AU2013337269A1 - Dual platform system for the delivery of nitric oxide - Google Patents
Dual platform system for the delivery of nitric oxide Download PDFInfo
- Publication number
- AU2013337269A1 AU2013337269A1 AU2013337269A AU2013337269A AU2013337269A1 AU 2013337269 A1 AU2013337269 A1 AU 2013337269A1 AU 2013337269 A AU2013337269 A AU 2013337269A AU 2013337269 A AU2013337269 A AU 2013337269A AU 2013337269 A1 AU2013337269 A1 AU 2013337269A1
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- Prior art keywords
- nitric oxide
- gas
- amount
- platform
- reservoir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
- A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
- A61M2016/102—Measuring a parameter of the content of the delivered gas
- A61M2016/1025—Measuring a parameter of the content of the delivered gas the O2 concentration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
- A61M2016/102—Measuring a parameter of the content of the delivered gas
- A61M2016/1035—Measuring a parameter of the content of the delivered gas the anaesthetic agent concentration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0208—Oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0266—Nitrogen (N)
- A61M2202/0275—Nitric oxide [NO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/40—Respiratory characteristics
- A61M2230/43—Composition of exhalation
- A61M2230/435—Composition of exhalation partial O2 pressure (P-O2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/40—Respiratory characteristics
- A61M2230/43—Composition of exhalation
- A61M2230/437—Composition of exhalation the anaesthetic agent concentration
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Filling Or Discharging Of Gas Storage Vessels (AREA)
- Chemical Kinetics & Catalysis (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2017204852A AU2017204852B2 (en) | 2012-11-05 | 2017-07-13 | Dual Platform System for the Delivery of Nitric Oxide |
Applications Claiming Priority (3)
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| US201261722595P | 2012-11-05 | 2012-11-05 | |
| US61/722,595 | 2012-11-05 | ||
| PCT/US2013/068415 WO2014071350A1 (en) | 2012-11-05 | 2013-11-05 | Dual platform system for the delivery of nitric oxide |
Related Child Applications (1)
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| AU2017204852A Division AU2017204852B2 (en) | 2012-11-05 | 2017-07-13 | Dual Platform System for the Delivery of Nitric Oxide |
Publications (1)
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| AU2013337269A1 true AU2013337269A1 (en) | 2015-05-21 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9425931D0 (en) * | 1994-12-22 | 1995-02-22 | Procter & Gamble | Cleansing compositions |
| US9651530B2 (en) * | 2013-01-14 | 2017-05-16 | Lifehealth, Llc | Methods and apparatus for measuring nitric oxide in fluid |
| US9753019B2 (en) * | 2013-01-14 | 2017-09-05 | Lifehealth, Llc | Measuring nitric oxide in fluid |
| JP6732654B2 (ja) | 2014-02-19 | 2020-07-29 | マリンクロット ホスピタル プロダクツ アイピー リミテッド | 一酸化窒素に曝される電気化学ガスセンサーの長期の感度変動を補償する方法 |
| WO2015172160A1 (en) | 2014-05-09 | 2015-11-12 | Ino Therapeutics Llc | Systems and methods for intelligent gas source management and/or systems and methods for delivery of therapeutic gas and/or enhanced performance verification for therapeutic gas delivery |
| US10525226B2 (en) * | 2014-05-14 | 2020-01-07 | Mallinckrodt Hospital Products IP Limited | Systems and methods for indicating lifetime of an NO2-to-NO reactor cartridge used to deliver NO for inhalation therapy to a patient |
| WO2016064928A1 (en) * | 2014-10-20 | 2016-04-28 | Geno Llc | Nitrogen dioxide storage cassette |
| ES2822215T3 (es) * | 2014-10-20 | 2021-04-29 | Massachusetts Gen Hospital | Sistemas y métodos de síntesis de óxido nítrico |
