AU2015311563B2 - Compositions and methods for treating and preventing inflammation - Google Patents

Compositions and methods for treating and preventing inflammation Download PDF

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AU2015311563B2
AU2015311563B2 AU2015311563A AU2015311563A AU2015311563B2 AU 2015311563 B2 AU2015311563 B2 AU 2015311563B2 AU 2015311563 A AU2015311563 A AU 2015311563A AU 2015311563 A AU2015311563 A AU 2015311563A AU 2015311563 B2 AU2015311563 B2 AU 2015311563B2
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nrp1
trap
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sema3a
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AU2015311563A1 (en
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Normand BEAULIEU
Przemyslaw SAPIEHA
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P31/04—Antibacterial agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
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AU2015311563A 2014-09-05 2015-09-08 Compositions and methods for treating and preventing inflammation Active AU2015311563B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462046459P 2014-09-05 2014-09-05
US62/046,459 2014-09-05
PCT/CA2015/050862 WO2016033699A1 (en) 2014-09-05 2015-09-08 Compositions and methods for treating and preventing inflammation

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AU2015311563A1 AU2015311563A1 (en) 2017-03-16
AU2015311563B2 true AU2015311563B2 (en) 2019-11-28

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JP (3) JP6692816B2 (enExample)
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AU (1) AU2015311563B2 (enExample)
CA (1) CA2960054C (enExample)
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JP6437462B2 (ja) 2013-02-21 2018-12-12 アールエスイーエム・リミテッド・パートナーシップ 眼内透過性亢進の予防及び治療におけるｓｅｍａ３ａの阻害
WO2016033699A1 (en) 2014-09-05 2016-03-10 Rsem, Limited Partnership Compositions and methods for treating and preventing inflammation
DK3353196T5 (da) * 2015-09-22 2024-09-30 Inst Nat Sante Rech Med Polypeptider, der er i stand til at inhibere bindingen mellem leptin og neuropilin-1
US20200056186A1 (en) * 2016-09-22 2020-02-20 Rsem, Limited Partnership Compositions comprising sasp modulators and senescence attenuators and uses thereof for modulating cellular senescence
US20190330640A1 (en) * 2017-01-09 2019-10-31 Secarna Pharmaceuticals Gmbh & Co. Kg Oligonucleotides inhibiting the expression of nrp1
CN110290785A (zh) * 2017-03-08 2019-09-27 日清奥利友集团株式会社 抗炎症剂、抗炎症用药物组合物、抗炎症用食品组合物
JOP20210300A1 (ar) * 2019-05-09 2023-01-30 Boehringer Ingelheim Int أجسام مضادة مضادة لسيما 3أ واستخداماتها في علاج أمراض العين أو البصر
TWI865542B (zh) 2019-06-12 2024-12-11 瑞士商諾華公司 利鈉肽受體1抗體及使用方法
TWI859339B (zh) * 2019-09-24 2024-10-21 德商百靈佳殷格翰國際股份有限公司 抗nrp1a抗體及其用於治療眼或眼部疾病之用途
CN112641928A (zh) * 2019-10-11 2021-04-13 田中纯美 一种用于血管新生、淋巴管新生相关疾病的多肽及其用途
EP4157312A4 (en) * 2020-05-27 2024-07-31 Baylor College of Medicine COMPOSITIONS AND METHODS FOR TREATING NEOVASCULARIZATION AND ISCHEMIC RETINOPATHIES BY TARGETING ANGIOGENESIS AND CHOLESTEROL TRANSPORT
WO2021258218A1 (en) * 2020-06-26 2021-12-30 Semathera Inc. Use of soluble nrp1 polypeptides for the treatment of coronavirus infections
US20230312684A1 (en) * 2020-07-31 2023-10-05 Pinetree Therapeutics, Inc. Neuropilin and angiotensin converting enzyme 2 fusion peptides for treating viral infections
CN118201628A (zh) 2021-09-08 2024-06-14 斯特拉斯堡大学 丛蛋白a1的跨膜肽拮抗剂及其治疗应用

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RS61703B1 (sr) 2021-05-31
LT3189074T (lt) 2021-06-10
JP2020147568A (ja) 2020-09-17
HRP20210577T1 (hr) 2021-05-28
HUE054204T2 (hu) 2021-08-30
EP3189074A4 (en) 2018-06-20
US10738122B2 (en) 2020-08-11
EP3189074A1 (en) 2017-07-12
US11649292B2 (en) 2023-05-16
SI3189074T1 (sl) 2021-08-31
CA2960054A1 (en) 2016-03-10
JP2017527616A (ja) 2017-09-21
KR102869487B1 (ko) 2025-10-14
PL3189074T3 (pl) 2021-08-02
US20170283502A1 (en) 2017-10-05
AU2015311563A1 (en) 2017-03-16
CN107207577B (zh) 2021-11-09
DK3189074T3 (da) 2021-04-19
US10766964B2 (en) 2020-09-08
WO2016033699A1 (en) 2016-03-10
US20230265199A1 (en) 2023-08-24
ES2865488T3 (es) 2021-10-15
JP7194146B2 (ja) 2022-12-21
JP6692816B2 (ja) 2020-05-13
PT3189074T (pt) 2021-04-19
EP3189074B1 (en) 2021-01-13
KR102696275B1 (ko) 2024-08-21
US20210061915A1 (en) 2021-03-04
CN107207577A (zh) 2017-09-26
JP2023022308A (ja) 2023-02-14
CN113980116A (zh) 2022-01-28
KR20240125991A (ko) 2024-08-20
KR20170044691A (ko) 2017-04-25
US20190359718A1 (en) 2019-11-28
CA2960054C (en) 2023-11-14

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