-10 | Isis Pharmaceuticals, Inc. | Phosphoramidate and phosphorothioamidate oligomeric compounds |
| GB9411515D0 (en) | 1994-06-09 | 1994-08-03 | Aromascan Plc | Detecting bacteria |
| GB9412633D0 (en) | 1994-06-23 | 1994-08-10 | Aromascan Plc | Semiconducting organic polymers |
| GB9412632D0 (en) | 1994-06-23 | 1994-08-10 | Aromascan Plc | Semiconducting organic polymers |
| US5681702A (en) | 1994-08-30 | 1997-10-28 | Chiron Corporation | Reduction of nonspecific hybridization by using novel base-pairing schemes |
| GB9425207D0 (en) | 1994-12-14 | 1995-02-15 | Aromascan Plc | Semi-conducting organic polymers |
| GB9503760D0 (en) | 1995-02-24 | 1995-04-12 | Aromascan Plc | Neural networks |
| US5770365A (en) | 1995-08-25 | 1998-06-23 | Tm Technologies, Inc. | Nucleic acid capture moieties |
| GB9523406D0 (en) | 1995-11-16 | 1996-01-17 | Aromascan Plc | Sensor transduction |
| US7014992B1 (en) | 1996-11-05 | 2006-03-21 | Clinical Micro Sensors, Inc. | Conductive oligomers attached to electrodes and nucleoside analogs |
| US7045285B1 (en) | 1996-11-05 | 2006-05-16 | Clinical Micro Sensors, Inc. | Electronic transfer moieties attached to peptide nucleic acids |
| US7381525B1 (en) | 1997-03-07 | 2008-06-03 | Clinical Micro Sensors, Inc. | AC/DC voltage apparatus for detection of nucleic acids |
| US7393645B2 (en) | 1996-11-05 | 2008-07-01 | Clinical Micro Sensors, Inc. | Compositions for the electronic detection of analytes utilizing monolayers |
| US6096273A (en) | 1996-11-05 | 2000-08-01 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
| US7160678B1 (en) | 1996-11-05 | 2007-01-09 | Clinical Micro Sensors, Inc. | Compositions for the electronic detection of analytes utilizing monolayers |
| GB9700012D0 (en) | 1997-01-02 | 1997-02-19 | Aromascan Plc | Improvements in the detection of bacteria |
| EP0970184A1 (en) | 1997-03-06 | 2000-01-12 | Osmetech PLC | Microorganism analysis means |
| US5993750A (en) * | 1997-04-11 | 1999-11-30 | Eastman Kodak Company | Integrated ceramic micro-chemical plant |
| US6013459A (en) | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
| DE69842134D1 (de) | 1997-06-12 | 2011-03-31 | Clinical Micro Sensors Inc | Elektronische verfahren und vorrichtung zum nachweis von analyten |
| GB9714166D0 (en) | 1997-07-05 | 1997-09-10 | Aromascan Plc | Apparatuses and methods for gas sampling |
| US6063573A (en) | 1998-01-27 | 2000-05-16 | Clinical Micro Sensors, Inc. | Cycling probe technology using electron transfer detection |
| JP2002500897A (ja) | 1998-01-27 | 2002-01-15 | クリニカル・マイクロ・センサーズ・インコーポレイテッド | 電子的核酸検出の増幅 |
| US6686150B1 (en) | 1998-01-27 | 2004-02-03 | Clinical Micro Sensors, Inc. | Amplification of nucleic acids with electronic detection |
| GB9805867D0 (en) | 1998-03-20 | 1998-05-13 | Aromascan Plc | Sensor manufacture |
| EP1075549B1 (en) | 1998-05-06 | 2008-09-03 | Clinical Micro Sensors, Inc. | Electronic methods for the detection of analytes utilizing monolayers |
| US7087148B1 (en) | 1998-06-23 | 2006-08-08 | Clinical Micro Sensors, Inc. | Binding acceleration techniques for the detection of analytes |
| US6761816B1 (en) | 1998-06-23 | 2004-07-13 | Clinical Micro Systems, Inc. | Printed circuit boards with monolayers and capture ligands |
| US6290839B1 (en) | 1998-06-23 | 2001-09-18 | Clinical Micro Sensors, Inc. | Systems for electrophoretic transport and detection of analytes |
| GB9818176D0 (en) | 1998-08-21 | 1998-10-14 | Aromascan Plc | Method for detecting microorganisms |
| US6740518B1 (en) | 1998-09-17 | 2004-05-25 | Clinical Micro Sensors, Inc. | Signal detection techniques for the detection of analytes |