| ES2856007T3 (es) * | 2014-12-19 | 2021-09-27 | Maquet Critical Care Ab | Aparato de entrega de gas aditivo con respaldo |
| CA2987046A1 (en) * | 2015-05-25 | 2016-12-01 | Geno Llc | Nitric oxide treatment system and method |
| BR112019004635A2 (pt) * | 2016-09-10 | 2019-06-18 | Vero Biotech LLC | sistema e método para liberação de óxido nítrico portátil |
| WO2018157175A1 (en) | 2017-02-27 | 2018-08-30 | Third Pole, Inc. | Systems and methods for ambulatory generation of nitric oxide |
| MX2020010523A (es) | 2017-02-27 | 2021-02-09 | Third Pole Inc | Sistemas y metodos para generar oxido nitrico. |
| BR112019016708B1 (pt) | 2017-02-27 | 2024-01-30 | Third Pole, Inc | Sistemas de geração de óxido nítrico |
| US10762727B2 (en) * | 2017-12-29 | 2020-09-01 | Loon Llc | Estimation of aerial vehicle state |
| EP4029458B1 (en) * | 2018-05-01 | 2024-07-31 | Stryker Corporation | A measurement unit configured for releasable attachment to a surgical instrument |
| US11754538B1 (en) * | 2018-07-18 | 2023-09-12 | Vero Biotech Inc. | Method and apparatus for automatic calibration |
| US11672938B1 (en) | 2018-07-18 | 2023-06-13 | Vero Biotech LLC | Start-up protocols for nitric oxide delivery device |
| BR112021010462A2 (pt) * | 2018-12-03 | 2021-08-24 | Mallinckrodt Hospital Products IP Unlimited Company | Módulo de sensor de gás |
| WO2020232414A1 (en) * | 2019-05-15 | 2020-11-19 | Third Pole, Inc. | Architectures for production of nitric oxide |
| EP3969416A4 (en) | 2019-05-15 | 2023-11-01 | Third Pole, Inc. | SYSTEMS AND DEVICES FOR GENERATING NITROGEN OXIDE |
| CN114269685A (zh) | 2019-05-15 | 2022-04-01 | 第三极股份有限公司 | 用于一氧化氮生成的电极 |
| US20210052842A1 (en) * | 2019-08-23 | 2021-02-25 | NOTA Laboratories, LLC | Nitric oxide generating systems for nasal inhalation |
| EP4069069A4 (en) | 2020-01-11 | 2024-07-03 | Third Pole, Inc. | SYSTEMS AND METHODS FOR NITROGEN OXIDE PRODUCTION WITH HUMIDITY CONTROL |
| DE102020112557A1 (de) * | 2020-05-08 | 2021-11-11 | Hamilton Medical Ag | Beatmungsvorrichtung, welche zur Ermittlung einer funktionellen Beeinträchtigung ihrer O2-Sensoranordnung ausgebildet ist |
| EP4167920A4 (en) | 2020-06-18 | 2024-06-12 | Third Pole, Inc. | Systems and methods for preventing and treating infections with nitric oxide |
| WO2022082072A1 (en) | 2020-10-16 | 2022-04-21 | Third Pole, Inc. | Nitric oxide generation process controls |
| EP4405019A4 (en) | 2021-09-23 | 2025-07-16 | Third Pole Inc | SYSTEMS AND METHODS FOR PROVIDING NITRIC OXIDE |
| WO2023201363A2 (en) | 2022-04-14 | 2023-10-19 | Third Pole, Inc. | Delivery of medicinal gas in a liquid medium |
| WO2024086364A1 (en) * | 2022-10-21 | 2024-04-25 | Vero Biotech Inc. | Systems, methods, and apparatus for producing nitric oxide |
| USD1073017S1 (en) | 2023-02-14 | 2025-04-29 | Mallinckrodt Pharmaceuticals Ireland Limited | Gas cylinder |
| USD1061594S1 (en) | 2023-02-14 | 2025-02-11 | Mallinckrodt Pharmaceuticals Ireland Limited | Display screen or portion thereof with graphical user interface |
| USD1069817S1 (en) | 2023-02-14 | 2025-04-08 | Mallinckrodt Pharmaceuticals Ireland Limited | Display screen or portion thereof with graphical user interface |
| USD1087129S1 (en) | 2023-02-14 | 2025-08-05 | Mallinckrodt Pharmaceuticals Ireland Limited | Display screen or portion thereof with graphical user interface |
| USD1060405S1 (en) | 2023-02-14 | 2025-02-04 | Mallinckrodt Pharmaceuticals Ireland Limited | Display screen or portion thereof with graphical user interface |
| USD1092732S1 (en) | 2023-02-14 | 2025-09-09 | Mallinckrodt Pharmaceuticals Ireland Limited | Injector module |
| USD1108635S1 (en) | 2023-02-14 | 2026-01-06 | Mallinckrodt Pharmaceuticals Ireland Limited | Therapeutic gas delivery device |
