AU2014285701C1 - RNAi agent for inhibition of Chikungunya virus - Google Patents

RNAi agent for inhibition of Chikungunya virus Download PDF

Info

Publication number
AU2014285701C1
AU2014285701C1 AU2014285701A AU2014285701A AU2014285701C1 AU 2014285701 C1 AU2014285701 C1 AU 2014285701C1 AU 2014285701 A AU2014285701 A AU 2014285701A AU 2014285701 A AU2014285701 A AU 2014285701A AU 2014285701 C1 AU2014285701 C1 AU 2014285701C1
Authority
AU
Australia
Prior art keywords
chikungunya virus
sirna
nivsi
rnai agent
chikungunya
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2014285701A
Other languages
English (en)
Other versions
AU2014285701B2 (en
AU2014285701A1 (en
Inventor
A. Vidya Arankalle
D. Mangesh Gokhale
Satyendra Kumar
S. Mandar Paingankar
Deepti Parashar
S. Sapna Shinde
B. A. Sudeep
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indian Council of Medical Research
Original Assignee
Indian Council of Medical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indian Council of Medical Research filed Critical Indian Council of Medical Research
Publication of AU2014285701A1 publication Critical patent/AU2014285701A1/en
Publication of AU2014285701B2 publication Critical patent/AU2014285701B2/en
Application granted granted Critical
Publication of AU2014285701C1 publication Critical patent/AU2014285701C1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2014285701A 2013-07-02 2014-07-02 RNAi agent for inhibition of Chikungunya virus Active AU2014285701C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1960/DEL/2013 2013-07-02
PCT/IN2014/000441 WO2015001570A1 (en) 2013-07-02 2014-07-02 Rnai agent for inhibition of chikungunya virus
IN1960DE2013 IN2013DE01960A (enExample) 2013-07-02 2014-07-02

Publications (3)

Publication Number Publication Date
AU2014285701A1 AU2014285701A1 (en) 2016-01-21
AU2014285701B2 AU2014285701B2 (en) 2021-04-01
AU2014285701C1 true AU2014285701C1 (en) 2021-07-15

Family

ID=51383914

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014285701A Active AU2014285701C1 (en) 2013-07-02 2014-07-02 RNAi agent for inhibition of Chikungunya virus

Country Status (6)

Country Link
US (1) US9574195B2 (enExample)
EP (1) EP3017046B1 (enExample)
CN (1) CN105392886B (enExample)
AU (1) AU2014285701C1 (enExample)
IN (1) IN2013DE01960A (enExample)
WO (1) WO2015001570A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20190572A (es) * 2017-07-06 2020-05-23 Arrowhead Pharmaceuticals Inc AGENTES DE iARN PARA LA INHIBICIÓN DE LA EXPRESIÓN DE ALFA-ENaC Y MÉTODOS DE USO

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
D Parashar ET AL, "[P1.62] RNA interference inhibits Chikungunya virus replication in mammalian cells", (2010-11-07), URL: http://elsevier.conference-services.net/resources/247/2020/pdf/ANTI2010_0023.pdf, (2014-12-11) *

Also Published As

Publication number Publication date
CN105392886A (zh) 2016-03-09
AU2014285701B2 (en) 2021-04-01
WO2015001570A1 (en) 2015-01-08
EP3017046A1 (en) 2016-05-11
US20160145621A1 (en) 2016-05-26
CN105392886B (zh) 2019-10-22
AU2014285701A1 (en) 2016-01-21
IN2013DE01960A (enExample) 2015-06-26
US9574195B2 (en) 2017-02-21
EP3017046B1 (en) 2019-09-11

Similar Documents

Publication Publication Date Title
Parashar et al. Administration of E2 and NS1 siRNAs inhibit chikungunya virus replication in vitro and protects mice infected with the virus
US8846632B2 (en) Nucleic acids for targeting multiple regions of the HCV genome
JP2005521393A5 (enExample)
Yang et al. Small interfering RNAs targeting the rabies virus nucleoprotein gene
Israsena et al. Inhibition of rabies virus replication by multiple artificial microRNAs
Chen et al. LGP2 plays extensive roles in modulating innate immune responses in Ctenopharyngodon idella kidney (CIK) cells
Fouad et al. In-vitro inhibition of spring viremia of carp virus replication by RNA interference targeting the RNA-dependent RNA polymerase gene
Li Xie y
Kim et al. Multiple shRNAs driven by U6 and CMV promoter enhances efficiency of antiviral effects against foot-and-mouth disease virus
Kim et al. Therapeutic application of RNA interference against foot-and-mouth disease virus in vitro and in vivo
Tan et al. Enhanced potency and efficacy of 29-mer shRNAs in inhibition of Enterovirus 71
Tan et al. Inhibition of enterovirus 71 infection by antisense octaguanidinium dendrimer-conjugated morpholino oligomers
Meshram et al. Evaluation of single and dual siRNAs targeting rabies virus glycoprotein and nucleoprotein genes for inhibition of virus multiplication in vitro
Xu et al. Adenovirus-vectored shRNAs targeted to the highly conserved regions of VP1 and 2B in tandem inhibits replication of foot-and-mouth disease virus both in vitro and in vivo
Xiao et al. Inhibition of highly pathogenic PRRSV replication in MARC-145 cells by artificial microRNAs
AU2014285701C1 (en) RNAi agent for inhibition of Chikungunya virus
US20210348167A1 (en) siNA MOLECULES, METHODS OF PRODUCTION AND USES THEREOF
Anantpadma et al. siRNA-mediated suppression of Japanese encephalitis virus replication in cultured cells and mice
Scott et al. Pathogenic effects of Rift Valley fever virus NSs gene are alleviated in cultured cells by expressed antiviral short hairpin RNAs
He et al. In vitro inhibition of transmissible gastroenteritis coronavirus replication in swine testicular cells by short hairpin RNAs targeting the ORF 7 gene
Arani et al. In vitro Inhibition of Border Disease Virus Replication With Lentivirus-Mediated shRNAs
Amjadimanesh et al. RNA interference targeting UL25 gene as a gene therapy approach against BHV-1
Ren et al. Effect of siRNAs on HSV-1 plaque formation and relative expression levels of RR mRNA
Rothe et al. Antiviral activity of highly potent siRNAs against echovirus 30 and its receptor
KR101077188B1 (ko) 구제역 바이러스 억제를 위한 ｓｉＲＮＡ를 발현하는 재조합 아데노바이러스

Legal Events

Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 06 APR 2021

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT FILED 06 APR 2021

FGA Letters patent sealed or granted (standard patent)