| US6541617B1 (en) | 1998-10-27 | 2003-04-01 | Clinical Micro Sensors, Inc. | Detection of target analytes using particles and electrodes |
| US6833267B1 (en) | 1998-12-30 | 2004-12-21 | Clinical Micro Sensors, Inc. | Tissue collection devices containing biosensors |
| US6432723B1 (en) | 1999-01-22 | 2002-08-13 | Clinical Micro Sensors, Inc. | Biosensors utilizing ligand induced conformation changes |
| US6565727B1 (en) | 1999-01-25 | 2003-05-20 | Nanolytics, Inc. | Actuators for microfluidics without moving parts |
| US6942771B1 (en) | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes |
| US20020177135A1 (en) | 1999-07-27 | 2002-11-28 | Doung Hau H. | Devices and methods for biochip multiplexing |
| US7312087B2 (en) | 2000-01-11 | 2007-12-25 | Clinical Micro Sensors, Inc. | Devices and methods for biochip multiplexing |
| CA2380258C (en) | 1999-07-26 | 2008-07-15 | Clinical Micro Sensors, Inc. | Sequence determination of nucleic acids using electronic detection |
| US6596483B1 (en) | 1999-11-12 | 2003-07-22 | Motorola, Inc. | System and method for detecting molecules using an active pixel sensor |
| US6361958B1 (en) | 1999-11-12 | 2002-03-26 | Motorola, Inc. | Biochannel assay for hybridization with biomaterial |
| US6875619B2 (en) | 1999-11-12 | 2005-04-05 | Motorola, Inc. | Microfluidic devices comprising biochannels |
| US6642046B1 (en) | 1999-12-09 | 2003-11-04 | Motorola, Inc. | Method and apparatus for performing biological reactions on a substrate surface |
| US6518024B2 (en) | 1999-12-13 | 2003-02-11 | Motorola, Inc. | Electrochemical detection of single base extension |
| US6824669B1 (en) | 2000-02-17 | 2004-11-30 | Motorola, Inc. | Protein and peptide sensors using electrical detection methods |
| US6753143B2 (en) | 2000-05-01 | 2004-06-22 | Clinical Micro Sensors, Inc. | Target analyte detection using asymmetrical self-assembled monolayers |
| US6602400B1 (en) | 2000-06-15 | 2003-08-05 | Motorola, Inc. | Method for enhanced bio-conjugation events |
| US6773566B2 (en) | 2000-08-31 | 2004-08-10 | Nanolytics, Inc. | Electrostatic actuators for microfluidics and methods for using same |
| GB0120062D0 (en) | 2001-08-17 | 2001-10-10 | Osmetech Plc | Detection of bacterial vaginosis |
| CA2501857A1 (en) * | 2002-10-09 | 2004-04-22 | The Board Of Trustees Of The University Of Illinois | Microfluidic systems and components |
| DK1859330T3 (da) | 2005-01-28 | 2012-10-15 | Univ Duke | Apparater og fremgangsmåder til håndtering af små dråber på et trykt kredsløbskort |
| EP1885885A4 (en) | 2005-05-11 | 2008-08-27 | Nanolytics Inc | METHOD OR DEVICE FOR CONDUCTING CHEMICAL OR BIOCHEMICAL REACTIONS AT MULTIPLE TEMPERATURES |
| CN101237934B (zh) | 2005-05-21 | 2012-12-19 | 先进液体逻辑公司 | 用亲水性聚合物助剂减弱生物分子的吸附 |
| US7919330B2 (en) | 2005-06-16 | 2011-04-05 | Advanced Liquid Logic, Inc. | Method of improving sensor detection of target molcules in a sample within a fluidic system |
| US20070184547A1 (en) * | 2005-10-11 | 2007-08-09 | Kalyan Handique | Polynucleotide sample preparation device |
| WO2007048111A2 (en) | 2005-10-22 | 2007-04-26 | Core-Microsolutions, Inc. | Droplet extraction from a liquid column for on-chip microfluidics |
| WO2007080129A1 (en) | 2006-01-13 | 2007-07-19 | A Chan Holding B.V. | Treatment and diagnosis of abnormal bone density with an inhibitor of the glypican-sclerostin interaction |
| WO2007112114A2 (en) * | 2006-03-24 | 2007-10-04 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
| US8492168B2 (en) | 2006-04-18 | 2013-07-23 | Advanced Liquid Logic Inc. | Droplet-based affinity assays |
| US8613889B2 (en) | 2006-04-13 | 2013-12-24 | Advanced Liquid Logic, Inc. | Droplet-based washing |
| US8637317B2 (en) | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Method of washing beads |
| US9476856B2 (en) | 2006-04-13 | 2016-10-25 | Advanced Liquid Logic, Inc. | Droplet-based affinity assays |
| US8637324B2 (en) | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| US8927296B2 (en) | 2006-04-18 | 2015-01-06 | Advanced Liquid Logic, Inc. | Method of reducing liquid volume surrounding beads |
| WO2007123908A2 (en) | 2006-04-18 | 2007-11-01 | Advanced Liquid Logic, Inc. | Droplet-based multiwell operations |
| US8809068B2 (en) | 2006-04-18 | 2014-08-19 | Advanced Liquid Logic, Inc. | Manipulation of beads in droplets and methods for manipulating droplets |
| US8716015B2 (en) | 2006-04-18 | 2014-05-06 | Advanced Liquid Logic, Inc. | Manipulation of cells on a droplet actuator |
| US8389297B2 (en) | 2006-04-18 | 2013-03-05 | Duke University | Droplet-based affinity assay device and system |
| US7901947B2 (en) | 2006-04-18 | 2011-03-08 | Advanced Liquid Logic, Inc. | Droplet-based particle sorting |
| US8658111B2 (en) | 2006-04-18 | 2014-02-25 | Advanced Liquid Logic, Inc. | Droplet actuators, modified fluids and methods |
| US8980198B2 (en) | 2006-04-18 | 2015-03-17 | Advanced Liquid Logic, Inc. | Filler fluids for droplet operations |
| US7763471B2 (en) | 2006-04-18 | 2010-07-27 | Advanced Liquid Logic, Inc. | Method of electrowetting droplet operations for protein crystallization |
| US7439014B2 (en) | 2006-04-18 | 2008-10-21 | Advanced Liquid Logic, Inc. | Droplet-based surface modification and washing |
| US7815871B2 (en) | 2006-04-18 | 2010-10-19 | Advanced Liquid Logic, Inc. | Droplet microactuator system |
| US8470606B2 (en) | 2006-04-18 | 2013-06-25 | Duke University | Manipulation of beads in droplets and methods for splitting droplets |
| US7816121B2 (en) | 2006-04-18 | 2010-10-19 | Advanced Liquid Logic, Inc. | Droplet actuation system and method |
| US8685754B2 (en) | 2006-04-18 | 2014-04-01 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods for immunoassays and washing |
| US7822510B2 (en) | 2006-05-09 | 2010-10-26 | Advanced Liquid Logic, Inc. | Systems, methods, and products for graphically illustrating and controlling a droplet actuator |
| US7939021B2 (en) | 2007-05-09 | 2011-05-10 | Advanced Liquid Logic, Inc. | Droplet actuator analyzer with cartridge |
| US8041463B2 (en) | 2006-05-09 | 2011-10-18 | Advanced Liquid Logic, Inc. | Modular droplet actuator drive |
| WO2009111769A2 (en) | 2008-03-07 | 2009-09-11 | Advanced Liquid Logic, Inc. | Reagent and sample preparation and loading on a fluidic device |
| US8685344B2 (en) | 2007-01-22 | 2014-04-01 | Advanced Liquid Logic, Inc. | Surface assisted fluid loading and droplet dispensing |
| AU2008212808B2 (en) | 2007-02-09 | 2013-09-12 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods employing magnetic beads |
| US8872527B2 (en) | 2007-02-15 | 2014-10-28 | Advanced Liquid Logic, Inc. | Capacitance detection in a droplet actuator |
| US7863035B2 (en) | 2007-02-15 | 2011-01-04 | Osmetech Technology Inc. | Fluidics devices |
| EP2121329B1 (en) | 2007-03-01 | 2014-05-14 | Advanced Liquid Logic, Inc. | Droplet actuator structures |
| CN101663403B (zh) | 2007-03-05 | 2013-04-24 | 先进流体逻辑公司 | 基于微滴的过氧化氢测定 |
| CN101652652B (zh) | 2007-03-13 | 2012-07-18 | 先进流体逻辑公司 | 改进吸光度检测的微滴执行机构装置、配置及方法 |
| EP2126038B1 (en) | 2007-03-22 | 2015-01-07 | Advanced Liquid Logic, Inc. | Enzymatic assays for a droplet actuator |
| US20100048410A1 (en) | 2007-03-22 | 2010-02-25 | Advanced Liquid Logic, Inc. | Bead Sorting on a Droplet Actuator |
| US8202686B2 (en) | 2007-03-22 | 2012-06-19 | Advanced Liquid Logic, Inc. | Enzyme assays for a droplet actuator |
| US8093062B2 (en) | 2007-03-22 | 2012-01-10 | Theodore Winger | Enzymatic assays using umbelliferone substrates with cyclodextrins in droplets in oil |
| EP2136920A2 (en) | 2007-03-23 | 2009-12-30 | Advanced Liquid Logic, Inc. | Droplet actuator loading and target concentration |
| KR20100016343A (ko) | 2007-04-10 | 2010-02-12 | 어드밴스드 리퀴드 로직, 아이엔씨. | 액적 분배 장치 및 그 방법 |
| WO2009011952A1 (en) | 2007-04-23 | 2009-01-22 | Advanced Liquid Logic, Inc. | Device and method for sample collection and concentration |
| US20100087012A1 (en) | 2007-04-23 | 2010-04-08 | Advanced Liquid Logic, Inc. | Sample Collector and Processor |
| US20100130369A1 (en) | 2007-04-23 | 2010-05-27 | Advanced Liquid Logic, Inc. | Bead-Based Multiplexed Analytical Methods and Instrumentation |
| US8951732B2 (en) | 2007-06-22 | 2015-02-10 | Advanced Liquid Logic, Inc. | Droplet-based nucleic acid amplification in a temperature gradient |
| US20100120130A1 (en) | 2007-08-08 | 2010-05-13 | Advanced Liquid Logic, Inc. | Droplet Actuator with Droplet Retention Structures |
| WO2009021173A1 (en) | 2007-08-08 | 2009-02-12 | Advanced Liquid Logic, Inc. | Use of additives for enhancing droplet operations |
| US8268246B2 (en) | 2007-08-09 | 2012-09-18 | Advanced Liquid Logic Inc | PCB droplet actuator fabrication |
| KR101451955B1 (ko) | 2007-08-24 | 2014-10-21 | 어드밴스드 리퀴드 로직, 아이엔씨. | 액적 작동기 상에서의 비드 조작법 |
| US8702938B2 (en) | 2007-09-04 | 2014-04-22 | Advanced Liquid Logic, Inc. | Droplet actuator with improved top substrate |
| US8460528B2 (en) | 2007-10-17 | 2013-06-11 | Advanced Liquid Logic Inc. | Reagent storage and reconstitution for a droplet actuator |
| WO2009052123A2 (en) | 2007-10-17 | 2009-04-23 | Advanced Liquid Logic, Inc. | Multiplexed detection schemes for a droplet actuator |
| WO2009052354A2 (en) | 2007-10-17 | 2009-04-23 | Advanced Liquid Logic, Inc. | Droplet actuator structures |
| WO2009052321A2 (en) | 2007-10-18 | 2009-04-23 | Advanced Liquid Logic, Inc. | Droplet actuators, systems and methods |
| WO2009061941A2 (en) | 2007-11-06 | 2009-05-14 | Osmetech Molecular Diagnostics | Baseless nucleotide analogues and uses thereof |
| US8562807B2 (en) | 2007-12-10 | 2013-10-22 | Advanced Liquid Logic Inc. | Droplet actuator configurations and methods |
| EP2237955A4 (en) | 2007-12-23 | 2016-04-20 | Advanced Liquid Logic Inc | DROPLET FORMATION ACTUATOR CONFIGURATIONS, AND METHODS OF PERFORMING DROPLET FORMING OPERATIONS |
| WO2009135205A2 (en) | 2008-05-02 | 2009-11-05 | Advanced Liquid Logic, Inc. | Droplet actuator techniques using coagulatable samples |
| WO2009137415A2 (en) | 2008-05-03 | 2009-11-12 | Advanced Liquid Logic, Inc. | Reagent and sample preparation, loading, and storage |
| US20110097763A1 (en) | 2008-05-13 | 2011-04-28 | Advanced Liquid Logic, Inc. | Thermal Cycling Method |
| DK2279405T3 (da) | 2008-05-13 | 2014-01-13 | Advanced Liquid Logic Inc | Dråbeaktuatorindretninger, -systemer og -fremgangsmåder |
| US20120261264A1 (en) | 2008-07-18 | 2012-10-18 | Advanced Liquid Logic, Inc. | Droplet Operations Device |
| WO2010019782A2 (en) | 2008-08-13 | 2010-02-18 | Advanced Liquid Logic, Inc. | Methods, systems, and products for conducting droplet operations |
| JP5492207B2 (ja) * | 2008-08-27 | 2014-05-14 | ライフ テクノロジーズ コーポレーション | 生物学的サンプルの処理装置および処理方法 |