| USD1092742S1 (en) | 2023-02-14 | 2025-09-09 | Mallinckrodt Pharmaceuticals Ireland Limited | Therapeutic gas cylinder bay |
| USD1064285S1 (en) | 2023-02-14 | 2025-02-25 | Mallinckrodt Pharmaceuticals Ireland Limited | Therapeutic gas delivery cart |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5558083A (en) * | 1993-11-22 | 1996-09-24 | Ohmeda Inc. | Nitric oxide delivery system |
| JP2001517108A (ja) * | 1997-01-17 | 2001-10-02 | メッサー オーストリア ゲゼルシャフト ミット ベシュレンクテル ハフツング | 制御されるガス供給システム |
| US7516742B2 (en) * | 1999-11-24 | 2009-04-14 | Cardinal Health 207, Inc. | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing |
| US20090107497A1 (en) * | 2007-10-29 | 2009-04-30 | Alex Stenzler | Method and device to prevent ventilator acquired pneumonia using nitric oxide |
| DE10115620A1 (de) * | 2001-03-29 | 2002-10-10 | Fritz Stephan Gmbh | Modulare Sauerstoff-Versorgungsanlage und Verfahren und Vorrichtung zur Steuerung der Anlage |
| US20040081580A1 (en) * | 2002-09-10 | 2004-04-29 | Doug Hole | Use of nitric oxide and a device in the therapeutic management of pathogens in mammals |
| US20080029093A1 (en) * | 2004-05-11 | 2008-02-07 | Alex Stenzler | Intermittent Dosing Of Nitric Oxide Gas |
| AU2005277397B2 (en) * | 2004-08-18 | 2011-08-25 | VERO Biotech LLC. | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US7618594B2 (en) * | 2004-08-18 | 2009-11-17 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US7174766B2 (en) * | 2005-05-24 | 2007-02-13 | Honeywell International Inc. | Calibration device for carbon dioxide sensor |
| US20070221225A1 (en) * | 2006-01-24 | 2007-09-27 | Larry Kutt | Simulated Altitude Method and Apparatus |
| CN104162200B (zh) * | 2006-02-09 | 2018-03-27 | 德卡产品有限公司 | 外围系统 |
| US20090065007A1 (en) * | 2007-09-06 | 2009-03-12 | Wilkinson William R | Oxygen concentrator apparatus and method |
| US8800344B2 (en) * | 2007-10-29 | 2014-08-12 | Poseidon Diving Systems Ab | Oxygen control in breathing apparatus |
| CA2713049C (en) * | 2008-01-28 | 2017-02-28 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| US20110245759A1 (en) * | 2008-07-30 | 2011-10-06 | Nitric Biotherapeutics, Inc. | Methods of Treating An Infection with Nitric Oxide |
| US8701657B2 (en) * | 2008-08-21 | 2014-04-22 | Geno Llc | Systems for generating nitric oxide |
| CA2797702C (en) * | 2010-04-26 | 2020-03-10 | VERO Biotech LLC. | Delivery of ultra pure nitric oxide (no) |
| CN103037928B (zh) * | 2010-04-27 | 2016-10-12 | 费雪派克医疗保健有限公司 | 用于向患者供应气体的装置 |
| DK2661300T3 (en) * | 2011-01-06 | 2018-01-15 | Ino Therapeutics Llc | Gas supply device and system |
-
2013
- 2013-11-05 AU AU2013337269A patent/AU2013337269A1/en not_active Abandoned
- 2013-11-05 EP EP13851309.8A patent/EP2914546B1/en not_active Not-in-force
- 2013-11-05 JP JP2015541843A patent/JP6325564B2/ja active Active
- 2013-11-05 CA CA2890203A patent/CA2890203A1/en not_active Abandoned
- 2013-11-05 WO PCT/US2013/068415 patent/WO2014071350A1/en not_active Ceased
- 2013-11-05 US US14/071,830 patent/US20140127081A1/en not_active Abandoned
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2017
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| US20140127081A1 (en) | 2014-05-08 |
| AU2017204852B2 (en) | 2019-06-13 |
| CA2890203A1 (en) | 2014-05-08 |
| EP2914546B1 (en) | 2019-07-10 |
| EP2914546A4 (en) | 2016-04-27 |
| JP2015537171A (ja) | 2015-12-24 |
| AU2017204852A1 (en) | 2017-08-03 |
| EP2914546A1 (en) | 2015-09-09 |
| WO2014071350A1 (en) | 2014-05-08 |
| JP6325564B2 (ja) | 2018-05-16 |
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| Date | Code | Title | Description |
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| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |