AU2014339815B2 - Methods of treating and preventing graft versus host disease - Google Patents

Methods of treating and preventing graft versus host disease Download PDF

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Publication number
AU2014339815B2
AU2014339815B2 AU2014339815A AU2014339815A AU2014339815B2 AU 2014339815 B2 AU2014339815 B2 AU 2014339815B2 AU 2014339815 A AU2014339815 A AU 2014339815A AU 2014339815 A AU2014339815 A AU 2014339815A AU 2014339815 B2 AU2014339815 B2 AU 2014339815B2
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Australia
Prior art keywords
gvhd
patient
ibrutinib
compound
substituted
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AU2014339815A1 (en
Inventor
John C. Byrd
Jason A. Dubovsky
Amy Jo Johnson
David Miklos
Natarajan Muthusamy
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Pharmacyclics LLC
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Pharmacyclics LLC
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Priority to AU2020204270A priority Critical patent/AU2020204270A1/en
Priority to AU2022202686A priority patent/AU2022202686B2/en
Priority to AU2023274176A priority patent/AU2023274176B2/en
Priority to AU2025263907A priority patent/AU2025263907A1/en
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2014339815A 2013-10-25 2014-10-24 Methods of treating and preventing graft versus host disease Active AU2014339815B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2020204270A AU2020204270A1 (en) 2013-10-25 2020-06-26 Methods of treating and preventing graft versus host disease
AU2022202686A AU2022202686B2 (en) 2013-10-25 2022-04-22 Methods of treating and preventing graft versus host disease
AU2023274176A AU2023274176B2 (en) 2013-10-25 2023-11-30 Methods of treating and preventing graft versus host disease
AU2025263907A AU2025263907A1 (en) 2013-10-25 2025-11-10 Methods of treating and preventing graft versus host disease

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201361895981P 2013-10-25 2013-10-25
US61/895,981 2013-10-25
US201361910945P 2013-12-02 2013-12-02
US61/910,945 2013-12-02
US201461973173P 2014-03-31 2014-03-31
US201461973176P 2014-03-31 2014-03-31
US61/973,173 2014-03-31
US61/973,176 2014-03-31
PCT/US2014/062277 WO2015061751A1 (en) 2013-10-25 2014-10-24 Methods of treating and preventing graft versus host disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020204270A Division AU2020204270A1 (en) 2013-10-25 2020-06-26 Methods of treating and preventing graft versus host disease

Publications (2)

Publication Number Publication Date
AU2014339815A1 AU2014339815A1 (en) 2016-06-02
AU2014339815B2 true AU2014339815B2 (en) 2020-03-26

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ID=52993667

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Application Number Title Priority Date Filing Date
AU2014339815A Active AU2014339815B2 (en) 2013-10-25 2014-10-24 Methods of treating and preventing graft versus host disease
AU2020204270A Abandoned AU2020204270A1 (en) 2013-10-25 2020-06-26 Methods of treating and preventing graft versus host disease
AU2022202686A Active AU2022202686B2 (en) 2013-10-25 2022-04-22 Methods of treating and preventing graft versus host disease
AU2023274176A Active AU2023274176B2 (en) 2013-10-25 2023-11-30 Methods of treating and preventing graft versus host disease
AU2025263907A Pending AU2025263907A1 (en) 2013-10-25 2025-11-10 Methods of treating and preventing graft versus host disease

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AU2020204270A Abandoned AU2020204270A1 (en) 2013-10-25 2020-06-26 Methods of treating and preventing graft versus host disease
AU2022202686A Active AU2022202686B2 (en) 2013-10-25 2022-04-22 Methods of treating and preventing graft versus host disease
AU2023274176A Active AU2023274176B2 (en) 2013-10-25 2023-11-30 Methods of treating and preventing graft versus host disease
AU2025263907A Pending AU2025263907A1 (en) 2013-10-25 2025-11-10 Methods of treating and preventing graft versus host disease

Country Status (14)

Country Link
US (7) US9795604B2 (OSRAM)
EP (2) EP3060218A4 (OSRAM)
JP (6) JP2016538270A (OSRAM)
KR (5) KR102452866B1 (OSRAM)
CN (2) CN106102745B (OSRAM)
AU (5) AU2014339815B2 (OSRAM)
CA (2) CA2928721C (OSRAM)
EA (1) EA201690745A1 (OSRAM)
IL (2) IL245183B (OSRAM)
MX (2) MX385122B (OSRAM)
PH (2) PH12016500768A1 (OSRAM)
TW (1) TWI620565B (OSRAM)
WO (1) WO2015061751A1 (OSRAM)
ZA (1) ZA202208792B (OSRAM)

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US20180185421A1 (en) * 2016-08-29 2018-07-05 Tokyo Metropolitan Government Composition comprising fecal microbiota
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US20220354629A1 (en) * 2018-01-09 2022-11-10 E2Bio Life Sciences, Llc Method and device for the enhancement of topical treatments for oral mucositis and other oral conditions
CN109481666B (zh) * 2018-12-21 2020-11-03 江苏省中医院 一种人体血液肿瘤pdx模型的建立方法
CN112439069A (zh) * 2019-08-28 2021-03-05 江苏恒瑞医药股份有限公司 一种vegfr抑制剂在制备治疗移植物抗宿主病的药物中的用途
US12496303B2 (en) 2020-10-19 2025-12-16 Washington University Conditioning agents for use in allogeneic hematopoietic stem cell transplantation
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