| US20110311980A1 (en) | 2008-12-15 | 2011-12-22 | Advanced Liquid Logic, Inc. | Nucleic Acid Amplification and Sequencing on a Droplet Actuator |
| US8877512B2 (en) | 2009-01-23 | 2014-11-04 | Advanced Liquid Logic, Inc. | Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator |
| US20100317093A1 (en) * | 2009-06-10 | 2010-12-16 | Cynvenio Biosystems, Inc. | Flexible pouch and cartridge with fluidic circuits |
| US9250234B2 (en) | 2011-01-19 | 2016-02-02 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (E-TRACE) immunoassay |
| US8926065B2 (en) | 2009-08-14 | 2015-01-06 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods |
| US8846414B2 (en) | 2009-09-29 | 2014-09-30 | Advanced Liquid Logic, Inc. | Detection of cardiac markers on a droplet actuator |
| WO2011057197A2 (en) | 2009-11-06 | 2011-05-12 | Advanced Liquid Logic, Inc. | Integrated droplet actuator for gel electrophoresis and molecular analysis |
| EP2516669B1 (en) | 2009-12-21 | 2016-10-12 | Advanced Liquid Logic, Inc. | Enzyme assays on a droplet actuator |
| JP5882234B2 (ja) | 2010-02-25 | 2016-03-09 | アドバンスト リキッド ロジック インコーポレイテッドＡｄｖａｎｃｅｄ Ｌｉｑｕｉｄ Ｌｏｇｉｃ， Ｉｎｃ． | 核酸ライブラリーの作製方法 |
| EP2553473A4 (en) | 2010-03-30 | 2016-08-10 | Advanced Liquid Logic Inc | DROPLET OPERATION PLATFORM |
| WO2012009320A2 (en) | 2010-07-15 | 2012-01-19 | Advanced Liquid Logic, Inc. | Systems for and methods of promoting cell lysis in droplet actuators |
| WO2012084615A1 (de) * | 2010-12-20 | 2012-06-28 | Boehringer Ingelheim Microparts Gmbh | Verfahren zum mischen wenigstens einer probenlösung mit wenigstens einem reagenz und vorrichtung |
| US8901043B2 (en) | 2011-07-06 | 2014-12-02 | Advanced Liquid Logic, Inc. | Systems for and methods of hybrid pyrosequencing |
| US20130017544A1 (en) | 2011-07-11 | 2013-01-17 | Advanced Liquid Logic Inc | High Resolution Melting Analysis on a Droplet Actuator |
| US20130018611A1 (en) | 2011-07-11 | 2013-01-17 | Advanced Liquid Logic Inc | Systems and Methods of Measuring Gap Height |
| US8894946B2 (en) * | 2011-10-21 | 2014-11-25 | Integenx Inc. | Sample preparation, processing and analysis systems |
| NZ701221A (en) * | 2012-04-27 | 2016-12-23 | Cepheid | Apparatus with heterogeneous processing modules |
| US20130331298A1 (en) * | 2012-06-06 | 2013-12-12 | Great Basin Scientific | Analyzer and disposable cartridge for molecular in vitro diagnostics |
| US20140322706A1 (en) * | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
| JP1628116S (enrdf_load_stackoverflow) | 2012-10-24 | 2019-04-01 | ||
| US9995742B2 (en) * | 2012-12-19 | 2018-06-12 | Dnae Group Holdings Limited | Sample entry |
| WO2014120998A1 (en) * | 2013-01-31 | 2014-08-07 | Luminex Corporation | Fluid retention plates and analysis cartridges |
-
2015
- 2015-11-10 EP EP25176830.5A patent/EP4578539A2/en active Pending
- 2015-11-10 WO PCT/US2015/059978 patent/WO2016077364A2/en active Application Filing
- 2015-11-10 JP JP2017544564A patent/JP2018502309A/ja active Pending
- 2015-11-10 EP EP20193203.5A patent/EP3831481B1/en active Active
- 2015-11-10 EP EP15797764.6A patent/EP3218108B1/en active Active
- 2015-11-10 AU AU2015346527A patent/AU2015346527A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3831481B1 (en) | 2025-06-18 |
| EP4578539A2 (en) | 2025-07-02 |
| EP3218108A2 (en) | 2017-09-20 |
| WO2016077364A3 (en) | 2016-08-11 |
| JP2018502309A (ja) | 2018-01-25 |
| WO2016077364A2 (en) | 2016-05-19 |
| EP3218108B1 (en) | 2020-09-02 |
| EP3831481A1 (en) | 2021-06-09 |
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| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |