AU2013219216A1 - Pyridyl Inhibitors of Hedgehog Signalling - Google Patents

Abstract

The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: (R 3) (R2)n wherein A, X, Y R1 , R2, R3, R4 , m and n are as described herein.

Description

Pyridyl Inhibitors of Hedgehog Signalling This application is a divisional of Australian Application No. 2011201229, filed on 18 March 2011, which is a divisional application of Australian Application No. 2005282722, filed on 2 September 2005, and is related to International Patent Application No. PCT/US2005/03 1284, filed on 2 September 2005, and claiming priority from U.S. Provisional Application No. 60/607,367, filed on 2 5 September 2004, each of which is incorporated herein by reference. FIELD OF THE INVENTION The present invention relates to organic compounds useful for therapy and/or prophylaxis in a mammal, in particular to pyridyl compounds that inhibit the hedgehog signaling pathway and are [0 useful in the treatment of hyperproliferative diseases and angiogenesis mediated diseases. BACKGROUND OF THE INVENTION Hedgehog (Hh) protein was first identified in Drosophila melanogaster as a segment-polarity gene involved in embryo patterning (Nusslein-Volhard et al., Roux. Arch. Dev. Biol. 193: 267-282 (1984)). [5 Three orthologs of Drosophila hedgehog (Sonic, Desert and Indian) were later identified to occur in all vertebrates including fish, birds and mammals. Desert hedgehog (DHh) is expressed principally in the testes, both in mouse embryonic development and in the adult rodent and human; Indian hedgehog (IHh) is involved in bone development during embryogenesis and in bone formation in the adult; and, Sonic hedgehog (SHh) is expressed at high levels in the notochord and floor plate of developing !0 vertebrate embryos. In vitro explant assays as well as ectopic expression of SHh in transgenic animals have shown that SHh plays a key role in neuronal tube patterning (Echelard et al., supra.; Ericson et al., Cell 81: 747-56 (1995); Marti et al., Nature 375: 322-5 (1995); Krauss et al., Cell 75, 1432-44 (1993); Riddle et al., Cell 75: 1401-16 (1993); Roelink et al, Cell 81:445-55 (1995); Hynes et al., Neuron 19: 15-26 (1997)). Hh also plays a role in the development of limbs (Krauss et al., Cell 25 75: 1431-44 (1993); Laufer et al., Cell 79, 993-1003 (1994)), somites (Fan and Tessier-Lavigne, Cell 79, 1175-86 (1994); Johnson et al., Cell 79: 1165-73 (1994)), lungs (Bellusci et al., Develop. 124: 53 63 (1997) and skin (Oro et al., Science 276: 817-21 (1997)). Likewise, IHh and DHh are involved in bone, gut and germinal cell development (Apelqvist et al., Curr. Biol. 7: 801-4 (1997); Bellusci et al., Dev. Suppl. 124: 53-63 (1997); Bitgood et al., Curr. Biol. 6: 298-304 (1996); Roberts et al., 30 Development 121: 3163-74 (1995)). 1 Human SHh is synthesized as a 45 kDa precursor protein that upon autocatalytic cleavage yields a 20 kDa N-terminal fragment that is responsible for normal hedgehog signaling activity; and a 25 kDa C-terminal fragment that is responsible for autoprocessing activity in which the N-terminal 5 fragment is conjugated to a cholesterol moiety (Lee, J.J., et al. (1994) Science 266, 1528- 1536; Bumcrot, D.A., et al. (1995), Mol. Cell Biol. 15, 2294-2303; Porter, J.A., et al. (1995) Nature 374, 363- 366). The N-terminal fragment consists of amino acid residues 24-197 of the full-length precursor sequence which remains membrane-associated through the cholesterol at its C-terminus (Porter, J.A., et al. (1996) Science 274, 255- 258; Porter, J.A., et al. (1995) Cell 86, 21-34). 10 Cholesterol conjugation is responsible for the tissue localization of the hedgehog signal. At the cell surface, the Hh signal is thought to be relayed by the 12 transmembrane domain protein Patched (Ptc) (Hooper and Scott, Cell 59: 751-65 (1989); Nakano et al., Nature 341: 508 13 (1989)) and the G-protein-coupled-like receptor Smoothened (Smo) (Alcedo et al., Cell 86: 15 221-232 (1996); van den Heuvel and Ingham, Nature 382: 547-551 (1996)). Both genetic and biochemical evidence support a receptor model where Ptc and Smo are part of a multicomponent receptor complex (Chen and Struhl, Cell 87: 553-63 (1996); Marigo et al., Nature 384: 176-9 (1996); Stone et al., Nature 384: 129-34 (1996)). Upon binding of Hh to Ptc, the normal inhibitory effect of Ptc on Smo is relieved, allowing Smo to transduce the Hh signal across the 20 plasma membrane. However, the exact mechanism by which Ptc controls Smo activity still has yet to be clarified. The signaling cascade initiated by Smo results in activation of Gli transcription factors that translocate into the nucleus where they control transcription of target genes. Gli has been shown 25 to influence transcription of Hh pathway inhibitors such as Ptc and Hipi in a negative feedback loop indicating that tight control the Hh pathway activity is required for proper cellular differentiation and organ formation. Uncontrolled activation of Hh signaling pathway are associated with malignancies in particular those of the brain, skin and muscle as well as angiogenesis. An explanation for this is that Hh pathway has been shown to regulate cell 30 proliferation in adults by activation of genes involved in cell cycle progression such as cyclin D which is involved in G1-S transition. Also, SHh blocks cell-cycle arrest mediated by p21, an inhibitor of cyclin dependent kinases. Hh signaling is further implicated in cancer by inducing components in the EGFR pathway (EGF, Her2) involved in proliferation as well as components in the PDGF (PDGFat) and VEGF pathways involved in angiogenesis. Loss of function mutations in 2 the Ptc gene have been identified in patients with the basal cell nevus syndrome (BCNS), a hereditary disease characterized by multiple basal cell carcinomas (BCCs). Dysfunctional Ptc gene mutations have also been associated with a large percentage of sporadic basal cell carcinoma tumors (Chidambaram et al., Cancer Research 56: 4599-601 (1996); Gailani et al., Nature Genet. 5 14: 78-81 (1996); Hahn et al., Cell 85: 841-51 (1996); Johnson et al., Science 272: 1668-71 (1996); Unden et al., Cancer Res. 56: 4562-5; Wicking et al., Am. J. Hum. Genet. 60: 21-6 (1997)). Loss of Ptc function is thought to cause an uncontrolled Smo signaling in basal cell carcinoma. Similarly, activating Smo mutations have been identified in sporadic BCC tumors (Xie et al., Nature 391: 90-2 (1998)), emphasizing the role of Smo as the signaling subunit in the receptor 10 complex for SHh. Various inhibitors of hedgehog signaling have been investigated such as Cyclopamine, a natural alkaloid that has been shown to arrest cell cycle at GO-GI and to induce apoptosis in SCLC. Cyclopamine is believed to inhibit Smo by binding to its heptahelical bundle. Forskolin has been 15 shown to inhibit the Hh pathway downstream from Smo by activating protein kinase A (PKA) which maintains Gli transcription factors inactive. Despite advances with these and other compounds, there remains a need for potent inhibitors of the hedgehog signaling pathway. 20 SUMMARY OF THE INVENTION In one aspect of the present invention there is provided novel hedgehog inhibitors having the general formula (I) (R3)Y A R1 25 (R2)n I wherein A is a carbocycle or heterocycle; X is alkylene, NR 4 C(O), NR 4 C(S), N(C(O)R 1 )C(O), NR 4 SO, NR 4

SO

2 , NR 4 C(O)NH, NR 4 C(S)NH, 30 C(O)NR 4 , C(S)NR 4 , NR 4 PO or NR 4 PO(OH); Y is absent, CHR 4 , 0, S, SO, SO 2 or NR 4 ; 3

R

1 is selected from the group consisting of alkyl, a carbocycle or a heterocycle each of which is optionally substituted with hydroxyl, halogen, amino, carbonyl, nitro, cyano, acyl, alkyl, haloalkyl, alkylsulfonyl, alkylsulfinyl, alkoxy, alkylcarbamoyl, alkanoylamine, alkylsulfamoyl, alkylsulfonamide, a carbocycle or a heterocycle; wherein said amino, 5 alkyl, acyl, alkylsulfonyl, alkylsulfinyl, alkoxy, alkylcarbamoyl, alkanoylamine, alkylsulfamoyl, alkylsulfonamide, carbocycle and heterocycle substituent is optionally substituted with amino, halogen, hydroxyl, carbonyl, or a carbocycle or heterocycle that is optionally substituted with hydroxyl, amino, halogen, haloalkyl, alkyl, alkoxy or acyl;

R

2 is halogen, hydroxyl, alkyl, acyl or alkoxy each optionally substituted with hydroxyl, halogen, 10 amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy;

R

3 is halogen, hydroxyl, carboxyl, alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, alkylsulfinyl, alkylsulfonyl, a carbocycle or a heterocycle wherein each alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, alkylsulfinyl, alkylsulfonyl, carbocycle and heterocycle is optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, 15 alkylsulfonyl or alkoxy;

R

4 is H or alkyl; m is 0-3; n is 0-3; and salts and solvates thereof. 20 In another aspect of the invention, there are provided compositions comprising compounds of formula I and a carrier, diluent or excipient. In another aspect of the invention, there is provided a method for treating cancer comprising 25 administering an effective amount of a compound of formula I to a mammal in need thereof. In another aspect of the invention, there is provided a method for inhibiting hedgehog signaling in a cell comprising contacting said cell with a compound of formula I. 30 In another aspect of the invention, there is provided a method for treating a disease or condition associated with the hedgehog signaling in a mammal, comprising administering to said mammal an effective amount of a compound of formula I. In another aspect of the invention, there are provided processes for preparing compounds of the 35 invention. 4 DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS "Acyl" means a carbonyl containing substituent represented by the formula -C(O)-R in which R is 5 H, alkyl, a carbocycle, a heterocycle, carbocycle-substituted alkyl or heterocycle-substituted alkyl wherein the alkyl, alkoxy, carbocycle and heterocycle are as defined herein. Acyl groups include alkanoyl (e.g. acetyl), aroyl (e.g. benzoyl), and heteroaroyl. "Alkyl" means a branched or unbranched, saturated or unsaturated (i.e. alkenyl, alkynyl) aliphatic 10 hydrocarbon group, having up to 12 carbon atoms unless otherwise specified. When used as part of another term, for example "alkylamino", the alkyl portion is preferably a saturated hydrocarbon chain, however also includes unsaturated hydrocarbon carbon chains such as "alkenylamino" and "alkynylamino. "Alkylphosphinate" means a -P(O)R-alkyl group wherein R is H, alkyl, carbocycle-alkyl or heterocycle-alkyl. Examples of preferred alkyl groups include methyl, ethyl, n 15 propyl, isopropyl, n-butyl, iso-butyl, sec-butyl, tert-butyl, n-pentyl, 2-methylbutyl, 2,2 dimethylpropyl, n-hexyl, 2-methylpentyl, 2,2-dimethylbutyl, n-heptyl, 3-heptyl, 2-methylhexyl, and the like. The terms "lower alkyl" "C 1

-C

4 alkyl" and "alkyl of 1 to 4 carbon atoms" are synonymous and used interchangeably to mean methyl, ethyl, 1-propyl, isopropyl, cyclopropyl, 1 butyl, sec-butyl or t-butyl. Unless specified, substituted, alkyl groups may contain one 20 (preferably), two, three or four substituents which may be the same or different. Examples of the above substituted alkyl groups include, but are not limited to; cyanomethyl, nitromethyl, hydroxymethyl, trityloxymethyl, propionyloxymethyl, aminomethyl, carboxymethyl, carboxyethyl, carboxypropyl, alkyloxycarbonylmethyl, allyloxycarbonylaminomethyl, carbamoyloxymethyl, methoxymethyl, ethoxymethyl, t-butoxymethyl, acetoxymethyl, chloromethyl, bromomethyl, 25 iodomethyl, trifluoromethyl, 6-hydroxyhexyl, 2,4-dichloro(n-butyl), 2-amino(iso-propyl), 2 carbamoyloxyethyl and the like. The alkyl group may also be substituted with a carbocycle group. Examples include cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, and cyclohexylmethyl groups, as well as the corresponding -ethyl, -propyl, -butyl, -pentyl, -hexyl groups, etc. Preferred substituted alkyls are substituted methyls e.g. a methyl group substituted by the same substituents 30 as the "substituted Cn-Cm alkyl" group. Examples of the substituted methyl group include groups such as hydroxymethyl, protected hydroxymethyl (e.g. tetrahydropyranyloxymethyl), acetoxymethyl, carbamoyloxymethyl, trifluoromethyl, chloromethyl, carboxymethyl, bromomethyl and iodomethyl. 35 "Amidine" or "amidino" means the group -C(NH)-NRR wherein each R is independently H, OH, alkyl, alkoxy, a carbocycle, a heterocycle, a carbocycle-substituted alkyl or a heterocycle 5 substituted alkyl; or both R groups together form a heterocycle. A preferred amidine is the group

-C(NH)-NH

2 . "Amino" denotes primary (i.e. -NH 2 ) , secondary (i.e. -NRH) and tertiary (i.e. -NRR) amines 5 wherein R is independently alkyl, a carbocycle (e.g. aryl) , a heterocycle (e.g. heteroaryl), carbocycle-substituted alkyl (e.g. benzyl) or a heterocycle-substituted alkyl or alternatively two R groups together with the nitrogen atom from which they depend form a heterocycle. Particular secondary and tertiary amines are alkylamine, dialkylamine, arylamine, diarylamine, aralkylamine and diaralkylamine. Particular secondary and tertiary amines are methylamine, ethylamine, 10 propylamine, isopropylamine, phenylamine, benzylamine dimethylamine, diethylamine, dipropylamine and diisopropylamine. "Amino-protecting group" as used herein refers to a derivative of the groups commonly employed to block or protect an amino group while reactions are carried out on other functional groups on 15 the compound. Examples of such protecting groups include carbamates, amides, alkyl and aryl groups, imines, as well as many N-heteroatom derivatives which can be removed to regenerate the desired amine group. Preferred amino protecting groups are Boc, Fmoc and Cbz. Further examples of these groups are found in T. W. Greene and P. G. M. Wuts, "Protective Groups in Organic Synthesis", 2 "d ed., John Wiley & Sons, Inc., New York, NY, 1991, chapter 7; E. Haslam, 20 "Protective Groups in Organic Chemistry", J. G. W. McOmie, Ed., Plenum Press, New York, NY, 1973, Chapter 5, and T.W. Greene, "Protective Groups in Organic Synthesis", John Wiley and Sons, New York, NY, 1981. The term "protected amino" refers to an amino group substituted with one of the above amino-protecting groups. 25 "Aryl" when used alone or as part of another term means a carbocyclic aromatic group whether or not fused having the number of carbon atoms designated or if no number is designated, up to 14 carbon atoms. Aryl groups include phenyl, naphthyl, biphenyl, phenanthrenyl, naphthacenyl, and the like (see e.g. Lang's Handbook of Chemistry (Dean, J. A., ed) 13 hed. Table 7-2 [1985]). In a particular embodiment aryl may be phenyl. Substituted phenyl or substituted aryl denotes a 30 phenyl group or aryl group substituted with one, two, three, four or five, such as 1-2, 1-3 or 1-4 substituents chosen, unless otherwise specified, from halogen (F, Cl, Br, I), hydroxy, protected hydroxy, cyano, nitro, alkyl (for example C 1

-C

6 alkyl), alkoxy (for example C 1

-C

6 alkoxy), benzyloxy, carboxy, protected carboxy, carboxymethyl, protected carboxymethyl, hydroxymethyl, protected hydroxymethyl, aminomethyl, protected aminomethyl, trifluoromethyl, 35 alkylsulfonylamino, arylsulfonylamino, heterocyclylsulfonylamino, heterocyclyl, aryl, or other groups specified. One or more methyne (CH) and/or methylene (CH 2 ) groups in these substituents 6 may in turn be substituted with a similar group as those denoted above. Examples of the term "substituted phenyl" includes but is not limited to a mono- or di(halo)phenyl group such as 2 chlorophenyl, 2-bromophenyl, 4-chlorophenyl, 2,6-dichlorophenyl, 2,5-dichlorophenyl, 3,4 dichlorophenyl, 3-chlorophenyl, 3-bromophenyl, 4-bromophenyl, 3,4-dibromophenyl, 3-chloro-4 5 fluorophenyl, 2-fluorophenyl and the like; a mono- or di(hydroxy)phenyl group such as 4 hydroxyphenyl, 3-hydroxyphenyl, 2,4-dihydroxyphenyl, the protected-hydroxy derivatives thereof and the like; a nitrophenyl group such as 3- or 4-nitrophenyl; a cyanophenyl group, for example, 4-cyanophenyl; a mono- or di(lower alkyl)phenyl group such as 4-methylphenyl, 2,4 dimethylphenyl, 2-methylphenyl, 4-(iso-propyl)phenyl, 4-ethylphenyl, 3-(n-propyl)phenyl and the 10 like; a mono or di(alkoxy)phenyl group, for example, 3,4-dimethoxyphenyl, 3-methoxy-4 benzyloxyphenyl, 3 -methoxy-4-(1 -chloromethyl)benzyloxy-phenyl, 3-ethoxyphenyl, 4 (isopropoxy)phenyl, 4-(t-butoxy)phenyl, 3-ethoxy-4-methoxyphenyl and the like; 3- or 4 trifluoromethylphenyl; a mono- or dicarboxyphenyl or (protected carboxy)phenyl group such 4 carboxyphenyl, ; a mono- or di(hydroxymethyl)phenyl or (protected hydroxymethyl)phenyl such 15 as 3-(protected hydroxymethyl)phenyl or 3,4-di(hydroxymethyl)phenyl; a mono- or di(aminomethyl)phenyl or (protected aminomethyl)phenyl such as 2-(aminomethyl)phenyl or 2,4 (protected aminomethyl)phenyl; or a mono- or di(N-(methylsulfonylamino))phenyl such as 3-(N methylsulfonylamino))phenyl. Also, the term "substituted phenyl" represents disubstituted phenyl groups where the substituents are different, for example, 3-methyl-4-hydroxyphenyl, 3 20 chloro-4-hydroxyphenyl, 2-methoxy-4-bromophenyl, 4-ethyl-2-hydroxyphenyl, 3-hydroxy-4 nitrophenyl, 2-hydroxy-4-chlorophenyl, and the like, as well as trisubstituted phenyl groups where the substituents are different, for example 3-methoxy-4-benzyloxy-6-methyl sulfonylamino, 3 methoxy-4-benzyloxy-6-phenyl sulfonylamino, and tetrasubstituted phenyl groups where the substituents are different such as 3-methoxy-4-benzyloxy-5-methyl-6-phenyl sulfonylamino. 25 Substituted phenyl groups include 2-chlorophenyl, 2-aminophenyl, 2-bromophenyl, 3 methoxyphenyl, 3-ethoxy-phenyl, 4-benzyloxyphenyl, 4-methoxyphenyl, 3-ethoxy-4 benzyloxyphenyl, 3,4-diethoxyphenyl, 3-methoxy-4-benzyloxyphenyl, 3-methoxy-4-(1 chloromethyl)benzyloxy-phenyl, 3-methoxy-4-(1-chloromethyl)benzyloxy -6- methyl sulfonyl aminophenyl groups. Fused aryl rings may also be substituted with any (for example 1, 2 or 3) of 30 the substituents specified herein in the same manner as substituted alkyl groups. "Carbamoyl" means an aminocarbonyl containing substituent represented by the formula C(O)N(R) 2 in which R is H, hydroxyl, alkoxy, alkyl, a carbocycle, a heterocycle, carbocycle substituted alkyl or alkoxy, or heterocycle-substituted alkyl or alkoxy wherein the alkyl, alkoxy, 35 carbocycle and heterocycle are as herein defined. Carbamoyl groups include alkylaminoecarbonyl (e.g. ethylaminocarbonyl, Et-NH-CO-), arylaminocarbonyl (e.g. 7 phenylaminocarbonyl), aralkylaminocarbonyl (e.g. benzoylaminocarbonyl) a heterocycleaminocarbonyl (e.g. piperizinylaminocarbonyl), and in particular a heteroarylaminocarbonyl (e.g. pyridylaminocarbonyl). 5 "Carbocyclyl", "carbocyclic", "carbocycle" and "carbocyclo" alone and when used as a moiety in a complex group such as a carbocycloalkyl group, refers to a mono-, bi-, or tricyclic aliphatic ring having 3 to 14 carbon atoms and preferably 3 to 7 carbon atoms which may be saturated or unsaturated, aromatic or non-aromatic. Preferred saturated carbocyclic groups include cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl groups and more preferred are cyclopropyl 10 and cyclohexyl and most preferred is cyclohexyl. Preferred unsaturated carbocycles are aromatic e.g. aryl groups as previously defined, the most preferred being phenyl. The terms "substituted carbocyclyl", "substituted carbocycle" and "substituted carbocyclo" unless otherwise specified mean these groups substituted by the same substituents as the "substituted alkyl" group. 15 "Carboxy-protecting group" as used herein refers to one of the ester derivatives of the carboxylic acid group commonly employed to block or protect the carboxylic acid group while reactions are carried out on other functional groups on the compound. Examples of such carboxylic acid protecting groups include 4-nitrobenzyl, 4-methoxybenzyl, 3,4-dimethoxybenzyl, 2,4 dimethoxybenzyl, 2,4,6-trimethoxybenzyl, 2,4,6-trimethylbenzyl, pentamethylbenzyl, 3,4 20 methylenedioxybenzyl, benzhydryl, 4,4'-dimethoxybenzhydryl, 2,2',4,4' tetramethoxybenzhydryl, alkyl such as t-butyl or t-amyl, trityl, 4-methoxytrityl, 4,4' dimethoxytrityl, 4,4',4"-trimethoxytrityl, 2-phenylprop-2-yl, trimethylsilyl, t-butyldimethylsilyl, phenacyl, 2,2,2-trichloroethyl, beta-(trimethylsilyl)ethyl, beta-(di(n-butyl)methylsilyl)ethyl, p toluenesulfonylethyl, 4-nitrobenzylsulfonylethyl, allyl, cinnamyl, 1-(trimethylsilylmethyl)prop-1 25 en-3-yl, and like moieties. The species of carboxy-protecting group employed is not critical so long as the derivatized carboxylic acid is stable to the condition of subsequent reaction(s) on other positions of the molecule and can be removed at the appropriate point without disrupting the remainder of the molecule. In particular, it is important not to subject a carboxy-protected molecule to strong nucleophilic bases, such as lithium hydroxide or NaOH, or reductive 30 conditions employing highly activated metal hydrides such as LiAlH 4 . (Such harsh removal conditions are also to be avoided when removing amino-protecting groups and hydroxy-protecting groups, discussed below.) Preferred carboxylic acid protecting groups are the alkyl (e.g. methyl, ethyl, t-butyl), allyl, benzyl and p-nitrobenzyl groups. Similar carboxy-protecting groups used in the cephalosporin, penicillin and peptide arts can also be used to protect a carboxy group 35 substituents. Further examples of these groups are found in T. W. Greene and P. G. M. Wuts, "Protective Groups in Organic Synthesis", 2 "d ed., John Wiley & Sons, Inc., New York, N.Y., 8 1991, chapter 5; E. Haslam, "Protective Groups in Organic Chemistry", J. G. W. McOmie, Ed., Plenum Press, New York, N.Y., 1973, Chapter 5, and T.W. Greene, "Protective Groups in Organic Synthesis", John Wiley and Sons, New York, NY, 1981, Chapter 5. The term "protected carboxy" refers to a carboxy group substituted with one of the above carboxy-protecting groups. 5 "Guanidine" means the group -NH-C(NH)-NHR wherein R is H, alkyl, a carbocycle, a heterocycle, a carbocycle-substituted alkyl, or a heterocycle-substituted alkyl. A particular guanidine group is -NH-C(NH)-NH 2 . 10 "Heterocyclic group", "heterocyclic", "heterocycle", "heterocyclyl", or "heterocyclo" alone and when used as a moiety in a complex group such as a heterocycloalkyl group, are used interchangeably and refer to any mono-, bi-, or tricyclic, saturated or unsaturated, aromatic (heteroaryl) or non-aromatic ring having the number of atoms designated, generally from 5 to about 14 ring atoms, where the ring atoms are carbon and at least one heteroatom (nitrogen, sulfur 15 or oxygen) and preferably 1 to 4 heteroatoms. "Heterocyclosulfonyl" means a -S0 2 -heterocycle group; "heterocyclosulfinyl" means a -SO-heterocycle group. Typically, a 5-membered ring has 0 to 2 double bonds and 6- or 7-membered ring has 0 to 3 double bonds and the nitrogen or sulfur heteroatoms may optionally be oxidized (e.g. SO, SO 2 ), and any nitrogen heteroatom may optionally be quaternized. Preferred non-aromatic heterocycles include morpholinyl 20 (morpholino), pyrrolidinyl, oxiranyl, oxetanyl, tetrahydrofuranyl, 2,3-dihydrofuranyl, 2H-pyranyl, tetrahydropyranyl, thiiranyl, thietanyl, tetrahydrothietanyl, aziridinyl, azetidinyl, 1 -methyl-2 pyrrolyl, piperazinyl and piperidinyl. A "heterocycloalkyl" group is a heterocycle group as defined above covalently bonded to an alkyl group as defined above. Preferred 5-membered heterocycles containing a sulfur or oxygen atom and one to three nitrogen atoms include thiazolyl, 25 in particular thiazol-2-yl and thiazol-2-yl N-oxide, thiadiazolyl, in particular 1,3,4-thiadiazol-5-yl and 1,2,4-thiadiazol-5-yl, oxazolyl, preferably oxazol-2-yl, and oxadiazolyl, such as 1,3,4 oxadiazol-5-yl, and 1,2,4-oxadiazol-5-yl. Preferred 5-membered ring heterocycles containing 2 to 4 nitrogen atoms include imidazolyl, preferably imidazol-2-yl; triazolyl, preferably 1,3,4-triazol 5-yl; 1,2,3-triazol-5-yl, 1,2,4-triazol-5-yl, and tetrazolyl, preferably 1H-tetrazol-5-yl. Preferred 30 benzo-fused 5-membered heterocycles are benzoxazol-2-yl, benzthiazol-2-yl and benzimidazol-2 yl. Preferred 6-membered heterocycles contain one to three nitrogen atoms and optionally a sulfur or oxygen atom, for example pyridyl, such as pyrid-2-yl, pyrid-3-yl, and pyrid-4-yl; pyrimidyl, preferably pyrimid-2-yl and pyrimid-4-yl; triazinyl, preferably 1,3,4-triazin-2-yl and 1,3,5-triazin-4-yl; pyridazinyl, in particular pyridazin-3-yl, and pyrazinyl. The pyridine N-oxides 35 and pyridazine N-oxides and the pyridyl, pyrimid-2-yl, pyrimid-4-yl, pyridazinyl and the 1,3,4 triazin-2-yl groups, are a preferred group. Substituents for optionally substituted heterocycles, 9 and further examples of the 5- and 6-membered ring systems discussed above can be found in W. Druckheimer et al., U.S. Patent No. 4,278,793. "Heteroaryl" alone and when used as a moiety in a complex group such as a heteroaralkyl group, 5 refers to any mono-, bi-, or tricyclic aromatic ring system having the number of atoms designated where at least one ring is a 5-, 6- or 7-membered ring containing from one to four heteroatoms selected from the group nitrogen, oxygen, and sulfur, and preferably at least one heteroatom is nitrogen (Lang's Handbook of Chemistry, supra). Included in the definition are any bicyclic groups where any of the above heteroaryl rings are fused to a benzene ring. Heteroaryls in which 10 nitrogen or oxygen is the heteroatom are preferred. The following ring systems are examples of the heteroaryl (whether substituted or unsubstituted) groups denoted by the term "heteroaryl": thienyl, furyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, tetrazolyl, thiatriazolyl, oxatriazolyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, thiazinyl, oxazinyl, triazinyl, thiadiazinyl, oxadiazinyl, dithiazinyl, dioxazinyl, 15 oxathiazinyl, tetrazinyl, thiatriazinyl, oxatriazinyl, dithiadiazinyl, imidazolinyl, dihydropyrimidyl, tetrahydropyrimidyl, tetrazolo[1,5-b]pyridazinyl and purinyl, as well as benzo-fused derivatives, for example benzoxazolyl, benzofuryl, benzothiazolyl, benzothiadiazolyl, benzotriazolyl, benzoimidazolyl and indolyl. A particularly preferred group of "heteroaryl" include; 1,3-thiazol 2-yl, 4-(carboxymethyl)-5-methyl-1,3-thiazol-2-yl, 4-(carboxymethyl)-5-methyl-1,3-thiazol-2-yl 20 sodium salt, 1,2,4-thiadiazol-5-yl, 3-methyl-1,2,4-thiadiazol-5-yl, 1,3,4-triazol-5-yl, 2-methyl 1,3,4-triazol-5-yl, 2-hydroxy-1,3,4-triazol-5-yl, 2-carboxy-4-methyl-1,3,4-triazol-5-yl sodium salt, 2-carboxy-4-methyl-1,3,4-triazol-5-yl, 1,3-oxazol-2-yl, 1,3,4-oxadiazol-5-yl, 2-methyl-1,3,4 oxadiazol-5-yl, 2-(hydroxymethyl)-1,3,4-oxadiazol-5-yl, 1,2,4-oxadiazol-5-yl, 1,3,4-thiadiazol-5 yl, 2-thiol-1,3,4-thiadiazol-5-yl, 2-(methylthio)-1,3,4-thiadiazol-5-yl, 2-amino-1,3,4-thiadiazol-5 25 yl, 1H-tetrazol-5-yl, 1-methyl-iH-tetrazol-5-yl, 1-(1-(dimethylamino)eth-2-yl)-1H-tetrazol-5-yl, 1 (carboxymethyl)-1H-tetrazol-5-yl, 1-(carboxymethyl)-1H-tetrazol-5-yl sodium salt, 1 (methylsulfonic acid)-IH-tetrazol-5-yl, 1-(methylsulfonic acid)-IH-tetrazol-5-yl sodium salt, 2 methyl-iH-tetrazol-5-yl, 1,2,3-triazol-5-yl, 1-methyl-1,2,3-triazol-5-yl, 2-methyl-1,2,3-triazol-5 yl, 4-methyl-1,2,3-triazol-5-yl, pyrid-2-yl N-oxide, 6-methoxy-2-(n-oxide)-pyridaz-3-yl, 6 30 hydroxypyridaz-3-yl, 1-methylpyrid-2-yl, 1-methylpyrid-4-yl, 2-hydroxypyrimid-4-yl, 1,4,5,6 tetrahydro-5,6-dioxo-4-methyl-as-triazin-3-yl, 1,4,5,6-tetrahydro-4-(formylmethyl)-5,6-dioxo-as triazin-3-yl, 2,5-dihydro-5-oxo-6-hydroxy-astriazin-3-yl, 2,5-dihydro-5-oxo-6-hydroxy-as-triazin 3-yl sodium salt, 2,5-dihydro-5-oxo-6-hydroxy-2-methyl-astriazin-3-yl sodium salt, 2,5-dihydro-5 oxo-6-hydroxy-2-methyl-as-triazin-3-yl, 2,5-dihydro-5-oxo-6-methoxy-2-methyl-as-triazin-3-yl, 35 2,5-dihydro-5-oxo-as-triazin-3-yl, 2,5-dihydro-5-oxo-2-methyl-as-triazin-3-yl, 2,5-dihydro-5-oxo 2,6-dimethyl-as-triazin-3-yl, tetrazolo[1,5-b]pyridazin-6-yl and 8-aminotetrazolo[1,5-b]-pyridazin 10 6-yl. An alternative group of "heteroaryl" includes; 4-(carboxymethyl)-5-methyl-1,3-thiazol-2 yl, 4-(carboxymethyl)-5-methyl-1,3-thiazol-2-yl sodium salt, 1,3,4-triazol-5-yl, 2-methyl-1,3,4 triazol-5-yl, 1H-tetrazol-5-yl, 1-methyl-iH-tetrazol-5-yl, 1-(1-(dimethylamino)eth-2-yl)-1H tetrazol-5-yl, 1-(carboxymethyl)-1H-tetrazol-5-yl, 1-(carboxymethyl)-1H-tetrazol-5-yl sodium 5 salt, 1-(methylsulfonic acid)- 1 H-tetrazol-5-yl, 1-(methylsulfonic acid)- 1 H-tetrazol-5-yl sodium salt, 1,2,3-triazol-5-yl, 1,4,5,6-tetrahydro-5,6-dioxo-4-methyl-as-triazin-3-yl, 1,4,5,6-tetrahydro-4 (2-formylmethyl)-5,6-dioxo-as-triazin-3-yl, 2,5-dihydro-5-oxo-6-hydroxy-2-methyl-as-triazin-3-yl sodium salt, 2,5-dihydro-5-oxo-6-hydroxy-2-methyl-as-triazin-3-yl, tetrazolo[1,5-b]pyridazin-6-yl, and 8-aminotetrazolo[1,5-b]pyridazin-6-yl. 10 "Hydroxy-protecting group" as used herein refers to a derivative of the hydroxy group commonly employed to block or protect the hydroxy group while reactions are carried out on other functional groups on the compound. Examples of such protecting groups include tetrahydropyranyloxy, benzoyl, acetoxy, carbamoyloxy, benzyl, and silylethers (e.g. TBS, 15 TBDPS) groups. Further examples of these groups are found in T. W. Greene and P. G. M. Wuts, "Protective Groups in Organic Synthesis", 2 "d ed., John Wiley & Sons, Inc., New York, NY, 1991, chapters 2-3; E. Haslam, "Protective Groups in Organic Chemistry", J. G. W. McOmie, Ed., Plenum Press, New York, NY, 1973, Chapter 5, and T.W. Greene, "Protective Groups in Organic Synthesis", John Wiley and Sons, New York, NY, 1981. The term "protected hydroxy" refers to 20 a hydroxy group substituted with one of the above hydroxy-protecting groups. "Pharmaceutically acceptable salts" include both acid and base addition salts. "Pharmaceutically acceptable acid addition salt" refers to those salts which retain the biological effectiveness and properties of the free bases and which are not biologically or otherwise undesirable, formed with 25 inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, carbonic acid, phosphoric acid and the like, and organic acids may be selected from aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic, carboxylic, and sulfonic classes of organic acids such as formic acid, acetic acid, propionic acid, glycolic acid, gluconic acid, lactic acid, pyruvic acid, oxalic acid, malic acid, maleic acid, maloneic acid, succinic acid, fumaric acid, 30 tartaric acid, citric acid, aspartic acid, ascorbic acid, glutamic acid, anthranilic acid, benzoic acid, cinnamic acid, mandelic acid, embonic acid, phenylacetic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicyclic acid and the like. "Pharmaceutically acceptable base addition salts" include those derived from inorganic bases 35 such as sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts and the like. Particularly preferred are the ammonium, potassium, 11 sodium, calcium and magnesium salts. Salts derived from pharmaceutically acceptable organic nontoxic bases includes salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, trimethylamine, diethylamine, TEA, tripropylamine, ethanolamine, 2 5 diethylaminoethanol, trimethamine, dicyclohexylamine, lysine, arginine, histidine, caffeine, procaine, hydrabamine, choline, betaine, ethylenediamine, glucosamine, methylglucamine, theobromine, purines, piperizine, piperidine, N-ethylpiperidine, polyamine resins and the like. Particularly preferred organic non-toxic bases are isopropylamine, diethylamine, ethanolamine, trimethamine, dicyclohexylamine, choline, and caffeine. 10 "Phosphinate" means -P(O)R-OR wehrein each R is independently H, alkyl, carbocycle, heterocycle, carbocycloalkyl or heterocycloalkyl. Particular phosphinate groups are alkylphosphinate (i.e. -P(O)R-0-alkyl), for example -P(O)Me-OEt. 15 "Sulfamoyl" means -S0 2

-N(R)

2 wherein each R is independently H, alkyl, carbocycle, heterocycle, carbocycloalkyl or heterocycloalkyl. Particular sulfamoyl groups are alkylsulfamoyl, for example methylsulfamoyl (-S0 2 -NHMe); arylsulfamoyl, for example phenylsulfamoyl; aralkylsulfamoyl, for example benzylsulfamoyl. 20 "Sulfinyl" means a -SO-R group wherein R is alkyl, carbocycle, heterocycle, carbocycloalkyl or heterocycloalkyl. Particular sulfinyl groups are alkylsulfinyl (i.e. -SO-alkyl), for example methylsulfinyl; arylsulfinyl (i.e. -SO-aryl) for example phenylsulfinyl; aralkylsulfinyl, for example benzylsulfinyl. 25 "Sulfonamide" means -NR-S0 2 -R wherein each R is independently H, alkyl, carbocycle, heterocycle, carbocycloalkyl or heterocycloalkyl), a carbocycle or a heterocycle. Particular sulfonamide groups are alkylsulfonamide (e.g. -NH-S0 2 -alkyl), for example methylsulfonamide; arylsulfonamdie (i.e. -NH-S0 2 -aryl) for example phenylsulfonamide; aralkylsulfonamide, for example benzylsulfonamide. 30 "Sulfonyl" means a -S0 2 -R group wherein R is alkyl, carbocycle, heterocycle, carbocycloalkyl or heterocycloalkyl. Particular sulfonyl groups are alkylsulfonyl (i.e. -S0 2 -alkyl), for example methylsulfonyl; arylsulfonyl, for example phenylsulfonyl; aralkylsulfonyl, for example 35 benzylsulfonyl. 12 The phrase "and salts and solvates thereof' as used herein means that compounds of the inventions may exist in one or a mixture of salts and solvate forms. For example a compound of the invention may be substantially pure in one particular salt or solvate form or else may be mixtures of two or more salt or solvate forms. 5 The present invention provides novel compounds having the general formula I: (R36m-- Xl R1 R KN Y A (R2)n 10 wherein A, X, Y, R 1 , R 2 , and R 3 are as defined herein. A is a carbocycle or heterocycle ring substituted with 0 to 3 (e.g. n is 0-3) R 2 groups selected from the group consisting of halogen, hydroxyl, alkyl, acyl or alkoxy each optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy;. In a particular embodiment, 15 A is optionally substituted aryl or heteroaryl. In particular embodiment A is optionally substituted benzene, thiophene, thiazole, imidazole, pyrrole, N-alkyl pyrrole, pyridine, pyrazole or N-alkyl 1 2 3 pyrazole. In a particular embodiment A is a ring selected from the group consisting of A', A , A , A4 A 5 , A 6 and A 7 : R2' Z2ZNN -, I

-

Z - Z 2 4 -N R2' (R )n R2' A A 2

A

3

A

4 20 NN (R2), (R2), (R2)1

A

5

A

6

A

7 wherein Z 1 is 0, S or NR 5 wherein R 5 is H or alkyl; Z 2 is CH, CR 2 or N; R 2 is halogen, hydroxyl, alkyl, acyl or alkoxy each optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, 25 alkylsulfonyl or alkoxy; R 2 is H, halogen, hydroxyl, alkyl, acyl or alkoxy each optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; and n is 0-3. 13 In a particular embodiment A is the ring of formula A'. In a particular embodiment, A is the ring of formula A wherein Z 1 is S and Z 2 is CH or N. In another embodiment, A is the ring of formula A1 wherein Z 1 is S and Z 2 is CH, i.e. thiophene. In another embodiment, A is the ring of formula A1 wherein Z 1 is S and Z 2 is N, i.e. thiazole. In another embodiment, A is the ring of formula A 1 5 wherein R 2 is H. In embodiment, A is the ring of formula A 1 wherein R 2 is methyl. In another embodiment, A is the ring A 1 wherein R 2 is methyl. In a particular embodiment A is ring A 2 . In another embodiment, A is the ring of formula A 1 wherein R 2 may be absent, i.e. n is 0. In another embodiment, n is 1 and R 2 is Cl. In another particular embodiment A is the ring of formula A 3 . In an embodiment, A is a ring of formula A 3 wherein Z 1 is S and Z 2 is N, i.e. a thiazole. In another 10 embodiment, A is a ring of formula A 3 wherein Z 1 is S, Z 2 is N and R 2 ' is Cl. In another embodiment, A is a ring of formula A 3 wherein Z 1 is S, Z 2 is CH (i.e. thiophene) and R2' is Cl. In a particular embodiment A is the ring Ai, A , A2a A3a A 3, A4a Asa A6a, A a,: 15 N N SI SIA C A la Alb A2 N CI C A 3 a A 3 b A4 N IC1 N 20 A5a

A

6 a A 7 a In a particular embodiment A is the ring of formula Aia. In another embodiment A is the ring of formula A. In another embodiment A is the ring of formula A 2 a. In another embodiment A is the ring of formula A 3 a. In another embodiment A is the ring of formula A 3 b. In another embodiment 4a 25 A is the ring of formula A 14 X is alkylene, NR 4 C(O), NR 4 C(S), N(C(O)R 1 )C(O), NR 4 SO, NR 4

SO

2 , NR 4 C(O)NH, NR 4 C(S)NH,

C(O)NR

4 , C(S)NR 4 , NR 4 PO or NR 4 PO(OH) wherein R 4 is H or alkyl. In a particular embodiment X is NR 4 C(O) which forms an amide linkage between ring A and R 1 . In another embodiment, X is

N

4 C(S), which forms a thioamide linkage between ring A and R 1 . In another embodiment, X is 5 NR 4 C(O)NH which forms a urea linkage between ring A and R 1 . In another embodiment X is

NR

4 C(S)NH which with NR 2 forms a thiourea linkage between ring A and R 1 . In another embodiment X is N(C(O)R 1 )C(O) i.e. a nitrogen with two -C(O)R 1 groups pending therefrom. Y is absent, CHR 4 , 0, S, SO, SO 2 or NR 4 wherein R 4 is as defined herein. In a particular 10 embodiment Y is CHR 4 . In a particular embodiment Y is NR 4 . In a particular embodiment Y is 0. In a particular embodiment Y is S. In a particular embodiment Y is SO. In a particular embodiment Y is SO 2 . In another embodiment Y is absent i.e. ring A is directly attached to the pyridyl ring at the 2-position. 15

R

1 is selected from the group consisting of alkyl, a carbocycle or a heterocycle each of which is optionally substituted with hydroxyl, halogen, amino, carboxyl, amidino, guanidino, carbonyl (i.e. =0), nitro, cyano, acyl, alkyl, haloalkyl, sulfonyl, sulfinyl, alkoxy, akylthio, carbamoyl, acylamino, sulfamoyl, sulfonamide, a carbocycle or a heterocycle; wherein said amino, amidino, alkyl, acyl, 20 sulfonyl, sulfinyl, alkoxy, alkylthio, carbamoyl, acylamino, sulfamoyl, sulfonamide, carbocycle and heterocycle substituent is optionally substituted with, halogen, haloakyl, hydroxyl, carboxyl, carbonyl, or an amino, alkyl, alkoxy, acyl, sulfonyl, sulfinyl, phosphinate, carbocycle or heterocycle that is optionally substituted with hydroxyl, carboxyl, carbonyl, amino, halogen, haloalkyl, alkyl, alkoxy, alkylthio, sulfonyl, sulfinyl, acyl, a carbocycle or a heterocycle. 25 In another embodiment R 1 is selected from the group consisting of alkyl, a carbocycle or a heterocycle each of which is optionally substituted with hydroxyl, halogen, amino, carbonyl, nitro, cyano, acyl, alkyl, haloalkyl, alkylsulfonyl, alkylsulfinyl, alkoxy, alkylcarbamoyl (i.e. -CONR alkyl wherein R is H or alkyl), alkanoylamine (i.e. -NRCO-alkyl wherein R is H or alkyl), 30 alkylsulfamoyl (i.e. -SO 2 NR-alkyl wherein R is H or alkyl), alkylsulfonamide (i.e. -NR-S0 2 -alkyl wherein R is H or alkyl), a carbocycle or a heterocycle; wherein said amino, alkyl, acyl, alkylsulfonyl, alkylsulfinyl, alkoxy, alkylcarbamoyl, alkanoylamine, alkylsulfamoyl, alkylsulfonamide, carbocycle and heterocycle substituent is optionally substituted with amino, halogen, hydroxyl, carbonyl, or a carbocycle or heterocycle that is optionally substituted with 35 hydroxyl, amino, halogen, haloalkyl, alkyl, alkoxy or acyl. 15 In a particular embodiment R 1 is an optionally substituted aryl or heteroaryl. In a particular embodiment R 1 is an optionally substituted phenyl group. In another particular embodiment R 1 is an optionally substituted pyridine group. In a particular embodiment R 1 is of formula Ila, Ilb, Ilc, Ild, Ile, If, I1g, Ih, IIi, Ij, Ilk, IIl, Ilm, Iln or Io: 5 (R6)o (R6)o -(R6)o Ila IIb IIc (R)O (R)O (RO)O 10 Ild Ile lIf (ROO (RO (RO N N N N H H IIg Ilh Ili (R6)o (R6)o (R e o N w QN 15 Ihj Ilk III (R6)o (R6)o (R6)o .C N 7NR7 NyN Ilm Iln Io 20 wherein W is 0, S or NR 7 wherein R 7 is H, alkyl, acyl, a carbocycle or a heterocycle wherein said alkyl, acyl, carbocycle and heterocycle are each optionally substituted with 1-3 amino, halogen, hydroxyl and haloalkyl; o is 0-3. In a particular embodiment W is S. 16

R

6 in each instance is independently hydroxyl, halogen, amino, carboxyl, amidino, guanidino, carbonyl, nitro, cyano, acyl, alkyl, haloalkyl, sulfonyl, sulfinyl, alkoxy, akylthio, carbamoyl, acylamino, sulfamoyl, sulfonamide, a carbocycle or a heterocycle; wherein said amino, amidino, alkyl, acyl, sulfonyl, sulfinyl, alkoxy, alkylthio, carbamoyl, acylamino, sulfamoyl, sulfonamide, 5 carbocycle and heterocycle substituent is optionally substituted with, halogen, haloakyl, hydroxyl, carboxyl, carbonyl, or an amino, alkyl, alkoxy, acyl, sulfonyl, sulfinyl, phosphinate, carbocycle or heterocycle that is optionally substituted with hydroxyl, carboxyl, carbonyl, amino, halogen, haloalkyl, alkyl, alkoxy, alkylthio, sulfonyl, sulfinyl, acyl, a carbocycle or a heterocycle. 10 In a particular embodiment R 6 in each instance is independently hydroxyl, halogen, amino, carbonyl, nitro, cyano, acyl, alkyl, sulfonyl, alkylsulfonyl, alkylsulfinyl, alkoxy, alkylcarbamoyl, alkanoylamine, alkylsulfamoyl, alkylsulfonamide, a carbocycle or a heterocycle; wherein said amino, alkyl, carbonyl, acyl, sulfonyl, alkylsulfonyl, alkylsulfinyl, alkoxy, alkylcarbamoyl, alkanoylamine, alkylsulfamoyl, alkylsulfonamide, carbocycle and heterocycle substituent is 15 optionally substituted with amino, halogen, hydroxyl, carbonyl, or a carbocycle or heterocycle that is optionally substituted with hydroxyl, amino, halogen, haloalkyl, alkyl, alkoxy or acyl. In a particular embodiment R 6 is independently in each instance optionally substituted alkyl (e.g. methyl, trifluoromethyl, dimethylaminomethyl, piperidinylmethyl, morpholinomethyl, 20 thiomorpholinomethyl); halogen (e.g. chloro); alkoxy (e.g. methoxy); carbonyl (e.g. morpholinocarbonyl, acetyl); a heterocycle (e.g. morpholino, N-methyl-piperazin-4-yl, N-acetyl piperazin-4-yl, 1H-1,2,4-triazole); alkylamino (e.g. i-butylamino, benzylamino, hydroxyethylamino, methoxyethylamino, dimethylaminoethylamino, morpholinoethylamino, morpholinopropylamino, pyrrolidin-2-one-substituted propylamino, imidazole-ethylamino, 25 imidazole-propylamino); arylamino (e.g. phenylamino); alkylcarbamoyl (e.g. dimethylcarbamoyl, i-butylaminocarbonyl); alkylsulfamoyl (e.g. propylaminosulfonyl, i-butylaminosulfonyl, dimethylaminosulfonyl, dimethylaminoethyl hydroxyethylaminosulfonyl, methoxyethylaminosulfonyl, methoxypropylaminosulfonyl, methylsulfonylethylaminosulfonyl, imidazole-substituted propylaminosulfonyl, hydroxypropylaminosulfonyl, 2 30 hydroxypropylaminosulfonyl ); or sulfonyl (e.g. methylsulfonyl, ethylsulfonyl, aminosulfonyl, dimethylaminopropylsulfonyl, N-methyl-piperazin-4-yl-sulfonyl, morpholino-4-yl-sulfonyl, trifluoromethylsulfonyl). In a particular embodiment R 7 is H. In another particular embodiment R 7 is optionally substituted 35 acyl. In another particular embodiment R 7 is optionally substituted alkyl (e.g. methyl). In another 17 particular embodiment R 7 is optionally substituted acyl (e.g. acetyl, benzoyl). In another particular embodiment R 7 is an optionally substituted aryl group (e.g. phenyl, benzyl). In a particular embodiment R 1 is the group of formula Ila. In such embodiment R 6 may be alkoxy 5 and o is 1, 2 or 3. Particular Ila groups are Ila - Ila 28 : OMe OMe OMe OMe OMe OMe OMe OMe OMe Me~ OMe Hal Ila 2 Ila 3 Ila 4 Ila 5 10 CI OMe OEt OPr Ila 6 Ila 7 Ila 8 Ila 9 Hal 0 CI CI - OPr CI CI 15 Ha" Ia1 2 Ila1 3 a1 4 Ha 5 18 CI CI N HAc IIa 16 Ila 7 Ia 1 8 Ila 9 Ila20

NH(CH

2

)

5

NH

2 CF 3 OEt

NO

2

NO

2 ' CF 3

NO

2 5 Ila 2 1 Ila 22 Ila 23 Ila 24 Ila 2 CI C OMe Ila 26 Ila 27 Ila 28 10 In another particular embodiment R 1 is the group of formula Ilb. In such embodiment R 6 may be alkyl or haloalkyl (e.g. CF 3 ). Particular Ilb groups are Ib' - Ilb 3 : N CF 3 N C N Ib 1 I1b 2 IIb 3 15 In a particular embodiment R 1 is the group of formula Ilc. In such embodiment W may be S and o is 0. In another particular embodiment R 1 is the group of formula Ild. In such embodiment o may be 0. In another particular embodiment R 1 is the group of formula Ile. In such embodiment o may be 0. In another particular embodiment R 1 is the group of formula Ilf. In such embodiment o may 20 be 0. 19 In another particular embodiment R 1 is the group of formula Iln. In such embodiment o may be 0 or 2 and R 6 may be alkyl or aryl. In a particular embodiment, group Iln has the formula Ilnl: Ph N 5 Iln' In another particular embodiment R 1 is the group of formula Io. In such embodiment o may be 0 or 2 and R 6 may be alkyl or aryl. In a particular embodiment, group Io has the formula Iol: NF 10 ,- N 1101

R

2 is halogen, hydroxyl, alkyl, acyl or alkoxy each optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy. n is 0-3, for example 0 or 1. In a particular 15 embodiment R 2 is hydroxyl. In a particular embodiment R 2 is alkyl or alkyl substituted with halogen, methyl or trifluoromethyl. In a particular embodiment R 2 is acyl, for example alkanoyl e.g. acetyl. In a particular embodiment R 2 is halogen, for example Cl or F. In another particular embodiment R 2 is alkoxy, for example methoxy or ethoxy. 20 R 3 is halogen, hydroxyl, carboxyl, alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, sulfinyl, sulfonyl, a carbocycle or a heterocycle wherein each alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, sulfinyl, sulfonyl, carbocycle and heterocycle is optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, sulfonyl or alkoxy. In a particular embodiment

R

3 is halogen, hydroxyl, carboxyl, alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, 25 alkylsulfinyl, alkylsulfonyl, a carbocycle or a heterocycle wherein each alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, alkylsulfinyl, alkylsulfonyl, carbocycle and heterocycle is optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; while m is 0 to 3. In a particular embodiment, R 3 is halogen (e.g. F), carboxyl, or optionally substituted alkyl (e.g. methyl, hydroxymethyl, dimethylaminomethyl), alkoxycarbonyl (e.g. 30 methoxycarbonyl) or carbamoyl (e.g. dimethylaminocarbonyl). In a particular embodiment m is 0, i.e. R 3 is absent. In another particular embodiment m is 1-3. In a particular embodiment, compounds of the invention are represented by the general formula Ib: 20 iR8 (R3)m {N X, R lb 5 wherein X, R 1 , R 3 and m are as defined herein and R 8 is halogen. In an embodiment, compounds of the invention have the general formula lb and X is NR 4 CO. In further embodiment, compounds are of formula lb and R 3 is H or methyl. In another particular embodiment, compounds of the invention are represented by the general 10 formula Ib': R8 (R)m < N x B (Rs~ Ib' wherein X, R 3 , R 6 , m and o are as defined herein; R 8 is a halogen; and ring B is a carbocycle or 15 heterocycle. In a particular embodiment R 8 is Cl. In a particular embodiment ring B is phenyl or pyridyl. In a particular embodiment X is NR 4 C(O) and R 4 is as defined herein. In another particular embodiment, compounds of the invention have the general formula Ic: (Ra)m CI N N S 20 X-R Ic wherein X, R 1 , R 3 and m are as defined herein. In an embodiment, compounds of the invention have the general formula lb and X is NR 4 CO. In a further embodiment, compounds are of formula Ic and R 3 is H or methyl and m is 0 or 1. 21 In another particular embodiment, compounds of the invention have the general formula Id:

(R

3 )m N N I N N 5 Id wherein X, R 1 , R 3 and m are as defined herein. In an embodiment, compounds of the invention have the general formula lb and X is NR 4 CO. In a further embodiment, compounds are of formula Id and R 3 is H, Cl or trifluoromethyl and m is 0 or 1. 10 Particular compounds of the invention include, but are not limited to the following: 1 2 CI NNC HNN N N 0

N

CF

3 N\ / N CF3

F

3 C CF 3 3 CI - -4 CI NN \ "N/ 0 HN \N/ OMe HN S MeO 0 5 6 CI Ci \\\ // N 0 HN HN /\ N0 N--

CF

3

CF

3 22 7 8 C -C\/- / 0 N 00 HN 0'

CF

3 11 10 CI 0 HN HN H N - N N 0 H N N 13 14 cI NN HN / / ~NHN No 0 15 16 cI \/ \N/ 0 N/ \ HN N 0

HN

/~ NN 23 17 18 N H 0 N N 0 HN

-

HN N NH HO$

F

3 C 19 20 cI CI "N N 0 / HN- \N 0 HN / 0 C/ \ N 21 22 c CI N -- N 0 \ N 0 HN N N - NN N HN O NH N 0 NO 24 \ / "N N 0N N 00H HN _N /\N-N -N 25 26 cl Cl \/ N 0 N 0 HN

HN

N 0 -N

S

24 27 28 cI \"/0 HN

HN

-N 29 30 cI \/ \ N 0 \N 0 HN HN HN N 31 32 CI \/ \ N 0 \N 0 \HN N HN / \ o - N 0 -N 00 33 34 \N 0 N 0 H N - H Ny s c-S-NH HN-\OH 0\\ OH 35 36 Cl cl \ / 0/ 0Clil N 0 HN HN -bc Me 25 37 38 CI cI N \ "N/ 0HN HNNN - N 39 cI 40 \/ "N/ c HN N HNN Me

S-NH

2 0~\ 41 42 N 0N HN C HN CI /\NN Cl 43 44 Cl Cl N N 0 N/ 0 HNJ HN F N 45 46 Cl Cl \ / 0/ \N 0 HN HN / 0 0 2 Me 47 48 Cl Cl \N 0 H N- NH 2 \~~ ~ "N 0H /2 N 0 26 49 50 cI cI N NH 51 52

F

3 C C N CF3 OMe 53 F3C CI 3 54 F3C- CI NI N NN H , N\ CF N N 0 HN HN __eO N NNN N N O NN -M 57 58 o NHN 0 HNH 27I / -N 0 "N/\/"N/ N 0 HN HN /0 N N0 HN j N 0 2 SN N-M 57 CI 582C 59 c N 60 cO N N HN HN o 0 NH 61 C N 62 c N \ N 0 \N 0 HHNHN HNfN \N HN 02S0 NH 63 CI 64 CI 65 66/ N 0 \N~ HN HN NN H HN 02 0 2 S--,,N H 65 CI 66 CI \ N 0 N 0 HN 4 HN S0 2 S0 2 MeO~N NH ~NH 28 67 cI 68 cI XNI 0 N 0 HN HN S0 2 )"So 2 MeO HO NH 0 69 CI 70 CI HN HN HN

-

SO

2 _OMe 71 c 72 I H N N N N N NH HN HN N-N NH 73 cI1 74 c I N0 0 \ N 0 HN

-

HN N NH 0 29 75 cI 76 cI N N HN HN / N 0 HN N HO z_.,-NH 77 cI 78 CI \N/ 0 \N/ 0 HN HN N MeO -NH 0 79 CI 80 cI N0 N 0 HN N HN HN OH 0 2 S N 81 CI 82 cI HN HN 0 2 S-NH N- HN OMe 83 Cl 84 CO N0 \ N 0 HN HN CI NH 0 N 0 N 30 85 cI 86 cI HN 0 NHN 0 N HN HN NH c NH HN NJ HN NH 0 N 87 CI 88 CI / \ "/ HN HN

CF

3 CF 89 CI 90 CI \N/ 0 \N/ 0 HN N H Cl Cl NH 91 Ci 92 0I \ / 0/ HNN NH Cl NH HO SO 93 Cl cl S94 N3-O HN H / NN

CF

3 NH 31 CI CI 95- NF3C 96 CI \

F

3 0 N 0 HNO HN Sc: CF 3 CI CI 97 98 H O\ / \ N N

CF

3 CF 3 CI CI 10 100 F3C HN HN /0N / 4N

CF

3 CF 3 101 0 102 HN HN /N \N /N 0

CF

3

CF

3 C Cl F\/\ 103 \ \/104 N 0 N 0 HNN

CF

3

CF

3 Cl Cl 105 _\\/106\// N 0 N 0 HN

-

HN / \N /2 N C F 3 N NH 32 107 108 10 / 0/ N 0 HN N HN N N / N N N NH NH 109 N 0 11 0 HN H NH NH 0 0N / ~N 0 II N 0 112 \/ 0/ \ / \ N 0 HN HN NH NH 0 / \N 0/

NH

2 0 N130N114 0/\ 11 / 0/ \N0 HN HN NH NH N 0 / N 0

NH

2 33 CI 115 N 0 116 CI HN \ "N/\/"N/ N 0 HN NH 0 NH 0 CI CI 117 0 118 N I HN CIc N N NH N OH 0 CI CI 119 120 N 0 HN Cl HN CI N N- N N 0 Cl Cl 121 0 122 - C HN Cl N 0 HN CI ON N ON N-S CI CI 123 0 124 0 1 "/ \/ N HN Cl HN Cl N 0 N 0 0 0 34 CI CI 125 0 126 N 0 12 / \ N 0 HN CI HN CI N NH N NH 00 CI CI 127 0 128 N 0 12 / \ N 0 HN CI HN CI NH N NH N 0 0 Cl Cl 129 0 130 \/ 0 HN Cl HN Cl / /N Q \ /'N NH NH 0 0 Cl Cl 131 0 132 N 0 HN CI HN CI / N / \ oN S\ Ns~ NH NH 0 0 Cl Cl 13N 0 134 \ / 0 HN Cl HN Cl /\ N 0 NH NH o o Cl Cl 13 N/ 0 136 \ / 0/ HN- Cl HN Cl N\/ N" S - NH NH NH 0 0 35 CI CI 137 0 138 \/ 0 HN CI HN CI N/N N' /\ 'N

N

NH NH 00 CI CI 139 140 HN CI HN CI / \ N>N NH N NH ---- N -NH N\_ Cl Cl 141 0 142 \/ 0 HN Cl HN Cl N \ O N - 0 - N 0 NH N Cl Cl 143 0 144 N 0 1 "/ \/ N HN Cl HN Cl 0 N NH NH CII

C

Cl Cl N0 140/ \ 145 N 146 N 0 HN Cl HN Cl NH N O OH0 Cl Cl 147 148 0 HN" HN . 36 00 36 CI CI 149 0 150 0 14 / \ N 0 HN CI HN CI ONH NH 0 CI CI 151 N 0 152 0 \ / \ N 0 HN CI HN CI NH NH O OH Cl Cl 153 154 N 0 15 / \ N 0 HN Cl HN Cl NH NH O 0 OH 0 Cl Cl 155 N 0 156 N 0 HN Cl HN Cl NH NH O 0 N Cl Cl 157 N 158 N 0 HN Cl HN Cl NH N 0 0 37 CI CI 159 \/ O 160 N HN cI HN cI NH NH OH 00 CI CI 161 162 HN ci HN c N N N NH NH 0 CI CI 16N 164 16 / 0 \N 0 HN Cl HN NH N Cl Cl 169 166 16 / 0 \N 0 HN Cl HN Cl OH NH NH 0 Cl Cl N\0 168\__ 1 "/ 0\ N3 0 HN

-

Cl1 HN NH2 0 N,. NN Cl Cl 16 N 0 170 \ / 0/ HN- Cl HN Cl N N- N NH 0 0 38 171 0 172 N 0 17 / \ N 0 HN cI HN F - IN /-+F H NH F HN 0 \ 173 N 0 174 \ / N HN HN "/ N 7 N / N N HN N N 17 N/ 0 176 \ / 0/ HN HN 79N NI8N HNH HN 0 N N 0 Cl CI 17 N 178 0 \ HN HN Cl N S-N 0 I 0 QH 19 N 0 180 \N 0 19 \/ / C\N0 HN- Cl HN Cl NH OHN 00 OH 39 181 182 HN CI HN CI N/ N N CI CI 183 0 184 \/ 0 HN CN HN CN

H

2 N NHo NH Cl Cl 185 N 188 0 HN Cl HN / OH /~ NHN CI CI 1879 1880 HN IHN Il H NH No Cl Cl N/ 0 19-\0\ HN- C HN Cl NoHN \- /0 NH N 18 0 N0 04 191 0 192 N 0 HN cI HN cI NH 11 0 NH N 00 19N\ /O 193 0 194 N 0/ HN HN \~~ "N \"N H 4NH N- HN - NH 00 195 0 196 N 195 7 / 1 9N HN HN / \N N NH NH N 00 199N 0 198 19 / \ N0 HN HN NH -NH 0 Cl Cl 19 N 0 200 0\ 199 \/ \ N0 HN- Cl HN 0 -NH N- S ' OH 0 41 CI CI N01 202 201 \' \ N0 HN cI HN 0 NH OH S CI CI 203 N-N N00 N 0204 \/ / HN F CI HN NH NH o N N 0-

NH

2 Cl CI N05 206 0 HN CI HN Cl NH NH o0 0 N Cl Cl Cl N070 N H 208 N \ CIN- CIN/ HN Cl HN Cl 4 -lNH NH Cl Cl N090 N210 N/ \ HN4 Cl HN Cl NH NH 0 ,/0

A

0 42 N 0 212 \ / 0/ 211 212/N HN CI HN CI N - N -/ I \- / -\ N 0 -S NO 0 0 CI CI N 0 214\/ / 213 5 / N 2N 0 HN C N N N I N N HN S NH HN N 0 0 0 Cl Cl N 0 216 \ / 0/ H H Cl 0 -0 Cl Cl N 0 218\' / 27\' "N/ 0N 0 HN- HN N NH N N Cl Cl N210 220 \/ / 21 / 0 \N 0 HN

-

Cl HN NH NH / NH / NH N N 43 221 \220 \N 0 22 / 0/ HN HN 0 -0 N / N CI CI 22 0 222 \ / 0 223HN N\/NNN HN Br HN N 0 CI CI N 0 224 \ / 0 HN

-

HN -0 - 0 S=O S -N -N HN O HN Cl Cl \N 0 226 \ / 0 HN

-

0 HN b\S S=0 S0 44 231 230 HO HN HN 0 -0 P-0 S=O CI FFCIFF 0 - 233 232 0) N 0 O N 0 HNF HN N / N / N F F FE FF I CI 0 - 23 -NH N 0 23N 0 HN HN C F NH F F ,O HN 2 " 236 \ / 0 3 I \/HN C HN HN 01 0

HN-S&

0 Cl Cl N 238 \/ / HN- HN N-N Cl Cl N o 240 \/ / 24 / 0/ N 0 H N H N NI NK 45 N 0 242 \/ 0 24HN \ HN H HN HNF / ~N 0 11S:::NH HN OOH CN HO c H 245 \/25 "N 0 N 0 HN HN N NH F HN 0- F N 0 246 \/ HN 4 HN 0 - 0

N-S:::HN-S-

0 N 0 250\/ / 24\/ \/ N 0 HN4 0 0 S \ cr 0vN \-/ 0 Cl Cl N 0252\/ / 251 / \/ N0 HN HN cr-S-N \/N-\ -rS-ND OH 0 OH0 Cl Cl N 0 254\/ / 23\"/ \/ N 0 H N 4 H N 4 AS-N 0 .S-N NH 0 0 46 \N 0 256 \ / 0/ HN HN ,-S-N N OS-N NH 0 0 \N 0 258 \ / 0/ 257 \/258 N 0 HN- HN- CI F /-F -- NH F O NH2 0 0 HN HN- I NH HN- / CI CI 6 N1 0 262 \/ 0 HNI HN CI - 0 NN Cl Cl \N 0 262 \ / 0 H5N 26N Cl 47O 0 0 Cl Cl N 0 2646 / \ 26 \/ 0 \N 0 HN- Cl HN- Cl ~HO -~HO 0" 0 47l 267 \268 HN HN /\HO / HO O 0 CI CI 269 N 270 N 26 / 0 \N 0 HN

-

HN N -- N O O CI CI \N 0 272 \ / 0/ 271 N 272 N 0 HN HN- CI /0 HO

NH

2 o 0 CI CI 273 \274 HN HN HO

-

-OH S-S O 0 Cl Cl N 0 276 \ / N 2757 \ N N780 HN

-

HN -N N N S48 0 0 Cl Cl \N 0 278 \ / 0/ HN- HN S-S/ 0 0 48 \N 0 280 \ / 0/ 279 280/N HN HN OH -SS 0 0 CI CI 285 286 N870 I282 N/ \ 289 290 28 / 0\ N 0 HN HN CI - OH 0 0 \ N 284 \ / 0/ HN CI HN 4 OH 0 0 Cl Cl N 0 286 \/ / 28 / 0\ N 0 HN4 Cl HN C1 0 0 0 Cl Cl \N 0 288 \ / 0/ HN Cl HN 0 0 N

N

Cl Cl N0 290 \N 0 HN HN- Cl 0 0 49 N 0 292 \/ 0 HN CI HN 0S 0 0 CI CI \N 0 294 \ / 0/ 293 294/N HN HN I N 0 0 CI CI 295 \ / 296 N HN 0 N -- N N 297 / 298 \"N0 HN N HN N Cl c 9 N9 300 \/ 297N N HO H N HN N 0 0 299 \/\/ N0 CI CI 301 \/ 302 N 0 HN HN N HO N HN N CI CI 303 \ " 3040 HN HN N HO N HN N CI CI 305 306 5 \"N \ N 0 HN N HN / N / \IN N OH CI CI 309310 / .307 \/ 0/ 30 N 0 HN HN \ N 0 N-=

N

0O NH \NH Cl Cl .0 \N 0 310 \ / \ 0 HN HN- NH 2 - 0 N s 0 N 51 CI 312 CI 311 0 N 0 HN HN HN I 0 0 0 Cl Cl N1 30 N3 1 4 N/ N 313 316 HN HN N / N N N NH NH Cl Cl N319 320 31 / 0 \N 0 HN HN / N /2 N N N NH NH Cl Cl .37N 0 318 "N/ 0 HN

-

HN N N N OH CN 0 O0 cl Cl .319 \/ 0/ 32 N 0 HN HN / N / N N No 0 52 CI CI 321 0 322 \/ 0 HN HN - \ NN -N HN N - N- N CI CI 323 0 324 \/ 0 HN HN N N N N-N NH N CI CI 325 0 326 \/ 0 HN N HN N / N / N N'N N-N N CI CI 327 0 328 \/ 0 HN HN N / HO N HN ... N H Cl Cl 329 \/ 330 N 0 HN HN / HO N HN HN NH 53 331 \ / 3320 HN HN HN N HN N N N N N HN \--N .337 338 HN HN N / N / N N-D N N-/ OH CI CI 33 336 \ / HN HN C HN -N\ 337~ 338 0 HN-H SO NN 00 .339 "N/ 0 340 \"/0 HN4 - HN4 / 0 0 0 54 cI ci 0 .341 342/N "N 0 340/\ HN- HN-4 /- N 0 0 S~o o= NH N 00 t ! 0 - N 0 0 0 0 .34 "/ 0 36\"/ 0 HN- N HN ND 0 cr-0 / 0t !/ 0 0 .347 0 350 0 HN NDHN 0o or- 0 0 /0 .4\N 0 3520/\ HN0 -N FHN - 0 NH F/ NH / 0 0 55o 353 0 354 HN 0 N HN /\NH /NHe /~ NH S~O HN 0 CI CI 355 \ " 356 \N NH 0 NH NH HN HN CI CI 357 358 HN N H HNF /-+F NH NH F HN HN CI CI 359 360 0 HN HN N 0 NH HN HN Cl Cl 361 0 362 \/ N HN HN NH NH HN HN Cl Cl 363 N 0 364 N \ 33 \ \// \N0 H H HN N N- NH HN HN 56 CI CI 365 366 HN HN /\ / \ / \ HN No HN NH CI CI 367 368 \ 36 \/ \ N0 HN HN N 0 N HN - HN Compounds of the invention may contain one or more asymmetric carbon atoms. Accordingly, the compounds may exist as diastereomers, enantiomers or mixtures thereof. The syntheses of the compounds may employ racemates, diastereomers or enantiomers as starting materials or as 5 intermediates. Diastereomeric compounds may be separated by chromatographic or crystallization methods. Similarly, enantiomeric mixtures may be separated using the same techniques or others known in the art. Each of the asymmetric carbon atoms may be in the R or S configuration and both of these configurations are within the scope of the invention. 10 The invention also encompasses prodrugs of the compounds described above. Suitable prodrugs include known amino-protecting and carboxy-protecting groups which are released, for example hydrolyzed, to yield the parent compound under physiologic conditions. A particular class of prodrugs are compounds in which a nitrogen atom in an amino, amidino, aminoalkyleneamino, iminoalkyleneamino or guanidino group is substituted with a hydroxy (OH) group, an 15 alkylcarbonyl (-CO-R) group, an alkoxycarbonyl (-CO-OR), an acyloxyalkyl-alkoxycarbonyl (-CO O-R-O-CO-R) group where R is a monovalent or divalent group and as defined above or a group having the formula -C(O)-O-CP1P2-haloalkyl, where P1 and P2 are the same or different and are H, lower alkyl, lower alkoxy, cyano, halo lower alkyl or aryl. Prodrug compounds may be prepared by reacting the compounds of the invention described above with an activated acyl 20 compound to bond a nitrogen atom in the compound of the invention to the carbonyl of the activated acyl compound. Suitable activated carbonyl compounds contain a good leaving group bonded to the carbonyl carbon and include acyl halides, acyl amines, acyl pyridinium salts, acyl alkoxides, in particular acyl phenoxides such as p-nitrophenoxy acyl, dinitrophenoxy acyl, fluorophenoxy acyl, and difluorophenoxy acyl. The reactions are generally exothermic and are 57 carried out in inert solvents at reduced temperatures such as -78 to about 50 C. The reactions are usually also carried out in the presence of an inorganic base such as potassium carbonate or sodium bicarbonate, or an organic base such as an amine, including pyridine, TEA, etc. One manner of preparing prodrugs is described in USSN 08/843,369 filed April 15, 1997 5 (corresponding to PCT publication W09846576) the contents of which are incorporated herein by reference in their entirety. SYNTHESIS 10 Compounds of the invention are prepared using standard organic synthetic techniques from commercially available starting materials and reagents. It will be appreciated that synthetic procedures employed in the preparation of compounds of the invention will depend on the particular substituents present in a compound and that various protection and deprotection procedures may be required as is standard in organic synthesis. Compounds of the invention in 15 which Y is absent may prepared by a Negishi coupling procedure according to the following general scheme 1: scheme 1 1,Br Pd(PPh 3

)

4 (R3)r A + (R3)TKN R N ZnBr 20 Ia in which the pyridyl zinc bromide (or alternatively pyridylzinc chloride) is reacted with an iodo or bromo substituted ring A to give the final compound Ia. Alternatively, compounds Ia of the invention may be prepared using a Suzuki coupling reaction of a borylated ring A to provide direct linkage between the appropriate pyridyl and ring A according to scheme 2. 25 58 scheme 2 1 0 [Pd] (R 3 ) K (R -O O- R1A R A , A B-B

(R

3 )m K)n o a N Br Ia 5 A halogen-substituted ring A is reacted with a boron ester such as pinacol diborane in the presence of palladium catalyst such as PdCl 2 (dppf) and the resulting boronate ester is heated with a 2 halogen-substituted pyridine and a palladium catalyst to give a final compound Ia of the invention. Compounds of the invention in which Y is NR 4 may prepared by palladium catalyzed amination of 10 halogen-substituted ring A with the desired 2-aminopyridine according to scheme 3. scheme 3 + Ri [Pd] R

(R

3 )m K + A R1 [N)(3 N- A R N NR 4 H R4 (R2)n (R )n Ib 15 Compounds of the invention in which X is NR 4 CO may be prepared by the general scheme 4 in which amine-substituted ring A is reacted with the desired acid chloride Cl-C(O)-R 1 . scheme 4 (R3)m - NR 4 H (R3) R4 R1 N Y- A N CI R, (R2)n Y(R2)n 20 0 Alternatively, such compounds may be prepared from by EDC catalyzed coupling of a carboxy substituted ring A with an amine-substituted R 1 group, i.e. R 1

-NR

4 H. The same scheme may be used to prepare thioamide compounds of the invention, i.e. X is NR 4 C(S), by employing an 25 appropriate thio acid chloride Cl-C(S)-R 1 in the acylation step. 59 Compounds of the invention in which X is C(O)NR 4 may be similarly prepared by reacting an amine-substituted ring A with a carboxy-substituted R 1 group and EDC catalyst according to scheme 5. 5 scheme 5 0 EDCr 0 (R3) O OH -R (R3) NNR1 N Y A + HR 4 N Y A R4 (R2)n (R2)n 10 A similar scheme may be used to prepare thioamide compounds of the invention, i.e. X is

C(S)NR

4 , by employing an appropriate thioic acid-substituted ring A (e.g. -C(S)OH) or by converting the amide with Lawesson's reagent.. 15 Compounds of the invention in which X is NR 4 C(O)NH may be prepared according to the general scheme 6 by reacting amine-substituted ring A with the appropriate isocyanate R 1 -NCO. Scheme 6

(R

3 )mA

NR

4 H RiNCO

(R

3 )m Y AR N Y A N Y-A Y (R2), (R ) 20 The same scheme may be used to prepare thiourea compounds of the invention, i.e. X is

NR

4 C(S)NH, by employing an appropriate isothiocyanate R 1 -NCS in place of the isocyanate R 1 NCO. 25 Compounds of the invention in which X is NR 4

SO

2 may be prepared according to the general scheme 7 by reacting an amine-substituted ring A with the appropriate sulfonyl chloride R 1 S(0 2 )Cl in the presence of a non-nucleophilic base such as TEA or diisopropylethylamine to form the desired sulfonamide . 60 Scheme 7

(R

3 )m - NR 4 H C-SO2-R 1 , base (R 3 )m K NR N Y- N Y- 02 (Rj (Rj 5 Compounds of the invention in which X is NR 4 SO are similarly prepared using the appropriate sulfinyl chloride R 1 -SO-Cl instead of the sulfonyl chloride R 1 -S(0 2 )Cl. Compounds of the invention having the structure of formula Ib' in which X is NHCO (i.e. formula Ib") may be prepared according to the general scheme 8 in which R 3 , R 6 , m and o are as defined 10 herein and Q is Cl, Br or I; Q' is halogen, OH, OR wherein R is an activating group; L is Br, I or OTf (e.g. O-SO2-CF 3 ): Scheme 8 IL (R3)m C (R N N Zn-Q 14

NO

2 NO 2 (a) (b) (c) 15 (R3) CI CI N N (R3)m-,N4 N Q -0 0N

NH

2 HN (d) (e) BIlV The zinc halide pyridine reagent (a) is reacted with 2-chloro-5-nitro-benzene reagent (b) in a Negishi coupling reaction in the presence of a suitable catalyst such as palladium 20 tetrakis(triphenylphosphine) complex (Pd(PPh 3 )4). In a particular embodiment, the palladium tetrakis(triphenylphosphine) catalyst is stablized with triphenylphosphine (PPh 3 ). In a particular embodiment Q is Br. In a particular embodiment L is I. In a particular embodiment, the coupling reaction is performed from about 50 0 C to about 60 0 C. 61 The nitrobenzene reagent (b) may be obtained from activating the corresponding amine (i.e. 2 chloro-5-nitroaniline) in an aqueous sulfuric acid solution with sodium nitrite and displacing with an L group (e.g. with KI, KBr). In a particular embodiment, L is I. In a particular embodiment the reaction is performed at less than about 15'C. 5 The resulting intermediate (c) is reduced, for example with Fe, Zn or SnCl 2 in presence of acid to give the amine intermediate (d). In a particular embodiment, intermediate (c) is reduced with Fe, for example, in the presence of AcOH in EtOH. In a particular embodiment, intermediate (c) is reduced with Zn, for example in the presence of AcOH in EtOH. In a partiuclar embodiment, 10 intermediate (c) is reduced with SnCl 2 , for example in the presence of HCl in EtOH. In a particular embodiment the reduction reaction is performed at about 60 0 C. Finally, intermediate (d) is reacted with an activated acid (e) to yield final compound Ib". In a particular embodiment, the activated acid (e) is an acid halide (e.g. Q' is chloride) or activated 15 ester (e.g. Q' is O-EDC). In a particular embodiment the final reaction is performed at about 0 0 C. The compounds of the invention inhibit the hedgehog signaling and are useful for the treatment of cancers associated with aberrant hedgehog signaling, for example when Patched fails to, or 20 inadequately, represses Smoothened (Ptc loss-of-function phenotype) and/or when Smoothened is active regardless of Patched repression (Smo gain-of-function phenotype). Examples of such cancer types include basal cell carcinoma, neuroectodermal tumors such as medullablastoma, meningioma, hemangioma, glioblastoma, pancreatic adenocarcinoma, squamous lung carcinoma, small-cell lung carcinoma, non-small cell lung carcinoma, chondrosarcoma, breast carcinoma, 25 rhabdomyosarcoma, oesophageal cancer, stomach cancer, biliary tract cancer, renal carcinoma, thyroid carcinoma. Compounds of the invention may be administered prior to, concomitantly with, or following administration of other anticancer treatments such as radiation therapy or chemotherapy. Suitable cytostatic chemotherapy compounds include, but are not limited to (i) antimetabolites, such as cytarabine, fludarabine, 5-fluoro-2'-deoxyuiridine, gemcitabine, 30 hydroxyurea or methotrexate; (ii) DNA-fragmenting agents, such as bleomycin, (iii) DNA crosslinking agents, such as chlorambucil, cisplatin, cyclophosphamide or nitrogen mustard; (iv) intercalating agents such as adriamycin (doxorubicin) or mitoxantrone; (v) protein synthesis inhibitors, such as L-asparaginase, cycloheximide, puromycin or diphteria toxin; (Vi) topoisomerase I poisons, such as camptothecin or topotecan; (vii) topoisomerase II poisons, such 35 as etoposide (VP-16) or teniposide; (viii) microtubule-directed agents, such as colcemid, colchicine, paclitaxel, vinblastine or vincristine; (ix) kinase inhibitors such as flavopiridol, 62 staurosporin, ST1571 (CPG 57148B) or UCN-01 (7-hydroxystaurosporine); (x) miscellaneous investigational agents such as thioplatin, PS-341, phenylbutyrate, ET-18- OCH 3 , or farnesyl transferase inhibitors (L-739749, L-744832); polyphenols such as quercetin, resveratrol, piceatannol, epigallocatechine gallate, theaflavins, flavanols, procyanidins, betulinic acid and 5 derivatives thereof; (xi) hormones such as glucocorticoids or fenretinide; (xii) hormone antagonists, such as tamoxifen, finasteride or LHRH antagonists. In a particular embodiment, compounds of the present invention are coadministered with a cytostatic compound selected from the group consisting of cisplatin, doxorubicin, taxol, taxotere and mitomycin C. 10 Another class of active compounds which can be used in the present invention are those which are able to sensitize for or induce apoptosis by binding to death receptors ("death receptor agonists"). Such agonists of death receptors include death receptor ligands such as tumor necrosis factor a (TNF-a), tumor necrosis factor B (TNF-B, lymphotoxin-at) , LT-B (lymphotoxin-B), TRAIL (Apo2L, DR4 ligand), CD95 (Fas, APO-1) ligand, TRAMP (DR3, Apo-3) ligand, DR6 ligand as 15 well as fragments and derivatives of any of said ligands. In a particular embodiment, the death receptor ligand is TNF-a. In another particular embodiment the death receptor ligand is Apo2L/TRAIL. Furthermore, death receptors agonists comprise agonistic antibodies to death receptors such as anti-CD95 antibody, anti-TRAIL-Ri (DR4) antibody, anti-TRAIL-R2 (DR5) antibody, anti-TRAIL-R3 antibody, anti-TRAIL-R4 antibody, anti-DR6 antibody, anti-TNF-R1 20 antibody and anti-TRAMP (DR3) antibody as well as fragments and derivatives of any of said antibodies. For the purpose of sensitizing cells for apoptosis, the compounds of the present invention can be also used in combination with radiation therapy. The phrase "radiation therapy" refers to the use of electromagnetic or particulate radiation in the treatment of neoplasia. Radiation therapy is based on 25 the principle that high-dose radiation delivered to a target area will result in the death of reproducing cells in both tumor and normal tissues. The radiation dosage regimen is generally defined in terms of radiation absorbed dose (rad), time and fractionation, and must be carefully defined by the oncologist. The amount of radiation a patient receives will depend on various consideration including the location of the tumor in relation to other organs of the body, and the 30 extent to which the tumor has spread. Examples of radiotherapeutic agents are provided in, but not limited to, radiation therapy and is known in the art (Hellman, Principles of Radiation Therapy, Cancer, in Principles I and Practice of Oncology, 24875 (Devita et al., 4th ed., vol 1, 1993). Recent advances in radiation therapy include three-dimensional conformal external beam radiation, intensity modulated radiation therapy (IMRT), stereotactic radiosurgery and brachytherapy 63 (interstitial radiation therapy), the latter placing the source of radiation directly into the tumor as implanted "seeds". These newer treatment modalities deliver greater doses of radiation to the tumor, which accounts for their increased effectiveness when compared to standard external beam radiation therapy. 5 Ionizing radiation with beta-emitting radionuclides is considered the most useful for radiotherapeutic applications because of the moderate linear energy transfer (LET) of the ionizing particle (electron) and its intermediate range (typically several millimeters in tissue). Gamma rays deliver dosage at lower levels over much greater distances. Alpha particles represent the other extreme, they deliver very high LET dosage, but have an extremely limited range and must, 10 therefore, be in intimate contact with the cells of the tissue to be treated. In addition, alpha emitters are generally heavy metals, which limits the possible chemistry and presents undue hazards from leakage of radionuclide from the area to be treated. Depending on the tumor to be treated all kinds of emitters are conceivable within the scope of the present invention. Furthermore, the present invention encompasses types of non-ionizing radiation like e.g. ultraviolet (UV) radiation, high 15 energy visible light, microwave radiation (hyperthermia therapy), infrared (IR) radiation and lasers. In a particular embodiment of the present invention UV radiation is applied. Compounds of the invention inhibit angiogenesis and are therefore useful in the treatment of diseases or conditions mediated by angiogenesis such as tumors, in particular solid tumors such as 20 colon, lung, pancreatic, ovarian, breast and glioma. Furthermore, compounds of the invention are useful for treating macular degeneration e.g. wet age-related macular degeneration. Compounds of the invention are also useful for treating inflammatory/immune diseases such as Crohn's, inflammatory bowel disease, Sjogren's syndrome, asthma, organ transplant rejection, systemic lupus erythmatoses, rheumatoid arthritis, psoriatic arthritis, psoriasis and multiple sclerosis. 25 Compounds of the invention are also useful as a depilatory. The invention also includes pharmaceutical compositions or medicaments containing the compounds of the invention and a therapeutically inert carrier, diluent or excipient, as well as methods of using the compounds of the invention to prepare such compositions and medicaments. 30 Typically, the compounds of the invention used in the methods of the invention are formulated by mixing at ambient temperature at the appropriate pH, and at the desired degree of purity, with physiologically acceptable carriers, i.e., carriers that are non-toxic to recipients at the dosages and concentrations employed into a galenical administration form. The pH of the formulation depends 64 mainly on the particular use and the concentration of compound, but may range from about 3 to about 8. A particular formulation is an acetate buffer at pH 5. The compounds for use herein may be in a sterile formulation. The compound may be stored as a solid composition, although lyophilized formulations or aqueous solutions are acceptable. 5 The composition of the invention will be formulated, dosed, and administered in a fashion consistent with good medical practice. Factors for consideration in this context include the particular disorder being treated, the particular mammal being treated, the clinical condition of the individual patient, the cause of the disorder, the site of delivery of the agent, the method of 10 administration, the scheduling of administration, and other factors known to medical practitioners. The "effective amount" of the compound to be administered will be governed by such considerations, and is the minimum amount necessary to decrease hedgehog pathway signaling or else is the minimum amount necessary to cause reduction in size, volume or mass of a tumor that is responsive to hedgehog signaling, or a reduction in the increase in size, volume or 15 mass of such a tumor relative to the increase in the absence of administering the compound of the invention. Alternatively "effective amount" of the compound means the amount necessary to reduce the number of malignant cells or the rate in increase of the number of malignant cells. Alternatively, "effective amount" is the amount of the compound of the invention required to increase survival of patients afflicted with an anti-hedgehog pathway sensitive tumor. Such 20 amount may be below the amount that is toxic to normal cells, or the mammal as a whole. With respect to non-malignant indications, "effective amount" means the amount of compound of the invention required to decrease severity of the particular indication or symptoms thereof. Generally, the initial pharmaceutically effective amount of the compound of the invention 25 administered parenterally per dose will be in the range of about 0.01 to about 100 mg/kg, for example about 0.1 to about 20 mg/kg of patient body weight per day, for example about 0.3 to about 15 mg/kg/day. Oral unit dosage forms, such as tablets and capsules, may contain from about 25 to about 1000 mg of the compound of the invention. 30 The compound of the invention may be administered by any suitable means, including oral, topical, transdermal, parenteral, subcutaneous, rectal, intraperitoneal, intrapulmonary, and intranasal, and, if desired for local treatment, intralesional administration. Parenteral infusions include intramuscular, intravenous, intraarterial, intraperitoneal, or subcutaneous administration. An example of a suitable oral dosage form is a tablet containing about 25mg, 50mg, 100mg, 35 250mg, or 500mg of the compound of the invention compounded with about 90-30 mg anhydrous lactose, about 5-40 mg sodium croscarmellose, about 5-30mg polyvinylpyrrolidone (PVP) K30, 65 and about 1-10 mg magnesium stearate. The powdered ingredients are first mixed together and then mixed with a solution of the PVP. The resulting composition can be dried, granulated, mixed with the magnesium stearate and compressed to tablet form using conventional equipment. An aerosol formulation can be prepared by dissolving the compound, for example 5-400 mg, of the 5 invention in a suitable buffer solution, e.g. a phosphate buffer, adding a tonicifier, e.g. a salt such sodium chloride, if desired. The solution is typically filtered, e.g. using a 0.2 micron filter, to remove impurities and contaminants. Topical formulations include ointments, creams, lotions, powders, solutions, pessaries, sprays, aerosols and capsules. Ointments and creams may be formulated with an aqueous or oily base with the addition of suitable thickening and/or gelling 10 agents and/or solvents. Such bases may include water and/or an oil such a liquid paraffin or a vegetable oil such as arachis oil or castor oil or a solvent such as a polyethylene glycol. Thickening agents which may be used include soft paraffin, aluminum stearate, cetostearyl alcohol, polyethylene glycols, microcrystalline wax and beeswax. Lotions may be formulated with an aqueous or oily base and may contain one or more emulsifying agents, stabilizing agents, 15 dispersing agents, suspending agents or thickening agents. Powders for external application may be formed with the aid of any suitable powder base e.g. talc, lactose or starch. Drops may be formulated with an aqueous or non-aqueous base also comprising one or more dispersing agents, solubilizing agents or suspending agents. 20 EXAMPLES The invention will be more fully understood by reference to the following examples. They should not, however, be construed as limiting the scope of the invention. Abbreviations used herein are as 25 follows: BuOH: butanol; DIPEA: diisopropylethylamine; DMA: NN-dimethylacetamide; 30 DMAP: 4- dimethylaminopyridine; DME: 1,2-dimethoxyethane; DMF: dimethylformamide; EDC: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; HATU: 0-(7-Azobenzotriazol- 1 -yl)- 1,1,3,3-tetramethyluronium hexafluorophosphate; 35 HPLC: high pressure liquid chromatography MPLC: medium pressure liquid chromatography 66 NBS: N-Bromosuccinimide; TEA: Triethylamine; TASF: tris(dimethylamino)sulfonium difluorotrimethylsilicate; THF: tetrahydrofuran; 5 EtOH: Ethanol; MeOH: Methanol; gL: microlitre 10 All reagents were obtained commercially unless otherwise noted. Reactions were performed using oven-dried glassware under an atmosphere of nitrogen. Air and moisture sensitive liquids and solutions were transferred via syringe or stainless steel cannula. Organic solutions were concentrated under reduced pressure (ca. 15 mm Hg) by rotary evaporation. Unless otherwise 15 noted all solvents used were obtained commercially. Chromatographic purification of products was accomplished by use of an Isco CombiFlash Companion and media. Reaction times are given for illustration only. The course of reactions was followed by thin-layer chromatography (TLC) and liquid chromatography-mass spectrometry (LC-MS). Thin-layer chromatography (TLC) was performed on EM Science silica gel 60 F 2 54 plates (250 tm). Visualization of the developed 20 chromatogram was accomplished by fluorescence quenching. LC-MS were acquired with a Shimadzu lOAD LC on a Phenomenex column (50 x 4.6 mm, 5 .tm) operating at 3 mL/min. A Shimadzu SPD-10A detector monitoring at 214 and 254 nm was used. Single quadrupole mass spectrometry was performed on an Applied Biosystems mass spectrometer. Nuclear magnetic resonance (NMR) spectra were acquired on a Varian Inova spectrometer operating at 400 MHz for 25 'H and are referenced internally to tetramethylsilane (TMS) in parts per million (ppm). Data for 'H NMR are recorded as follows: chemical shift (6, ppm), multiplicity (s, singlet; bs, broad singlet; d, doublet; t, triplet; q, quartet; quint, quintet; sext, sextet; hept, heptet; m, multiplet; bm, broad multiplet), and integration. The structure and purity of all final products were assessed by at least one of the following techniques: LC-MS, NMR, TLC. 30 Example 1 General Procedure Compounds of examples 2-51 were prepared according to the following general procedures. 35 A: Suzuki Coupling Procedure 67 R CI O CI CI 1',- (dppBf A N PdCl2(dppf) R Pd(PPh 3

)

4 HN 0B-B HN 0 HN 0 Ar Ar N Br Ar 2 M aq. Potassium carbonate (5.0 eq) and 4:1 toluene:ethanol mixture (2.5 mL) were added to a 5 microwave vial charged with the appropriate boronate ester (2.6 eq), aryl halide (0.35 mmol, 1.0 eq), and Pd(PPh 3

)

4 (0.04 eq). The vial was sealed and heated with stirring in the microwave to 160 'C for ten minutes. The solution was poured onto 2 M aq. Sodium hydroxide (20 mL), extracted with ethyl acetate (2 x 20 mL), dried (MgSO 4 ), and concentrated. Purification of the crude product by chromatography on silica gel (conditions given below) afforded the desired product. 10 B: Negishi Coupling Procedure CI R X CI Pd(PPh 3

)

4 N HN O R ArRHN 0 N ZnBr Ar 15 X= IorBr R = H, 3-Me, 4-Me, 5-Me, 6-Me Aryl zinc bromide (0.5 M in THF, 2.5 eq) was added to an oven-dried microwave vial charged with the appropriate aryl halide (1.0 eq) and Pd(PPh 3

)

4 (0.04 eq). The vial was sealed and heated 20 with stirring in the microwave to 140 'C for 10 minutes. The crude reaction mixture was concentrated and purified by chromatography on silica gel (conditions given below) to afford the desired product. 25 C: Iron Reduction of Aryl Nitro Group 68 CI CI R R Fe, AcOH,

NO

2 EtOH

NH

2 R = I or pyridin-2-yl The appropriate nitro aryl (1 mmol, 1 eq) in AcOH/EtOH (1:1, 0.42 M) was added slowly to a 5 solution of Iron powder (6.0 eq) in AcOH/EtOH (1:2, 2 M) at 60 'C. The solution was stirred at 70 'C for 30-60 minutes. The reaction mixture was cooled to 23 'C, filtered through celite, washed with ethyl acetate, and concentrated. The oily residue was dissolved in ethyl acetate (30 mL), washed with saturated aq. NaHCO 3 (2 x 15 mL) and water (2 x 10 mL), dried (MgSO4), and concentrated. The oily residue was used with out further purification. 10 D: Amide Bond Formation CI CI R R ArCOCI,

NH

2 Et 3 N, CH 2 C1 2 H N O Ar R = I or pyridin-2-yl 15 Acid chloride (1.05-1.1 eq) was added to a solution of aniline (1.0 eq) and TEA (1.1-1.5 eq) in methylene chloride at the indicated temperature. The solution was stirred for 0.5-3 hours, poured onto saturated aq. NaHCO 3 , extracted twice with methylene chloride, dried (MgSO4), and concentrated. Purification of the crude product by chromatography on silica gel (conditions given 20 below) afforded the desired product. E: EDC Amide Bond Formation CI CI R I + HO O E R EDC, CH 3 Cl Ar

NH

4 Cl, H 2 0

NH

2 CH 3 Cl extraction HN O 25 Ar 69 R = I or pyridin-2-yl Carboxylic acid (1.1 eq) was added to a solution of aniline (1.0 eq) and EDC (1.4 eq) in methylene chloride (0.7 M in aniline). The solution was stirred at 23 'C for 2 hours, poured onto a 1:1 5 mixture of saturated aq. NH 4 C1 and water, extracted twice with methylene chloride, dried (MgSO 4 ), and concentrated. Purification of the crude product by chromatography on silica gel (conditions given below) afforded the desired product. 10 F: addition of amines to 2-chloropyridine CI CI O FO - N0 FIN___N 0 HN R H HN R N N R R' N BuOH N CI N-R' [R = H, CH 3 R NHRR' = ethanolamine, analine, benzylamine, 2-methylpropylamine, N-methylpiperazine, morpholine, 2-morpholinoethylamine 15 Primary or secondary amine (5 eq) in either BuOH or a mixture of BuOH/ethylene gylcol was heated to 170 to 220 'C for 20 min in a sealed tube. The BuOH was removed under reduced pressure. In cases where ethylene glycol was used, the reaction was diluted with water, and the product was extracted into ethyl acetate, dried (MgSO 4 ), and concentrated. The crude residue was 20 purified by reverse phase HPLC to afford the desired product. G: Amide bond coupling with HATU CI CI N N N+ HO 01 1_ _ HATU, DIPEA, DMF Ar NaOH or NaHCO 3

NH

2 ethyl acetate extraction H N O 25 Ar 70 Aniline (1.0 eq) was added to a mixture of carboxylic acid (1.1 eq), HATU (1.1 eq) and DIPEA (2 eq) in DMF (0.1 - 0.2 M). After stirring overnight, the reaction mixture was diluted with 0.1 N sodium hydroxide or saturated NaHCO 3 , extracted into ethyl acetate and the combined organic layers were washed with brine. The organic layer was dried (MgSO 4 ), concentrated and the crude 5 mixture was purified by reverse phase HPLC. H: Preparation of sulfonamide benzoic acids HO 0 HO 0 + HNH ,N DIPEA/MeOH 4,0 R O cl 0 N-R' 10 R Chlororsulfonylbenzoic acid (1.0 eq) was added to a solution of amine (1.1 eq) in 10-20% DIPEA/methanol (1 M) at 4 C. After 1 h, the reaction mixture was concentrated, and the crude residue was purified by reverse phase HPLC. 15 I : Stannylation of 2-pyridyl triflates Pd(PPh 3

)

4 (R3) __ (Me 3 Sn) 2 , LiCI (R3)m- N OTf Dioxane/Toluene N SnMe 3 A solution of tetrakis-triphenylphosphinepalladium (0.04 eq.) in toluene (1 mL) was added to degassed solution of aryltriflate (1 eq), bis-trialkyltin (1.05 eq), and lithium chloride (3 eq) in 20 dioxane. Heated to reflux for 2 hours, cooled to 23 'C, diluted with ethyl acetate, washed with 10% NH 4 0Haq) and brine, dried (MgSO 4 ) and concentrated. The crude material was used without further purification. 25 J: Stannylation of substituted pyridines 1. dimethylaminoethanol nBuLi, hexane (R3)m 0 (R3)m, N 2. Me 3 SnC1 N Sn Me 3 n-Butyl lithium (6 eq, 2.5 M in hexanes) was added dropwise to a solution of dimethylaminoethanol (3 eq) in hexane at 0 'C. The solution was stirred at 0 'C for thirty minutes 71 before dropwise addition of the substituted pyridine (1 eq). The solution was stirred at 0 'C for an additional hour, then cooled to -78 'C. A solution of trialkyltin in hexane was added dropwise. The solution was stirred at -78 'C for thirty minutes, warmed to 0 'C, quenched with water, extracted twice with ether, dried (MgSO 4 ), and concentrated. 5 K: Stille Coupling CI Pd 2 (dba) 3

.R

3 CI PPh 3 , K- N

(R

3 )m + NMP N N SnMe 3 microwave HN. O HNrO R1 R1 10 Palladium catalyst (0.02 eq) was added to a degassed solution of aryliodide (1 eq), arylstannane (2 eq), and triphenylphosphine (0.16 eq) in NMP. Heated in the microwave to 130 'C for 15 minutes. The reaction mixture was diluted with ethylacetate, washed with 10% NH 4 0H(aq) and brine, dried (MgSO 4 ), concentrated and purified by silica gel chromatography. 15 L: Synthesis of alkylethers HO N CI RO . CI N alkyl iodide N Cs 2

CO

3 , NMP microwave HN 0 HN O R1 R1 A solution of hydroxypyridine (1 eq), alkyliodide (excess), and cesium carbonate in NMP was 20 heated in the microwave to 100 'C for ten minutes. The reaction mixture was diluted with ethylacetate, washed with 10% NH 4 0H(aq) and brine, dried (MgSO 4 ), concentrated and purified by silica gel chromatography. 25 M: Methyl Ester Saponification 72 0 0 R R R R LiOH 1:1 THFH\20 0 0 O HO The methyl ester (leq) was hydrolyzed with LiOH (2eq) in 50/50 THF/water mix. Upon completion of the reaction the THF was evaporated under reduced pressure and the solution is acidified with HCl to pH 2. The resultant solid was filtered and dried to give the pure acid. 5 N: Bromination in the presence of a free acid functionality o 0 HO R HO R /O- R Benzoyl Peroxide / \ - nbs, AcOH Benzene A Br The paramethylbenzoic acid (leq) was combined with Benzoyl Peroxide (0.leq) and N 10 Bromosuccinimde (0.9eq) in a solution of 5%AcOH in Benzene and heated in the microwave at 120OC for 5-15minutes. The product was separated from the starting material and di-bromo product via ISCO flash chromatography with an ethyl acetate (with 1% AcOH) and hexanes solvent system. 15 0: Sodium Methanesulfinate displacement of Bromine o o R R R R

-

NaSO 2

CH

3 DMF O Br S 0 To the bromine starting material (leq) was added sodium methanesulfinate (2eq) in DMF and heated to 120 C in the microwave for 5 minutes. Alternatively, the reaction was heated to 60C in 20 an oil bath for several hours until completed. Reaction mixture was concentrated under reduced pressure and extracted in ethyl acetate and water. The organic layer was dried over Magnesium Sulfate, filtered and concentrated in vacuo to yield generic methylsulfone. 73 P: Amine displacement of Bromine 0 0 Y R Y R RRNH / R Br N R To the bromo starting material (leq) was added appropriate amine (3eq) in either DMSO or BuOH and stirred at room temperature until complete. For less nucleophilic amines or anilines, the 5 reactions were forced to completion using microwave conditions ranging from 150O-170C for 15 minutes. Crude reactions were concentrated to dryness and either extracted with ethyl acetate and saturated bicarbonate if the reaction resulted in an intermediate or purified via HPLC if the reaction resulted in a final product. 10 Q: Thiol displacement of halogen o 0 R R R- -- RSH K2CO3 Br DMF R The paramethylbromo benzoate (leq) was treated with Potassium (or Cesium) Carbonate (1.5eq) and appropriate thiol derivative (1,1eq) in DMF (or CH 3 CN) and stirred overnight at room 15 temperature. The DMF was evaporated in vacuo and the reaction was extracted with ethyl acetate and water. The organic layer was dried over Magnesium Sulfate , filtered and concentrated to yield the thiol or derivatized thiol compound. 20 R: Oxone Oxidation o 0 R R oxone 2:1 MeOH/H 2 0 / S\ R R Derivatized thiol (leq) was dissolved in MeOH while Oxone (2eq) was seperately dissolved in half the amount of water. Once all the oxone was dissolved, the solution was added to the thiol in MeOH solution at once and stirred until complete. The MeOH was evaporated in vacuo and the 74 remaining water was extracted twice with Ethyl Acetate. The organic layer was dried over Magnesium Sulfate and concentrated to yield the sulfone. 5 S: Thiolysis of epoxides at alumina surfaces R R R R R A1 2 0 3 , Et 2 0 SH S R OH R 10 A mixture of epoxides (1.0 eq), thiophenol (1.5 eq) and neutral aluminum oxide (-70 eq) in diethyl ether was stirred for 3 h at room temperature while being monitored by TLC. The reaction mixture was filtered through Celite, washed with ethyl acetate and concentrated. Purified by silica gel chromatography (0-40% ethyl acetate/hexane) to yield p -hydroxysulfide product. 15 T: Conversion of nitrile group to carboxylic acid 0 NC R HO R NaOH H20 S-R S-R A solution of benzonitrile (1.0 eq) and sodium hydroxide (2.0 eq) in H 2 0 was heated to 120 0 C for 2h. The reaction mixture was cooled to room temperature and acidified with HCl to pH 2. The 20 resulting solid was filtered to afford the pure acid product. U. Alkylation of phenols 75 R 0 R 0 R-I or R-Br OH Cs 2

CO

3 , DMF 0 O *0 *40 The phenol was dissolved in DMF (1.0 ml). Cesium carbonate (1.0 eq.) and an alkyl bromide or alkyl iodide (1.0 to 2.0 eq.) were added, and the reaction was stirred at room temperature for 18 hrs 5 or 50'C for 1 to 24 hours. The reaction was quenched in water, and extracted with ethyl acetate twice. The organic extracts were washed with water once, brine once, dried with MgSO 4 , and evaporated to a crude oil which was purified on reverse phase HPLC. 10 V. Amide bond formation with an acid chloride and an aniline R O R 0 MP-Carbonate 0 THF, CH 2 Cl 2 0 + N R

NH

2 CI R 0 H S S-- # 0 The aniline was dissolved in THF (1.5 ml) and dichloromethane (1.5 ml). MP-Carbonate (1.5 eq.) 15 and an acid chloride (1.1 eq.) were added, and the solution was stirred at room temperature for 18 hours. The reaction was diluted with methanol and dichloromethane, and filtered to remove the MP-Carbonate. The mother liquors were evaporated to a solid and purified by reverse phase HPLC. 20 W. Amidine formation from an imidate R 0 R O H 0'R R HN 0HN N R 76 A solution of freshly formed imidate in methanol was treated with a primary or secondary amine (1.5 eq.) at room temperature for 18 hours. The methanol was removed on a rotary evaporator and the residue purified by reverse phase HPLC. 5 Example 2 6-(2-morpholinoethylamino)-N-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-3 carboxamide CI ' N 0 HN / \ NH N 10 0 Procedure F was performed using N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-chloro-3-carboxamide (50 mg) and 2-morpholinoethylamine in butanol (0.5 mL). The crude reaction was purified by reverse phase HPLC to yield 6-(2-morpholinoethylamino)-N-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-3 15 carboxamide as a white solid. MS (Q1) 438.3 (M)*. Example 3 N,N-(4-Chloro-3-(pyridin-2-yl)phenyl)-bis[6-(trifluoromethyl)-2-methylpyridine 3]-carboxamide CI N o N 0 N\, N

F

3 C

CF

3 20 77 Procedure B was performed with 2-pyridylzinc bromide (4 mL, 2.0 mmol, 0.5 M in THF) and 3 bromo-4-chloro-nitrobenzene (236 mg, 1.0 mmol). Purified by chromatography on silica gel (10% ethyl acetate/hexanes) to yield 2-(2-chloro-5-nitrophenyl)pyridine as a light yellow solid. 5 Procedure C was performed with 2-(2-chloro-5-nitrophenyl)pyridine (122 mg, 0.52 mmol) to yield 4-chloro-3-(pyridin-2-yl)aniline as a light yellow solid, which was used without further purification. Procedure D was performed using 4-chloro-3-(pyridin-2-yl)aniline (40 mg, 0.2 mmol). The crude 10 residue was purified by silica gel chromatography (15-60% ethyl acetate/hexanes) to yield N,N-(4 Chloro-3-(pyridin-2-yl)phenyl)-bis[6-(trifluoromethyl)-2-methylpyridine-3]-carboxamide as an oily residue: TLC Rf = 0.42 (35% ethyl acetate/hexanes); 'H NMR (CDCl 3 , 400 MHz) a 8.72 (m, 1H), 7.84 (d, 2HO, 7.77 (dd, 1H), 7.68 (m, 1H), 7.57 (d, 1H), 7.51 (m, 3H), 7.33 (m, 1H), 7.12 (dd, 1H), 2.78 (s, 6H); MS (Q1) 579 (M)*. 15 Example 4 N-(4-Chloro-3-(pyridin-3-yl)phenyl)-3,5-dimethoxybenzamide CI N/ 0 HN OMe MeO 4-Chloro-3-(pyridin-2-yl)aniline (40 mg, 0.2 mmol) was used in procedure D with 3,5 20 dimethoxybenzoyl chloride (43 mg, 0.216 mmol) at 23 'C for 2 hours. The crude residue was purified by crystallization (CH 2 Cl 2 /hexanes) to yield N-(4-chloro-3-(pyridin-3-yl)phenyl)-3,5 dimethoxybenzamide as an off-white solid: TLC Rf = 0.30 (15% ethyl acetate/hexanes); 'H NMR (CDCl 3 , 400 MHz) a 8.72 (m, 1H), 7.91 (m, 1H), 7.88 (dd, 1H), 7.78 (m, 2H), 7.74 (dd, 1H), 748 (d, 1H), 7.35 (m, 1H), 6.96 (d, 2H), 6.62 (t, 1H), 3.82 (s, 6H); MS (Q1) 369 (M)*. 25 Example 5 5-Acetyl-N-(4-chloro-3-(pyridin-2-yl)phenyl)thiophene-2-carboxamide 78 CI Nd 0 HN S 0 4-Chloro-3-iodoaniline (2.5 g, 9.88 mmol) was used in Procedure E with 5-acetylthiophene-2 carboxylic acid (1.85 g, 10.8 mmol) at 23 'C for 2 hours. The crude material was purified by silica 5 gel chromatography (20-100% ethyl acetate/hexanes) to yield 5-Acetyl-N-(4-chloro-3 iodophenyl)thiophene-2-carboxamide as a yellow solid. 5-Acetyl-N-(4-chloro-3-iodophenyl)thiophene-2-carboxamide (202 mg, 0.5 mmol) was used in Procedure B with 2-pyridylzincbromide (2.5 mL, 1.25 mmol, 0.5 M in THF). Purified by silica gel 10 chromatography (10-100% ethyl acetate/hexanes) to yield 5-acetyl-N-(4-chloro-3-(pyridin-2 yl)phenyl)thiophene-2-carboxamide as a yellow solid: TLC Rf = 0.19 (50% ethyl acetate/hexanes); 'H NMR (CDCl 3 , 400 MHz) a 8.96 ( bs, 1H), 8.67 ( d, 1H), 7.79 (dt, 1H), 7.68 (m, 3H), 7.61 (d, 1H), 7.58 (d, 1H), 7.37 (d, 1H), 7.32 (m, 1H), 2.58 (s, 3H); MS (Q1) 357.0 (M)*. 15 Example 6 N-(4-Chloro-3-(3-methylpyridin-2-yl)phenyl)-6-(trifluoromethyl)-2 methylpyridine-3-carboxamide CI \/ /\ \Nl 0

N

CF

3 N-(4-Chloro-3-iodophenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamide (142 mg, 0.32 20 mmol) was used in Procedure B with 6-methyl-2-pyridylzinc bromide (1.75 mL, of a 0.5 M in THF). Purified by silica gel chromatography (5-100% Ethyl acetate/Hexanes) to yield N-(4-chloro 3-(3-methylpyridin-2-yl)phenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamide as a white solid: TLC Rf = 0.23 (30% ethyl acetate/hexanes); 'H NMR (CDCl 3 , 400 MHz) a 8.81 (bs, 1H), 7.95 (dd, 1H), 7.67 (m, 3H), 7.53 (t, 2H), 7.38 (d, 1H), 7.07 (d, 1H), 2.71 (s, 3H), 2.43 (s, 3H); MS 25 (Q1) 406.1 (M)*. 79 Example 7 N-(4-Chloro-3-(5-methylpyridin-2-yl)phenyl)-6-(trifluoromethyl)-2 methylpyridine-3-carboxamide CI N 0 HN / \

CF

3 N-(4-Chloro-3-iodophenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamide (150 mg, 0.34 5 mmol) was used in Procedure B with 4-methyl-2-pyridylzinc bromide (1.7 mL of a 0.5 M in THF). Purified by silica gel chromatography (5-75% Ethyl acetate/Hexanes) to yield N-(4-chloro-3-(5 methylpyridin-2-yl)phenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamide as a white solid: TLC Rf = 0.23 (35% ethyl acetate/hexanes); 'H NMR (CDCl 3 , 400 MHz) a 10.62 (bs, 1H), 8.12 (dd, 1H), 7.89 (d, 1H), 7.58 (d, 1H), 7.47 (m, 3H), 7.18 (d, 1H), 6.89 (d, 1H), 2.62 (s, 3H), 2.38 (s, 10 3H); MS (Q1) 406.3 (M)*. Example 8 5-Acetyl-N-(4-chloro-3-(5-methylpyridin-2-yl)phenyl)thiophene-2-carboxamide CI N 0 HN S 5-Acetyl-N-(4-chloro-3-iodophenyl)thiophene-2-carboxamide (203 mg, 0.5 mmol), was used in 15 Procedure B with 4-methyl-2-pyridylzinc bromide (2.5 mL, 1.25 mmol, 0.5 M in THF). Purified by silica gel chromatography (30-100% ethyl acetate/hexanes) to yield 5-acetyl-N-(4-chloro-3-(5 methylpyridin-2-yl)phenyl)thiophene-2-carboxamide as a yellow solid: TLC Rf = 0.25 (50% ethyl acetate/hexanes); 'H NMR (CDCl 3 , 400 MHz) a 9.52 (bs, 1H), 8.51 (d, 1H), 7.60 (m, 4H), 7.39 (s, 1H), 7.29 (d, 1H), 7.14 (d, 1H), 2.55 (s, 3H), 2.42 (s, 3H); MS (Q1) 371 (M)*. 20 80 Example 9 N-(4-Chloro-3-(4-methylpyridin-2-yl)phenyl)-6-(trifluoromethyl)-2 methylpyridine-3-carboxamide CI --N 0 HN

N

CF

3 Procedure B was performed with N-(4-Chloro-3-iodophenyl)-6-(trifluoromethyl)-2-methylpyridine 5 3-carboxamide (440 mg, 1.0 mmol) and 4-methyl-2-pyridylzinc bromide (5 mL of a 0.5 M solution in THF). The crude residue was purified silica gel chromatography (5-100% Ethyl acetate/Hexanes) to yield N-(4-chloro-3-(4-methylpyridin-2-yl)phenyl)-6-(trifluoromethyl)-2 methylpyridine-3-carboxamide as a white solid: TLC Rf = 0.43 (35% ethyl acetate/hexanes); 'H NMR (CDCl 3 , 400 MHz) a 10.39 (bs, 1H), 8.11 (dd, 1H), 7.87 (s, 1H), 7.61 (d, 1H), 7.59 (d, 1H), 10 7.49 (m, 3H), 2.66 (s, 3H), 2.21 (s, 3H); MS (Q1) 406.1 (M)*. Example 10 N-(4-chloro-3-(6-methylpyridin-2-yl)phenyl)-3,5-dimethylisoxazole-4 CI /N 0 HN carboxamide O 15 4-Chloro-3-iodoaniline (1.01 g, 4 mmol) was used in procedure E with 3,5-dimethyl-4 isoxazolecarboxylic acid (0.565 g, 4 mmol), EDC (1.32 g, 6.8 mmol), TEA (0.5 mL), DMAP (50 mg, 0.4 mmol) at 23 'C for overnight. The crude reaction was purified by silica gel chromatography (0-15% ethyl acetate/CH 2 Cl 2 ) to yield 3,5-dimethyl-N-(4-chloro-3 iodophenyl)isoxazole-4-carboxamide as a white solid. 20 Procedure B was performed with 3,5-dimethyl-N-(4-chloro-3-iodophenyl)isoxazole-4-carboxamide (190 mg, 0.5 mmol) and 3-methyl-2-pyridylzinc bromide (2.5 mL of a 0.5 M solution in THF). The crude reaction was purified by silica gel chromatography (5-100% Ethyl acetate/Hexanes) to yield N-(4-chloro-3-(6-methylpyridin-2-yl)phenyl)-3,5-dimethylisoxazole-4-carboxamide as a white 25 solid: TLC Rf = 0.43 (50% ethyl acetate/hexanes); 'H NMR (CDCl 3 , 400 MHz) a 8.52 (bs, 1H), 7.68 (m, 2H), 7.48 (m, 3H), 2.70 (s, 3H), 2.49 (s, 3H), 2.21 (s, 3H); MS (Q1) 342.3 (M)*. 81 Example 11 N-(4-chloro-3-(pyridin-2-ylamino)phenyl)-6-(trifluoromethyl)-2-methylpyridine-3 carboxamide CI -- 0 N HN N~ 5

CF

3 N-(4-Chloro-3-iodophenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamide (220 mg, 0.5 mmol), 2-aminopyridine (40 mg, 0.42 mmol), potassium t-butoxide (66 mg, 0.59 mmol), Pd 2 (dba) 3 (20 mg, 0.21 mmol), dppf (24 mg, 0.042 mmol) in toluene (2.1 mL) were heated to 100 'C for 1.5 days. The solution was cooled to 23 'C, diluted with ether, filtered through celite, washed with 10 ethyl acetate, and concentrated. Purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2 ylamino)phenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamide as a white solid: 'H NMR (CDCl 3 , 400 MHz) 6 11.53 (s, 1H), 9.68 (s, 1H), 8.05 (m, 2H), 7.85 (m, 2H), 7.55 (d, 1H), 7.26 (d, 1H), 7.13 (dd, 1H), 6.91 (t, 1H), 6.88 (d, 1H), 2.75 (s, 3H); MS (Q1) 407.0 (M)*. 15 Example 12 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(4-methylpiperazin-1-yl)pyridine-3 carboxamide CI \ N 0 HN N N Procedure F was performed using N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-chloro-3-carboxamide (50 20 mg) and N-methylpiperazine in butanol (0.5 mL). The crude reaction was purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(4-methylpiperazin-1-yl)pyridine-3 carboxamide as a white solid. MS (Q1) 408.4 (M)*. 25 Example 13 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(isobutylamino)pyridine-3-carboxamide 82 CI \N 0 HN HN Procedure F was performed using N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-chloro-3-carboxamide (50 mg) and 2-methylpropylamine in butanol (0.5 mL). The crude reaction was purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(isobutylamino)pyridine-3 5 carboxamide as a white solid. MS (Q1) 381.1 (M)*. Example 14 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-morpholinopyridine-3-carboxamide CI \ N 0 HN / \N N 100 10 0 Procedure F was performed using N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-chloro-3-carboxamide (50 mg) and morpholine in butanol (0.5 mL). The crude reaction was purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-morpholinopyridine-3-carboxamide as a white solid. 15 MS (Q1) 401.3 (M)*. Example 15 6-(benzylamino)-N-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-3-carboxamide CI \N 0 HN N H N 20 83 Procedure F was performed using N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-chloro-3-carboxamide (50 mg) and benzylamine in butanol (0.5 mL). The crude reaction was purified by reverse phase HPLC to yield 6-(benzylamino)-N-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-3-carboxamide as a white 5 solid. MS (Q1) 415.1 (M)*. Example 16 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(phenylamino)pyridine-3-carboxamide CI \ N 0 HN / \N HN / 10 Procedure F was performed using N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-chloro-3-carboxamide (50 mg) and analine in butanol (0.5 mL). The crude reaction was purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(phenylamino)pyridine-3-carboxamide as a white solid. MS (Q1) 401.0 (M)*. 15 Example 17 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-6-(trifluoromethyl)-2-methylpyridine-3 carboxamide CI N 0 HN / \

CF

3 Procedure C was performed with 1-chloro-2-iodo-4-nitrobenzene (283 mg, 1 mmol) to produce 4 20 chloro-3-iodoaniline which was used without further purification. Procedure D was performed with 4-chloro-3-iodoaniline (225 mg, 0.889 mmol) and 6 (trifluoromethyl)-2-methylpyridine-3-carbonyl chloride (237 mg, 0/93 mmol, 1.05 eq) at 0 'C for 30 minutes. The crude residue was purified by silica gel chromatography (2-50% ethyl 25 acetate/hexanes) to yield N-(4-chloro-3-iodophenyl)-6-(trifluoromethyl)-2-methylpyridine-3 carboxamide as a white solid. 84 Procedure B was performed using N-(4-Chloro-3-iodophenyl)-6-(trifluoromethyl)-2 methylpyridine-3-carboxamide (88 mg, 0.2 mmol) with 2-pyridylzinc bromide (1 mL, 0.5 mmol, 0.5 M in THF). Purified by silica gel chromatography (10-80% ethyl acetate/hexanes) to yield N (4-chloro-3-(pyridin-2-yl)phenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamide as a yellow 5 solid: TLC Rf = 0.28 (35% ethyl acetate/hexanes); TLC Rf = 0.28 (35% ethyl acetate/hexanes); 'H NMR (CDCl 3 , 400 MHz) 8.88 (bs, 1H), 8.41 (d, 1H), 7.96 (dd, 1H), 7.74 (m, 4H), 7.52 (d, 1H), 7.22 (m, 1H), 2.75 (s, 3H); MS (Q1) 392 (M)*. An alternative synthetic procedure is as follows. 75g (435 mmol) of 2-chloro-5-nitroaniline was 10 added to a solution of water (600 mL) and conc. sulfuric acid (60 mL) in a 3L 3-neck flask equipped for mechanical stirring. The solution was cooled to 0 'C and a solution of sodium nitrite (34.2 g, 496 mmol) in water (130 mL) was added slowly. The mixture was stirred for hr. and then a solution of potassium iodide (130 g, 783 mmol) in water (520 mL) was added dropwise over hr keeping the temperature below 15'C. The solution was stirred for 2 hr, then extracted with 15 EtOAc (3 x 500 mL). The combined organic extracts were washed with sat. Na 2

S

2

O

3 (2x 500 mL), dried (Na 2

SO

4 ), and concentrated. The crude iodide was dissolved in hot iPrOH (500 mL) and hexanes (200 mL) were added. The reaction was allowed to cool with stirring and the product was collected by suction filtration after stirring at 0 0 C for 2hr yielding 90g (318 mmol, 73%) 2-chloro 5-nitro-iodobenzene as a light tan crystalline solid. 20 The 2-chloro-5-nitro-iodobenzene (5g, 17.6 mmol) was dissolved in 5 mL DMA in an oven dried flask and a 0.5M solution of 2-pyridylzincbromide (53 mL, 26.5 mmol, 0.5 M in THF) was added. The solution was degassed with N 2 for hr., the PPh 3 (0.185g, 0.7 mmol) and Pd(PPh 3

)

4 (0.825g, 0.7 mmol) were added, rinsed in with several mLs THF and the solution was degassed for a further 25 10 min before heating to 60'C under N 2 . The reaction was complete by TLC in -8h, cooled to RT, and poured into a 1:1 mixture of EtOAc/2.5N NaOH (500 mL). This solution was stirred for 10 min, passed through a course fritted filter containing celite to remove the solid, and then extracted. The organics were washed with brine and concentrated to a brown solid. The combined aqueous layers were backextracted with Et 2 0 (1 x 200 mL). This was used to suspend the crude product, 30 which was extracted with IN HCl (1 x 200 mL, 3 x 100 mL). The combined aqueous extracts were cooled to OC, diluted with EtOAc (250 mL), and made basic with ION NaOH (100 mL). This solution was separated, the aqueous layer extracted with EtOAc, and the combined organics were dried over Na 2

SO

4 and charcoal with stirring. This solution was filtered through celite and concentrated to yield pure 4-chloro-3-(pyridin-2-yl)nitrobenzene (2.47g, 10.5 mmol, 60% yield) 35 which was used in the next reaction without further purification. 85 4-chloro-3-(pyridin-2-yl)nitrobenzene (1.47g, 6.26 mmol) was suspended in EtOH (35 mL), and the SnCl 2 (3.87g; 20.4 mmol) and conc. HCl (5 mL) were added and rinsed in with a further 5 mLs EtOH. The solution was placed in a 40'C oil bath and heated to 60'C. The solution was stirred at 5 60'C for 1 hr., cooled to RT and diluted with 1 N HCl (100 mL). This solution was poured into an Et 2 0/1 N HCl solution (100 mL:150 mL) and extracted. The aqueous layer was diluted with EtOAc (250 mL), cooled to OC, and made basic with 10 N NaOH (50 mL). This solution was extracted (EtOAc, 2x), and the combined organics were washed with brine and dried over Na 2

SO

4 and charcoal. Suction filtration through celite gave a clear colorless solution which was 10 concentrated to yield 4-chloro-3-(pyridine-2-yl)aniline (1.21g, 5.93 mmol, 94% yield) as a cream colored crystalline solid which was used in the next reaction without further purification. 6-(trifluoromethyl)-2-methylpyridine-3-carbonyl chloride (1.68g, 7.51 mmol) in 3 mL THF was added dropwise to a solution of 4-chloro-3-(pyridine-2-yl)aniline (1.21g, 5.93 mmol) in THF (15 15 mL) at 0 0 C. The solution was stirred for 10 min., poured into EtOAc and washed with saturated aq. NaHCO 3 (2x), and brine. The organics were dried (Na 2

SO

4 ) and concentrated. The crude product was suspended in iPrOAc/Et 2 O (10 mL, 1:1), stirred at 0 0 C for hr, and collected by suction filtration to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(trifluoromethyl)-2-methylpyridine-3 carboxamide (2.04g, 5.21 mmol, 88% yield) as a white solid: TLC Rf = 0.28 (35% EtOAc/Hex); 20 'H NMR (CDCl 3 , 400 MHz) 6 8.88 (bs, 1H), 8.41 (d, 1H), 7.96 (dd, 1H), 7.74 (m, 4H), 7.52 (d, 1H), 7.22 (m, 1H), 2.75 (s, 3H); MS (Q1) 392 (M)*. Example 18 6-(2-hydroxyethylamino)-N-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-3 carboxamide CI \N/ 0 HN

N-

NH 25 HO Procedure F was performed using N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-chloro-3-carboxamide (50 mg) and ethanolamine in butanol (0.5 mL). The crude reaction was purified by reverse phase HPLC to yield 6-(2-hydroxyethylamino)-N-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-3 carboxamide as a white solid. MS (Q1) 369.0 (M)*. 30 86 Example 19 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(trifluoromethylsulfonyl)benzamide CI \ N 0 HN /\

F

3 C 4-(trifluoromethylthio)benzoic acid (200 mg, 0.9 mmol) was dissolved in water (2 mL) and acetic acid (4 mL) and treated with potassium permanganate (711 mg, 4.5 mmol) at room temperature. 5 The reaction was allowed to stir for 16 h, diluted with ethyl acetate and washed with water. The organic layer was dried (MgSO 4 ) and concentrated to yield 4-(trifluoromethylsulfone)benzoic acid. General procedure G was performed using 4-(trifluoromethylsulfone)benzoic acid and 4-chloro-3 (pyridin-2-yl)aniline. The crude reaction mixture was purified by reverse phase HPLC to yield N 10 (4-chloro-3-(pyridin-2-yl)phenyl)-4-(trifluoromethylsulfonyl)benzamide. MS (Q1) 440.95 (M)*. Example 20 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(ethylsulfonyl)benzamide CI \ N 0 HN / \ s_0 15 General procedure G was performed using 4-(ethylthio)benzoic acid and 4-chloro-3-(pyridin-2 yl)aniline to produce N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(ethylthio)benzamide. A solution of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(ethylthio)benzamide (40 mg, 0.11 mmol) in 20 MeOH (3 mL), cooled to 0' C was treated with oxone (133 mg, 0.22 mmol), and the ice bath was removed. After lh of stirring, the reaction mixture was concentrated, and the residue was dissolved in ethyl acetate. The organic solution was washed with water, dried (MgSO 4 ) and concentrated. The crude reaction mixture was purified by reverse phase HPLC to yeild N-(4 chloro-3-(pyridin-2-yl)phenyl)-4-(ethylsulfonyl)benzamide. MS (Q1) 401.0 (M)*. 25 87 Example 21 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((dimethylamino)methyl) benzamide CI \ N 0 HN CI -N/ N 5 General procedure G was used to couple 4-(BOC-aminomethyl)-2-chloro-benzoic acid and 4 chloro-3-(pyridin-2-yl)aniline to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)-phenyl)-4-(BOC aminomethyl)-benzamide with . The crude reaction mixture was treated to TFA and trace water for 1 h prior to concentrating to dryness to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)-phenyl)-4 (aminomethyl)-benzamide. 10 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(aminomethyl)benzamide (80 mg, 0.20 mmol) was dissolved in DMF (5 mL) and treated with AcOH (10 uL), paraformaldehyde (43 mg, 0.47 mmol), and sodium triacetoxyborohydride (125 mg, 0.59 mmol). After stirring for 16 h, the solvent was evaporated and the residue was dissolved in ethyl acetate. The organic layer was washed with 1 N 15 Sodium hydroxide, dried (MgSO 4 ) and concentrated. The crude product was purified by reverse phase HPLC to produce 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((dimethylamino)methyl) benzamide. MS (Q1) 400.0 (M)*. Example 22 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(morpholinomethyl)pyridine-3-carboxamide CI \ N 0 HN / \N N 0 20 6-methylnicotinic acid (100 mg 0.14 mmol) was dissolved in 10% AcOH/benzene (1 mL) and treated with NBS (117 mg, 0.18 mmol) and benzoylperoxide (18 mg, 0.07 mmol). The reaction mixture was heated in a sealed microwave reactor at 120' C for 1 min. The reaction mixture was 25 diluted with ethyl acetate, washed with saturated aqueous NaHCO 3 , dried (MgSO 4 ), concentrated and purified by silica gel chromatography to yield 6-(bromomethyl)pyridine-3-carboxylic acid. 88 6-(bromomethyl)pyridine-3-carboxylic acid was coupled to 4-chloro-3-(pyridin-2-yl)aniline as described in general procedure E to yield 6-(bromomethyl)-N-(4-chloro-3-(pyridin-2 yl)phenyl)pyridine-3-carboxamide. 5 6-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-3-carboxamide was dissolved in DMSO (1 mL) treated with morpholine (33 uL) for 1 h. The reaction was concentrated, and the crude residue was purified by reverse phase HPLC to produce N-(4-chloro-3-(pyridin-2-yl)phenyl) 6-(morpholinomethyl)pyridine-3-carboxamide. MS (Q1) 409.3 (M)*. 10 Example 23 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((pyrimidin-2-ylamino)methy)benzamide CI N 0 HN NH N 4-(bromomethyl)benzoic acid was coupled to 4-chloro-3-(pyridin-2-yl)aniline as described in 15 general procedure E to yield 4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide. 4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide (85 mg) was dissolved in DMSO (0.5 mL) and treated with 2-aminopyridine (59 mg) at 150' C in a sealed microwave reactor for 5 min. The reaction mixture was concentrated, and the crude residue was purified by reverse phase 20 HPLC to produce pure N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((pyrimidin-2 ylamino)methyl)benzamide. MS (Q1) 416.3 (M)*. Example 24 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-((4-methylpiperazin-1-yl)methyl)pyridine-3 carboxamide CI \N 0 HN / N N N 25 89 6-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-3-carboxamide was dissolved in 1 mL of DMSO and stirred for 1 h with N-methylpiperazine. The reaction was concentrated, and the crude residue was purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6 5 ((4-methylpiperazin-1-yl)methyl)pyridine-3-carboxamide as a pure product. MS (Q1) 422.3 (M)*. Example 25 4-((4-acetylpiperazin-1-yl)methyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl) benzamide CI \N 0 HN N N 10 6-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-3-carboxamide (85 mg) was dissolved in DMSO (1 mL) and stirred for 1 h with N-acetylpiperazine. The reaction mixture was concentrated, and the crude residue was purified by revered phase HPLC to yield 4-((4 acetylpiperazin-1-yl)methyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl) benzamide. MS (Q1) 449.1 (M)*. 15 Example 26 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(thiomorpholinomethyl)benzamide CI "N 0 HN N S 20 4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide (85 mg) was dissolved in DMSO (1 mL) and stirred for 1 h with thiomorpholine. The reaction mixture was concentrated, and the crude residue was purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (thiomorpholinomethyl)benzamide. MS (Q1) 424.0 (M)*. 25 Example 27 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(morpholinomethyl)benzamide 90 CI \ N 0 HN N 0 V-/ 4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide (85 mg) was dissolved in DMSO (1 mL) and stirred for 1 h with morpholine. The reaction mixture was concentrated, and the crude 5 residue was purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (morpholinomethyl)benzamide. MS (Q1) 408.4 (M)*. Example 28 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((piperidin-1-yl)methyl)benzamide CI \ N 0 HN 10 N 4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide (85 mg) was dissolved in DMSO (1 mL) and stirred for 1 h with piperdine. The reaction mixture was concentrated, and the crude residue was purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 15 ((piperidin-1-yl)methyl)benzamide. MS (Q1) 406.4 (M)*. Example 29 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((4-methylpiperazin-1-yl)methyl) benzamide CI \N 0 HN N

N

20 4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide (85 mg) was dissolved in DMSO (1 mL) and stirred for 1 h with methylpiperazine. The reaction mixture was concentrated, and the crude residue was purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 ((4-methylpiperazin-1-yl)methyl) benzamide. MS (Q1) 421.3 (M)*. 91 Example 30 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((dimethylamino)methyl)benzamide CI \ N 0 HN // N 5 Procedure G was used to couple BOC-4-(aminomethyl)benzoic acid (48 mg) with 4-chloro-3 (pyridin-2-yl)aniline (35 mg). The crude reaction mixture was treated with TFA (1 mL) containing trace amounts of water for 1 h. The reaction mixture was concentrated to yield 4-(aminomethyl)-N (4-chloro-3-(pyridin-2-yl)phenyl)benzamide. 10 4-(aminomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide (80 mg) was dissolved in DMF (5 mL) and treated with AcOH (10 -L), paraformaldehyde (48 mg), and sodium triacetoxyborohydride (125 mg) for 16 h. The reaction mixture was concentrated, and the crude residue was dissolved in ethyl acetate and washed with 1 N sodium hydroxide, dried (MgSO 4 ) and 15 concentrated. The crude product was purified by reverse phase HPLC to yield N-(4-chloro-3 (pyridin-2-yl)phenyl)-4-((dimethylamino)methyl)benzamide. MS (Q1) 365.0 (M)*. Example 31 N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-[(2-methylpropyl)aminosulfonyl] benzamide CI \ N 0 20 HN Procedure H was performed to couple 3-(chlorosulfonyl)benzoic acid with sec-butyl amine to produce 3-(sec-butylsulfamoyl)benzoic acid which was purified by reverse phase HPLC. 25 Procedure G was used to couple 3-(sec-butylsulfamoyl)benzoic acid with 4-chloro-3-(pyridin-2 yl)aniline (28 mg) to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-[(2 methylpropyl)aminosulfonyl]-benzamide. MS (Q1) 444.0 (M)*. 92 Example 32 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-morpholinylsulfonyl)-benzamide CI N 0 HN / \N 5 Procedure H was performed to couple 4-(chlorosulfonyl)benzoic acid with morpholine to produce 4-(morpholinosulfamoyl)benzoic acid which was purified by reverse phase HPLC. Procedure G was used to couple 4-(morpholinosulfamoyl)benzoic acid with 4-chloro-3-(pyridin-2 yl)aniline (34 mg) to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-morpholinylsulfonyl) 10 benzamide. MS (Q1) 458.1 (M)*. Example 33 N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-(4-morpholinylsulfonyl)-benzamide CI N 0 HN 0 / \ ko N 0 15 Procedure H was performed to couple 3-(chlorosulfonyl)benzoic acid with morpholine to produce 3-(morpholinosulfamoyl)benzoic acid which was purified by reverse phase HPLC. Procedure G was used to couple 3-(morpholinosulfamoyl)benzoic acid with 4-chloro-3-(pyridin-2 yl)aniline (25 mg) to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-(4-morpholinylsulfonyl) 20 benzamide. MS (Q1) 458.1 (M)*. Example 34 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-[(2-hydroxyethyl)amino]sulfonyl] benzamide 93 CI \ N 0 HN .i-Sk-NH / \ \ OH Procedure H was performed to couple 4-(chlorosulfonyl)benzoic acid with ethanolamine to produce 4-(2-hydroxyethylsulfamoyl)benzoic acid which was purified by reverse phase HPLC. 5 Procedure G was used to couple 4-(2-hydroxyethylsulfamoyl)benzoic acid with 4-chloro-3 (pyridin-2-yl)aniline (42 mg) to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-[(2 hydroxyethyl)amino]sulfonyl]-benzamide. MS (Q1) 431.9 (M)*. 10 Example 35 N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-[(2-hydroxyethyl)amino]sulfonyl] benzamide CI N 0 HN 0 / \ \.O HN- OH \OH Procedure H was performed to couple 3-(chlorosulfonyl)benzoic acid with ethanolamine to 15 produce 3-(2-hydroxyethylsulfamoyl)benzoic acid which was purified by reverse phase HPLC. Procedure G was used to couple 3-(2-hydroxyethylsulfamoyl)benzoic acid with 4-chloro-3 (pyridin-2-yl)aniline (42 mg) to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-[(2 hydroxyethyl)amino]sulfonyl]-benzamide. MS (Q1) 432.0 (M)*. 20 Example 36 N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-(4-morpholinylsulfonyl)-benzamide 94 CI \ / 0/ O 0 HN O 0 / \ y-O N Procedure H was performed to couple 3-(chlorosulfonyl)benzoic acid with piperazine to produce 3-(N-methylpiperazinosulfamoyl)benzoic acid which was purified by reverse phase HPLC. 5 Procedure G was used to couple 3-(N-methylpiperazinosulfamoyl)benzoic acid with 4-chloro-3 (pyridin-2-yl)aniline (50 mg) to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-(4 morpholinylsulfonyl)-benzamide. MS (Q1) 471.0 (M)*. 10 Example 37 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide CI \ N 0 HN CI1 Me Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline (50 mg) and 2-chloro-4 methylsulfonylbenzoic acid to produce 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 15 (methylsulfonyl)benzamide. MS (Q1) 421.0 (M)*. The product was then dissolved in 1 N HCI solution followed by freebasing with 0.5 N NaOH solution (pH to 11). The resulting precipitate was filtered and vacuum-dry. Procedure D may also be used to couple 4-chloro-3-(pyridin-2-yl)aniline and 2-chloro-4 20 (methylsulfonyl)benzoyl chloride to produce 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (methylsulfonyl)benzamide which is collected by suction filtration and the HCl salt is washed with Et 2 0 (or alternatively with MTBE). This material is freebased using EtOAc/aq NaHCO 3 and the organics are dried and concentrated to the solid freebase. This material is then crystallized from acetone:EtOAc (80:20, approx lOmL/g) which is then finally recrystallized from hot slurry of 25 iPrOAc. 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide HCl salt may 95 also be dissolved in distilled water followed by freebasing with 0.5 N NaOH solution (pH to 11) and filtering and vacuum drying the precipitate. 5 Example 38 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(1H-1,2,4-triazol-1 -yl)pyridine-3 carboxamide CI HN0 N N N-N )N Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline (40 mg) and 6-(1H-1,2,4-triazol 10 1-yl)pyridine-3-carboxylic acid to produce N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(1H-1,2,4-triazol 1-yl)pyridine-3-carboxamide. MS (Q1) 377.0 (M)*. Example 39 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-[(dimethylamino)sulfonyl]-benzamide CI \N 0 HN / -N 15 Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline (50 mg) and 4 [(dimethylamino)sulfonyl]benzoic acid to produce N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 [(dimethylamino)sulfonyl]-benzamide. MS (Qi) 416.0 (M)*. 20 Example 40 N-(4-chloro-3-(pyridin-2-yl)phenyl)-5-(methylsulfonyl)thiophene-2-carboxamide 96 CI HN / S 0 M, II S=O Me Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline (40 mg) and 5 (methylsulfonyl)thiophene-2-carboxylic acid to produce N-(4-chloro-3-(pyridin-2-yl)phenyl)-5 5 (methylsulfonyl)thiophene-2-carboxamide. MS (Q1) 393.0 (M)*. Example 41 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(aminosulfonyl)-benzamide CI \N 0 HN o<VNH2 0 10 Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline (30 mg) and 4 carboxybenzenesulfonamide to produce N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(aminosulfonyl) benzamide. MS (Q1) 388.0 (M)*. Example 42 2,6-dichloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-3-carboxamide 15 CI \ N 0 HN CI / N CI Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline (50 mg) and 2,6-dichloronicotinic acid to produce 2,6-dichloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-3-carboxamide. MS (Q1) 20 378.1 (M)*. Example 43 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide 97 CI HN CI Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline (50 mg) and 2-chlorobenzoic acid 5 to produce 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide. MS (Q1) 343.1 (M)*. Example 44 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-fluoropyridine-3-carboxamide CI \ N 0 HN F / \N 10 Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline (50 mg) and 2-fluoronicotinic acid to produce N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-fluoropyridine-3-carboxamide. MS (Q1) 328.1 (M)*. 15 Example 45 N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-methylthiophene-2-carboxamide CI \ N 0 HN S Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline (50 mg) and 3-methyl-2 20 thiophenecarboxylic acid to produce N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-methylthiophene-2 carboxamide. MS (Q1) 329.0 (M)*. Example 46 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-5-(methylsulfonyl)benzamide 98 CI \N 0 HN 0 ci / 0 Me Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline and 2-chloro-5 (methanesulfonyl)benzoic acid to produce 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-5 5 (methylsulfonyl)benzamide. MS (Q1) 420.95 (M)*. Example 47 N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-(methylsulfonyl)benzamide CI \N 0 HN 0 / \ ipo 10 Me Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline and 3-(methanesulfonyl)benzoic acid to produce N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-(methylsulfonyl)benzamide. MS (Q1) 387.2 (M)+. 15 Example 48 2-amino-N-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-3-carboxamide CI \N 0 HN

NH

2 / \N Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline (50 mg) and 2-aminonicotinic 20 acid to produce 2-amino-N-(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-3-carboxamide. MS (Q1) 325.2 (M)*. Example 49 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-methoxybenzamide 25 99 CI \N 0 HN 0 Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline and 4-methoxylbenzoic acid to produce N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-methoxybenzamide. MS (Q1) 341.2 (M)*. 5 Example 50 N-benzyl-5-chloro-4-(pyridin-2-yl)thiazol-2-amine CI N N H 10 A solution of 2-(Bromoacetyl)pyridine hydrobromide (100 mg, 0.36 mmol) in ethanol (2 mL) was treated with 1-benzyl-2-thiourea (90 mg, 0.54 mmol). The resulting yellow solution was concentrated, and the crude residue was purified on reverse phase HPLC to produce N-benzyl-4 (pyridin-2-yl)thiazol-2-amine. 15 A solution of N-benzyl-4-(pyridin-2-yl)thiazol-2-amine (60 mg, 0.23 mmol) in DMF (2 mL) was cooled to 0 C and treated with N-chlorosuccinimide (33 mg, 0.25 mmol), and the reaction mixture was allowed to warm to room temperature. The solvent was evaporated, and the product was purified on reverse phase HPLC to produce N-benzyl-5-chloro-4-(pyridin-2-yl)thiazol-2-amine. MS (Q1) 302.2 (M)*. 20 Example 51 4-chloro-N-(3,5-dimethoxyphenyl)-3-(pyridin-2-yl)benzamide CI \ / \ / N NH -0 100 A solution of 3-bromo-4-chlorobenzoic acid (250 mg, 1.1 mmol) in DMF (2 mL) was treated with PyBop (550 mg, 1.1 mmol) and DIPEA (370 uL, 2.1 mmol). After stirring the reaction mixture for 5 min. 3,5-dimethoxy analine (105 mg, 0.69 mmol) was added and the reaction was stirred for 16 h. The reaction mixture was diluted with ethyl acetate and washed with 0.1 N HCl, 0.1 N sodium 5 hydroxide and Brine, successively. The organic layer was dried (MgSO 4 ) and concentrated, and crude 3-bromo-4-chloro-N-(3,5-dimethoxyphenyl)benzamide was used without further purification. 3-bromo-4-chloro-N-(3,5-dimethoxyphenyl)benzamide was dissolved in 0.5 M 2 pyridylzincbromide (2.5 mL) and treated with Pd(PPh) 3

)

4 (20 mg, 0.02 mmol). The reaction 10 mixture was heated to 155 C in a sealed tube for 20 min. in a microwave reactor. The resultant solution was diluted with Ethyl acetate and washed with 0.1 N sodium hydroxide and then brine. The organic layer was dried (MgSO 4 ) and concentrated, and the crude residue was partially purified by silica gel chromatography. Pure 4-chloro-N-(3,5-dimethoxyphenyl)-3-(pyridin-2 yl)benzamide was obtained by a second purification on reverse phase HPLC. MS (Q1) 369.1 (M)*. 15 Example 52 N-(3-(3,5-bis(trifluoromethyl)phenyl)propyl)-4-chloro-3-(pyridin-2 yl)benzenamine CI \/ \/0 HN

CF

3

F

3 C 20 A solution of 3,5-bis(trifluoromethyl)hydrocinnamic acid (1.0 g, 3.5 mmol) and TEA (0.46 g, 4.5 mmol) in THF (16 mL) was cooled to -40'C (ethanol-water/dry ice bath). To this mixture was dropwise added isobutyl chloroformate (0.56 g, 4.1 mmol) and stirring was continued for another 1.5 hours while the temperature of the cooling bath was maintained between -40 'C and -20 'C. Solid NaBH 4 (0.53 g, 14 mmol) was added, followed by H 2 0 (1.3 mL). The cloudy mixture was 25 stirred overnight while warming to room temperature. After concentrating in vacuo, the residue was partitioned between ethyl acetate and water. The aqueous layer was acidified to pH 1 with 37% HCl and extracted with ethyl acetate. The combined organic layers were washed sequentially with saturated NaHCO 3 , and brine, then dried (MgSO 4 ) and concentrated. The resulting oil was purified by flash silica gel chromatography (6:4 ethyl ether-hexane) to yield 3-[3',5' 30 bis(trifluoromethyl)phenyl] -1 -propanol. 101 3-[3',5'-bis(trifluoromethyl)phenyl]-1-propanol (0.88 g, 3.2 mmol) and CBr 4 (1.3 g, 4.0 mmol) were dissolved in CH 2 Cl 2 (5 mL) and cooled to OC. Triphenylphosphine (1.3 g, 4.8 mmol) was added in three portions over 0.5 h. The mixture was stirred at 0 'C for 10 min., then diluted with pentane (30 mL) and sat. NaHCO 3 (30 mL). The aqueous layer was separated and washed with 5 ethyl ether, and the combined organic layers were dried (MgSO 4 ) and concentrated. The residue was purified by silica gel flash chromatography (99:1 ethyl ether-hexane) to yield 0.8 g, (74%) of the 3-[3',5'-bis(trifluoromethyl)phenyl]-1-bromopropane. 4-chloro-3-(2'-pyridyl)aniline (10 mg, 0.05 mmol), 3-[3',5'-bis(trifluoromethyl)phenyl]-1 10 bromopropane (34 mg, 0.1 mmol) and K 2

CO

3 (14 mg, 0.1 mmol) in DMF (1 mL) was stirred at 100 0 C overnight. The reaction mixture was acidified with IN HCl (aq.) and extracted with ethyl acetate. The combined organic layers were washed with brine, dried (MgSO 4 ) and concentrated. The crude was purified by preparative HPLC to yield N-(3-(3,5 bis(trifluoromethyl)phenyl)propyl)-4-chloro-3-(pyridin-2-yl)benzenamine. 15 Example 53 N-(4-chloro-3-(5-(trifluoromethyl)pyridin-2-yl)phenyl)-2-methyl-6 (trifluoromethyl)nicotinamide CI

F

3 C O N0 HN / \N

CF

3 N-(4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-methyl-6 20 (trifluoromethyl)nicotinamide (- 0.5 mmol) was used in Procedure A with 5-trifluoromethyl-2 bromopyridine (113 mg, 0.5 mmol). Purified by silica gel chromatography (5-50% ethyl acetate/hexanes) to yield N-(4-chloro-3-(5-(trifluoromethyl)pyridin-2-yl)phenyl)-2-methyl-6 (trifluoromethyl)nicotinamide as a white foam: TLC Rf = 0.30 (15% ethyl acetate/hexanes); MS (Q1) 460 (M)*. 25 Example 54 N-(4-chloro-3-(5-(trifluoromethyl)pyridin-2-yl)phenyl)-4 (methylsulfonyl)benzamide 102 CI

F

3 C / N H HN/ $0 N-(4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-(methylsulfonyl)benzamide (- 1.0 mmol) was used in Procedure A with 5-trifluoromethyl-2-bromopyridine (226 mg, 1 mmol). Purified by silica gel chromatography (0-10% acetone/dichloromethane) to yield N-(4-chloro-3-(5 5 (trifluoromethyl)pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide as a white solid: MS (Q1) 455 (M)+. Example 55 N-(4-chloro-3-(5-chloropyridin-2-yl)phenyl)-2-methyl-6 10 (trifluoromethyl)nicotinamide CI CI / N H-)0 HN / NN

CF

3 5-chloropyridin-2-yl trifluoromethanesulfonate (4.12 mmol) was used in Procedure I with trimethyltin chloride to yield 5-chloro-2-(trimethylstannyl)pyridine. The crude material (-4 mmol) was used in Procedure K with N-(4-chloro-3-iodophenyl)-2-methyl-6 15 (trifluoromethyl)nicotinamide (2 mmol). Purified by silica gel chromatography (0-50% ethyl acetate/hexane) to yield N-(4-chloro-3-(5-chloropyridin-2-yl)phenyl)-2-methyl-6 (trifluoromethyl)nicotinamide as a white solid: TLC Rf = 0.48 (25% ethyl acetate/hexanes); MS (Q1) 427 (M)*. 20 Example 56 N-(4-chloro-3-(6-chloropyridin-2-yl)phenyl)-2-methyl-6 (trifluoromethyl)nicotinamide CI \N 0 CI HN N

CF

3 103 6-chloropyridin-2-yl trifluoromethanesulfonate (4.12 mmol) was used in Procedure I with trimethyltin chloride to yield 2-chloro-6-(trimethylstannyl)pyridine. The crude material (-4 mmol) was used in Procedure K with N-(4-chloro-3-iodophenyl)-2-methyl-6 (trifluoromethyl)nicotinamide (2 mmol). Purified by silica gel chromatography (5-45% ethyl 5 acetate/hexane) to yield N-(4-chloro-3-(6-chloropyridin-2-yl)phenyl)-2-methyl-6 (trifluoromethyl)nicotinamide as a white solid: TLC Rf = 0.45 (25% ethyl acetate/hexanes); MS (Q1) 426 (M)*. 10 Example 57 N-(4-chloro-3-(5-hydroxypyridin-2-yl)phenyl)-2-methyl-6 (trifluoromethyl)nicotinamide CI N HN N

CF

3 3-(triisopropylsilyloxy)pyridine (2.66 mmol) was used in Procedure J with hexamethyldistannane to yield 5-(triisopropylsilyloxy)-2-(trimethylstannyl)pyridine. The crude material (-0.55 mmol) 15 was used in Procedure K with N-(4-chloro-3-iodophenyl)-2-methyl-6 (trifluoromethyl)nicotinamide (0.17 mmol). Purified by silica gel chromatography (0-40% ethyl acetate/hexane) to yield N-(4-chloro-3-(5-(triisopropylsilyloxy)pyridin-2-yl)phenyl)-2-methyl-6 (trifluoromethyl)nicotinamide as a yellow oil. N-(4-chloro-3-(5-(triisopropylsilyloxy)pyridin-2 yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide (1 mmol) was treated with TBAF (2 mL, 1 M 20 in THF) in THF (1 mL) at 23 'C for thirty minutes, concentrated, redissolved in ethyl acetate, washed with brine, dried (MgSO 4 ), and concentrated. The crude solid was purified by silica gel chromatography (0-10 % isopropanol/dichloromethane) to yield N-(4-chloro-3-(5-hydroxypyridin 2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide as a white solid: TLC Rf = 0.59 (10% ethyl acetate/hexanes); MS (Q1) 408 (M)*. 25 Example 58 N-(4-chloro-3-(5-methoxypyridin-2-yl)phenyl)-2-methyl-6 (trifluoromethyl)nicotinamide 104 CI 0/ C\1 / "N 0 HN / \N

CF

3 N-(4-chloro-3-(5-hydroxypyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide (0.12 mmol) was used in Procedure L with excess iodomethane. Purified by silica gel chromatography (0-100% ethyl acetate/hexane) to yield N-(4-chloro-3-(5-methoxypyridin-2-yl)phenyl)-2-methyl-6 5 (trifluoromethyl)nicotinamide as a white solid: TLC Rf = 0.57 (50% ethyl acetate/hexanes); MS (Q1) 423(M)*. Example 59 N-(4-chloro-3-(5-ethoxypyridin-2-yl)phenyl)-2-methyl-6 10 (trifluoromethyl)nicotinamide CI O-CO IN 0 HN N

CF

3 N-(4-chloro-3-(5-hydroxypyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide (0.05 mmol) was used in Procedure L with excess iodoethane. Purified by silica gel chromatography (0 100% ethyl acetate/hexane) to yield N-(4-chloro-3-(5-ethoxypyridin-2-yl)phenyl)-2-methyl-6 15 (trifluoromethyl)nicotinamide as a white solid: TLC Rf = 0.64 (50% ethyl acetate/hexanes); MS (Q1) 436 (M)*. Example 60 N-(4-chloro-3-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)phenyl)-2-methyl-6 20 (trifluoromethyl)nicotinamide CI F3C 0 HN \N / N

CF

3 105 N-(4-chloro-3-(5-hydroxypyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide (0.12 mmol) was used in Procedure L with excess trifluoroethyl iodide. Purified by silica gel chromatography (0-40% ethyl acetate/hexane) to yield N-(4-chloro-3-(5-(2,2,2 trifluoroethoxy)pyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide as a white solid: 5 TLC Rf = 0.64 (40% ethyl acetate/hexanes); MS (Q1) 490 (M)*. Example 61 N-(4-chloro-3-(4-ethylpyridin-2-yl)phenyl)-2-methyl-6 (trifluoromethyl)nicotinamide CI \ / \ / N 0 HN N 10 CF 3 N-(4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-methyl-6 (trifluoromethyl)nicotinamide (- 1 mmol) was used in Procedure A with 4-ethyl-2-bromopyridine (1 mmol). Purified by silica gel chromatography (0-60% ethyl acetate/hexanes) to yield N-(4 chloro-3-(4-ethylpyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide as a tan solid: MS 15 (Q1) 419 (M)*. Example 62 N-(4-chloro-3-(5-fluoropyridin-2-yl)phenyl)-2-methyl-6 (trifluoromethyl)nicotinamide CI F\/ \// N 0 HN N 20

CF

3 N-(4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-methyl-6 (trifluoromethyl)nicotinamide (- 1 mmol) was used in Procedure A with 5-fluoro-2-bromopyridine (1 mmol). Purified by silica gel chromatography (5-45% ethyl acetate/hexanes) to yield N-(4 25 chloro-3-(5-fluoropyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide as a tan solid: MS (Q1) 409 (M)*. 106 Example 63 N-(4-chloro-3-(5-phenylpyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl) nicotinamide CI \C/ 0/ HN / N 5

CF

3 5-phenylpyridin-2-yl trifluoromethanesulfonate (1.5 mmol) was used in Procedure J with trimethyltin chloride to yield 5-phenyl-2-(trimethylstannyl)pyridine. The crude material (-1.25 mmol) was used in Procedure K with N-(4-chloro-3-iodophenyl)-2-methyl-6 (trifluoromethyl)nicotinamide (1 mmol). Purified by silica gel chromatography (1% 10 acetone/methylene chloride) to yield N-(4-chloro-3-(5-phenylpyridin-2-yl)phenyl)-2-methyl-6 (trifluoromethyl)nicotinamideas a tan solid: TLC Rf = 0.15 (1% acetone/methylene chloride); MS (Q1) 467 (M)*. 15 Example 64 (S)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(3-methylpiperazin-1-yl)nicotinamide CI \ N 0 HN N N NH Procedure F was performed using N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-chloro-3-carboxamide (50 20 mg) and 75 mg of (S)-2-methylpiperazine in 0.75 mL of butanol at 160'C for 60 min. Purification by reverse phase HPLC yielded (S)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(3-methylpiperazin-1 yl)nicotinamide. MS (Q1) 408 (M)*. 25 Example 65 (R)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(3-methylpiperazin-1-yl)nicotinamide 107 CI \N 0 HN / N N NH Procedure F was performed using N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-chloro-3-carboxamide (50 5 mg) and 75 mg of (R)-2-methylpiperazine in 0.75 mL of butanol at 160'C for 60 min. Purification by reverse phase HPLC yielded (R)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(3-methylpiperazin-1 yl)nicotinamide. MS (Q1) 408 (M)*. 10 Example 66 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-((3S,5R)-3,5-dimethylpiperazin-1 yl)nicotinamide CI HN N NH 15 Procedure F was performed using N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-chloro-3-carboxamide (75 mg) and 114 mg of 2,6-dimethylpiperazine in 1 mL of butanol at 160'C for 60 min. Purification by reverse phase HPLC yielded N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-((3S,5R)-3,5 dimethylpiperazin-1-yl)nicotinamide. MS (Q1) 422.1 (M)*. 20 Example 67 N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(pyridin-3-yl)terephthalamide 108 CI \ N 0 HN NH 0 / N 320 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 400 mg of 4-(methoxycarbonyl)benzoic acid via Procedure G to give methyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoate. 4-(4 5 chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoate was then hydrolyzed via Prodedure M to give 550 mg of 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid. 50 mg of 4-(4-chloro-3 (pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 3-aminopyridine via Procedure G. The organic layer was evaporated to dryness and purified on reverse phase HPLC to yield N 1 -(4 chloro-3-(pyridin-2-yl)phenyl)-N 4 -(pyridin-3-yl)terephthalamide. MS (Q1) 429 (M)*. 10 Example 68 N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(6-methoxypyridin-3-yl)terephthalamide CI \N 0 HN NH N 0 15 50 mg of 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2-methoxy-5 aminopyridine via Procedure G. The product was purified on reverse phase HPLC to yield N 1 -(4 chloro-3-(pyridin-2-yl)phenyl)-N 4 -(6-methoxypyridin-3-yl)terephthalamide. MS (Q1) 459 (M)*. 20 Example 69 N 1 -(6-aminopyridin-3-yl)-N 4 -(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide 109 CI HN NH 0 / N

NH

2 50 mg of 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2,5 diaminopyridine via Procedure G. The prodcut was purified on reverse phase HPLC to yield N 1 5 (6-aminopyridin-3-yl)-N 4 -(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide. MS (Q1) 444 (M)*. Example 70 N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(pyridin-2-ylmethyl)terephthalamide CI \N 0 HN NH N 10 0 50 mg of 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2 (aminomethyl)pyridine via Procedure G. The product was purified on reverse phase HPLC to yield N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(pyridin-2-ylmethyl)terephthalamide. MS (Q1) 443 15 (M)*. Example 71 N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -isopropylterephthalamide 110 CI N 0 HN NH 0 50 mg of 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to isopropylamine via Procedure G. The product was purified on reverse phase HPLC to yield N 1 -(4 5 chloro-3-(pyridin-2-yl)phenyl)-N 4 -isopropylterephthalamide. MS (Q1) 394 (M)*. Example 72 N 1 -tert-butyl-N4-(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide CI \ N 0 HN NH 10 50 mg of 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to tert butylamine via Procedure G. The product was purified on reverse phase HPLC to yield N 1 -tert butyl-N 4 -(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide. MS (Q1) 408 (M)*. 15 Example 73 N 4 -tert-butyl-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide CI \ N 0 HN CI NH 111 67 mL of 2-chloro-1,4-dimethylbenzene and 356 g of Potassium Permanganate were refluxed in 1.5 L of H 2 0 for several hours and monitored for disappearance of starting material by TLC. The Potassium Permanganate was filtered and the reaction mixture was acidified and filtered to yield 2 5 chloroterephthalic acid. 46.8 g of 2-chloroterephthalic acid was treated with a saturated HCl gas solution in MeOH overnight at room temperature. The reaction mixture was concentrated, subjected to basic workup and dried to yield the dimethyl 2-chloroterephthalate. 20 g of dimethyl 2-chloroterephthalate was cooled to OC in DCM and 87 mL of a IM in DCM solution of BBr 3 was added dropwise over several hours. The reaction mixture was subsequently warmed to room 10 temperature and stirred until complete. Following basic workup, 2-chloro-4 (methoxycarbonyl)benzoic acid was purified by ISCO Combi-Flash. 959 mg of 2-chloro-4 (methoxycarbonyl)benzoic acid was coupled to 750 mg of 4-chloro-3-(pyridin-2-yl)aniline via procedure G. 1 g of methyl 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoate was hydrolyzed via Procedure M to give 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic 15 acid. 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to tert-butylamine via Procedure G. The product was purified on reverse phase HPLC to yield N 4 ter t-butyl-2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide. MS (Q1) 443.2 (M)*. 20 Example 74 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-(2-hydroxyethyl)piperazine-1 carbonyl)benzamide CI \N 0 HN CI N

N

0 OH 25 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to N-(2 hydroxyethyl)piperazine via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-(2-hydroxyethyl)piperazine-1 carbonyl)benzamide. MS (Q1) 499 (M)*. 30 112 Example 75 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-methylpiperazine-1 carbonyl)benzamide CI \N 0 HN CI N N 0 5 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 1 methylpiperazine via Procedure G. The product was purified on reverse phase HPLC to yield 2 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-methylpiperazine-1-carbonyl)benzamide. MS (Q1) 469 (M)*. 10 Example 76 4-(4-acetylpiperazine-1-carbonyl)-2-chloro-N-(4-chloro-3-(pyridin-2 yl)phenyl)benzamide CI N 0 HN CI N N 15 0 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 1 acetylpiperazine via Procedure G. The product was purified on reverse phase HPLC to yield 4-(4 acetylpiperazine-1-carbonyl)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide. MS (Q1) 20 497 (M)*. Example 77 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-(methylsulfonyl)piperazine-1 carbonyl)benzamide 113 CI HN CI / \ / N N-Szze 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 1 sulfonylpiperazine via Procedure G. The product was purified on reverse phase HPLC to yield 2 5 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-(methylsulfonyl)piperazine-1 carbonyl)benzamide. MS (Q1) 533 (M)*. Example 78 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(morpholine-4 10 carbonyl)benzamide CI \N 0 HN CI N 0 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 15 morpholine via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(morpholine-4-carbonyl)benzamide. MS (Q1) 456 (M)*. Example 79 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(3,5-dimethylpiperazine-1 20 carbonyl)benzamide 114 CI N 0 HN CI N NH 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2,6 dimethylpiperazine via Procedure G. The product was purified on reverse phase HPLC to yield 2 5 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(3,5-dimethylpiperazine-1-carbonyl)benzamide. MS (Q1) 483 (M)*. Example 80 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(pyridin-3 10 ylmethyl)terephthalamide CI \N 0 HN CI NH N 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 3 15 (aminomethyl)pyridine via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(pyridin-3-ylmethyl)terephthalamide. MS (Q 1) 477 (M)*. 20 Example 81 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(pyridin-2 ylmethyl)terephthalamide 115 CI \N 0 HN CI NH N 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2 (aminomethyl)pyridine via Procedure G. The product was purified on reverse phase HPLC to 5 yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(pyridin-2-ylmethyl)terephthalamide. MS (Q 1) 477 (M)*. Example 82 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(pyridin-4-yl)terephthalamide 10 CI \N 0 HN CI N NH 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 4 aminopyridine via Procedure G. The product was purified on reverse phase HPLC to yield 2 15 chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(pyridin-4-yl)terephthalamide. MS (Q1) 463 (M)*. Example 83 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(pyridin-3-yl)terephthalamide CI \N 0 HN CI / \ / NNj NH 20 0 116 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 3 aminopyridine via Procedure G. The product was purified on reverse phase HPLC to yield 2 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(pyridin-3-yl)terephthalamide. MS (Q1) 463 (M)*. 5 Example 84 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(thiomorpholine-4 carbonyl)benzamide (S-oxidized thiomorpholine) CI \N 0 HN CI / N S 10 0 N S 100 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to thiomorpholine via Procedure G. Crude 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (thiomorpholine-4-carbonyl)benzamide was reacted via Procedure R to oxidize the thiomorpholine 15 sulfur and purified via reverse phase HPLC to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl) 4-(thiomorpholine-4-carbonyl)benzamide (in which the thiomorpholline sulfur is oxidized to SO 2 ). MS (Q1) 504 (M)*. 20 Example 85 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(thiazolidine-3 carbonyl)benzamide (S-oxidized thiazolidine) CI N 0 HN CI N 0 117 100 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to thiazolidine via Procedure G. Crude 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(thiazolidine 3-carbonyl)benzamide was reacted via Procedure R and purified via reverse phase HPLC to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(thiazolidine-3-carbonyl)benzamide (in which the 5 thiazolidine sulfur is oxidized to SO 2 ). MS (Qi) 490 (M)*. Example 86 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1-methyl-iH-pyrazol-5 yl)terephthalamide 10 CI \N 0 HN CI - N NH 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 5 amino-1-methylpyrazole via Procedure G. The product was purified on reverse phase HPLC to 15 yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1-methyl-iH-pyrazol-5 yl)terephthalamide. MS (Qi) 466 (M)*. Example 87 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(isoxazol-5-yl)terephthalamide 20 CI \N 0 HN CI \-N NH 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 5 aminoisoxazole via Procedure G. The product was purified on reverse phase HPLC to yield 2 25 chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(isoxazol-5-yl)terephthalamide. MS (Q1) 463 (M)+. 118 Example 88 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(4,5-dihydrothiazol-2 yl)terephthalamide 5 CI \N 0 HN CI N S NH 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2 amino-4,5-dihydrothiazole via Procedure G. The product was purified on reverse phase HPLC to 10 yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(4,5-dihydrothiazol-2-yl)terephthalamide. MS (Q1) 471 (M)*. Example 89 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1H-imidazol-2 15 yl)terephthalamide CI \N 0 HN CI N NH NH 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2 20 aminoimidazole via Procedure G. The product was purified on reverse phase HPLC to yield 2 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1H-imidazol-2-yl)terephthalamide. MS (Q1) 452 (M)+. 25 Example 90 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(4H-1,2,4-triazol-4 yl)terephthalamide 119 CI \N 0 HN CI N-'N -/N NH 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 4 5 amino-1,2,4-triazole via Procedure G. The product was purified on reverse phase HPLC to yield 2 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(4H-1,2,4-triazol-4-yl)terephthalamide. MS (Q1) 453 (M)*. 10 Example 91 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(thiazol-2-yl)terephthalamide CI \N 0 HN CI N S NH 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2 15 aminothiazole via Procedure G. The product was purified on reverse phase HPLC to yield 2 chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(thiazol-2-yl)terephthalamide. MS (Q1) 469 (M)*. Example 92 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1H-1,2,4-triazol-5 20 yl)terephthalamide 120 CI \N 0 HN CI / \ N'ON

-

NH NH 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 3 amino-1,2,4-triazole via Procedure G. The product was purified on reverse phase HPLC to yield 2 5 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1H-1,2,4-triazol-5-yl)terephthalamide. MS (Q1) 453 (M)*. Example 93 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(thiazolidine-3 10 carbonyl)benzamide CI \N 0 HN CI N 0 \_ 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to thiazoline via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N 15 (4-chloro-3-(pyridin-2-yl)phenyl)-4-(thiazolidine-3-carbonyl)benzamide. MS (Q1) 459 (M)*. Example 94 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(4,5-dihydrooxazol-2 yl)terephthalamide 20 CI \N 0 HN CI N o NH 0 121 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2 amino-4,5-dihydrooxazole via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(4,5-dihydrooxazol-2-yl)terephthalamide. 5 MS (Q1) 456 (M)*. Example 95 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(1,4,5,6-tetrahydropyrimidine-1 carbonyl)benzamide 10 CI \N 0 HN CI N ON 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 1,4,5,6-tetrahydropyrimidine via Procedure G. The product was purified on reverse phase HPLC 15 to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(1,4,5,6-tetrahydropyrimidine-1 carbonyl)benzamide. MS (Q1) 454 (M)*. Example 96 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(3-oxopiperazine-1 20 carbonyl)benzamide CI \N 0 HN CI 0 N NH 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 3 25 oxopiperazine via Procedure G. The product was purified on reverse phase HPLC to yield 2 122 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(3-oxopiperazine- 1 -carbonyl)benzamide. MS (Q1) 470 (M)*. 5 Example 97 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -methoxyterephthalamide CI N 0 HN CI NH 0 0 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to N 10 methylhydroxylamine hydrochloride via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -methoxyterephthalamide. MS (Q1) 417 (M)*. 15 Example 98 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -hydroxyterephthalamide CI \N 0 HN CI NH 0 OH 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 20 hydroxylamine hydrochloride via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -hydroxyterephthalamide. MS (Q1) 403 (M)+. 25 Example 99 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(pyrrolidine-1-carbonyl)benzamide 123 CI \N 0 HN CI N 0 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to pyrolidine via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N 5 (4-chloro-3-(pyridin-2-yl)phenyl)-4-(pyrrolidine-1-carbonyl)benzamide. MS (Q1) 441 (M)*. Example 100 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(ethylsulfonylmethyl)benzamide 10 CI \N 0 HN 0 - o go Ethanesulfonyl chloride was reduced to sodium ethanesulfinate according to the procedure in J. Med. Chem. 1989, vol. 32, no. 11, p 2 4 3 6 . Briefly, 2.5 ml of ethanesulfonyl chloride was added 15 dropwise to a solution of 3.67 g of sodium carbonate and 5.51 g of sodium sulfate in 13 mL of water. After completion of the reaction the water was evaporated and the solids were suspended in ethanol and heated to 80' C for 1 h prior to filtering the solids. The filtrate was then evaporated to give 2.5 grams of the sodium ethanesulfinate. 293 mg of the sodium ethansulfinate was combined with 230 mg of methyl (4-bromoethyl)benzoate in 2 mL of DMF and heated to 120 C for 5 min in 20 a microwave reactor. The reaction was then extracted with Ethyl Acetate and Brine to give 250 mg of methyl 4-(ethylsulfonylmethyl)benzoate after evaporation of the organic layer. 200 mg of methyl 4-(ethylsulfonylmethyl)benzoate was hydrolyzed via Procedure M to give 119 mg of 4 (ethylsulfonylmethyl)benzoic acid. 50 mg of 4-(ethylsulfonylmethyl)benzoic acid was coupled with 67mg of 4-chloro-3 25 (pyridin-2-yl)aniline via Procedure G. This product was recrystallized from methanol to yield N (4-chloro-3-(pyridin-2-yl)phenyl)-4-(ethylsulfonylmethyl)benzamide. MS (Q1) 415 (M)*. 124 Example 101 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-( isopropylsulfonylmethyl)benzamide CI \ N 0 HN - 0 5 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(isopropylsulfonylmethyl)benzamide was prepared using the same procedure as N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(ethylsulfonylmethyl)benzamide except propane-2-sulfonyl chloride was substituted for ethanesulfonyl chloride. The product was 10 purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (isopropylsulfonylmethyl)benzamide. MS (Q1) 429 (M)*. Example 102 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -ethylterephthalamide 15 CI \N 0 HN CI NH 0 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to ethylamine via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro 20 N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -ethylterephthalamide. MS (Q1) 415 (M)*. Example 103 (S)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -((tetrahydrofuran-2 yl)methyl)terephthalamide 25 125 CI \N 0 HN CI NH 0 \ 0 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to (S) (+)-tetrahydrofurylamine via Procedure G. The product was purified on reverse phase HPLC to 5 yield (S)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -((tetrahydrofuran-2 yl)methyl)terephthalamide. MS (Q1) 471 (M)*. Example 104 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(3 10 methoxypropyl)terephthalamide CI \N 0 HN CI NH 0 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 3 15 methoxypropylamine via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(3-methoxypropyl)terephthalamide. MS (Q1) 459 (M)*. 20 Example 105 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(3 hydroxypropyl)terephthalamide 126 CI N 0 HN CI NH OH 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 3 hydroxypropylamine via Procedure G. The product was purified on reverse phase HPLC to yield 5 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(3-hydroxypropyl)terephthalamide. MS (Q1) 445 (M)*. Example 106 (S)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1-hydroxypropan-2 10 yl)terephthalamide CI \ N 0 HN CI NH 0 OH 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to (S)-2 15 amino-1-propanol via Procedure G. The product was purified on reverse phase HPLC to yield (S) 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1-hydroxypropan-2-yl)terephthalamide. MS (Q 1) 445 (M)*. 20 Example 107 (S)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1-methoxypropan-2 yl)terephthalamide 127 CI \N 0 HN CI NH 0

O

75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to (S)-1 methoxy-2-propylamine via Procedure G. The product was purified on reverse phase HPLC to 5 yield (S)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1-methoxypropan-2 yl)terephthalamide. MS (Q1) 459 (M)*. Example 108 N 4 -(3-(1H-imidazol-1-yl)propyl)-2-chloro-N 1 -(4-chloro-3-(pyridin-2 10 yl)phenyl)terephthalamide CI N 0 HN CI NH 0 N 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 1-(3 15 aminopropyl)imidazole via Procedure G. The product was purified on reverse phase HPLC to yield N 4 -(3-(1H-imidazol-1-yl)propyl)-2-chloro-N 1 -(4-chloro-3-(pyridin-2 yl)phenyl)terephthalamide. MS (Q1) 495 (M)*. 20 Example 109 N 4 -(2-(1H-imidazol-4-yl)ethyl)-2-chloro-N 1 -(4-chloro-3-(pyridin-2 yl)phenyl)terephthalamide 128 CI \ N 0 HN CI NH 0 N NH 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to hystamine via Procedure G. The product was purified on reverse phase HPLC to yield N 4 -(2-(1H 5 imidazol-4-yl)ethyl)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide. MS (Q1) 481 (M)+. Example 110 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -methylterephthalamide 10 CI \N 0 HN CI NH 0 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to methylamine hydrochloride via Procedure G. The product was purified on reverse phase HPLC to 15 yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -methylterephthalamide. MS (Q1) 401 (M)+. Example 111 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4

,N

4 -diethylterephthalamide 20 129 CI \N 0 HN CI N 0 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to diethylamine hydrochloride via Procedure G. The product was purified on reverse phase HPLC to 5 yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4

,N

4 -diethylterephthalamide. MS (Q1) 443 (M)+ Example 112 (S)-2-chloro-N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-(2-hydroxypropyl) 10 terephthalamide CI N 0 HN CI NH OH 0 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to (S)-1 15 amino-2-propanol via Procedure G. The product was purified on reverse phase HPLC to yield (S) 2-chloro-N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-(2-hydroxypropyl)terephthalamide. MS (Q1) 444 (M)*. 20 Example 113 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2 methoxyethyl)terephthalamide 130 CI \N 0 HN CI NH 0 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2 methoxyethanamine via Procedure G. The product was purified on reverse phase HPLC to yield 2 5 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2-methoxyethyl)terephthalamide. MS (Q1) 444 (M)+. Example 114 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1-methylpiperidin-4 10 yl)terephthalamide CI \N 0 HN CI N NH 0 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 4 15 amino-1-methylpiperidine via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1-methylpiperidin-4-yl)terephthalamide. MS (Q1) 483 (M)*. 20 Example 115 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(3 (diethylamino)propyl)terephthalamide 131 CI HN CI N NH 0 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to N,N diethylpropylenediamine via Procedure G. The product was purified on reverse phase HPLC to 5 yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(3-(diethylamino)propyl)terephthalamide. MS (Q1) 499 (M)*. Example 116 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2-(pyrrolidin-1 10 yl)ethyl)terephthalamide CI \//\\ \N 0 HN

-

CI N NH 0 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to N-(2 15 aminoethyl)pyrrolidine via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2-(pyrrolidin-1-yl)ethyl)terephthalamide. MS (Q1) 483 (M)*. 20 Example 117 N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4

,N

4 ,2-trimethylterephthalamide 132 CI \N 0 HN // N o In a sealed tube, 1.94 g of dimethyl 2-bromoterephthalate was dissolved in 4 mL of HMPA and 5 degassed with nitrogen prior to adding 1.1 mL of tetramethyl tin and 0.077 g of palladium tetrakistriphenylphosphene. After sealing the tube, the reaction was heated to 650 C for 16 h. The reaction was then partitioned into ethylether and water and extracted. The organic layers were washed with 5% ammonium hydroxide, IN HCl, again with 5% ammonium hydroxide, and finally with water. Filtration of the solvent through sodium sulfate and evaporation gave 1.44 g of crude 10 dimethyl 2-methylterephthalate. 210 mg of dimethyl 2-methylterephthalate was hydrolyzed via Procedure M to give 4-(methoxycarbonyl)-3-methylbenzoic acid. Silica gel chromatography was performed (0% to 70% EtOAc gradient in Hexanes) to yield 115 mg of 4-(methoxycarbonyl)-3 methylbenzoic acid. 4-(methoxycarbonyl)-3-methylbenzoic acid was then coupled to dimethylamine hydrochloride via Procedure G. The crude methyl 4-(dimethylcarbamoyl)-2 15 methylbenzoate was then hydrolyzed via Procedure M to give 110 mg of 4-(dimethylcarbamoyl)-2 methylbenzoic acid. 4-chloro-3-(pyridin-2-yl)aniline was coupled to 110 mg of 4 (dimethylcarbamoyl)-2-methylbenzoic acid via Procedure G to yield N 1 -(4-chloro-3-(pyridin-2 yl)phenyl)-N 4

,N

4 ,2-trimethylterephthalamide. MS (Q1) 394 (M)*. 20 Example 118 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -propylterephthalamide CI \N 0 HN CI NH 0 133 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to propylamine via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro

N

1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -propylterephthalamide. MS (Q1) 430 (M)*. 5 Example 119 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2-hydroxyethyl)terephthalamide CI \N 0 HN CI OH NH 0 10 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to propanolamine via Procedure G. The product was purified on reverse phase HPLC to yield 2 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2-hydroxyethyl)terephthalamide. MS (Q1) 428 (M)+. 15 Example 120 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide CI \N 0 HN CI

NH

2 0 20 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to ammonium chloride via Procedure G. The product was purified on reverse phase HPLC to yield 2 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide. MS (Q1) 386 (M)*. 25 Example 121 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(1H-tetrazol-1-yl)benzamide 134 CI \N 0 HN NN'N Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline (50 mg) and 4-(1H-tetrazol-1 yl)benzoic acid to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(1H-tetrazol-1-yl)benzamide. MS 5 (Q1) 421.0 (M)*. Example 122 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-ethylpiperazine-1 carbonyl)benzamide 10 CI \N 0 HN CI N N 0 \ 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 1 ethylpiperazine via Procedure G. The product was purified on reverse phase HPLC to yield 2 15 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-ethylpiperazine-1-carbonyl)benzamide. MS (Q1) 483 (M)*. Example 123 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(piperazine-1-carbonyl)benzamide 20 135 CI \N 0 HN CI N NH 0 50 mg 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to Boc piperazine via Procedure G. The organic layer was evaporated to dryness and treated with TFA. 5 After 1 h the TFA was removed and the crude was purified on reverse phase HPLC to yield 2 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(piperazine-1-carbonyl)benzamide. MS (Q1) 455 (M)+. 10 Example 124 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2,2,2 trifluoroethyl)terephthalamide CI \N 0 HN CI F /-+ F NH F 0 15 75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2,2,2 trifluoroethylamine via Procedure G. The product was purified on reverse phase HPLC to yield 2 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2,2,2-trifluoroethyl)terephthalamide. MS (Q1) 469 (M)*. 20 Example 125 6-(2-(1H-imidazol-5-yl)ethylamino)-N-(4-chloro-3-(pyridin-2 yl)phenyl)nicotinamide 136 CI \N 0 HN / \N H HN Procedure F was performed using N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-chloro-3-carboxamide (50 mg) and 100 mg of hystamine in butanol (0.5 mL). The crude reaction was purified by reverse 5 phase HPLC to yield 6-(2-(1H-imidazol-5-yl)ethylamino)-N-(4-chloro-3-(pyridin-2 yl)phenyl)nicotinamide. MS (Q1) 419 (M)*. Example 126 6-(4-acetylpiperazin-1-yl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)nicotinamide 10 CI \ / 0/ HN N N \O Procedure F was performed using N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-chloro-3-carboxamide (50 mg) and 0.12 mL of acetylpiperazine in butanol (0.5 mL). The crude reaction was purified by 15 reverse phase HPLC to yield 6-(4-acetylpiperazin-1-yl)-N-(4-chloro-3-(pyridin-2 yl)phenyl)nicotinamide. MS (Q1) 436 (M)*. Example 127 6-(3-(1H-imidazol-1-yl)propylamino)-N-(4-chloro-3-(pyridin-2 20 yl)phenyl)nicotinamide 137 CI \N 0 HN / \N HN N Procedure F was performed using N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-chloro-3-carboxamide (50 mg) and 125 mg of 1-(3-aminopropyl)imidazole in butanol (0.5 mL). The crude reaction was 5 purified by reverse phase HPLC to yield 6-(3-(1H-imidazol-1-yl)propylamino)-N-(4-chloro-3 (pyridin-2-yl)phenyl)nicotinamide. MS (Q1) 433 (M)*. Example 128 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(3-(2-oxopyrrolidin-1 10 yl)propylamino)nicotinamide CI \N 0 HN / \N HN N Procedure F was performed using N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-chloro-3-carboxamide (50 15 mg) and 0.42 mL of 1-(3-aminopropyl)-2-pyrrolidinone in butanol (0.5 mL). The crude reaction was purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(3-(2 oxopyrrolidin-1-yl)propylamino)nicotinamide. MS (Q1) 450 (M)*. 20 Example 129 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(3-morpholinopropylamino)nicotinamide 138 CI \N 0 HN / \N HN N 0 Procedure F was performed using N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-chloro-3-carboxamide (50 mg) and 0.14 mL of N-(3-aminopropyl)morpholine in butanol (0.5 mL). The crude reaction was 5 purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(3 morpholinopropylamino)nicotinamide. MS (Q1) 452 (M)*. Example 130 N-(4-chloro-3-(pyridin-2-yl)phenyl)benzo[d][1,2,3]thiadiazole-5-carboxamide 10 CI \ / 0/ N 0 H N S' 50 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to benzo-1,2,3-thiadiazole-5-carboxylic acid 15 via Procedure G. The crude product was purified via reverse phase HPLC to yield N-(4-chloro-3 (pyridin-2-yl)phenyl)benzo[d][1,2,3]thiadiazole-5-carboxamide. MS (Q1) 367 (M)*. Example 131 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -((1S,2R)-2-hydroxy-2,3-dihydro 20 1 H-inden- 1 -yl)terephthalamide 139 CI N 0 HN CI NH OH 60 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to (1S,2R)-1-amino-2,3-dihydro-1H-inden-2-ol via Procedure G. The crude product was purified on 5 reverse phase HPLC to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -((1S,2R)-2-hydroxy 2,3-dihydro-1H-inden-1-yl)terephthalamide. MS (Q1) 518.2 (M)*. Example 132 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -((1R,2S)-2-hydroxy-2,3-dihydro 10 1 H-inden- 1 -yl)terephthalamide CI \N 0 HN CI NH OH 0 60 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to (1R,2S)-1-amino-2,3-dihydro-1H-inden-2-ol via Procedure G. The crude product was purified on 15 reverse phase HPLC to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -((1R,2S)-2-hydroxy 2,3-dihydro-1H-inden-1-yl)terephthalamide. MS (Q1) 518.2 (M)*. Example 133 N 4 -benzyl-2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2-hydroxyethyl) 20 terephthalamide 140 CI \N 0 HN CI N 0 OH 40 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2 (benzylamino)ethanol via Procedure G. The crude product was purified on reverse phase HPLC to 5 yield N 4 -benzyl-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2 hydroxyethyl)terephthalamide. MS (Q1) 520 (M)*. Example 134 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -methyl-N 4 -(pyridin-2 10 ylmethyl)terephthalamide CI \N 0 HN CI N N 40 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to N methyl-1-(pyridin-2-yl)methanamine via Procedure G. The crude product was purified on reverse 15 phase HPLC to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -methyl-N 4 -(pyridin-2 ylmethyl)terephthalamide. MS (Q1) 491 (M)*. Example 135 N 4 -benzyl-2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 20 methylterephthalamide 141 CI \N 0 HN CI N 0 40 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to N methyl-1-phenylmethanamine via Procedure G. The crude product was purified on reverse phase 5 HPLC to yield N 4 -benzyl-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -methylterephthalamide. MS (Q1) 490.1 (M)*. Example 136 N 4 -(2-aminobenzyl)-2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide 10 CI \N 0 HN CI

H

2 N NH 0 60 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to N 1 phenylethane-1,2-diamine via Procedure G. The crude product was purified on reverse phase 15 HPLC to yield N 4 -(2-aminobenzyl)-2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide. MS (Q1) 491 (M)*. Example 137 N 4 -benzyl-2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide 20 142 CI \N 0 HN CI NH 0 60 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to benzylamine via Procedure G. The crude product was purified on reverse phase HPLC to yield N 4 5 benzyl-2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide. MS (Q1) 476 (M)*. Example 138 (R)-2-chloro-N -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2-hydroxy-1 phenylethyl)terephthalamide 10 CI \N 0 HN CI OH NH " 60 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to (R) 2-amino-2-phenylethanol via Procedure G. The crude product was purified on reverse phase 15 HPLC to yield (R)-2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2-hydroxy-1 phenylethyl)terephthalamide. MS (Q1) 506 (M)*. Example 139 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(4-methyl-1,4-diazepan-1-yl)nicotinamide 20 143 CI \N 0 HN / N N 50 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)nicotinamide was reacted with 1-methyl-1,4 diazepane via Procedure F. The reaction was evaporated to dryness and purified on reverse phase 5 HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(4-methyl-1,4-diazepan-1-yl)nicotinamide. MS (Q1) 422 (M)*. Example 140 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(1,4-diazepan-1-yl)nicotinamide 10 CI \N 0 HN / \N NH 50 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)nicotinamide was reacted with 1,4 diazepane via Procedure F. The reaction was evaporated to dryness and purified on reverse phase 15 HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(1,4-diazepan-1-yl)nicotinamide. MS (Q1) 408 (M)*. Example 141 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2 20 (phenylamino)ethyl)terephthalamide 144 CI N0 HN CI NH 0 HN / 62 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to N 1 phenylethane-1,2-diamine via Procedure G. The crude product was purified on reverse phase 5 HPLC to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2 (phenylamino)ethyl)terephthalamide. MS (Q1) 505.1 (M)*. Example 142 (S)-2-chloro-N -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2-hydroxy-1 10 phenylethyl)terephthalamide CI \N 0 HN CI OH NH 0 62 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to (S)-2 15 amino-2-phenylethanol via Procedure G. The crude product was purified on reverse phase HPLC to yield (S)-2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2-hydroxy-1 phenylethyl)terephthalamide. MS (Q1) 506 (M)*. 20 Example 143 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1-phenylethyl)terephthalamide 145 CI \N 0 HN CI NH 0 O 62 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 1 phenylethanamine via Procedure G. The crude product was purified on reverse phase HPLC to 5 yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1-phenylethyl)terephthalamide. MS (Q1) 490.1 (M)*. Exampl 144 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(4-(methylsulfonyl)benzyl) 10 terephthalamide CI N 0 HN CI NH 0 62 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to (4 15 (methylsulfonyl)phenyl)methanamine via Procedure G. The crude product was purified on reverse phase HPLC to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(4 (methylsulfonyl)benzyl)terephthalamide. MS (Q1) 554 (M)*. 20 Example 145 N-(3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzyl)picolinamide 146 CI \N 0 HN CI NH N 70 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-((tert-butoxycarbonylamino)methyl)-2 chlorobenzoic acid via Procedure G to yield tert-butyl 3-chloro-4-(4-chloro-3-(pyridin-2 5 yl)phenylcarbamoyl)benzylcarbamate. Tert-butyl 3-chloro-4-(4-chloro-3-(pyridin-2 yl)phenylcarbamoyl)benzylcarbamate was subsequently treated with 4N HCl in Dioxane to remove the Boc protecting group and form the HCl salt of 4-(aminomethyl)-2-chloro-N-(4-chloro-3 (pyridin-2-yl)phenyl)benzamide. 54 mg of the crude HCl salt of 4-(aminomethyl)-2-chloro-N-(4 chloro-3-(pyridin-2-yl)phenyl)benzamide was coupled to picolinic acid via Procedure G. The 10 crude product was purified by reverse phase HPLC to yield N-(3-chloro-4-(4-chloro-3-(pyridin-2 yl)phenylcarbamoyl)benzyl)picolinamide. MS (Q1) 477.3 (M)*. Example 146 N-(4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzyl)picolinamide 15 CI \N 0 HN NH N 70 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-((tert butoxycarbonylamino)methyl)benzoic acid via Procedure G to yield tert-butyl 4-(4-chloro-3 20 (pyridin-2-yl)phenylcarbamoyl)benzylcarbamate. Tert-butyl 4-(4-chloro-3-(pyridin-2 yl)phenylcarbamoyl)benzylcarbamate was subsequently treated with 4N HCl in Dioxane to remove the Boc protecting group and form the HCl salt of 4-(aminomethyl)-N-(4-chloro-3-(pyridin-2 yl)phenyl)benzamide. 50 mg of the crude HCl salt of 4-(aminomethyl)-N-(4-chloro-3-(pyridin-2 yl)phenyl)benzamide was coupled to picolinic acid via Procedure G. The crude product was 147 purified by reverse phase HPLC to yield N-(4-(4-chloro-3-(pyridin-2 yl)phenylcarbamoyl)benzyl)picolinamide. MS (Q1) 443.3 (M)*. 5 Example 147 N 5 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 2 -isopropylpyridine-2,5-dicarboxamide CI N 0 HN / NN NH 0 250 mg of 5-(methoxycarbonyl)picolinic acid was coupled to isopropylamine via Procedure G. 10 Crude methyl 6-(isopropylcarbamoyl)nicotinate was hydrolyzed via Procedure M to yield 227 mg of 6-(isopropylcarbamoyl)nicotinic acid. 60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 6-(isopropylcarbamoyl)nicotinic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield N 5 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 2 -isopropylpyridine-2,5 dicarboxamide. MS (Q1) 395.1 (M)*. 15 Example 148 N2-tert-butyl-N 5 -(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-2,5-dicarboxamide CI \ N 0 HN / NN NH 0 20 250 mg of 5-(methoxycarbonyl)picolinic acid was coupled to tert-butylamine via Procedure G. Crude methyl 6-(tert-butylcarbamoyl)nicotinate was hydrolyzed via Procedure M to yield 250 mg of 6-(tert-butylcarbamoyl)nicotinic acid. 60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 6-(tert-butylcarbamoyl)nicotinic acid via Procedure G. The crude product was purified by reverse 148 phase HPLC to yield N 2 -tert-butyl-N 5 -(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-2,5 dicarboxamide. MS (Q1) 409 (M)*. 5 Example 149 N 5 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 2 -(pyridin-2-ylmethyl)pyridine-2,5 dicarboxamide CI \N 0 HN N NH N 0 250 mg of 5-(methoxycarbonyl)picolinic acid was coupled to pyridin-2-ylmethanamine via 10 Procedure G. Crude methyl 6-(pyridin-2-ylmethylcarbamoyl)nicotinate was hydrolyzed via Procedure M to yield 250 mg of 6-(pyridin-2-ylmethylcarbamoyl)nicotinic acid. 60 mg of 4 chloro-3-(pyridin-2-yl)aniline was coupled to 6-(pyridin-2-ylmethylcarbamoyl)nicotinic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield N 5 -(4-chloro-3 (pyridin-2-yl)phenyl)-N 2 -(pyridin-2-ylmethyl)pyridine-2,5-dicarboxamide. MS (Q1) 444.1 (M)*. 15 Example 150 N 2 -benzyl-N 5 -(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-2,5-dicarboxamide CI N 0 HNN / \N NH 20 250 mg of 5-(methoxycarbonyl)picolinic acid was coupled to benzylamine via Procedure G. Crude methyl 6-(benzylcarbamoyl)nicotinate was hydrolyzed via Procedure M to yield 300 mg of 6 (benzylcarbamoyl)nicotinic acid. 60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 6 (benzylcarbamoyl)nicotinic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield N 2 -benzyl-N 5 -(4-chloro-3-(pyridin-2-yl)phenyl)pyridine-2,5-dicarboxamide. 25 MS (Q1) 443.1 (M)*. 149 Example 151 N 5 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 2 -(6-methoxypyridin-3-yl)pyridine-2,5 dicarboxamide 5 CI \N 0 HN / N NH N 0_ 0 250 mg of 5-(methoxycarbonyl)picolinic acid was coupled to 6-methoxypyridin-3-amine via Procedure G. Crude methyl 6-(6-methoxypyridin-3-ylcarbamoyl)nicotinate was hydrolyzed via 10 Procedure M to yield 196 mg of 6-(6-methoxypyridin-3-ylcarbamoyl)nicotinic acid. 60 mg of 4 chloro-3-(pyridin-2-yl)aniline was coupled to 6-(6-methoxypyridin-3-ylcarbamoyl)nicotinic acid via Procedure G. The crude product was recrystallized to yield pure N 5 -(4-chloro-3-(pyridin-2 yl)phenyl)-N 2 -(6-methoxypyridin-3-yl)pyridine-2,5-dicarboxamide. MS (Q1) 460 (M)*. 15 Example 152 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -((6-methylpyridin-2-yl)methyl) terephthalamide CI 0 HN CI N H

N

20 2.5 mL of Diisopropylazodicarboxylate in 1.5mL of THF was added dropwise to a solution of 250 mg of (6-methylpyridin-2-yl)methanol, 2.8g of Triphenylphosphine and 1.6 g of isoindoline-1,3 dione in anhydrous THF at room temperature. The reaction was stirred for 2 hours and monitored 150 by TLC. Upon complection, the solvent was concentrated, the crude material was extracted in water and Chloroform 3 times and dried over Magnesium Sulfate. The crude was purified via ISCO Combi-Flash to yield 2-((6-methylpyridin-2-yl)methyl)isoindoline-1,3-dione. 350 mg of 2 ((6-methylpyridin-2-yl)methyl)isoindoline-1,3-dione was treated with 440 pL of Hydrazine 5 Monohydrate in EtOH and refluxed for several hours to yield (6-methylpyridin-2-yl)methanamine. The crude (6-methylpyridin-2-yl)methanamine was evaporated and directly coupled to 50mg of 3 chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid via Procedure G. The crude product was purified on reverse phase HPLC to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2 yl)phenyl)-N 4 -((6-methylpyridin-2-yl)methyl)terephthalamide. MS (Q1) 491.1 (M)*. 10 Example 153 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((2 hydroxypropylsulfonyl)methyl)benzamide CI \N 0 HN S~ OH 15 1 g of methyl 4-(bromomethyl)benzoate was reacted with 1-mercaptopropan-2-ol via Procedure Q. 1 g of methyl 4-((2-hydroxypropylthio)methyl)benzoate was oxidized with 2g of MCPBA in DCM at -78C to form crude methyl 4-((2-hydroxypropylsulfonyl)methyl)benzoate. The reaction was 20 evaporated and purified by ISCO Combi-Flash to yield 567 mg of pure methyl 4-((2 hydroxypropylsulfonyl)methyl)benzoate which was subsequently hydrolyzed via Procedure M to give 328 mg of 4-((2-hydroxypropylsulfonyl)methyl)benzoic acid. 50 mg of 4-chloro-3-(pyridin 2-yl)aniline was coupled to 4-((2-hydroxypropylsulfonyl)methyl)benzoic acid via Procedure G. The crude product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2 25 yl)phenyl)-4-((2-hydroxypropylsulfonyl)methyl)benzamide. MS (Q1) 445.3 (M)*. Example 154 (R)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2 hydroxypropyl)terephthalamide 30 151 CI N 0 HN CI NH OH 0 100 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to (R) 2-amino-2-phenylethanol via Procedure G. The crude product was purified on reverse phase 5 HPLC to yield (R)-2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2 hydroxypropyl)terephthalamide. MS (Q1) 444.3 (M)*. Example 155 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((2-(dimethylamino)ethylsulfonyl)methyl) 10 benzamide CI \N 0 HN

S;

N

500 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(bromomethyl)benzoic acid via Procedure E. 170 mg of 4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide was 15 reacted with 2-(dimethylamino)ethanethiol hydrochloride via Procedure Q. 140mg of crude N-(4 chloro-3-(pyridin-2-yl)phenyl)-4-((2-(dimethylamino)ethylthio)methyl)benzamide was reacted with oxone via Procedure R. The crude product was purified by reverse phase HPLC to yield N-(4 chloro-3-(pyridin-2-yl)phenyl)-4-((2-(dimethylamino)ethylsulfonyl)methyl)benzamide. MS (Q1) 458.3 (M)*. 20 Example 156 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(6-methoxypyridin-3 yl)terephthalamide 152 CI \/ /\ N 0 HN CI NH 0 -\ 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 6 methoxypyridin-3-amine via Procedure G. The crude product was purified on reverse phase HPLC 5 to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(6-methoxypyridin-3-yl)terephthalamide. MS (Q1) 493 (M)*. Example 157 N 4 -(6-aminopyridin-3-yl)-2-chloro-N -(4-chloro-3-(pyridin-2-yl)phenyl) 10 terephthalamide CI \N 0 HN CI NH 0 N

NH

2 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 15 pyridine-2,5-diamine via Procedure G. The crude product was purified on reverse phase HPLC to yield N 4 -(6-aminopyridin-3-yl)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)terephthalamide. MS (Q1) 478 (M)*. 20 Example 158 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(6-chloropyridin-3 yl)terephthalamide 153 CI (N 0 HN CI NH 0 -\ CI 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 6 chloropyridin-3-amine via Procedure G. The crude product was purified on reverse phase HPLC 5 to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(6-chloropyridin-3-yl)terephthalamide. MS (Q1) 497 (M)*. Example 159 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(pyridin-2-yl)terephthalamide 10 CI N 0 HN CI NH O N 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to pyridin-2-amine via Procedure G. The crude product was purified on reverse phase HPLC to yield 15 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(pyridin-2-yl)terephthalamide. MS (Q1) 463 (M)+. Example 160 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(piperidin-4 20 ylmethyl)terephthalamide 154 CI N0 HN CI NH 0 NH 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to piperidin-4-ylmethanamine via Procedure G. The crude product was purified on reverse phase 5 HPLC to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(piperidin-4 ylmethyl)terephthalamide. MS (Q1) 483 (M)*. Example 161 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1,3-dimethyl-1H-pyrazol-5 10 yl)terephthalamide CI N 0 HN CI NH 0 N N 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 1,3 15 dimethyl-1H-pyrazol-5-amine via Procedure G. The crude product was purified on reverse phase HPLC to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(1,3-dimethyl-1H-pyrazol-5 yl)terephthalamide. MS (Q1) 480 (M)*. 20 Example162 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2-(methylsulfonyl)ethyl) terephthalamide 155 CI \N 0 HN CI NH 00 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to 2 (methylsulfonyl)ethanamine via Procedure G. The crude product was purified on reverse phase 5 HPLC to yield 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -(2 (methylsulfonyl)ethyl)terephthalamide. MS (Q1) 492 (M)*. Example 163 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -isopropylterephthalamide 10 CI N 0 HN CI NH 0 50 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to isopropylamine via Procedure G. The crude product was purified on reverse phase HPLC to yield 15 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4 -isopropylterephthalamide. MS (Q1) 428 (M)*. Example 164 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-(2-methoxyethyl)methyl sulfonamido)benzamide 20 156 CI \N 0 HN CI /\ -s' N-\ 1- 0 IO \ 0 To 5 g of methyl 2-chloro-4-nitrobenzoate in 100 mL of EtOH was added 20 g of Tin (II) Chloride in portions. The reaction was heated to 55 C and monitored by TLC until complete. Solvent was concentrated and extraction was performed in Ethyl Acetate and water with TEA to reduce 5 emulsions. The organic layer was dried over Magnesium Sulfate, filtered and concentrated to give 3.9 g of methyl 4-amino-2-chlorobenzoate. 1 g of methyl 4-amino-2-chlorobenzoate was cooled to OC in DCM with 485 pL of Pyridine before Methanesulfonyl Chloride was added dropwise. The reaction was allowed to warm to room temperature and stir overnight. Solvent was concentrated and the crude material was dissolved in Ethyl Acetate and extracted with saturated bicarbonate 10 solution and then brine. The crude material was dried over Magnesium Sulfate, filtered and concentrated to give 1.54 g of methyl 2-chloro-4-(methylsulfonamido)benzoate. 107 pL of 1 bromo-2-methoxyethane and 556 mg of Cesium Carbonate were added to 150 mg of methyl 2 chloro-4-(methylsulfonamido)benzoate in DMF and stirred at room temperature for 16 hours. The reaction mixture was extracted in Ethyl Acetate twice with saturated bicarbonate and once with 15 brine, dried over Magnesium Sulfate, filtered and concentrated to give methyl 2-chloro-4-(N-(2 methoxyethyl)methylsulfonamido)benzoate. 182 mg of methyl 2-chloro-4-(N-(2 methoxyethyl)methylsulfonamido)benzoate was hydrolyzed via Procedure M to yield 169 mg of crude 2-chloro-4-(N-(2-methoxyethyl)methylsulfonamido)benzoic acid. 65 mg of 4-chloro-3 (pyridin-2-yl)aniline was coupled to 2-chloro-4-(N-(2-methoxyethyl)methylsulfonamido)benzoic 20 acid via Procedure G. The crude product was purified by reverse phase HPLC to yield 2-chloro-N (4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-(2-methoxyethyl)methysulfonamido)benzamide. MS (Q1) 494 (M)*. 25 Example 165 4-(N-(2-(1H-pyrrol-1-yl)ethyl)methylsulfonamido)-2-chloro-N-(4-chloro-3 (pyridin-2-yl)phenyl)benzamide 157 CI \N 0 HN CI O N 200 pL of 1-(2-bromoethyl)-1H-pyrrole and 556 mg of Cesium Carbonate were added to 150 mg of methyl 2-chloro-4-(methylsulfonamido)benzoate in DMF and stirred at room temperature for 16 5 hours. The reaction mixture was extracted in Ethyl Acetate twice with saturated bicarbonate and once with brine, dried over Magnesium Sulfate, filtered and concentrated to give methyl 4-(N-(2 (1H-pyrrol-1-yl)ethyl)methylsulfonamido)-2-chlorobenzoate. 230 mg of methyl 4-(N-(2-(1H pyrrol-1-yl)ethyl)methylsulfonamido)-2-chlorobenzoate was hydrolyzed via Procedure M to yield 221 mg of crude 4-(N-(2-(1H-pyrrol-1-yl)ethyl)methylsulfonamido)-2-chlorobenzoic acid. 10 64 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(N-(2-(1H-pyrrol-1 yl)ethyl)methylsulfonamido)-2-chlorobenzoic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield 4-(N-(2-(1H-pyrrol-1-yl)ethyl)methylsulfonamido)-2 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide. MS (Q1) 529 (M)*. 15 Example 166 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-isobutylmethylsulfonamido) benzamide CI \N 0 HN CI N /\ I I 0-O 0 20 175 pL of 1-iodo-2-methylpropane and 740 mg of Cesium Carbonate were added to 200 mg of methyl 2-chloro-4-(methylsulfonamido)benzoate in 2 mL of DMF and stirred in the microwave at 140C for 30 minutes. The reaction mixture was extracted in Ethyl Acetate twice with water, dried over Magnesium Sulfate, filtered, concentrated and purified on ISCO Combi-Flash to give methyl 158 2-chloro-4-(N-isobutylmethylsulfonamido)benzoate. 120 mg of methyl 2-chloro-4-(N isobutylmethylsulfonamido)benzoate was hydrolyzed via Procedure M to yield 110 mg of crude 2 chloro-4-(N-isobutylmethylsulfonamido)benzoic acid. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 2-chloro-4-(N-isobutylmethylsulfonamido)benzoic acid via Procedure G. The 5 crude product was purified by reverse phase HPLC to yield 2-chloro-N-(4-chloro-3-(pyridin-2 yl)phenyl)-4-(N-isobutylmethylsulfonamido)benzamide. MS (Q1) 492 (M)*. Example 167 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-(2-morpholinoethyl)methyl 10 sulfonamido)benzamide CI \N 0 HN CI N -N'0 O_ 0 1.2 g of 4-(2-chloroethyl)morpholine and 2.5 g of Cesium Carbonate were added to 334 mg of 15 methyl 2-chloro-4-(methylsulfonamido)benzoate in 7 mL of DMF and stirred in the microwave at 150C for 30 minutes. The reaction mixture was extracted in Ethyl Acetate twice with water, dried over Magnesium Sulfate, filtered, concentrated to give crude methyl 2-chloro-4-(N-(2 morpholinoethyl)methylsulfonamido)benzoate. 476 mg of methyl 2-chloro-4-(N-(2 morpholinoethyl)methylsulfonamido)benzoate was hydrolyzed via Procedure M and purified by 20 reverse phase HPLC to yield 460 mg of crude 2-chloro-4-(N-(2 morpholinoethyl)methylsulfonamido)benzoic acid. 100 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 2-chloro-4-(N-(2-morpholinoethyl)methylsulfonamido)benzoic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield 2-chloro-N-(4-chloro-3 (pyridin-2-yl)phenyl)-4-(N-(2-morpholinoethyl)methylsulfonamido)benzamide. MS (Q1) 549 25 (M)*. Example 168 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-4-(methylsulfonylmethyl)benzamide 159 CI \N 0 HN - 0 go 410 mg of dimethyl 2-methylterephthalate was hydrolyzed via Procedure M and purified by ISCO Combi-Flash to afford 4-(methoxycarbonyl)-3-methylbenzoic acid. 255 mg of 4 5 (methoxycarbonyl)-3-methylbenzoic acid was cooled to OC in 2 mL of THF before a solution of 2.6 mL of IM BH 3 -THF complex in THF was added dropwise. The ice bath was subsequently removed and the reaction was stirred at room temperature until reaction stalled out at -50% complete by TLC. The reaction was re-cooled to OC and another 2.6 mL of BH 3 -THF was added dropwise before the ice bath was removed. Upon completion, the reaction was re-cooled to O C 10 and quenched with 3N HCl dropwise. The aqueous layer was extracted 2 times with Ethyl Acetate and the organic layer was then extracted once with bicarbonate solution and brine, dried over Magnesium Sulfate, filtered and concentrated to give methyl 4-(hydroxymethyl)-2-methylbenzoate. 220 mg of methyl 4-(hydroxymethyl)-2-methylbenzoate was cooled to OC in 5 mL of DCM before adding 260 mg of Triphenylphosphine and 395 mg of NBS. The reaction was concentrated and 15 directly purified via ISCO Combi-Flash to give pure methyl 4-(bromomethyl)-2-methylbenzoate. 255 mg of methyl 4-(bromomethyl)-2-methylbenzoate was reacted via Procedure 0 to give methyl 2-methyl-4-(methylsulfonylmethyl)benzoate. 250 mg of methyl 2-methyl-4 (methylsulfonylmethyl)benzoate was then hydrolyzed upon heating to 45 C for 1 hour via Procedure M to give 2-methyl-4-(methylsulfonylmethyl)benzoic acid. 202 mg of 4-chloro-3 20 (pyridin-2-yl)aniline was coupled to 2-methyl-4-(methylsulfonylmethyl)benzoic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2 yl)phenyl)-2-methyl-4-(methylsulfonylmethyl)benzamide. MS (Q1) 415 (M)*. 25 Example 169 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-methylmethyl sulfonamido)benzamide 160 CI \N 0 HN CI - 0 / \ 78 pL of iodomethane and 447 mg of Cesium Carbonate were added to 300 mg of methyl 2-chloro 4-(methylsulfonamido)benzoate in 3 mL of DMF and stirred at room temperature for 16 hours. 5 The reaction mixture was extracted in Ethyl Acetate twice with saturated bicarbonate and once with brine, dried over Magnesium Sulfate, filtered and concentrated to give crude methyl 2-chloro 4-(N-methylmethylsulfonamido)benzoate. 295 mg of methyl 2-chloro-4-(N methylmethylsulfonamido)benzoate was hydrolyzed via Procedure M to yield 249 mg of 2-chloro 4-(N-methylmethylsulfonamido)benzoic acid. 10 100 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 2-chloro-4-(N methylmethylsulfonamido)benzoic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N methylmethylsulfonamido)benzamide. MS (Q1) 450 (M)*. 15 Example 170 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((2-oxopiperazin-1-yl)methyl)benzamide CI \N 0 HN N NH 20 500 mg of methyl 4-(bromomethyl)benzoate was reacted with 480 mg of tert-butyl 3 oxopiperazine-1-carboxylate and 1 g of Cesium Carbonate in 9 mL of DMF at 45'C. Upon completion, the reaction was extracted in Ethyl Acetate 2 times saturated bicarbonate, dried over Magnesium Sulfate, filtered and concentrated to give tert-butyl 4-(4-(methoxycarbonyl)benzyl)-3 oxopiperazine- 1 -carboxylate. 613 mg of tert-butyl 4-(4-(methoxycarbonyl)benzyl)-3 25 oxopiperazine-1-carboxylate was hydrolyzed via Procedure M to give 4-((4-(tert-butoxycarbonyl) 2-oxopiperazin-1-yl)methyl)benzoic acid. 200 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled 161 to 4-((4-(tert-butoxycarbonyl)-2-oxopiperazin-1-yl)methyl)benzoic acid via Procedure G. The crude product was extracted twice with saturated bicarbonate in Ethyl Acetate, dried over Magnesium Sulfate, filtered and concentrated to give crude tert-butyl 4-(4-(4-chloro-3-(pyridin-2 yl)phenylcarbamoyl)benzyl)-3-oxopiperazine-1-carboxylate. 4N HCl was subsequently added to 5 crude tert-butyl 4-(4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzyl)-3-oxopiperazine-1 carboxylate and concentrated to give the HCl salt of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((2 oxopiperazin-1-yl)methyl)benzamide. The reaction was purified by reverse phase HPLC to give pure N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((2-oxopiperazin-1-yl)methyl)benzamide. MS (Q1) 421.3 (M)*. 10 Example 171 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((4-methyl-2-oxopiperazin-1 yl)methyl)benzamide CI \/ \ N N 15 To 200 mg of the HCl salt of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((2-oxopiperazin-1 yl)methyl)benzamide was added 55 mg of Paraformaldehyde and 185 mg of Sodium Triacetoxyborohydride in 1 mL of 2% AcOH in DMF. After completion, the reaction is extracted 20 once with bicarbonate and brine in Ethyl Acetate, dried over Magnesium Sulfate, concentrated and purified by reverse phase HPLC to give pure N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((4-methyl-2 oxopiperazin-1-yl)methyl)benzamide. MS (Q1) 435.3 (M)*. 25 Example 172 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((4,5-dihydro-1H-imidazol-2 ylamino)methyl)benzamide 162 CI \N 0 HN CI NH / NH N 100 mg of the crude HCl salt of 4-(aminomethyl)-2-chloro-N-(4-chloro-3-(pyridin-2 yl)phenyl)benzamide was reacted with 72 mg of 1-(4,5-dihydro-1H-imidazol-2-yl)-3,5-dimethyl 5 1H-pyrazole and 100 pL of DIPEA in 500 pL of DMF in the microwave at 150'C for 5 minutes. The crude product was concentrated to dryness and purified by reverse phase HPLC to yield 2 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((4,5-dihydro-1H-imidazol-2 ylamino)methyl)benzamide. MS (Q1) 440 (M)*. 10 Example 173 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((4,5-dihydro-1H-imidazol-2 ylamino)methyl)benzamide CI \N 0 HN NH / NH N 15 100 mg of the crude HCl salt of 4-(aminomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide was reacted with 80 mg of 1-(4,5-dihydro-1H-imidazol-2-yl)-3,5-dimethyl-1H-pyrazole and 110 pL of DIPEA in 1 mL of DMF in the microwave at 150'C for 5 minutes. The crude product was concentrated to dryness and purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2 20 yl)phenyl)-4-((4,5-dihydro-1H-imidazol-2-ylamino)methyl)benzamide. MS (Q1) 406 (M)*. Example 174 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((pyridin-2-ylsulfonyl)methy)benzamide 163 CI \N 0 HN 0 - O gO N 500 mg of methyl 4-(bromomethyl)benzoate was reacted with pyridine-2-thiol via Procedure Q. 260 mg of methyl 4-((pyridin-2-ylthio)methyl)benzoate was reacted via Procedure R to give methyl 5 4-((pyridin-2-ylsulfonyl)methyl)benzoate. 275 mg of methyl 4-((pyridin-2 ylsulfonyl)methyl)benzoate was hydrolyzed via Procedure M to give 4-((pyridin-2 ylsulfonyl)methyl)benzoic acid. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4 ((pyridin-2-ylsulfonyl)methyl)benzoic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield pure N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((pyridin-2 10 ylsulfonyl)methyl)benzamide. MS (Q1) 464.1 (M)*. Example 175 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-methylmethylsulfonamido)benzamide CI \N 0 HN - 0 15 500 mg of methyl 4-(methylamino)benzoate was cooled to 0C in DCM with 270 pL of Pyridine before 260 pL Methanesulfonyl Chloride was added dropwise. Reaction was allowed to warm to room temperature and stir overnight. Solvent was concentrated and the crude material was 20 dissolved in Ethyl Acetate and extracted with 0.1N NaOH solution twice. Crude material was dried over Magnesium Sulfate, filtered and concentrated to give methyl 4-(N methylmethylsulfonamido)benzoate. 698 mg of methyl 4-(N-methylmethylsulfonamido)benzoate was hydrolyzed via Procedure M to give 4-(N-methylmethylsulfonamido)benzoic acid. 100 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(N-methylmethylsulfonamido)benzoic acid via 164 Procedure G. The crude product was purified by reverse phase HPLC to yield pure N-(4-chloro-3 (pyridin-2-yl)phenyl)-4-(N-methylmethylsulfonamido)benzamide. MS (Q1) 416.3 (M)*. 5 Example 176 2-bromo-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethy)benzamide CI \N 0 HN Br - 0 go 1.2 g of 2-bromo-4-methylbenzoic acid was brominated via Procedure N. 100 mg of 4-chloro-3 10 (pyridin-2-yl)aniline was coupled to 160 mg of 2-bromo-4-(bromomethyl)benzoic acid via Procedure E. 213 mg of 2-bromo-4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide was reacted via Procedure 0 to give 2-bromo-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (methylsulfonylmethyl)benzamide which was purified by reverse phase HPLC to afford pure 2 bromo-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide. MS (Q1) 481.2 15 (M)*. Example 177 4-((4H-1,2,4-triazol-3-ylsulfinyl)methyl)-N-(4-chloro-3-(pyridin-2 yl)phenyl)benzamide 20 CI \N 0 HN 0 S HN N 500 mg of methyl 4-(bromomethyl)benzoate was reacted with 4H-1,2,4-triazole-3-thiol via Procedure Q. 542 mg of methyl 4-((4H-1,2,4-triazol-3-ylthio)methyl)benzoate was subsequently 25 reacted via Procedure R to give an approximate 1:9 mixture of methyl 4-((4H-1,2,4-triazol-3 165 ylsulfinyl)methyl)benzoate and methyl 4-((4H-1,2,4-triazol-3-ylsulfonyl)methyl)benzoate. The mixture of 467 mg was hydrolyzed via Procedure M to give 4-((4H-1,2,4-triazol-3 ylsulfinyl)methyl)benzoic acid and 4-((4H-1,2,4-triazol-3-ylsulfonyl)methyl)benzoic acid. 107 mg of the mixture of 4-((4H-1,2,4-triazol-3-ylsulfinyl)methyl)benzoic acid and 4-((4H-1,2,4-triazol-3 5 ylsulfonyl)methyl)benzoic acid was coupled to 75 mg of 4-chloro-3-(pyridin-2-yl)aniline via Procedure G. The mixture was seperated on reverse phase HPLC to give 4-((4H-1,2,4-triazol-3 ylsulfinyl)methyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide. MS (Q1) 438.1 (M)*. 10 Example 178 4-((4H-1,2,4-triazol-3-ylsulfonyl)methyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl) benzamide CI \N 0 HN 0 S=O -N HN,,,N 15 107 mg of a mixture of 4-((4H-1,2,4-triazol-3-ylsulfinyl)methyl)benzoic acid and 4-((4H-1,2,4 triazol-3-ylsulfonyl)methyl)benzoic acid was coupled to 75 mg of 4-chloro-3-(pyridin-2-yl)aniline via Procedure G. The mixture was seperated on reverse phase HPLC to give 4-((4H-1,2,4-triazol 3-ylsulfonyl)methyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide. MS (Q1) 454.3 (M)*. 20 Example 179 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((4-methyl-4H-1,2,4-triazol-3-ylsulfinyl) methyl)benzamide CI \N 0 HN / 0 S 1N 166 500 mg of methyl 4-(bromomethyl)benzoate was reacted with 4-methyl-4H-1,2,4-triazole-3-thiol via Procedure Q. 804 mg of methyl 4-((4-methyl-4H-1,2,4-triazol-3-ylthio)methyl)benzoate was subsequently reacted via Procedure R to give an approximate 1:9 mixture of methyl 4-((4-methyl 5 4H-1,2,4-triazol-3-ylsulfinyl)methyl)benzoate and methyl 4-((4-methyl-4H-1,2,4-triazol-3 ylsulfonyl)methyl)benzoate. The mixture of 740 mg was hydrolyzed via Procedure M to give 4 ((4-methyl-4H-1,2,4-triazol-3-ylsulfinyl)methyl)benzoic acid and 4-((4-methyl-4H-1,2,4-triazol-3 ylsulfonyl)methyl)benzoic acid. 114 mg of the mixture of 4-((4-methyl-4H-1,2,4-triazol-3 ylsulfinyl)methyl)benzoic acid and 4-((4-methyl-4H-1,2,4-triazol-3-ylsulfonyl)methyl)benzoic acid 10 was coupled to 75 mg of 4-chloro-3-(pyridin-2-yl)aniline via Procedure G. The mixture was seperated on reverse phase HPLC to give N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((4-methyl-4H 1,2,4-triazol-3-ylsulfinyl)methyl)benzamide. MS (Q1) 452.3 (M)*. 15 Example 180 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((4-methyl-4H-1,2,4-triazol-3-ylsulfonyl) methyl)benzamide CI N 0 HNN 0 11 S=O

--

N 20 114 mg of the mixture of 4-((4-methyl-4H-1,2,4-triazol-3-ylsulfinyl)methyl)benzoic acid and 4-((4 methyl-4H-1,2,4-triazol-3-ylsulfonyl)methyl)benzoic acid was coupled to 75 mg of 4-chloro-3 (pyridin-2-yl)aniline via Procedure G. The mixture was separated on reverse phase HPLC to give N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((4-methyl-4H-1,2,4-triazol-3-ylsulfonyl)methyl)benzamide. MS (Q1) 468.1 (M)*. 25 Example 181 N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-(methylsulfonylmethyl)benzamide 167 CI \N 0 HN 0 300 mg of methyl 3-(bromomethyl)benzoate was reacted via Procedure 0 to give methyl 3 (methylsulfonylmethyl)benzoate. 230 mg of methyl 3-(methylsulfonylmethyl)benzoate was 5 reacted via Procedure M to give 3-(methylsulfonylmethyl)benzoic acid. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 3-(methylsulfonylmethyl)benzoic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield pure N-(4 chloro-3-(pyridin-2-yl)phenyl)-3-(methylsulfonylmethyl)benzamide. MS (Q1) 401 (M)*. 10 Example 182 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methoxy-4 (methylsulfonylmethyl)benzamide CI \N 0 HN 0 -0 s=o 15 900 mg of 2-methoxy-4-methylbenzoic acid was brominated via Procedure N to afford 4 (bromomethyl)-2-methoxybenzoic acid. 100 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 132 mg of 4-(bromomethyl)-2-methoxybenzoic acid via Procedure E. 211 mg of 4-(bromomethyl) N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methoxybenzamide was reacted via Procedure 0 and 20 purified by reverse phase HPLC to yield pure N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methoxy-4 (methylsulfonylmethyl)benzamide. MS (Q1) 431 (M)*. Example 183 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(1-(methylsulfonyl)ethyl)benzamide 25 168 CI \N 0 HN -0 s=o 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 93 mg of 4-(1-bromoethyl)benzoic acid via Procedure E. 153 mg of 4-(1-bromoethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide was 5 reacted via Procedure 0 and purified by reverse phase HPLC to give pure N-(4-chloro-3-(pyridin 2-yl)phenyl)-4-(1-(methylsulfonyl)ethyl)benzamide. MS (Q1) 415.3 (M)*. Example 184 ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzyl(methyl)phosphinate 10 CI \N 0 HN 0 P-0 90 mg of 4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide was reacted with 45 pL of diethyl methylphosphonite in the microwave at 120'C for 5 minutes. The reaction was 15 evaporated to dryness and purified by reverse phase HPLC to give pure ethyl 4-(4-chloro-3 (pyridin-2-yl)phenylcarbamoyl)benzyl(methyl)phosphinate. MS (Q1) 429 (M)*. Example 185 N-(4-chloro-3-(5-(hydroxymethyl)pyridin-2-yl)phenyl)-4-(methylsulfonyl 20 methyl)benzamide 169 CI HO O HN - 0 S=O 75 mL of (5-methylpyridin-2-yl)zinc(II) bromide was reacted with 4 g of 1-chloro-2-iodo-4 nitrobenzene via Procedure B. To 935 mg of 2-(2-chloro-5-nitrophenyl)-5-methylpyridine in 5 mL 5 of Sulfuric Acid was slowly added 2.25 g of Chromium (III) Oxide and the reaction was stirred for several hours at room temperature until complete. Icewater was added to dilute the reaction and the aqueous layer was extracted 3 times with Ethyl Acetate. The organic layers were combined, dried over Magnesium Sulfate, filtered and concentrated to give 6-(2-chloro-5 nitrophenyl)nicotinic acid. 704 mg of 6-(2-chloro-5-nitrophenyl)nicotinic acid was esterified with 10 3.1 mL of 4N HCl in Dioxane in 20 mL of MeOH. The reaction was concentrated and subjected to basic workup, dried over Magnesium Sulfate, filtered and concentrated to give methyl 6-(2-chloro 5-nitrophenyl)nicotinate. 681 mg of methyl 6-(2-chloro-5-nitrophenyl)nicotinate was treated with 2.1 g of Tin (II) Chloride and 1 mL of HCl in 25 mL of EtOH. Upon completion, EtOH was concentrated and the reaction was extracted with Ethyl Acetate and water with TEA to decrease 15 emulsions. The organic layer was dried over Magnesium Sulfate, filtered and concentrated to give crude methyl 6-(5-amino-2-chlorophenyl)nicotinate. 296 mg of methyl 6-(5-amino-2 chlorophenyl)nicotinate was coupled to 266 mg of 4-(methylsulfonylmethyl)benzoic acid via Procedure G. To 518 mg of methyl 6-(2-chloro-5-(4 (methylsulfonylmethyl)benzamido)phenyl)nicotinate at 0C in 20 mL of EtOH was slowly added 20 640 mg of Sodium Borohydride. The reaction was subsquently refluxed for 1 hour until complete, quenched with water and extracted with Ethyl Acetate. The organic layer was dried over Magnesium Sulfate, filtered, concentrated and purified by reverse phase HPLC to give pure N-(4 chloro-3-(5-(hydroxymethyl)pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide. MS (Q1) 431.1 (M)*. 25 Example 186 6-(2-chloro-5-(2-methyl-6-(trifluoromethyl)nicotinamido)phenyl)nicotinate 170 CI 0 -O O HN / \N F F F 200 mg of methyl 6-(5-amino-2-chlorophenyl)nicotinate was treated with 255 pL of 2-methyl-6 (trifluoromethyl)nicotinoyl chloride via Procedure D and purified by reverse phase HPLC to give 5 pure 6-(2-chloro-5-(2-methyl-6-(trifluoromethyl)nicotinamido)phenyl)nicotinate. MS (Q1) 450 (M)*. Example 187 N-(4-chloro-3-(5-(hydroxymethyl)pyridin-2-yl)phenyl)-2-methyl-6 10 (trifluoromethyl)nicotinamide CI HO O 0 HN / \N F F F To 110 mg of methyl 6-(2-chloro-5-(2-methyl-6-(trifluoromethyl)nicotinamido)phenyl)nicotinate at 15 0 C in 5 mL of EtOH was slowly added 148 mg of Sodium Borohydride. The reaction was subsquently refluxed for 1 hour until complete, quenched with water and extracted with Ethyl Acetate. The organic layer was dried over Magnesium Sulfate, filtered, concentrated and purified by reverse phase HPLC to give pure N-(4-chloro-3-(5-(hydroxymethyl)pyridin-2-yl)phenyl)-2 methyl-6-(trifluoromethyl)nicotinamide. MS (Q1) 422.1 (M)*. 20 Example 188 N-(4-chloro-3-(5-(methylcarbamoyl)pyridin-2-yl)phenyl)-2-methyl-6 (trifluoromethyl)nicotinamide 171 CI 0 O NH N 0 HN / \N F F F 120 mg of 6-(2-chloro-5-(2-methyl-6-(trifluoromethyl)nicotinamido)phenyl)nicotinate was hydrolyzed via Procedure M. 112 mg of 6-(2-chloro-5-(2-methyl-6 5 (trifluoromethyl)nicotinamido)phenyl)nicotinic acid was coupled to Methylamine Hydrochloride via Procedure G and purified by reverse phase HPLC to give pure N-(4-chloro-3-(5 (methylcarbamoyl)pyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide. MS (Q1) 449 (M)+. 10 Example 189 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((2,2,2 trifluoroethylamino)methyl)benzamide. CI \N 0 HN CI NH F F F 15 To 24.9 g of 2-chloro-4-(methoxycarbonyl)benzoic acid and 2 mL of Sulfuric Acid in 350 mL of DCM was added isobutylene gas at -78'C until the solvent was saturated and capped off securely. Let go several days at room temperature and re-cool to -78'C before removing cap. Concentrate solvent, extract with Ethyl Acetate and bicarbonate, dry with Magnesium Sulfate, filter and 20 concentrate to give 31.4 g of 1-tert-butyl 4-methyl 2-chloroterephthalate. 3.35 g of 1-tert-butyl 4 methyl 2-chloroterephthalate was hydrolyzed via Procedure M. 2.5 g of 4-(tert-butoxycarbonyl)-3 chlorobenzoic acid was was cooled to OC in 25 mL of THF before a solution of 19.5 mL of IM

BH

3 -THF complex in THF was added dropwise. The ice bath was subsequently removed and the reaction was stirred at room temperature until reaction stalled out at -50% complete by TLC. The 25 reaction is re-cooled to 0C and another 19.5 mL of BH 3 -THF is added dropwise before the ice 172 bath is removed. Upon completion, the reaction is re-cooled to 0C and quenched with 3N HCl dropwise. The aqueous layer was extracted two times with Ethyl Acetate and the organic layer was then extracted once with bicarbonate solution and brine, dried over Magnesium Sulfate, filtered and concentrated to give tert-butyl 2-chloro-4-(hydroxymethyl)benzoate. 564 mg of tert 5 butyl 2-chloro-4-(hydroxymethyl)benzoate was cooled to OC in 5 mL of DCM before adding 665 mg of Triphenylphosphine and 417 mg of NBS. Reaction was concentrated and directly purified via ISCO Combi-Flash to give pure tert-butyl 2-chloro-4-(hydroxymethyl)benzoate. 147 mg of tert-butyl 4-(bromomethyl)-2-chlorobenzoate was reacted with 2,2,2-trifluoroethanamine in DMSO via Procedure P. 141 mg of tert-butyl 2-chloro-4-((2,2,2-trifluoroethylamino)methyl)benzoate was 10 treated with 4N HCl in Dioxane at 45'C and concentrated to give 2-chloro-4-((2,2,2 trifluoroethylamino)methyl)benzoic acid. 50 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 75 mg of 2-chloro-4-((2,2,2-trifluoroethylamino)methyl)benzoic acid via Procedure G . The crude product was purified by reverse phase HPLC to give pure 2-chloro-N-(4-chloro-3-(pyridin-2 yl)phenyl)-4-((2,2,2-trifluoroethylamino)methyl)benzamide. MS (Q1) 454.6 (M)*. 15 Example 190 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide CI \N 0 HN CI - 0 go 20 3.01 g of tert-butyl 4-(bromomethyl)-2-chlorobenzoate was reacted via Procedure 0 to give tert butyl 2-chloro-4-(methylsulfonylmethyl)benzoate. 1.2 g of tert-butyl 2-chloro-4 (methylsulfonylmethyl)benzoate was treated with 10 mL of 4N HCl in Dioxane at 45 C and concentrated upon completion to give crude 2-chloro-4-(methylsulfonylmethyl)benzoic acid. 775 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 1 g of 2-chloro-4 25 (methylsulfonylmethyl)benzoic acid via Procedure G. The crude product was purified by reverse phase HPLC to give pure 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (methylsulfonylmethyl)benzamide. MS (Q1) 435 (M)*. 30 Example 191 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(methylsulfonamido)nicotinamide 173 CI \N 0 HN / NN -0 HN_-:--O 100 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)nicotinamide was reacted with methanesulfonamide and 108 pL of 2-tert-Butylimino-2-diethylamino-1,3-dimethyl-perhydro 5 1,3,2-diazaphosphorine via Procedure F. The crude reaction was concentrated to dryness and purified by reverse phase HPLC to give pure N-(4-chloro-3-(pyridin-2-yl)phenyl)-6 (methylsulfonamido)nicotinamide. MS (Qi) 403 (M)*. 10 Example 192 4-((1H-1,2,4-triazol-1-yl)methyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide CI \/ /\ N 0 HNN \-N 88 mg of 4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide was coupled to 45 mg 15 of 1H-1,2,4-triazole via Procedure P. The reaction was evaporated to dryness and purified by reverse phase HPLC to yield 4-((1H-1,2,4-triazol-1-yl)methyl)-N-(4-chloro-3-(pyridin-2 yl)phenyl)benzamide. MS (Qi) 390 (M)*. 20 Example 193 4-((1H-1,2,3-triazol-1-yl)methyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide 174 CI N 0 HN

/\-

N 88 mg of 4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide was coupled to 40 pL of 1H-1,2,3-triazole via Procedure P. The reaction was evaporated to dryness and purified by reverse 5 phase HPLC to yield 4-((1H-1,2,3-triazol-1-yl)methyl)-N-(4-chloro-3-(pyridin-2 yl)phenyl)benzamide. MS (Q1) 390.1 (M)*. Example 194 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((3,5-dimethyl-1H-pyrazol-1 10 yl)methyl)benzamide CI \N 0 HN N7 70 mg of 4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide was coupled to 50 mg of 15 3,5-dimethyl-1H-pyrazole via Procedure P. The reaction was evaporated to dryness and purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((3,5-dimethyl-1H-pyrazol 1-yl)methyl)benzamide. MS (Q1) 417.3 (M)*. 20 Example 195 4-((1H-pyrazol-1-yl)methyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide 175 CI \N 0 HN N N 70 mg of 4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide was coupled to 36 mg of 1H-pyrazole via Procedure P. The reaction was evaporated to dryness and purified by reverse 5 phase HPLC to yield 4-((1H-pyrazol-1-yl)methyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide. MS (Q1) 389.3 (M)*. Example 196 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(methylsulfonylmethyl)nicotinamide 10 CI \N 0 HN / \N 0 1.2 g of 6-methylnicotinic acid was brominated via Procedure N to give 6-(bromomethyl)nicotinic acid. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 87 mg of 6-(bromomethyl)nicotinic 15 acid via Procedure E. 145 mg of 6-(bromomethyl)-N-(4-chloro-3-(pyridin-2 yl)phenyl)nicotinamide was reacted via Procedure 0 and purified by reverse phase HPLC to yield pure N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(methylsulfonylmethyl)nicotinamide. MS (Q1) 402 (M)+. 20 Example 197 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-hydroxycarbamimidoyl)benzamide 176 CI \N 0 HN NH HN OH 240 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 207 mg of 4-cyanobenzoic acid via 5 Procedure G. To 445 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-cyanobenzamide and 2.5 mL of DIPEA in 10 mL of EtOH was added 793 mg Hydroxylamine Hydrochloride and heated to 60'C until reaction was complete. The solvent was subsequently evaporated, extracted twice with water in Ethyl Acetate, dried with Magnesium Sulfate, filtered and concentrated. The crude product was purified by reverse phase HPLC to give pure N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N 10 hydroxycarbamimidoyl)benzamide. MS (Q1) 367.4 (M)*. Example 198 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-methoxycarbamimidoyl)benzamide CI N 0 HN NH 15 HN 0 100 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-hydroxycarbamimidoyl)benzamide was cooled to 0C in 1.5 mL of Dioxane. 5 mL of 2N NaOH was slowly added followed by dropwise addition of 33 pL of dimethylsulfate. The ice bath was removed and reaction was stirred at room 20 temperature for 1 hour. The reaction was subsequently evaporated and extracted with water twice in Ethyl Acetate, dried with Magnesium Sulfate, filtered and concentrated to yield pure N-(4 chloro-3-(pyridin-2-yl)phenyl)-4-(N-methoxycarbamimidoyl)benzamide. MS (Q1) 381 (M)*. 25 Example 199 N-(4-chloro-3-(4-(hydroxymethyl)pyridin-2-yl)phenyl)-2-methyl-6 (trifluoromethyl)nicotinamide 177 HO CI N HN N F F F 75 mL of (4-methylpyridin-2-yl)zinc(II) bromide was reacted with 4 g of 1-chloro-2-iodo-4 5 nitrobenzene via Procedure B. To 300 mg of 2-(2-chloro-5-nitrophenyl)-4-methylpyridine in 1.5 mL of Sulfuric Acid was slowly added 362 mg of Chromium (III) Oxide and the reaction was stirred for several hours at room temperature until complete. Icewater was added to dilute the reaction and the aqueous layer was extracted 3 times with Ethyl Acetate. The organic layers were combined, dried over Magnesium Sulfate, filtered and concentrated to give 2-(2-chloro-5 10 nitrophenyl)isonicotinic acid. 300 mg of 2-(2-chloro-5-nitrophenyl)isonicotinic acid was esterified with 750 iL of 4N HCl in Dioxane in 10 mL of MeOH at 55C for 16 hours. The reaction was concentrated and subjected to basic workup, dried over Magnesium Sulfate, filtered and concentrated to give methyl 2-(2-chloro-5-nitrophenyl)isonicotinate. 259 mg of methyl 2-(2 chloro-5-nitrophenyl)isonicotinate was treated with 200 mg of Tin (II) Chloride and 500 pL of HCl 15 in 10 mL of EtOH. Upon completion, EtOH was concentrated and the reaction was extracted with Ethyl Acetate and water with TEA to decrease emulsions. The organic layer was dried over Magnesium Sulfate, filtered and concentrated to give crude methyl 2-(5-amino-2 chlorophenyl)isonicotinate. 240 mg of methyl methyl 2-(5-amino-2-chlorophenyl)isonicotinate was treated with 204 pL of 2-methyl-6-(trifluoromethyl)nicotinoyl chloride via Procedure D. To 20 100 mg of methyl 2-(2-chloro-5-(2-methyl-6-(trifluoromethyl)nicotinamido)phenyl)isonicotinate at 0C in 5 mL of EtOH was slowly added 135 mg of Sodium Borohydride. The reaction was subsquently refluxed for 1 hour until complete, quenched with water and extracted with Ethyl Acetate. The organic layer was dried over Magnesium Sulfate, filtered, concentrated and purified by reverse phase HPLC to give pure N-(4-chloro-3-(4-(hydroxymethyl)pyridin-2-yl)phenyl)-2 25 methyl-6-(trifluoromethyl)nicotinamide. MS (Q1) 422.1 (M)*. Example 200 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylamide)benzamide 178 CI \N 0 HN 0 -1 O 300 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 270 mg of 4-nitrobenzoic acid via Procedure G. To 520 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-nitrobenzamide in 2.5 mL of 5 HCl in 10 mL of EtOH was added 1.3 g of Tin (II) Chloride and stirred at 55C. Upon completion, the reaction was concentratd and extracted with Ethyl Acetate in water with TEA to reduce emulsions. The organic layer was dried over Magnesium Sulfate, filtered and concentrated to give 4-amino-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide. 100 mg of 4-amino-N-(4-chloro-3 (pyridin-2-yl)phenyl)benzamide was reacted with 30 pL of Methanesulfonyl Chloride and 90 pL 10 DIPEA in 500 pL DCM. The reaction mixture was evaporated, subjected to basic workup conditions and purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (methylsulfonylamide)benzamide. MS (Q1) 402 (M)*. 15 Example 201 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(1-methylethylsulfonamido)benzamide CI \N 0 HN - 0 HN-SO 151 mg of 4-amino-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide was reacted with 105 pL of 20 propane-2-sulfonyl chloride and 205 pL DIPEA in 500 pL DCM. The reaction mixture was evaporated, subjected to basic workup conditions and purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(1-methylethylsulfonamido)benzamide. MS (Q1) 430 (M)*. 25 Example 202 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide 179 CI \N 0 HN 0 90 1 g of methyl 4-(bromomethyl)benzoate was reacted via Procedure 0. 2.77 g of methyl 4 5 (methylsulfonylmethyl)benzoate was hydrolyzed via Procedure M. Ig of 4-chloro-3-(pyridin-2 yl)aniline was coupled to 1.15 g of 4-(methylsulfonylmethyl)benzoic acid via Procedure G. The crude product was subjected to basic workup and recrystallized with 1:1 Ratio of Isopropylacetate and Ether to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide. MS (Q1) 401 (M)*. 10 Example 203 4-(4-acetylpiperazin-1-ylsulfonyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide CI \N 0 HN 0 \ --- 0 15 1 g of 4-(chlorosulfonyl)benzoic acid was reacted with 646 pL of 1-(piperazin-1-yl)ethanone via Procedure H. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 125 mg of 4-(4 acetylpiperazin-1-ylsulfonyl)benzoic acid via Procedure G and purified by reverse phase HPLC to yield 4-(4-acetylpiperazin-1-ylsulfonyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide. MS (Q1) 20 499.4 (M)*. Example 204 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-(2-hydroxyethyl)piperazin-1 ylsulfonyl)benzamide 25 180 CI \ / 0 HN S-N N OH 1 g of 4-(chlorosulfonyl)benzoic acid was reacted with 615 pL of 2-(piperazin-1-yl)ethanol via Procedure H. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 125 mg of 4-(4-(3 5 hydroxypropyl)piperazin-1-ylsulfonyl)benzoic acid by Procedure G and purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-(2-hydroxyethyl)piperazin-1 ylsulfonyl)benzamide. MS (Q1) 501.3 (M)*. 10 Example 205 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-hydroxypiperidin-1 ylsulfonyl)benzamide CI \N 0 HN cr \\-ND OH OH 0 15 1 g of 4-(chlorosulfonyl)benzoic acid was reacted with 506 pL of piperidin-4-ol via Procedure H. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 114 mg of 4-(4-hydroxypiperidin-1 ylsulfonyl)benzoic acid via Procedure G and purified by reverse phase HPLC to yield N-(4-chloro 3-(pyridin-2-yl)phenyl)-4-(4-hydroxypiperidin-1-ylsulfonyl)benzamide. MS (Q1) 472.3 (M)*. 20 Example 206 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2,6 dimethylmorpholinosulfonyl)benzamide 181 CI \N 0

HN

/ ~\ Or SN O 0 1 g of 4-(chlorosulfonyl)benzoic acid was reacted with 616 pL of 2,6-dimethylmorpholine via Procedure H. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 120 mg of 4-(2,6 5 dimethylmorpholinosulfonyl)benzoic acid via Procedure G and purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2,6-dimethylmorpholinosulfonyl)benzamide. MS (Q1) 486.3 (M)*. 10 Example 207 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(3,5-dimethylpiperazin-1 ylsulfonyl)benzamide CI \N 0 HN S-N NH 05- \\ 0 15 1 g of 4-(chlorosulfonyl)benzoic acid was reacted with 570 mg of 2,6-dimethylpiperazine via Procedure H. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 119 mg of 4-(3,5 dimethylpiperazin-1-ylsulfonyl)benzoic acid via Procedure G and purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(3,5-dimethylpiperazin-1-ylsulfonyl)benzamide. MS (Q1) 485.4 (M)*. 20 Example 208 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-ethylpiperazin-1-ylsulfonyl)benzamide 182 CI \N 0 HN ,S-N N 0 1 g of 4-(chlorosulfonyl)benzoic acid was reacted with 570 mg of 1 -ethylpiperazine via Procedure H. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(4-ethylpiperazin-1 5 ylsulfonyl)benzoic acid via Procedure G and purified by reverse phase HPLC to yield N-(4-chloro 3-(pyridin-2-yl)phenyl)-4-(4-ethylpiperazin-1-ylsulfonyl). MS (Q1) 485 (M)*. Example 209 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(piperazin-1-ylsulfonyl)benzamide 10 CI \N 0 HN S-N NH 0 1 g of 4-(chlorosulfonyl)benzoic acid was reacted with 931 mg of tert-butyl piperazine-1 carboxylate via Procedure H. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 150 mg of 15 4-(4-(tert-butoxycarbonyl)piperazin-1-ylsulfonyl)benzoic acid via Procedure G. The crude product was subjected to basic workup conditions, treated with TFA to remove the Boc group and purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(piperazin-1 ylsulfonyl)benzamide. MS (Q1) 457.1 (M)*. 20 Example 210 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-(2,2,2 trifluoroethyl)sulfamoyl)benzamide 183 CI \N 0 HN F /-+ F S-NH F 0 - \\ 0 1 g of 4-(chlorosulfonyl)benzoic acid was reacted with 500 pL of 2,2,2-trifluoroethanamine via Procedure H. 60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 92 mg of 4-(N-(2,2,2 5 trifluoroethyl)sulfamoyl)benzoic acid by Procedure G and purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-(2,2,2-trifluoroethyl)sulfamoyl)benzamide. MS (Q1) 470 (M)*. 10 Example 211 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-sulfamoylbenzamide CI HN CI CASbNH 2 A solution of 818 mg of Sodium Nitrite in 13 mL of water was added dropwise to a solution of 2g 15 of methyl 4-amino-2-chlorobenzoate in 5 mL of HCl and 15 mL of AcOH at 0 C. The reaction was removed from the ice bath and stirred at room temperature for 15 minutes. Simultaneously a solution of 460 mg of Copper II Chloride Dihydrate in 1 mL of water was added to a saturated solution of sulfur dioxide gas in 10 mL of AcOH at 0 C. The cooled solution containing Copper II Chloride and sulfur dioxide gas was slowly added to the re-cooled initial solution containing 20 Sodium Nitrite. The reaction was warmed to room temperature and stirred until gas no longer evolved. The reaction was filtered through celite and poured into a beaker of stirred icewater until a yellow-orange solid crashed out. The icewater solution was filtered thru a Buchner funnel to collect the methyl 2-chloro-4-(chlorosulfonyl)benzoate precipitate and was dried for 24 hours under vacuum. Ig of methyl 2-chloro-4-(chlorosulfonyl)benzoate was added to a solution of 2 mL 25 of 2M solution of Ammonia in MeOH and 970 pL DIPEA in 5 mL MeOH. Upon completion the 184 reaction was concentrated, extracted twice with saturated bicarbonate, dried with Magnesium Sulfate, filtered and concentrated to give methyl 2-chloro-4-sulfamoylbenzoate. 777 mg of methyl 2-chloro-4-sulfamoylbenzoate was hydrolyzed via Procedure M to yield crude 2-chloro-4 sulfamoylbenzoic acid. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 91 mg of crude 5 2-chloro-4-sulfamoylbenzoic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-sulfamoylbenzamide. MS (Q 1) 422 (M)*. 10 Example 212 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(piperidin-4-ylmethyl)benzamide CI \N 0 HN NH 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 125 mg of 4-((1-(tert butoxycarbonyl)piperidin-4-yl)methyl)benzoic acid via Procedure G. The crude product was treated with 4N HCl in Dioxane, evaporated and purified by reverse phase HPLC to yield N-(4 15 chloro-3-(pyridin-2-yl)phenyl)-4-(piperidin-4-ylmethyl)benzamide. MS (Q1) 406.1 (M)*. Example 213 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonamido)benzamide CI \N 0 HN CI - 200 20 0 4.2 g of methyl 2-chloro-4-(methylsulfonamido)benzoate was hydrolyzed via Procedure M. 1 g of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 1.35 g of 2-chloro-4-(methylsulfonamido)benzoic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield 2-chloro-N 25 (4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonamido)benzamide. MS (Q1) 436.1 (M)*. 185 Example 214 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(1H-imidazol-1-yl)benzamide CI \N 0 HN / \ N 5 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 78 mg of 4-(1H-imidazol-1-yl)benzoic acid via Procedure G . The crude product was purified by reverse phase HPLC to yield N-(4 chloro-3-(pyridin-2-yl)phenyl)-4-(1H-imidazol-1-yl)benzamide. MS (Q1) 375.3 (M)*. 10 Example 215 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-hydroxy-2 methylpropylsulfonyl)-benzamide CI \N 0 HN CI

-

OH O \ 0 15 8 g of methyl 4-amino-2-chlorobenzoate was dissolved in 16 mL of MeOH, 8 mL of H 2 0 and 8 mL of concentrated hydrochloric acid and was then cooled to 0 C. A solution of 3.9 g of sodium nitrite in 15 mL of H 2 0 was added dropwise over 30 min. The reaction was stirred at 0 C for an additional lh. The cold diazonating mixture was added to a solution of 13.8 g of potassium ethyl xanthate in 10 mL of H 2 0 at 50-60 C. The reaction was heated to 65 C for 2h and monitored by 20 TLC until complete. The mixture was cooled to 25 C and extracted with ethyl acetate. The combined organic extracts were washed with brine, dried (MgSO 4 ), and concentrated. Purified by silica gel chromatography (0-10% ethyl acetate/hexane) to afford methyl 2-chloro-4 (ethoxycarbonothioylthio)benzoate. A solution of 2.6 g of sodium hydroxide in 20 mL of H 2 0 was added to 5.9 g of methyl 2-chloro-4-(ethoxycarbonothioylthio)benzoate in 40 mL of EtOH The 25 reaction mixture was heated to 70 C for lh. Upon completion, the mixture was cooled to 25 'C, 186 and then acidified to pH 3 by the addition of 10 N HCl. The solid was filtered and washed with

H

2 0 to give 2-chloro-4-mercaptobenzonic acid. 3.8 g of 2-chloro-4-mercaptobenzonic acid in 40 mL of 5% sulfuric acid-methanol was refluxed under nitrogen atmosphere for 3h. After concentration of the reaction mixture, 10 mL of H 2 0 was added and the resulting mixture was 5 made alkaline with sodium hydrogen carbonate, and extracted with ethyl acetate. The organic layer was washed with brine, dried (MgSO 4 ), and evaporated to yield methyl 2-chloro-4 mercaptobenzoate. 80 mg of isobutylene oxide was reacted with methyl 2-chloro-4 mercaptobenzoate via Procedure S to afford methyl 2-chloro-4-(2-hydroxy-2 methylpropylthio)benzoate. 190 mg of methyl 2-chloro-4-(2-hydroxy-2 10 methylpropylthio)benzoate was hydrolyzed via Procedure M to give 2-chloro-4-(2-hydroxy-2 methylpropylthio)benzoic acid. 160 mg of 2-chloro-4-(2-hydroxy-2-methylpropylthio)benzoic acid was reacted via procedure R to give 2-chloro-4-(2-hydroxy-2-methylpropylsulfonyl)benzoic acid. 60 mg of 4-chloro-3-(pyridine-2-yl)aniline was coupled to 2-chloro-4- (2-hydroxy-2 methylpropylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase 15 HPLC to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-hydroxy-2 methylpropylsulfonyl)benzamide. MS (Q1) 479.1 (M)*. Example 216 (R)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-hydroxy-2 20 phenylethylsulfonyl)benzamide CI (N 0 HN- CH - s On \ O 0 150 mg of (R)-styrene oxide was reacted with methyl 2-chloro-4-mercaptobenzoate via Procedure S to afford (R)-methyl 2-chloro-4-(2-hydroxy-2-phenylethylthio)benzoate. 190 mg of (R)-methyl 25 2-chloro-4-(2-hydroxy-2-phenylethylthio)benzoate was hydrolyzed via Procedure M to give (R)-2 chloro-4-(2-hydroxy-2-phenylethylthio)benzoic acid. 170 mg of (R)-2-chloro-4-(2-hydroxy-2 phenylethylthio)benzoic acid was reacted via Procedure R to give (R)-2-chloro-4-(2-hydroxy-2 phenylethylsulfonyl)benzoic acid. 60 mg of 4-chloro-3-(pyridine-2-yl)aniline was coupled to (R) 2-chloro-4-(2-hydroxy-2-phenylethylsulfonyl)benzoic acid via Procedure G. The product was 30 purified on reverse phase HPLC to yield (R)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2 hydroxy-2-phenylethylsulfonyl)benzamide. MS (Q1) 527.2 (M)*. 187 Example 217 (S)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-hydroxy-2-phenylethyl sulfonyl)benzamide 5 CI \N 0 HN- CI -S 0 119 mg of (S)-styrene oxide was reacted with methyl 2-chloro-4-mercaptobenzoate via Procedure S to afford (S)-methyl 2-chloro-4-(2-hydroxy-2-phenylethylthio)benzoate. 230 mg of (S)-methyl-2 10 chloro-4-(2-hydroxy-2-phenylethylthio)benzoate was hydrolyzed via Procedure M to give (S)-2 chloro-4-(2-hydroxy-2-phenylethylthio)benzoic acid. 180 mg of (S)-2-chloro-4-(2-hydroxy-2 phenylethylthio)benzoic acid was reacted via Procedure R to give (S)-2-chloro-4-(2-hydroxy-2 phenylethylsulfonyl)benzoic acid. 60 mg of 4-chloro-3-(pyridine-2-yl)aniline was coupled to (S) 2-chloro-4-(2-hydroxy-2-phenylethylsulfonyl)benzoic acid via Procedure G. The product was 15 purified on reverse phase HPLC to yield (S)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2 hydroxy-2-phenylethylsulfonyl)benzamide. MS (Q1) 527.0 (M)*. Example 218 (R)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-hydroxypropysulfonyl) 20 benzamide CI \N 0 HN CI HO O \ 0 140 mg of (R)-propylene oxide was reacted with methyl 2-chloro-4-mercaptobenzoate via Procedure S to afford (R)-methyl 2-chloro-4-(2-hydroxypropylthio)benzoate. 435 mg of (R) 25 methyl-2-chloro-4-(2-hydroxypropylthio)benzoate was hydrolyzed via Procedure M to give (R)-2 188 chloro-4-(2-hydroxypropylthio)benzoic acid. 403 mg of (R)-2-chloro-4-(2 hydroxypropylthio)benzoic acid was reacted via Procedure R to give (R)-2-chloro-4-(2 hydroxypropylsulfonyl)benzoic acid. 298 mg of 4-chloro-3-(pyridine-2-yl)aniline was coupled to (R)-2-chloro-4-(2-hydroxypropylsulfonyl)benzoic acid via Procedure G. The product was purified 5 on reverse phase HPLC to yield (R)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2 hydroxypropylsulfonyl)benzamide. MS (Q1) 465.1 (M)*. Example 219 (S)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-hydroxypropysulfonyl) 10 benzamide CI N 0 HN CI HO O ' 0 86 mg of (S)-propylene oxide was reacted with methyl 2-chloro-4-mercaptobenzoate via Procedure 15 S to afford (S)-methyl 2-chloro-4-(2-hydroxypropylthio)benzoate. 275 mg of (S)-methyl-2-chloro 4-(2-hydroxypropylthio)benzoate was hydrolyzed via Procedure M to give (S)-2-chloro-4-(2 hydroxypropylthio)benzoic acid. 220 mg of (S)-2-chloro-4-(2-hydroxypropylthio)benzoic acid was reacted via Procedure R to give (S)-2-chloro-4-(2-hydroxypropylsulfonyl)benzoic acid. 70 mg of 4-chloro-3-(pyridine-2-yl)aniline was coupled to (S)-2-chloro-4-(2-hydroxypropylsulfonyl)benzoic 20 acid via Procedure G. The product was purified on reverse phase HPLC to yield (S)-2-chloro-N (4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-hydroxypropylsulfonyl)benzamide. MS (Q1) 465.0 (M)* Example 220 (R)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-hydroxypropylsulfonyl)benzamide CI \N 0 HN HO 25 0 189 100 mg of (R)-propylene oxide was reacted with methyl 4-mercaptobenzoate via Procedure S to afford (R)-methyl 4-(2-hydroxypropylthio)benzoate. 169 mg of (R)-methyl 4-(2 hydroxypropylthio)benzoate was reacted via Procedure R to give (R)-methyl 4-(2 5 hydroxypropylsulfonyl)benzoate. 179 mg of (R)-methyl 4-(2-hydroxypropylsulfonyl)benzoate was hydrolyzed via Procedure M to give (R)-4-(2-hydroxypropylsulfonyl)benzoic acid. 45 mg of 4 chloro-3-(pyridine-2-yl)aniline was coupled to (R)-4-(2-hydroxypropylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield (R)-N-(4-chloro-3 (pyridin-2-yl)phenyl)-4-(2-hydroxypropylsulfonyl)benzamide. MS (Q1) 431.2 (M)*. 10 Example 221 (S)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-hydroxypropylsulfonyl)benzamide CI \N 0 HN HO O'" 0 15 150 mg of (S)-propylene oxide was reacted with methyl 4-mercaptobenzoate via Procedure S to afford (S)-methyl 4-(2-hydroxypropylthio)benzoate. 650 mg of (S)-methyl 4-(2 hydroxypropylthio)benzoate was reacted via Procedure R to give (S)-methyl 4-(2 hydroxypropylsulfonyl)benzoate. 350 mg of (S)-methyl 4-(2-hydroxypropylsulfonyl)benzoate was hydrolyzed via Procedure M to give (S)-4-(2-hydroxypropylsulfonyl)benzoic acid. 45 mg of 4 20 chloro-3-(pyridine-2-yl)aniline was coupled to (S)-4-(2-hydroxypropylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield (S)-N-(4-chloro-3 (pyridin-2-yl)phenyl)-4-(2-hydroxypropylsulfonyl)benzamide. MS (Q1) 431.3 (M)*. 25 Example 222 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(pyridin-3-ylmethylsulfonyl)benzamide 190 CI \N 0 HN 0 "\ 0 Ig of 3-(bromomethyl)pyridine hydrobromide was reacted with methyl 4-mercaptobenzoate via Procedure Q to afford methyl 4-(pyridin-3-ylmethylthio)benzoate. 980 mg of methyl 4-(pyridin-3 5 ylmethylthio)benzoate was reacted via Procedure R to give methyl 4-(pyridin-3 ylmethylsulfonyl)benzoate. 760 mg of methyl 4-(pyridin-3-ylmethylsulfonyl)benzoate was hydrolyzed via Procedure M to give 4-(pyridin-3-ylmethylsulfonyl)benzoic acid. 60 mg of 4 chloro-3-(pyridin-2-yl)aniline was coupled to 4-(pyridin-3-ylmethylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2 10 yl)phenyl)-4-(pyridin-3-ylmethylsulfonyl)benzamide. MS (Q1) 464.1 (M)*. Example 223 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(pyridin-2-ylmethylsulfonyl)benzamide CI \ / 0/ N 0 HN 15 0 Ig of 2-(bromomethyl)pyridine hydrobromide was reacted with methyl 4-mercaptobenzoate via Procedure Q to afford methyl 4-(pyridin-2-ylmethylthio)benzoate. 500 mg of methyl 4-(pyridin-2 ylmethylthio)benzoate was reacted via Procedure R to give methyl 4-(pyridin-2 20 ylmethylsulfonyl)benzoate. 470 mg of methyl 4-(pyridin-2-ylmethylsulfonyl)benzoate was hydrolyzed via Procedure M to give 4-(pyridin-2-ylmethylsulfonyl)benzoic acid. 70 mg of 4 chloro-3-(pyridin-2-yl)aniline was coupled to 4-(pyridin-2-ylmethylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2 yl)phenyl)-4-(pyridin-2-ylmethylsulfonyl)benzamide. MS (Q1) 464.1 (M)*. 25 191 Example 224 4-(2-amino-2-oxoethylsulfonyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide CI \N 0 HN

NH

2 0 5 2.5 g of 2-bromoacetamide was reacted with methyl 4-mercaptobenzoate via Procedure Q to afford methyl 4-(2-amino-2-oxoethylthio)benzoate. 2.6 g of methyl 4-(2-amino-2-oxoethylthio)benzoate was reacted via Procedure R to give methyl 4-(2-amino-2-oxoethylsulfonyl)benzoate. 1 g of methyl 4-(2-amino-2-oxoethylsulfonyl)benzoate was hydrolyzed via Procedure M to give 4-(2 10 amino-2-oxoethylsulfonyl)benzoic acid. 150 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(2-amino-2-oxoethylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield 4-(2-amino-2-oxoethylsulfonyl)-N-(4-chloro-3-(pyridin-2 yl)phenyl)benzamide. MS (Q1) 430.2 (M)*. 15 Example 225 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2 hydroxypropylsulfonyl)benzamide CI \N 0 HN CI HO O ' 0 20 2 g of 2-chloro-4-fluorobenzonitrile was reacted with 1-mercapto-2-propanol via Procedure Q to afford 2-chloro-4-(2-hydroxypropylthio)benzonitrile. 2.5 g of 2-chloro-4-(2 hydroxypropylthio)benzonitrile was reacted via Procedure T to give 2-chloro-4-(2 hydroxypropylthio)benzoic acid. 2.1 g of 2-chloro-4-(2-hydroxypropylthio)benzoic acid was 25 reacted via Procedure R to give 2-chloro-4-(2-hydroxypropylsulfonyl)benzoic acid. 70 mg of 4 192 chloro-3-(pyridin-2-yl)aniline was coupled to 2-chloro-4-(2-hydroxypropylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N-(4-chloro 3-(pyridin-2-yl)phenyl)-4-(2-hydroxypropylsulfonyl)benzamide. MS (Q1) 465.2 (M)*. 5 Example 226 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-hydroxypropylsulfonyl)-2 methylbenzamide CI \N 0 HN HO O \ 0 10 2 g of 4-bromo-2-methylbenzonitrile was reacted with 1-mercapto-2-propanol via Procedure Q to afford 4-(2-hydroxypropylthio)-2-methylbenzonitrile. 950 mg of 4-(2-hydroxypropylthio)-2 methylbenzonitrile was reacted via Procedure T to give 4-(2-hydroxypropylthio)-2-methylbenzoic acid. 1.0 g of 4-(2-hydroxypropylthio)-2-methylbenzoic acid was reacted via Procedure R to give 15 4-(2-hydroxypropylsulfonyl)-2-methylbenzoic acid. 100 mg of 4-chloro-3-(pyridin-2 yl)aniline was coupled to 4-(2-hydroxypropylsulfonyl)-2-methylbenzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (2-hydroxypropylsulfonyl)-2-methylbenzamide. MS (Q1) 445.3 (M)*. 20 Example 227 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-hydroxyethylsulfonyl)benzamide CI \N 0 HN O OH 0 5 g of 4-fluorobenzonitrile was used in Procedure Q with 2-mercaptoethanol to afford 4-(2 25 hydroxyethylthio)benzonitrile. 900 mg of 4-(2-hydroxyethylthio)benzonitrile was reacted via 193 Procedure T to give 4-(2-hydroxyethylthio)benzoic acid. 1.0 g of 4-(2-hydroxyethylthio)benzoic acid was reacted via Procedure R to give 4-(2-hydroxyethylsulfonyl)benzoic acid. 80 mg of 4 chloro-3-(pyridin-2-yl)aniline was coupled to 4-(2-hydroxyethylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2 5 yl)phenyl)-4-(2-hydroxyethylsulfonyl)benzamide. MS (Q1) 417.0 (M)*. Example 228 4-(2-(1H-imidazol-1-yl)ethylsulfonyl)-N-(4-chloro-3-(pyridin-2 yl)phenyl)benzamide 10 CI \N 0 HN --- N 0 4 g of 4-(2-hydroxyethylthio)benzonitrile was reacted via Procedure R to yield 4-(2 15 hydroxyethylsulfonyl)benzonitrile. 3.0 g of triphenylphosphine was added to a solution of 2 g of 4-(2-hydroxyethylsulfonyl)benzonitrile and 4.7 g of carbon tetrabromide in dichloromethane at 0 0 C. The reaction mixture was allowed to warm to room temperature and stirred for lh. The mixture was diluted with dichloromethane, washed with H 2 0, dried (MgSO 4 ) and evaporated. Purified by silica gel chromatography (0-70% ethyl acetate/hexane) to afford 4-(2 20 bromoethylsulfonyl)benzonitrile. 250 mg of 4-(2-bromoethylsulfonyl)benzonitrile was used in Procedure P with imidazole to give 4-(2-(1H-imidazol-1-yl)ethylsulfonyl)benzonitrile. 300 mg of 4-(2-(1H-imidazol-1-yl)ethylsulfonyl)benzonitrile was reacted via Procedure T to give 4-(2-(1H imidazol-1-yl)ethylsulfonyl)benzoic acid. 60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(2-(1H-imidazol-1-yl)ethylsulfonyl)benzoic acid via Procedure G. The product was 25 purified on reverse phase HPLC to yield 4-(2-(1H-imidazol-1-yl)ethylsulfonyl)-N-(4-chloro-3 (pyridin-2-yl)phenyl)benzamide. MS (Q1) 467.1 (M)*. Example 229 4-(2-(1H-pyrazol-1-yl)ethylsulfonyl)-N-(4-chloro-3-(pyridin-2 30 yl)phenyl)benzamide 194 CI \N 0 HN - N / \\N 0 250 mg of 4-(2-bromoethylsulfonyl)benzonitrile was used in Procedure P with pyrazole to yield 4 (2-(1 H-pyrazole- 1 -yl)ethylsulfonyl)benzonitrile. 300 mg of 4-(2-(1H-pyrazole-1 5 yl)ethylsulfonyl)benzonitrile was reacted via Procedure T to give 4-(2-(1H-pyrazole-1 yl)ethylsulfonyl)benzoic acid. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(2 (1H-pyrazole-1-yl)ethylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield 4-(2-(1H-pyrazol-1-yl)ethylsulfonyl)-N-(4-chloro-3-(pyridin-2 yl)phenyl)benzamide. MS (Q1) 467.0 (M)*. 10 Example 230 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-(4-methyl-1H-imidazol-1 yl)ethylsulfonyl)benzamide CI \N 0 HN --- N 04 \ 15 0 270 mg of 4-(2-bromoethylsulfonyl)benzonitrile was used in Procedure P with 4-methylimidazole to yield 4-(2-(4-methyl-1H-imidazole-1-yl)ethylsulfonyl)benzonitrile. 320 mg of 4-(2-(4-methyl 1H-imidazole-1-yl)ethylsulfonyl)benzonitrile was reacted via Procedure T to give 4-(2-(4-methyl 20 1H-imidazole-1-yl)ethylsulfonyl)benzoic acid. 70 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(2-(4-methyl-1H-imidazole-1 yl)ethylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-(4-methyl-1H-imidazol-1 yl)ethylsulfonyl)benzamide. MS (Q1) 481.0 (M)*. 25 195 Example 231 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-(3-methyl-1H-1,2,4-triazol-1 yl)ethylsulfonyl)benzamide. CI \N 0 HN / N 5 O To a stirred suspension of 10 g of thiosemicarbazide in 100 mL of pyridine was slowly added 7.8 ml of acetyl chloride at 0 C. The temperature was maintained throughout the addition (0 C - 4 C). The reaction mixture was allowed to warm to room temperature and stirred for 16 h. 10 Evaporation gave 1 -acetyl thiosemicarbazide. The crude 1 -acetyl thiosemicarbazide was dissolved in 70 mL of MeOH and 12 g of sodium methoxide, and was refluxed for 10 h. The solvent was removed and the residue was dissolved in H 2 0, then acidified to pH 2 by the addition of IN HCl. The resulting solid was filtered and washed with H 2 0 to give 3-methyl-1,2,4-triazole-5-thiol. 1 g of 3-methyl-1,2,4-triazole-5-thiol was added to a solution of 61 mg of sodium nitrite in 3 ml of 15 nitric acid and 6 mL of H 2 0 at 0 0 C. The reaction mixture was stirred for ih at 0 0 C, and basified with saturated sodium carbonate and concentrated. The residue was dissolved with MeOH and filtered. The filtrate was evaporated to give 3-methyl-1,2,4-triazole. 230 mg of 4-(2 bromoethylsulfonyl)benzonitrile was used in Procedure P with 3-methyl-1,2,4-triazole to yield 4 (2-(3-methyl-1H-1,2,4-triazole-1-yl)ethylsulfonyl)benzonitrile. 310 mg of 4-(2-(3-methyl-1H 20 1,2,4-triazole-1-yl)ethylsulfonyl)benzonitrile was reacted via Procedure T to give 4-(2-(3-methyl 1H-1,2,4-triazole-1-yl)ethylsulfonyl)benzoic acid. 60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(2-(3-methyl-iH-1,2,4-triazole 1-yl)ethylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-(3-methyl-1H-1,2,4-triazol-1 25 yl)ethylsulfonyl)benzamide. MS (Q1) 482.1 (M)*. Example 232 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(3-hydroxypropylsulfonyl)benzamide 196 CI \N 0 HN OH -S 0 5 g of 4-fluorobenzonitrile was used in Procedure Q with 3-mercapto-1-propanol to afford 4-(3 hydroxypropylthio)benzonitrile. 1.8 g of 4-(3-hydroxypropylthio)benzonitrile was reacted via 5 Procedure T to give 4-(3-hydroxypropylthio)benzoic acid. 1.2 g of 4-(3 hydroxypropylthio)benzoic acid was reacted via Procedure R to give 4-(3 hydroxypropylsulfonyl)benzoic acid. 50 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4 (3-hydroxypropylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(3-hydroxypropylsulfonyl)benzamide. 10 MS (Q1) 431.3 (M)*. Example 233 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-methoxyethylsulfonyl)benzamide CI \N 0 HN / \ - 0 00 15 0 A mixture of 500 mg of methyl 4-mercaptobenzoate, 1.6 g of potassium carbonate, 1.2 g of 2 bromoethylmethylether and 329 mg of tetrabutylammonium iodide in 10 mL of acetone was refluxed for 16 h. The reaction mixture was diluted with ethyl acetate, washed with H 2 0 and 20 concentrated. Purified by silica gel chromatography (0-50% ethyl acetate/ hexane) to yield 4-(2 methoxyethylthio)benzoate. 240 mg of 4-(2-methoxyethylthio)benzoate was reacted via Procedure R to give 4-(2-methoxyethylsulfonyl)benzoate. 120 mg of 4-(2-methoxyethylsulfonyl)benzoate was hydrolyzed via Procedure M to yield 4-(2-methoxyethylsulfonyl)benzoic acid. 50 mg of 4 chloro-3-(pyridin-2-yl)aniline was coupled to 4-(2-methoxyethylsulfonyl)benzoic acid via 197 Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2 yl)phenyl)-4-(2-methoxyethylsulfonyl)benzamide. MS (Q1) 431.0 (M)*. 5 Example 234 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(propylsulfonyl)benzamide CI \N 0 HN / \ 0 1 g of 4-fluorobenzonitrile was used in Procedure Q with 1-propanethiol to afford 4 10 (propylthio)benzonitrile. 860 mg of 4-(propylthio)benzonitrile was reacted via Procedure T to give 4-(propylthio)benzoic acid. 700 mg of 4-(propylthio)benzoic acid was reacted via Procedure R to give 4-(propylsulfonyl)benzoic acid. 60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4 (propylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(propylsulfonyl)benzamide. MS (Q1) 415.0 (M)*. 15 Example 235 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2 hydroxyethylsulfonyl)benzamide CI \N 0 HN CI

-

OH O " 20 0 4 g of 2-chloro-4-fluorobenzonitrile was used in Procedure Q with 2-mercaptoethanol to afford 2 chloro-4-(2-hydroxyethylthio)benzonitrile. 1 g of 2-chloro-4-(2-hydroxyethylthio)benzonitrile was reacted via Procedure T to give 2-chloro-4-(2-hydroxyethylthio)benzoic acid. 1 g of 2-chloro-4-(2 25 hydroxyethylthio)benzoic acid was reacted via Procedure R to yield 2-chloro-4-(2 198 hydroxyethylsulfonyl)benzoic acid. 50 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 2 chloro-4-(2-hydroxyethylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2 hydroxyethylsulfonyl)benzamide. MS (Q1) 451.0(M)*. 5 Example 236 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(3 hydroxypropylsulfonyl)benzamide CI \N 0 HN CI OH -S 10 0 4 g of 2-chloro-4-fluorobenzonitrile was used in Procedure Q with 3-mercapto-1-propanol to afford 2-chloro-4-(3-hydroxypropylthio)benzonitrile. 1 g of 2-chloro-4-(3 hydroxypropylthio)benzonitrile was reacted via Procedure T to give 2-chloro-4-(3 15 hydroxypropylthio)benzoic acid. 1.2 g of 2-chloro-4-(3-hydroxypropylthio)benzoic acid was reacted via Procedure R to yield 2-chloro-4-(2-hydroxypropylsulfonyl)benzoic acid. 75 mg of 4 chloro-3-(pyridin-2-yl)aniline was coupled to 2-chloro-4-(2-hydroxypropylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N-(4-chloro 3-(pyridin-2-yl)phenyl)-4-(3-hydroxypropylsulfonyl)benzamide. MS (Q1) 465.0 (M)*. 20 Example 237 4-(allylsulfonyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide CI \N 0 HN /" \ 0 199 7.3 g of 4-(3-hydroxypropylthio)benzonitrile was reacted via Procedure R to yield 4-(3 hydroxypropylsulfonyl)benzonitrile. 1.9 g of NBS was added to a solution of 2 g of 4-(3 hydroxypropylsulfonyl)benzonitrile and 2.8 g of triphenylphosphine in 10 mL of dichloromethane at 0 C. The reaction mixture was stirred at 0 -5 C for 1h. The mixture was diluted with 5 dichloromethane, washed with H 2 0, dried (MgSO 4 ) and evaporated. Purified by silica gel chromatography (10-70% ethyl acetate/hexane) to afford 4-(3-bromopropylsulfonyl)benzonitrile. 300 mg of 4-(3-bromopropylsulfonyl)benzonitrile was reacted via Procedure T to give 4 (allylsulfonyl)benzoic acid. 40 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4 (allylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to 10 yield 4-(allylsulfonyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide. MS (Q1) 413.2 (M)*. Example 238 4-(allylsulfonyl)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide CI \N 0 HN CI / \ 15 0 115 mg of NBS was added to a solution of 200 mg of 2-chloro-N-(4-chloro-3-(pyridin-2 yl)phenyl)-4-(3-hydroxypropylsulfonyl)benzamide and 169 mg of triphenylphosphine in 3 mL of dichloromethane at 0 0 C. The reaction mixture was stirred at 0 -5 0 C for lh. The mixture was 20 diluted with dichloromethane, washed with H 2 0, dried (MgSO 4 ) and evaporated. Purified by prep TLC plate (60% ethyl acetate/hexane) to afford 4-(3-bromopropylsulfonyl)-2-chloro-N-(4-chloro 3-(pyridin-2-yl)phenyl)benzamide. 60 mg of 4-(3-bromopropylsulfonyl)-2-chloro-N-(4-chloro-3 (pyridin-2-yl)phenyl)benzamide and 111 mg of cesium carbonate in 0.5 mL of DMF were heated to 100 0 C in a sealed microwave reactor for 20 min. The reaction mixture was evaporated, and the 25 product was purified on reverse phase HPLC to yield 4-(allylsulfonyl)-2-chloro-N-(4-chloro-3 (pyridin-2-yl)phenyl)benzamide. MS (Q1) 448.0 (M)*. Example 239 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(3-morpholinopropylsulfonyl) 30 benzamide 200 CI \N 0 HN CI 0 -S 0 120 mg of 4-(3-bromopropylsulfonyl)-2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide was used in Procedure P with morpholine to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(3 5 morpholinopropylsulfonyl)benzamide. MS (Q1) 534.0 (M)*. Example 240 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-oxopyrrolidin-1-yl)benzamide CI \N 0 HN CI 0 N 10 A mixture of 500 mg of 2-chloro-4-florobenzonitrile, 821 mg of 2-pyrrolidinone and 3 g of cesium carbonate in 5 mL of DMF was heated to 100 0 C in a sealed microwave reactor for 15 min. The reaction mixture was diluted with ethyl acetate, washed with H 2 0, dried (MgSO 4 ) and evaporated. 15 Purified by silica gel chromatography (20-80% ethyl acetate/hexane) to afford 2-chloro-4-(2 oxopyrrolidin-1-yl)benzonitrile. 890 mg of 2-chloro-4-(2-oxopyrrolidin-1-yl)benzonitrile was reacted via Procedure T to give 2-chloro-4-(2-oxopyrrolidin-1-yl)benzoic acid. 80 mg of 4-chloro 3-(pyridin-2-yl)aniline was coupled to 2-chloro-4-(2-oxopyrrolidin-1-yl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N-(4-chloro-3-(pyridin-2 20 yl)phenyl)-4-(2-oxopyrrolidin-1-yl)benzamide. MS (Q1) 426.2 (M)*. Example 241 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-oxooxazolidin-3-yl)benzamide 201 CI \N 0 HN 0 A mixture of 1 g of methyl 4-iodobenzoate, 399 mg of 2-oxozolidone, 1.1 g of potassium carbonate, 34 mg of N, N'-dimethylethylenediamine and 73 mg of copper iodide in 10 mL of 5 toluene was heated to 150 C in a sealed microwave reactor for 2h. The reaction mixture was diluted with ethyl acetate, washed with H 2 0, dried (MgSO 4 ) and evaporated. Purified by silica gel chromatography (20-70% ethyl acetate/hexane) to afford methyl 4-(2-oxooxazolidin-3-yl)benzoate. 530 mg of methyl 4-(2-oxooxazolidin-3-yl)benzoate was hydrolyzed via Procedure M to give 4-(2 oxooxazolidin-3-yl)benzoic acid. 70 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(2 10 oxooxazolidin-3-yl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-oxooxazolidin-3-yl)benzamide. MS (Q1) 394.2 (M)*. 15 Example 242 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(ethylsulfonyl)-2-methylbenzamide CI \N 0 HN S 0 4 g of 4-bromo-2-methylbenzonitrile was used in Procedure Q with ethanethiol to afford 4 20 (ethylthio)-2-methylbenzonitrile. 2 g of 4-(ethylthio)-2-methylbenzonitrile was reacted via Procedure R to give 4-(ethylsulfonyl)-2-methylbenzonitrile. 2.5 g of 4-(ethylsulfonyl)-2 methylbenzonitrile was reacted via Procedure T to give 4-(ethylsulfonyl)-2-methylbenzoic acid. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(ethylsulfonyl)-2-methylbenzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3 25 (pyridin-2-yl)phenyl)-4-(ethylsulfonyl)-2-methylbenzamide. MS (Q1) 415.0 (M)*. 202 Example 243 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(ethylsulfonyl)benzamide CI \N 0 HN CI S 5 0 4 g of 2-chloro-4-fluorobenzonitrile was used in Procedure Q with ethanethiol to afford 2-chloro-4 (ethylthio)benzonitrile. 2 g of 2-chloro-4-(ethylthio)benzonitrile was reacted via Procedure T to give 2-chloro-4-(ethylthio)benzoic acid. 1.5 g of 2-chloro-4-(ethylthio)benzoic acid was reacted 10 via Procedure R to yield 2-chloro-4-(ethylsulfonyl)benzoic acid. 75 mg of 4-chloro-3-(pyridin-2 yl)aniline was coupled to 2-chloro-4-(ethylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (ethylsulfonyl)benzamide. MS (Q1) 435.1 (M)*. 15 Example 244 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(isopropylsulfonyl)benzamide CI \N 0 HN CI / \~ 0 20 2 g of 2-chloro-4-fluorobenzonitrile was used in Procedure Q with 2-propanethiol to afford 2 chloro-4-(isopropylthio)benzonitrile. 1.6 g of 2-chloro-4-(isopropythio)benzonitrile was reacted via Procedure T to give 2-chloro-4-(isopropylthio)benzoic acid. 1 g of 2-chloro-4 (isopropylthio)benzoic acid was reacted via Procedure R to give 2-chloro-4 (isopropylsulfonyl)benzoic acid. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 2 25 chloro-4-(isopropylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse 203 phase HPLC to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (isopropylsulfonyl)benzamide. MS (Q1) 449.1 (M)*. 5 Example 245 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(isopropylsulfonyl)benzamide CI \N 0 HN 0 2 g of 4-fluorobenzonitrile was used in Procedure Q with 2-propanethiol to afford 4 10 (isopropylthio)benzonitrile. 900 mg of 4-(isopropythio)benzonitrile was reacted via Procedure T to give 4-(isopropylthio)benzoic acid. 730 mg of 4-(isopropylthio)benzoic acid was reacted via Procedure R to give 4-(isopropylsulfonyl)benzoic acid. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(isopropylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(isopropylsulfonyl)benzamide. 15 MS (Q1) 415.0 (M) Example 246 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-4-(methylsulfonyl)benzamide CI \N 0 HN 20 0 A solution of 500 mg of 4-bromo-2-methylbenzonitrile and 268 mg of sodium thiomethoxide in 3 mL of DMF was stirred for lh. The reaction mixture was diluted with ethyl acetate, washed with

H

2 0, dried (MgSO 4 ) and evaporated to afford 2-methyl-4-(methylthio)benzonitrile. 400 mg of 2 25 methyl-4-(methylthio)benzonitrile was reacted via Procedure T to give 2-methyl-4 204 (methylthio)benzoic acid. 430 mg of 2-methyl-4-(methylthio)benzoic acid was reacted via Procedure R to yield 2-methyl-4-(methylsulfonyl)benzoic acid. 60 mg of 4-chloro-3-(pyridin-2 yl)aniline was coupled to 2-methyl-4-(methylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-4 5 (methylsulfonyl)benzamide. MS (Q1) 401.0 (M)*. Example 247 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(methylsulfonyl)nicotinamide CI \N 0 HN / N O \ 10 0 1 g of methyl 6-chloronicotinate was reacted via Procedure 0 to yield methyl 6 (methylsulfonyl)nicotinate. 1 g of methyl 6-(methylsulfonyl)nicotinate was hydrolyzed via Procedure M to give 6-(methylsulfonyl)nicotinic acid. 100 mg of 4-chloro-3-(pyridin-2-yl)aniline 15 was coupled to 6-(methylsulfonyl)nicotinic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(methylsulfonyl)nicotinamide. MS (Q1) 388.1 (M)*. 20 Example 248 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-4-phenylpyrimidine-5-carboxamide CI \ / \ NN N N

/N-

50 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-methyl-2-phenyl-5-pyrimidine 25 carboxylic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4 chloro-3-(pyridin-2-yl)phenyl)-2-methyl-4-phenylpyrimidine-5-carboxamide. MS (Q1) 401.1 (M)*. 205 Example 249 N-(4-chloro-3-(pyridin-2-yl)phenyl)-1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4 carboxamide CI N 0 HN 5 N F 50 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 1-(4-fluorophenyl)-5-methyl-1H pyrazole-4-carboxylic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4 10 carboxamide. MS (Q1) 407.0 (M)*. Example 250 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)nicotinamide CI \N 0 HN / \N 15 CI A mixture of 450 mg of 4-chloro-3-(pyridin-2-yl)aniline, 427 mg of 6-chloronicotinyl chloride and 1.9 g of PS-DIEA in 10 mL of dichloromethane was shook on the shaker for 3h. The reaction mixture was filtered and washed with dichloromethane. The filtrate was concentrated to yield 6 20 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)nicotinamide. MS (Q1) 344.2 (M)*. Example 251 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(4-ethylpiperazin-1-yl)nicotinamide 206 CI \N 0

HN

N / N N Procedure F was performed using 50 mg of 6-chloro-N-(4-chloro-3-(pyridin-2 yl)phenyl)nicotinamide and 93 pL of 1-ethylpiperazine in 0.5 mL of BuOH. Purified by reverse 5 phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(4-ethylpiperazin-1-yl)nicotinamide. MS (Q1) 422.0 (M)*. Example 252 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(4-(2-hydroxyethyl)piperazin-1 10 yl)nicotinamide CI HN N C N N OH Procedure F was performed using 50 mg of 6-chloro-N-(4-chloro-3-(pyridin-2 15 yl)phenyl)nicotinamide and 90 pL of 1-(2-hydroxyethyl)piperazine in 0.5 mL of BuOH. Purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(4-(2 hydroxyethyl)piperazin-1-yl)nicotinamide. MS (Q1) 438.0 (M)*. 20 Example 253 (R)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(2-hydroxypropylamino)nicotinamide. 207 CI \N 0 HN N HO HN Procedure F was performed using 50 mg of 6-chloro-N-(4-chloro-3-(pyridin-2 yl)phenyl)nicotinamide and 57 pL of R-1-Amino-2--propanol in 0.5 mL of BuOH. Purified by 5 reverse phase HPLC to yield (R)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(2 hydroxypropylamino)nicotinamide. MS (Q1) 383.4 (M)*. Example 254 (S)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(2-hydroxypropylamino)nicotinamide 10 CI \N 0 HN N HO HN Procedure F was performed using 50 mg of 6-chloro-N-(4-chloro-3-(pyridin-2 yl)phenyl)nicotinamide and 57 pL of S-1-Amino-2--propanol in 0.5 mL of BuOH. Purified by 15 reverse phase HPLC to yield (S)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(2 hydroxypropylamino)nicotinamide. MS (Q1) 383.4 (M)*. Example 255 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(2,6-dimethylmorpholino)nicotinamide 20 CI \N 0 HN / \N N 0 208 Procedure F was performed using 50 mg of 6-chloro-N-(4-chloro-3-(pyridin-2 yl)phenyl)nicotinamide and 90 pL of 2,6-dimethylmorpholine in 0.5 mL of BuOH. Purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(2,6 5 dimethylmorpholino)nicotinamide. MS (Q1) 423.4 (M)*. Example 256 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(4-hydroxypiperidin-1-yl)nicotinamide CI \N 0 HN IN / N 10 OH Procedure F was performed using 50 mg of 6-chloro-N-(4-chloro-3-(pyridin-2 yl)phenyl)nicotinamide and 74 mg of 4-hydroxypiperidine in 0.5 mL of BuOH. Purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(4-hydroxypiperidin-1 15 yl)nicotinamide. MS (Q1) 409.3 (M)*. Example 257 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(3,5-dimethyl-1H-pyrazol-1-yl)nicotinamide CI \ / 0/ HN / N N N 20 21 mg of sodium hydride was added to a solution of 84 mg of 3,5-dimethylpyrazole in 2 mL of DMF. The reaction mixture was stirred for 10 min, and then added 100 mg of 6-chloro-N-(4 chloro-3-(pyridin-2-yl)phenyl)nicotinamide. The reaction was heated to 140 0 C for 16h. The 209 mixture was quenched with MeOH and evaporated. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(3,5-dimethyl-1H-pyrazol-1-yl)nicotinamide. MS (Q1) 404.3 (M)*. 5 Example 258 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(3-oxopiperidin-1-yl)nicotinamide CI \N 0 HN N NH 10 Procedure F was performed using 50 mg of 6-chloro-N-(4-chloro-3-(pyridin-2 yl)phenyl)nicotinamide and 29 mg of piperazin-2-one in 0.5 mL of BuOH. Purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(3-oxopiperidin-1-yl)nicotinamide. MS (Q1) 408.3 (M)*. 15 Example 259 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-oxopiperazin-1-yl)benzamide CI \N 0 HN / 0 N NH 20 A mixture of 1 g of methyl 4-iodobenzoate, 920 mg of 4-Boc-piperazinone, 1.1 g of potassium carbonate, 32 mg of N, N'-dimethylethylenediamine and 70 mg of copper iodide in 10 mL of toluene was heated to 150 0 C in a sealed microwave reactor for 3h. The reaction mixture was diluted with ethyl acetate, washed with H 2 0, dried (MgSO 4 ) and evaporated. Purified by silica gel chromatography (20-80% ethyl acetate/hexane) to afford tert-butyl 4-(4 210 (methoxycarbonyl)phenyl)-3-oxopiperazine- 1 -carboxylate. 500 mg of tert-butyl 4-(4 (methoxycarbonyl)phenyl)-3-oxopiperazine-1-carboxylate was hydrolyzed via Procedure M to give 4-(4-(tert-buthoxycarbonyl)-2-oxopiperazin-1-yl)benzoic acid. 100 mg of 4-chloro-3-(pyridin-2 yl)aniline was coupled to 4-(4-(tert-buthoxycarbonyl)-2-oxopiperazin-1-yl)benzoic acid via 5 Procedure G. The reaction mixture was diluted with ethyl acetate, washed with 0.1 N sodium hydroxide and brine, dried (MgSO 4 ) and evaporated to afford tert-butyl 4-(4-(4-chloro-3-(pyridin 2-yl)phenylcarbamoyl)phenyl)-3-oxopiperazine-1-carboxylate. 300 mg of crude tert-butyl 4-(4-(4 chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl)-3-oxopiperazine-1-carboxylate was treated with TFA (2 mL) containing trace amounts of H 2 0 for 1h. The reaction mixture was evaporated and 10 the crude product was purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2 yl)phenyl)-4-(2-oxopiperazin-1-yl)benzamide. MS (Q1) 407.3 (M)*. Example 260 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-methyl-2-oxopiperazin-1-yl)benzamide 15 CI HN N N 120 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2-oxopiperazin-1-yl)benzamide was dissolved in 2 mL of DMF and then treated with 53 mg of paraformaldehyde, 187 mg of sodium 20 triacetoxyborohydride and 0.2 mL of AcOH. After stirring 16 h, the reaction mixture was evaporated and the crude product was purified by reverse phase HPLC to yield N-(4-chloro-3 (pyridin-2-yl)phenyl)-4-(4-methyl-2-oxopiperazin-1-yl)benzamide. MS (Q1) 421.3 (M)*. 25 Example 261 2-amino-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide 211 CI HN

NH

2 O \ 0 2.2 g of methyl 4-(methylsulfonyl)-2-nitrobenzoate was reacted via Procedure C to afford methyl 2-amino-4-(methylsulfonyl)benzoate. 500 mg of methyl 2-amino-4-(methylsulfonyl)benzoate was 5 hydrolyzed via Procedure M to give 2-amino-4-(methylsulfonyl)benzoic acid. 100 mg of 4-chloro 3-(pyridin-2-yl)aniline was coupled to 2-amino-4-(methylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield 2-amino-N-(4-chloro-3-(pyridin-2 yl)phenyl)-4-(methylsulfonyl)benzamide. MS (Q1) 402.0 (M)*. 10 Example 262 2-acetamido-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide CI \N 0 HN- HN4 0 / \ 0 15 20 pL of acetyl chloride was added to a solution of 90 mg of 2-amino-N-(4-chloro-3-(pyridin-2 yl)phenyl)-4-(methylsulfonyl)benzamide in 2 mL of pyridine at 0 0 C. The reaction mixture was allowed to warm to room temperature and stirred for 2h. The reaction was quenched with MeOH and evaporated. The product was purified on reverse phase HPLC to yield 2-acetamido-N-(4 chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide. MS (Q1) 444.0 (M)*. 20 Example 263 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-iodo-4-(methylsulfonyl)benzamide 212 CI HN I / \X 0 600 mg of methyl 2-amino-4-(methylsulfonyl)benzoate was added to a solution of 4 mL of H 2 0 and 1 mL of concentrated sulfuric acid. The solution was cooled to 0 C and a solution of 206 mg 5 of sodium nitrite in 1 mL of H 2 0 was added slowly. The reaction mixture was stirred for 2 h and then a solution of 782 mg of potassium iodide in 2 mL of H 2 0 was added dropwise at 0 C. The reaction was allowed to warm to room temperature and stirred for 5 h. The mixture was extracted with ethyl acetate. The combined organic extracts were washed with saturated Na 2

S

2

O

3 , dried (MgSO 4 ) and evaporated. Purified by silica gel chromatography (5-50% ethyl acetate/hexane) to 10 afford methyl 2-iodo-4-(methylsulfonyl)benzoate. 160 mg of methyl 2-iodo-4 (methylsulfonyl)benzoate was hydrolyzed via Procedure M to give 2-iodo-4 (methylsulfonyl)benzoic acid. 60 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 2-iodo-4 (methylsulfonyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-iodo-4-(methylsulfonyl)benzamide. MS (Q1) 513.0 15 (M)*. Example 264 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-((3S,5R)-3,5-dimethylpiperazin-1-yl)-2 methylnicotinamide CI \N 0 HN / \N N NH 20 Stoichiometric amounts (0.04 mol) of methyl proplolate and ethyl 3-aminocrotonate were heated to 140 0 C for lh. 1 g of the crude (2E,4Z)-methyl-4-(1-aminoethylidene)-5-oxooct-2-enoate in 4 mL of DMF was heated to 230 0 C in a sealed microwave reactor for 40 min. The reaction mixture was 213 diluted with ethyl acetate, washed with H 2 0, dried (MgSO 4 ) and evaporated to afford crude ethyl 6-hydroxy-2-methylnicotinate. A mixture of 800 mg of crude ethyl 6-hydroxy-2-methylnicotinate in 4 mL of phosphorus oxychloride was heated to 150 C in a sealed microwave reactor for 15 min. The reaction mixture was poured into ice/water, extracted with diethyl ether. The combined 5 organic layers were dried (MgSO 4 ) and evaporated. Purified by silica gel chromatograph (0-20% ethyl acetate/hexane) to yield ethyl 6-chloro-2-methylnicotinate. 400 mg of ethyl 6-chloro-2 methylnicotinate was hydrolyzed via Procedure M to give 6-chloro-2-methylnicotinic acid. 300 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 6-chloro-2-methylnicotinic acid via Procedure G. The reaction mixture was diluted with ethyl acetate, washed with 0.1 N sodium hydroxide and 10 brine, dried (MgSO 4 ) and evaporated to afford 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide. Procedure F was performed using 100 mg of 6-chloro-N-(4-chloro-3-(pyridin 2-yl)phenyl)-2-methylnicotinamide and 128 mg of 2,6-dimethylpiperazine in 1 mL of BuOH. Purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-((3S,5R)-3,5 dimethylpiperazin-1-yl)-2-methylnicotinamide. MS (Q1) 436.3 (M)*. 15 Example 265 (S)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(3-methylpiperazin-1 yl)nicotinamide CI \ / 0/ HNN N N NH 20 Procedure F was performed using 100 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide and 112 mg of S-(-)-2-methylpiperizine in 1 mL of BuOH. Purified by reverse phase HPLC to yield (S)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(3 methylpiperazin-1-yl)nicotinamide. MS (Q1) 422.3 (M)*. 25 Example 266 (R)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(3-methylpiperazin-1 yl)nicotinamide. 214 CI \N 0 HN / \N N NH Procedure F was performed using 100 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide and 112 mg of R-(+)-2-methylpiperizine in 1 mL of BuOH. Purified by 5 reverse phase HPLC to yield (R)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(3 methylpiperazin-1-yl)nicotinamide. MS (Q1) 422.3 (M)*. Example 267 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(3-methylpiperazin-1 10 yl)nicotinamide CI \ / 0/ HNN N N NH Procedure F was performed using 100 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide and 112 mg of 2-methylpiperizine in 1 mL of BuOH. Purified by reverse 15 phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(3-methylpiperazin-1 yl)nicotinamide. MS (Q1) 422.3 (M)*. Example 268 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(4-(2-hydroxyacetyl)piperazin-1-yl)-2 20 methylnicotinamide 215 CI \N 0 HN / \N N N OH 0 100 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(piperazin-1-yl)nicotinamide was coupled to glycolic acid via Procedure G. The product was purified on reverse phase HPLC to 5 yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(4-(2-hydroxyacetyl)piperazin-l-yl)-2 methylnicotinamide. MS (Q1) 466.3 (M)*. Example 269 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(4-(methylsulfonyl)piperazin-1 10 yl)nicotinamide CI \N 0 HN / N 0 N N 0 1.3 mL of methanesulfonyl chloride was slowly added to a solution of 2 g of 1 -Boc-piperazine and 1.3 mL of pyridine in 6 mL of dichloromethane at 0 0 C. The reaction mixture was allowed to 15 warm to room temperature and stirred for 2h while being monitored by TLC. Upon completion, the mixture was diluted with dichloromethane, washed with H 2 0, dried (MgSO 4 ) and evaporated. Purified by silica gel chromatograph (20-100% ethyl acetate/hexane) to afford tert-butyl-4 (methylsulfonyl)piperazine-1-carboxylate. 930 mg of tert-butyl-4-(methylsulfonyl)piperazine-1 carboxylate was treated with 4N HCl in dioxane for 2h. The reaction mixture was evaporated to 20 give the HCl salt of 1-(methylsulfonyl)piperazine. Procedure F was performed using 50 mg of 6 chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methylnicotinamide, 69 mg of 1 (methylsulfonyl)piperazine and DIEPA(1 eq) in 0.5 mL of BuOH. Purified by reverse phase 216 HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(4-(methylsulfonyl)piperazin-1 yl)nicotinamide. MS (Q1) 486.3 (M)*. 5 Example 270 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-thiomorpholinonicotinamide CI \N 0 HN N S Procedure F was performed using 90 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 10 methylnicotinamide and 78 pL of thiomorpholine in 1 mL of BuOH. Purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-thiomorpholinonicotinamide. MS (Q1) 425.3 (M)*. 15 Example 271 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-sulfonylmorpholinonicotinamide CI \N 0 HN N / N &ZO 0 100 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-thiomorpholinonicotinamide was 20 reacted via produce R. The product was purified on reverse phase HPLC to yield N-(4-chloro-3 (pyridin-2-yl)phenyl)-2-methyl-6-sulfonylmorpholinonicotinamide. MS (Q1) 457.3 (M)*. 217 Example 272 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(2-(pyrrolidin-1-yl)ethylamino) nicotinamide CI \N 0 HN / \N HN N 5 Procedure F was performed using 100 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide and 70 pL of 1-(2-aminoethyl)pyrrolidine in 1 mL of BuOH. Purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(2-(pyrrolidin-1 yl)ethylamino)nicotinamide. MS (Q1) 436.0 (M)*. 10 Example 273 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-((2-(dimethylamino)ethyl)(methyl)amino) 2-methylnicotinamide CI CN 0 HN N NN 15 Procedure F was performed using 60 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide and 66 pL of N,N,N'-trimethylethylenediamine in 0.5 mL of BuOH. Purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-((2 (dimethylamino)ethyl)(methyl)amino)-2-methylnicotinamide. MS (Q1) 424.0 (M)*. 20 Example 274 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(3-oxopiperazin-1-yl)nicotinamide 218 CI \ / 0/ N 0 HN / N NH Procedure F was performed using 100 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide and 84 mg of piperazine-2-one in 1 mL of BuOH. Purified by reverse phase 5 HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(3-oxopiperazin-1-yl)nicotinamide. MS (Q1) 422.3 (M)*. Example 275 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(3-methyl-1H-1,2,4-triazol-1 10 yl)nicotinamide CI \/ 0/ N 0 H N / \N N'-N N A mixture of 57 mg of 3-methyl-1,2,4-triazol and 16 mg of sodium hydride in 2 mL of DMF was stirred for 10 min. 80 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methylnicotinamide 15 was added. The reaction was heated to 140 0 C for 16h. The reaction mixture was quenched with MeOH and evaporated. Purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2 yl)phenyl)-2-methyl-6-(3-methyl-1H-1,2,4-triazol-1-yl)nicotinamide. MS (Qi) 405.3 (M)*. 20 Example 276 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(1H-1,2,4-triazol-1 yl)nicotinamide 219 CI \ / 0/ HN / N N-N A mixture of 41 mg of 1,2,4-triazol and 14 mg of sodium hydride in 2 mL of DMF was stirred for 10 min. 70 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methylnicotinamide was added. 5 The reaction was heated to 140 C for 6h. The reaction mixture was quenched with MeOH and evaporated. Purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methyl-6-(1H-1,2,4-triazol-1-yl)nicotinamide. MS (Q1) 391.4 (M)*. 10 Example 277 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(1H-pyrazol-1-yl)nicotinamide CI \ / 0/ HN /NN N N A mixture of 52 mg of pyrazole and 18 mg of sodium hydride in 2 mL of DMF were stirred for 10 15 min. 90 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methylnicotinamide was added. The reaction was heated to 140 0 C for 5h. The reaction mixture was quenched with MeOH and evaporated. Purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methyl-6-(1H-pyrazol-1-yl)nicotinamide. MS (Q1) 390.0 (M)*. 20 Example 278 N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(piperazin-1-yl)nicotinamide 220 CI \N 0 HN / N NH Procedure F was performed using 80 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide and 209 mg of 1-Boc-piperizine in 1 mL of BuOH. The reaction mixture 5 was evaporated to afford tert-butyl 4-(5-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)-6 methylpyridin-2-yl)piperazine- 1 -carboxylate. 150 mg of tert-butyl 4-(5-(4-chloro-3-(pyridin-2 yl)phenylcarbamoyl)-6-methylpyridin-2-yl)piperazine-1-carboxylate was treated with TFA (1 mL) containing trace amounts of H 2 0 for 2 h. The reaction mixture was diluted with ethyl acetate, washed with 0.1N sodium hydroxide and brine, dried (MgSO 4 ) and evaporated. Purified by 10 reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-2-methyl-6-(piperazin-1 yl)nicotinamide. MS (Q1) 408.3 (M)*. Example 279 (R)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(2-hydroxypropylamino)-2 methylnicotinamide CI \N 0 HN N HO 15 HN Procedure F was performed using 60 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide and 116 pL of R-(-)-1-amino-2-propanol in 0.5 mL of BuOH. Purified by reverse phase HPLC to yield (R)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(2-hydroxypropylamino) 20 2-methylnicotinamide. MS (Q1) 397.4 (M)*. Example 280 (S)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(2-hydroxypropylamino)-2 methylnicotinamide 221 CI HN N HO HN Procedure F was performed using 60 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide and 116 pL of S-(+)-1-amino-2-propanol in 0.5 mL of BuOH. Purified by 5 reverse phase HPLC to yield (S)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(2-hydroxypropylamino)-2 methylnicotinamide. MS (Q1) 397.4 (M)*. Example 281 6-(2-(1H-imidazol-4-yl)ethylamino)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 10 methylnicotinamide CI \N 0 HN HN NH Procedure F was performed using 60 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide and 93 mg of histamine in 0.5 mL of BuOH. Purified by reverse phase HPLC 15 to yield 6-(2-(1H-imidazol-4-yl)ethylamino)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide. MS (Q1) 433.0 (M) Example 282 6-(4-acetylpiperazin-1-yl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 20 methylnicotinamide 222 CI \N 0 HN / \N

N

N O Procedure F was performed using 55 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide and 99 mg of 1-acetylpiperazine in 0.5 mL of BuOH. Purified by reverse 5 phase HPLC to yield 6-(4-acetylpiperazin-1-yl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide. MS (Q1) 450.4 (M)*. Example 283 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(2,6-dimethylmorpholino)-2 10 methylnicotinamide CI \N 0 HN / \N N 0 Procedure F was performed using 55 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide and 95 mg of 2,6-dimethylmorpholine in 0.5 mL of BuOH. Purified by 15 reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(2,6-dimethylmorpholino)-2 methylnicotinamide. MS (Q1) 436.2 (M)*. Example 284 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(4-hydroxypiperidin-1-yl)-2 20 methylnicotinamide 223 CI \N 0 HN / N OH Procedure F was performed using 55 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide and 78 mg of 4-hydropiperidine in 0.5 mL of BuOH. Purified by reverse 5 phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(4-hydroxypiperidin-1-yl)-2 methylnicotinamide. MS (Q1) 422.1 (M)*. Example 285 6-(3-(1H-imidazol-1-yl)propylamino)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 10 methylnicotinamide CI HN N / NN N HN Procedure F was performed using 55 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide and 92 pL of 1-(3-aminopropyl)-imidazole in 0.5 mL of BuOH. Purified by 15 reverse phase HPLC to yield 6-(3-(1H-imidazol-1-yl)propylamino)-N-(4-chloro-3-(pyridin-2 yl)phenyl)-2-methylnicotinamide. MS (Q1) 446.1 (M)*. Example 286 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(isobutylamino)-2-methylnicotinamide CI \N 0 HN N 20 HN 224 Procedure F was performed using 50 mg of 6-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-2 methylnicotinamide and 70 pL of isobutylamine in 0.5 mL of BuOH. Purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(isobutylamino)-2-methylnicotinamide. MS (Q1) 395.4 (M)*. 5 Example 287 2-chloro-N 1 -(4-chloro-3-(pyridin-2-yl)phenyl)-N 4

,N

4 -dimethylterephthalamide CI \' \/ N 0 HN CI 0 -N 10 290 mg of dimethylamine hydrochloride was coupled to 1 g of 4-(tert-butoxycarbonyl)-3 chlorobenzoic acid via Procedure G. The reaction mixture was diluted with ethyl acetate, washed with 0.1 N HCl, 0.1 N NaOH and brine, dried (MgSO 4 ) and evaporated to afford tert-butyl 2 chloro-4-(dimethylcarbamoyl)benzoate. 1.ig of tert-butyl 2-chloro-4 15 (dimethylcarbamoyl)benzoate was treated with TFA (4 mL) containing trace amounts of H 2 0 for 2 h. The reaction mixture was evaporated, and then added 0.1 N HCl. The resulting solid was filtered and washed with H 2 0 to yield 2-chloro-4-(dimethylcarbamoyl)benzoic acid. 100 mg of 4 chloro-3-(pyridine-2-yl)aniline was coupled to 2-chloro-4-(dimethylcarbamoyl)benzoic acid via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N 1 -(4-chloro-3 20 (pyridin-2-yl)phenyl)-N 4

,N

4 -dimethylterephthalamide. MS (Q1) 414.1 (M)*. Example 288 N-(4-chloro-3-(pyridin-2-yl)phenyl)-6-(morpholine-4-carbonyl)nicotinamide 25 225 CI \/ \/ N 0 HN / \N 0 CN 0 63 mg of morpholine was coupled to 120 mg of 5-(methoxycarbonyl)pyridine-2-carboxylic acid via Procedure G. The reaction mixture was diluted with ethyl acetate, washed with saturated sodium 5 bicarbonate and brine, dried (MgSO 4 ) and evaporated to afford methyl 6-(morpholine-4 carbonyl)nicotinate. 180 mg of methyl 6-(morpholine-4-carbonyl)nicotinate was hydrolyzed via Procedure M to give 6-(morpholine-4-carbonyl)nicotinic acid. 100 mg of 4-chloro-3-(pyridine-2 yl)aniline was coupled to 6-(morpholine-4-carbonyl)nicotinic acid via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro- N-(4-chloro-3-(pyridin-2-yl)phenyl)-6 10 (morpholine-4-carbonyl)nicotinamide. MS (Q1) 423.4 (M)*. Example 289 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-3-hydroxy-4 (methylsulfonylmethyl)benzamide 15 CI \N 0 HN /\OH s=O 0 3-Hydroxy-4-methylbenzoic acid (6.86 g, 45.1 mmol) was dissolved in methanol (200 ml). 4N HCl in 1,4-dioxane (34 ml, 0.135 mmol HCl) was added and the solution heated to 55 0 C for 18 20 hours. The solvent was concentrated on a rotary evaporator, and then partitioned between water and ethyl acetate. The aqueous portion was extracted with ethyl acetate once, and the ethyl acetate extracts were combined and washed with water once, brine once, dried with MgSO 4 , and evaporated to methyl 3-hydroxy-4-methylbenzoate as a crude tan solid (6.66 g) which was used without purification. Methyl 3-hydroxy-4-methylbenzoate (6.66 g, 40.1 mmol) was dissolved in 226 dichloromethane (200 ml), treated with pyridine (4.3 ml, 60.2 mmol), and cooled in an ice water bath. Acetyl chloride (3.6 ml, 50.1 mmol) was added dropwise. The solution was allowed to warm to room temperature, with stirring, over 18 hours. The solution was washed with 1 N aqueous HCl twice, water once, brine once, dried with MgSO 4 , and evaporated to methyl 3 5 acetoxy-4-methylbenzoate as a crude tan oil (6.93 g) which was used without purification. Methyl 3-acetoxy-4-methylbenzoate (6.38 g, 30.6 mmol) was dissolved in carbon tetrachloride (130 ml) and treated with benzoic peroxyanhydride (200 mg, 0.83 mmol) and NBS (5.45 g, 30.6 mmol), then heated to 85'C for 3 hours. After cooling to room temperature, the solution was filtered through Celite 545 and evaporated to a crude yellow solid which was purified by silica gel flash 10 chromatography (5% dichloromethane/hexanes increasing to 35% dichloromethane/hexanes) to yield methyl 3-acetoxy-4-(bromomethyl)benzoate as an off white solid (4.18 g). Methyl 3-acetoxy 4-(bromomethyl)benzoate (2.00 g, 6.97 mmol) was used in procedure 0 to afford methyl 3 acetoxy-4-(methylsulfonylmethyl)benzoate as a white solid (1.67 g) which was used without purification. Methyl 3-acetoxy-4-(methylsulfonylmethyl)benzoate (1.67 g, 5.83 mmol) was 15 saponified via procedure M to afford 3-hydroxy-4-(methylsulfonylmethyl)benzoic acid as a white solid (1.05 g) which was used without purification. 3-Hydroxy-4-(methylsulfonylmethyl)benzoic acid (860 mg, 3.74 mmol) was dissolved in 1,4-dioxane (25 ml) and treated with thionyl chloride (8 ml) and DMF (5 drops), then heated to 50'C for 2 hours. The reaction was cooled and evaporated to an oil. The oil residue was dissolved in dichloromethane (40 ml), cooled in an ice 20 water bath, and treated dropwise with a solution of 4-chloro-3-(pyridin-2-yl)aniline (767 mg, 3.74 mmol) in dichloromethane (30 ml). The reaction was stirred 18 hours, allowing to warm to room temperature. The reaction was diluted with dichloromethane (40 ml) and stirred vigorously with water (50 ml) while acidifying to pH 6 with 1 M citric acid. The dichloromethane portion was separated, and enough methanol was added to dissolve precipitating solids. The solution was 25 washed with water once, brine once, dried with MgSO 4 , and evaporated to a solid which was triturated with dichloromethane, filtered, and air dried to yield 909 mg of crude product. A portion (20 mg) was purified on reverse phase HPLC to yield 16 mg of purified N-(4-chloro-3-(pyridin-2 yl)phenyl)-3-hydroxy-4-(methylsulfonylmethyl)benzamide as a white solid. MS (Q1) 417 (M)*. 30 Example 290 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-3-isobutoxy-4 (methylsulfonylmethyl)benzamide 227 CI \N 0 HN SO 0 N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-hydroxy-4-(methylsulfonylmethyl)benzamide (50 mg, 0.12 mmol) was treated with 1-bromo-2-methylpropane (26 1i, 0.24 mmol) via procedure U to yield 19 5 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-isobutoxy-4-(methylsulfonylmethyl)benzamide. MS (Q1) 473 (M)*. Example 291 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-3-methoxy-4 10 (methylsulfonylmethyl)benzamide CI \N 0 HN 0 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-3-hydroxy-4-(methylsulfonylmethyl)benzamide (50 mg, 0.12 15 mmol) was treated with iodomethane (7.5 1i, 0.12 mmol) via procedure U to yield 12 mg of N-(4 chloro-3-(pyridin-2-yl)phenyl)-3-methoxy-4-(methylsulfonylmethyl)benzamide. MS (Q1) 431 (M)+. 20 Example 292 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-3-ethoxy-4 (methylsulfonylmethyl)benzamide 228 CI \N 0 HN / \ /o 0 S=O 0 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-3-hydroxy-4-(methylsulfonylmethyl)benzamide (50 mg, 0.12 mmol) was treated with iodoethane (10 1i, 0.12 mmol) via procedure U to yield 22 mg of N-(4 5 chloro-3-(pyridin-2-yl)phenyl)-3-ethoxy-4-(methylsulfonylmethyl)benzamide. MS (Q1) 445 (M)*. Example 293 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-3-(2-(4-(methylsulfonyl)piperazin-1 yl)ethoxy)-4-(methylsulfonylmethyl)benzamide 10 CI 0 0// \N 0N HN N /\o 0 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-3-hydroxy-4-(methylsulfonylmethyl)benzamide (1.00 g, 2.40 mmol) was dissolved in DMF (20 ml). Cesium carbonate (1.56 g, 4.8 mmol) and 1,2 15 dibromoethane (0.83 ml, 9.6 mmol) were added, and the reaction was stirred at 50'C for 18 hours. The reaction was quenched with water, basified with 10% aqueous NaOH, and extracted with ethyl acetate twice. The ethyl extracts were washed with water once, brine once, dried with MgSO 4 , and evaporated to a crude oil which was purified by chromatography (25% hexanes in ethyl acetate) to yield 490 mg of 3-(2-bromoethoxy)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 20 (methylsulfonylmethyl)benzamide as a yellow solid. 3-(2-Bromoethoxy)-N-(4-chloro-3-(pyridin-2 yl)phenyl)-4-(methylsulfonylmethyl)benzamide (100 mg, 0.19 mmol) was dissolved in DMF (2.0 ml), and potassium carbonate (32 mg, 0.23 mmol) and tert-butyl piperazine-1-carboxylate (38 mg, 0.21 mmol) were added. The reaction was stirred for 18 hours at room temperature, quenched in water, and extracted with ethyl acetate twice. The ethyl acetate extracts were washed with water 25 once, brine once, dried with MgSO 4 , and evaporated to a crude oil. The oil was dissolved in 229 dichloromethane (1 ml) and treated with trifluoroacetic acid (3 ml) for 1 hour. The reaction was evaporated to dryness, and the crude solid was purified on reverse phase HPLC to yield 63 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)-3-(2-(piperazin-1 yl)ethoxy)benzamide as a white solid. N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4 5 (methylsulfonylmethyl)-3-(2-(piperazin-1-yl)ethoxy)benzamide (30 mg, 0.047 mmol) was dissolved in dichloromethane (1.5 ml) and THF (1.0 ml). N-ethyl-N-isopropylpropan-2-amine (18 1i, 0.10 mmol) and methanesulfonyl chloride (4 il, 0.051 mmol) were added, and the reaction stirred at room temperature for 72 hours. Additional N-ethyl-N-isopropylpropan-2-amine (9 1i, 0.051 mmol) and methanesulfonyl chloride (4 1i, 0.051 mmol) were added and the reaction stirred 10 for 2 hours. After a further addition of methanesulfonyl chloride (4 1i, 0.051 mmol), the reaction was stirred for 2 hours and evaporated to a crude solid which was purified on reverse phase HPLC to yield 8 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-(2-(4-(methylsulfonyl)piperazin-1 yl)ethoxy)-4-(methylsulfonylmethyl)benzamide. MS (Q1) 607 (M)*. 15 Example 294 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)-3-(2-(3 oxopiperazin-1-yl)ethoxy)benzamide CI \/"N/ NH N 0 0 HN N / / 0 20 3-(2-Bromoethoxy)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide (50 mg, 0.095 mmol) was dissolved in DMF (1.0 ml) and treated with potassium carbonate (18 mg, 0.13 mmol) and piperazin-2-one (11 mg, 0.11 mmol) for 18 hours. The reaction was heated for 2.0 hours at 50'C, then additional potassium carbonate (18 mg, 0.13 mmol) and piperazin-2-one (11 25 mg, 0.11 mmol) was added. After 2 hours, the reaction was quenched in 5% NaOH and extracted with ethyl acetate twice. The ethyl acetate extracts were washed with water once, brine once, dried with MgS04, and purified by reverse phase HPLC to yield 16 mg of N-(4-chloro-3-(pyridin 2-yl)phenyl)-4-(methylsulfonylmethyl)-3-(2-(3-oxopiperazin-1-yl)ethoxy)benzamide. MS (Q1) 558 (M)+. 30 230 Example 295 3-(2-(4-Acetylpiperazin-1-yl)ethoxy)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (methylsulfonylmethyl)benzamide CI \N 0N HN N / / 0 5 3-(2-Bromoethoxy)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide (50 mg, 0.095 mmol) was dissolved in DMF (1.0 ml) and treated with potassium carbonate (18 mg, 0.13 mmol) and 1-(piperazin-1-yl)ethanone (15 mg, 0.11 mmol) for 18 hours. The reaction was heated for 2.0 hours at 50'C, then additional potassium carbonate (18 mg, 0.13 mmol) and 1 10 (piperazin-1-yl)ethanone (15 mg, 0.11 mmol) was added. After 2 hours, the reaction was quenched in 5% NaOH and extracted with ethyl acetate twice. The ethyl acetate extracts were washed with water once, brine once, dried with MgSO 4 , and purified by reverse phase HPLC to yield 18 mg of 3-(2-(4-acetylpiperazin-1-yl)ethoxy)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (methylsulfonylmethyl)benzamide. MS (Q1) 543 (M)*. 15 Example 296 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-3-(2-(2,6-dimethylmorpholino)ethoxy)-4 (methylsulfonylmethyl)benzamide CI \ / 0 0 HN N 0 / 20 0 3-(2-Bromoethoxy)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide (50 mg, 0.095 mmol) was dissolved in DMF (1.0 ml) and treated with potassium carbonate (18 mg, 0.13 mmol) and 2,6-dimethylmorpholine (14 1i, 0.11 mmol), and stirred at room temperature for 25 18 hours. The reaction was quenched in 5% NaOH and extracted with ethyl acetate twice. The 231 ethyl acetate extracts were washed with water once, brine once, dried with MgSO 4 , and purified by reverse phase HPLC to yield 20 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-3-(2-(2,6 dimethylmorpholino)ethoxy)-4-(methylsulfonylmethyl)benzamide. MS (Q1) 571 (M)*. 5 Example 297 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)-3-(2 morpholinoethoxy)benzamide CI N 00 HN N / / 0 10 3-(2-Bromoethoxy)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide (50 mg, 0.095 mmol) was dissolved in acetonitrile (1.0 ml) and DMF (1.0 ml), treated with potassium carbonate (16 mg, 0.12 mmol) and morpholine (10 1i, 0.11 mmol), and stirred 18 hours at room temperature. The reaction was heated to 50'C for 8 hours, and then was allowed to stir 18 hours at 15 room temperature. The reaction was quenched in water and extracted with ethyl acetate twice. The ethyl acetate extracts were washed with water once, brine once, dried with MgSO 4 , and evaporated to an oil which was purified by reverse phase HPLC to yield 30 mg of N-(4-chloro-3 (pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)-3-(2-morpholinoethoxy)benzamide. MS (Q1) 530 (M)+. 20 Example 298 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)-3-(2-(piperidin-1 yl)ethoxy)benzamide CI \N 0 HN N / / 25 0 232 3-(2-Bromoethoxy)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide (50 mg, 0.095 mmol) was dissolved in dichloromethane (1.0 ml), treated with triethylamine (20 1i, 0.15 mmol) and piperidine (11 1i, 0.11 mmol), and stirred 2.0 hours at room temperature. 5 Acetonitrile (0.25 ml) and N-ethyl-N-isopropylpropan-2-amine (25 1i, 0.19 mmol) were added, and the reaction was stirred for an additional 45 hours. The reaction was quenched in water and extracted with dichloromethane twice. The dichloromethane extracts were washed with water once, brine once, dried with MgSO 4 , and evaporated to an solid which was purified by reverse phase HPLC to yield 17 mg N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)-3-(2 10 (piperidin-1-yl)ethoxy)benzamide. MS (Q1) 528 (M)*. Example 299 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)-3-(2-(pyrrolidin-1 yl)ethoxy)benzamide 15 CI \N 0 HN N / S=O 0 3-(2-Bromoethoxy)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide (40 mg, 0.076 mmol) was dissolved in acetonitrile (1.0 ml) and DMF (1.0 ml), treated with potassium 20 carbonate (16 mg, 0.12 mmol) and pyrrolidine (7 1i, 0.084 mmol), and stirred 18 hours at room temperature. The reaction was quenched in water and extracted with ethyl acetate twice. The ethyl acetate extracts were washed with water once, brine once, dried with MgSO 4 , and evaporated to an oil which was purified by reverse phase HPLC to yield 30 mg of N-(4-chloro-3-(pyridin-2 yl)phenyl)-4-(methylsulfonylmethyl)-3-(2-(pyrrolidin-1-yl)ethoxy)benzamide. MS (Q1) 514 (M)*. 25 Example 300 3-Amino-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide 233 CI \N 0 HN

NH

2 S=O 0 4-(Bromomethyl)-3-nitrobenzoic acid (2.00 g, 7.69 mmol) was dissolved in methanol (20 ml) and treated with 1 drop of concentrated sulfuric acid, then stirred 72 hours at room temperature. An 5 additional 3 drops of concentrated sulfuric acid was added, and the reaction stirred at 50'C for 24 hours. The solvent was concentrated on a rotary evaporator, diluted with ethyl acetate, and washed with water twice, saturated NaHCO 3 once, water once, brine once, dried with MgSO 4 , and evaporated to a 1.82 g of a yellow oil, methyl 4-(bromomethyl)-3-nitrobenzoate and used without purification. Methyl 4-(bromomethyl)-3-nitrobenzoate (1.82 g, 6.64 mmol) was used in procedure 10 0 to afford 1.66 g of methyl 4-(methylsulfonylmethyl)-3-nitrobenzoate as a solid which was used without purification. Methyl 4-(methylsulfonylmethyl)-3-nitrobenzoate (1.66 g, 6.07 mmol) was saponified via procedure M to afford 1.21 g of 4-(methylsulfonylmethyl)-3-nitrobenzoic acid as an orange solid, which was used without purification. 4-(Methylsulfonylmethyl)-3-nitrobenzoic acid (639 mg, 2.46 mmol) was dissolved in 1,4-dioxane (15 ml), treated with thionyl chloride (1.0 ml) 15 and DMF (1 drop), and stirred at room temperature for 18 hours, then at 50'C for 8 hours, then at room temperature for 18 hours. After an additional 4.0 hours at 50'C, the solvents and excess thionyl chloride were removed via rotary evaporator, and the residue was dissolved dichloromethane (25.0 ml) and treated with N-ethyl-N-isopropylpropan-2-amine (1.7 ml, 9.8 mmol) and 4-chloro-3-(pyridin-2-yl)aniline (503 mg, 2.46 mmol) and stirred for 20 min at room 20 temperature, over which time a solid precipitated. Water was added, and the mixture was filtered and air dried, to afford 797 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)-3 nitrobenzamide as a tan-yellow solid. N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4 (methylsulfonylmethyl)-3-nitrobenzamide (786 mg, 1.76 mmol) was dissolved in ethanol (74 ml) and concentrated HCl (12 ml). Tin(II) chloride dihydrate (1.31 g, 5.82 mmol) was added and the 25 reaction was heated to 55'C for 2.5 hours. The reaction was cooled in an ice bath and triethylamine (10 ml) was added to basify the solution. The reaction was evaporated to a yellow solid which was slurried in ethyl acetate. The slurry was filtered through Celite 545, and the mother liquors were washed with water twice, brine once, dried with MgSO 4 , and evaporated to 552 mg of as a crude yellow solid, 20 mg of which was purified by reverse phase HPLC to afford 30 13 mg of purified 3-amino-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (methylsulfonylmethyl)benzamide. MS (Q1) 416 (M)*. 234 Example 301 3-Acetamido-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (methylsulfonylmethyl)benzamide CI HN 0 NH 0% 5 / SO 3-Amino-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide (30 mg, 0.072 mmol) was reacted with acetyl chloride (5.6 1i, 0.079 mol) via procedure V to afford 19 mg of 3 acetamido-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide as a white 10 solid. MS (Q1) 458 (M)*. Example 302 N-(5-(4-Chloro-3-(pyridin-2-yl)phenylcarbamoyl)-2 (methylsulfonylmethyl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide 15 CI N N 0 HN 0 N F NH F S=O 0 3-Amino-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide (30 mg, 0.072 mmol) was reacted with 2-methyl-6-(trifluoromethyl)nicotinoyl chloride (19 mg, 0.079 mmol) via 20 procedure V to afford 16 mg of N-(5-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)-2 (methylsulfonylmethyl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide as a white solid. MS (Q1) 603 (M)*. 235 Example 303 3-Benzamido-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 (methylsulfonylmethyl)benzamide CI HN O NH 0 5 3-Amino-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide (30 mg, 0.072 mmol) was reacted with benzoyl chloride (9 1i, 0.079 mmol) via procedure V to afford 17 mg of 3 benzamido-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide as a white solid. MS (Q1) 520 (M)*. 10 Example 304 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)-3-(2-(pyrrolidin-1 yl)acetamido)benzamide CI N N 0 HN- 0 NO NH 15 0 3-Amino-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide (100 mg, 0.24 mmol) was dissolved in 1,4-dioxane (5.0 ml), treated with triethylamine (274 1i, 1.97 mmol) and 2-bromoacetyl bromide (121 1i, 1.39 mmol). The reaction was heated to reflux for 10 minutes, 20 and stirred at room temperature for 18 hours. The reaction was quenched with water, and extracted twice with ethyl acetate. The ethyl acetate extracts were filtered, washed with water once, brine once, dried with MgSO 4 , evaporated to 158 mg of a crude brown oil, 3-(2 bromoacetamido)-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)benzamide, which was used without further purification. Crude 3-(2-bromoacetamido)-N-(4-chloro-3-(pyridin-2 25 yl)phenyl)-4-(methylsulfonyl-methyl)benzamide (158 mg) was dissolved in DMF, treated with N 236 ethyl-N-isopropylpropan-2-amine (61 1i, 0.35 mmol) and pyrrolidine (27 1i, 0.32 mmol), and stirred at room temperature for 18 hours. The reaction was quenched with water and extracted with ethyl acetate twice. The ethyl acetate extracts were washed with water once, brine once, dried with MgSO 4 , evaporated to a tan solid which was purified by reverse phase HPLC to afford 5 27 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonylmethyl)-3-(2-(pyrrolidin-1 yl)acetamido)benzamide as a white powder. MS (Q1) 527 (M)*. Example 305 4-(N-(3-(1H-Imidazol-4-yl)propyl)carbamimidoyl)-N-(4-chloro-3-(pyridin-2 10 yl)phenyl)benzamide CI \N 0 HN NH NH HN 4-Chloro-3-(pyridin-2-yl)aniline (687 mg, 3.36 mmol) was dissolved in dichloromethane (8.0 ml) 15 and THF (8.0 ml), treated with pyridine (0.33 ml, 4.0 mmol), and cooled to OC. 4-Cyanobenzoyl chloride (612 mg, 3.7 mmol) was added and the reaction was stirred for 1.0 hour. The reaction was diluted with dichloromethane and methanol was added to dissolve all solids. The solution was washed with water once, brine once, dried with MgSO 4 , and evaporated to an orange solid which was purified by silica gel flash column chromatography (50% ethyl acetate/50% hexanes) to afford 20 908 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-cyanobenzamide as a yellow solid. N-(4-Chloro 3-(pyridin-2-yl)phenyl)-4-cyanobenzamide (500 mg, 1.5 mmol) was slurried in ethanol (75 ml) and heated until just dissolved. The solution was cooled in an ice bath, and saturated with HCl gas. The solution was heated briefly to 70'C to dissolve precipitated solids, cooled in an ice bath, and resaturated with HCl gas. The solution was then stored at 0 0 C for 18 hours. The solution was 25 saturated again with HCl gas, heated to 70'C until all solids dissolved, cooled to OC, resaturated with HCl gas, and stored at 0 0 C for 18 hours. Finally, nitrogen gas was bubbled through the solution for 1.0 hour, and the solution was evaporated to dryness. The residue was dissolved in methanol, treated with MP-carbonate (2.57 g) and stirred 30 min. The solution was filtered to afford a neutral, methanolic solution of ethyl 4-(4-chloro-3-(pyridin-2 30 yl)phenylcarbamoyl)benzimidate, which was diluted with enough methanol to make a 0.075 M solution. 237 Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol solution, 0.15 mmol) was treated with 3-(1H-imidazol-4-yl)propan-1-amine (27 pl, 0.23 mmol) via procedure W to afford 83 mg of 4-(N-(3-(1H-imidazol-4-yl)propyl)carbamimidoyl)-N-(4-chloro-3 5 (pyridin-2-yl)phenyl)benzamide. MS (Q1) 459 (M)*. Example 306 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(N-(2-(pyrrolidin-2 yl)ethyl)carbamimidoyl)benzamide 10 CI \N 0 HN NH NH HN Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol solution, 0.15 mmol) was treated with 2-(pyrrolidin-2-yl)ethanamine (28 pl, 0.23 mmol) via 15 procedure W to afford 90 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-(2-(pyrrolidin-2 yl)ethyl)carbamimidoyl)benzamide. MS (Q1) 448 (M)*. Example 307 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(N-((tetrahydrofuran-2 20 yl)methyl)carbamimidoyl)benzamide CI \N 0 HN 0 NH HN Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol 25 solution, 0.15 mmol) was treated with (tetrahydrofuran-2-yl)methanamine (23 pl, 0.23 mmol) via 238 procedure W to afford 76 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-((tetrahydrofuran-2 yl)methyl)carbamimidoyl)benzamide. MS (Q1) 435 (M)*. 5 Example 308 4-(N-(2-(1H-Imidazol-4-yl)ethyl)carbamimidoyl)-N-(4-chloro-3-(pyridin-2 yl)phenyl)benzamide CI \//\\ \N 0 HN- N//^NH NH HN 10 Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol solution, 0.15 mmol) was treated with 2-(1H-imidazol-4-yl)ethanamine (25 mg, 0.23 mmol) via procedure W to afford 90 mg of 4-(N-(2-(1H-imidazol-4-yl)ethyl)carbamimidoyl)-N-(4-chloro-3 (pyridin-2-yl)phenyl)benzamide. MS (Q1) 445 (M)*. 15 Example 309 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(N-(2,2,2 trifluoroethyl)carbamimidoyl)benzamide CI \N 0 HN F NH F HN 20 Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol solution, 0.15 mmol) was treated with 2,2,2-trifluoroethanamine (18 p 1 , 0.23 mmol) via procedure W to afford 56 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-(2,2,2 trifluoroethyl)carbamimidoyl)benzamide. MS (Q1) 433 (M)*. 25 239 Example 310 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-((2,6-dimethylmorpholino)(imino)methyl) benzamide CI N 0 HN N 0 HN 5 Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol solution, 0.15 mmol) was treated with 2,6-dimethylmorpholine (28 pl, 0.23 mmol) via procedure W to afford 74 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-((2,6 dimethylmorpholino)(imino)methyl)-benzamide. MS (Q1) 449 (M)*. 10 Example 311 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(N-(3-methoxypropyl)carbamimidoyl) benzamide CI \N 0 HN / \0 NH 15 HN Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol solution, 0.15 mmol) was treated with 3-methoxypropan-1-amine (23 p l, 0.23 mmol) via procedure W to afford 68 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-(3-methoxypropyl)carbamimidoyl) 20 benzamide. MS (Q1) 423 (M)*. Example 312 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(N-(2 methoxyethyl)carbamimidoyl)benzamide 25 240 CI \N 0 HN NH HN Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol solution, 0.15 mmol) was treated with 2-methoxyethanamine (19 pl, 0.23 mmol) via procedure W 5 to afford 50 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-(2 methoxyethyl)carbamimidoyl)benzamide. MS (Q1) 409 (M)*. Example 313 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(N-cyclohexylcarbamimidoyl)benzamide 10 CI \N 0 HN NH HN Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol solution, 0.15 mmol) was treated with cyclohexanamine (26 pl, 0.23 mmol) via procedure W to 15 afford 30 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-cyclohexylcarbamimidoyl)benzamide. MS (Q1) 433 (M)*. Example 314 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(imino(4-methylpiperazin-1 20 yl)methyl)benzamide 241 CI \N 0 HN N N HN V Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol solution, 0.15 mmol) was treated with 1 -methylpiperazine (23 mg, 0.23 mmol) via procedure W to 5 afford 35 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(imino(4-methylpiperazin-1 yl)methyl)benzamide. MS (Q1) 434 (M)*. Example 315 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(N-propylcarbamimidoyl)benzamide 10 CI \N 0 HN NH HN Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol solution, 0.15 mmol) was treated with propan-1-amine (18 pl, 0.23 mmol) via procedure W to 15 afford 39 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-propylcarbamimidoyl)benzamide. MS (Q1) 393 (M)*. Example 316 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(imino(pyrrolidin-1-yl)methyl)benzamide 20 CI \//\\ HN H HN 242 Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol solution, 0.15 mmol) was treated with pyrrolidine (19 p 1 , 0.23 mmol) via procedure W to afford 25 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(imino(pyrrolidin-1-yl)methyl)benzamide. MS (Q1) 5 405 (M)*. Example 317 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(N-phenylcarbamimidoyl)benzamide CI \N 0 HN / \ / \ NH 10 HN Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol solution, 0.15 mmol) was treated with aniline (21 p 1 , 0.23 mmol) via procedure W to afford 7 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(N-phenylcarbamimidoyl)benzamide. MS (Q1) 427 (M)*. 15 Example 318 N-(4-Chloro-3-(pyridin-2-yl)phenyl)-4-(imino(morpholino)methyl)benzamide CI \N 0 HN N 0 HN 20 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-cyanobenzamide (300 mg, 0.899 mmol) was slurried in 45 ml ethanol and treated with 10 ml of ethanol saturated with HCl. The reaction was stored at 0 0 C for 3 days, then heated to 75'C for 3.0 hours, and cooled to room temperature for 18 hours. The reaction was cooled in an ice bath, and saturated with HCl gas. After storing at 0 0 C for an 25 additional 3 days, N 2 gas was bubbled through the solution for 1.0 hour, and the solution was diluted with enough ethanol to make a 0.0155 M solution of ethyl 4-(4-chloro-3-(pyridin-2 243 yl)phenylcarbamoyl)benzimidate. Ethyl 4-(4-chloro-3-(pyridin-2 yl)phenylcarbamoyl)benzimidate (17.5 ml of a 0.0155 M ethanol solution, 0.27 mmol) was treated with morpholine (1.0 ml, 11.4 mmol) for 3 days. The ethanol was evaporated, and the residue purified by reverse phase HPLC to afford 30 mg of N-(4-chloro-3-(pyridin-2-yl)phenyl)-4 5 (imino(morpholino)methyl)benzamide. MS (Q1) 421 (M)*. Example 319 N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(imino(piperidin-1-yl)methyl)benzamide CI \N 0 HN 10 HN N Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (17.5 ml of a 0.0155 M solution, 0.27 mmol) was treated with piperidine (1.0 ml, 10.0 mmol) for 3 days. The ethanol was evaporated, and the residue purified by reverse phase HPLC to afford 26 mg of N-(4-chloro-3 15 (pyridin-2-yl)phenyl)-4-(imino(piperidin-1-yl)methyl)benzamide. MS (Q1) 419 (M)*. Example 320 Hedgehog signalling inhibition assays 20 Mouse Reporter Cell lines - 1OT1/2-GliLuc [S12] cells (derived from cell line C3H1OT1/2 ATCC #CCL-226) ; Mouse Embryonic Fibroblasts); Growth Medium: Dulbecco's modified Eagles' Medium (DMEM) supplemented with 10% Fetal Bovine Serum (FBS), 10 units/mL penicillin, 100 ug/mL streptomycin, 2mM glutamine, and 1OmM HEPES. 25 Human Reporter Cell lines - HEPM-GliLuc [MZ24] - cells (derived from HEPM, Human Embryonic Palatal Mesenchyme ATCC #CRL-1486); Growth Medium: Minimum Essential Medium (MEM; with Earle's salts) supplemented with 10-20% Fetal Bovine Serium (FBS), 10 units/mL penicillin, 100ug/mL streptomycin, 2mM glutamine, and 10mM HEPES pH 7.2. 30 Sonic hedgehog - recombinant human SHh N-terminal octylated conjugate. 244 Microtiter Plates (MTPs) - For the Luciferase assay cells are plated in 96-well MTPs (White, Flat-bottom, Clear-View). 5 Luciferase-Assay Medium - DMEM supplemented with 0.5% FBS, 10 units/mL penicillin, 100ug/mL streptomycin, 2mM glutamine, and 1OmM HEPES pH 7.2. PBS/Ca/Mg Mix - Phosphate Buffered Saline (PBS) supplemented with 0.5mM CaCl 2 and ImM MgCl 2 . 10 Assay Procedure S12 and MZ24 cells genetically modified to contain a luciferase reporter gene driven by the hedgehog-reseponsive Gli promoter were maintained on tissue culture dishes in Growth Medium 15 at 37 0 C and 5% CO 2 . Cell cultures were passaged at sub-confluency at every 3-4 days. (1:20 to 1:40 for s12; 1:3 to 1:10 for MZ24). Cells were harvested and diluted in Growth Medium such that they could be plated in a microtitre plate at 10,000-20,000 cells (s12), or 20,000-30,000 cells (MZ24), per 100ul, per well. Cells were further incubated for -24-48 hours at 37 0 C and 5% CO 2 . 20 After -24-48 hour incubation the Growth Medium in the microtitre plates was replaced by Luciferase-Assay Medium (100 ul per well), with and without Sonic hedgehog-octyl conjugate, at 0.1-0.3 ug/ml (S12) or 0.5-1.0 ug/ml (MZ24), and test compounds. Cells were then further incubated for and additional 24 hrs. 25 Microtitre plates were then subjected to the luciferase reporter gene assay kit (LucLite T m ), with modifications to the manufacturer's procedure wherein medium was removed and the substrate was reconstituted with 1:1 PBS/Ca/Mg : lysis buffer instead of straight lysis buffer. In brief, the PBS/Ca/Mg was mixed 1:1 with lysis buffer and 1OmL were added to each substrate vial (of the 1000-assay kit). Then the assay media from the microtitre plate was discarded, and 100ul of this 30 substrate mix was added to each well. Plates were incubated at room termperature for 20-30 minutes and then the Relative Light Units (RLUS) representing the relative expression level of the luciferase reporter gene were determined with a Topcount reader (Packard) or an Analyst reader (Molecular Devices). Compounds of the invention tested in the assays demonstrated reduced Gli expression in the reporter cell lines indicating hedgehog pathway signalling 35 inhibition. 245 The term "comprise" and variants of the term such as "comprises" or "comprising" are used herein to denote the inclusion of a stated integer or stated integers but not to exclude any other integer or any other integers, unless in the context or usage an exclusive interpretation of the term is required. 5 Any reference to publications cited in this specification is not an admission that the disclosures constitute common general knowledge in Australia. 246

Claims (37)

1. A compound of formula I: (R3)Y A R1 5 (R2)n wherein A is a carbocycle or heterocycle; X is alkylene, NR 4 C(O), NR 4 C(S), N(C(O)R 1 )C(O), NR 4 SO, NR 4 SO 2 , NR 4 C(O)NH, 10 NR 4 C(S)NH, C(O)NR 4 , C(S)NR 4 , NR 4 PO or NR 4 PO(OH); Y is absent, CHR 4 , 0, S, SO, SO 2 or NR 4 ; R 1 is selected from the group consisting of alkyl, a carbocycle or a heterocycle each of which is optionally substituted with hydroxyl, halogen, amino, carboxyl, amidino, guanidino, carbonyl, nitro, cyano, acyl, alkyl, haloalkyl, sulfonyl, sulfinyl, alkoxy, 15 akylthio, carbamoyl, acylamino, sulfamoyl, sulfonamide, a carbocycle or a heterocycle; wherein said amino, amidino, alkyl, acyl, sulfonyl, sulfinyl, alkoxy, alkylthio, carbamoyl, acylamino, sulfamoyl, sulfonamide, carbocycle and heterocycle substituent is optionally substituted with, halogen, haloakyl, hydroxyl, carboxyl, carbonyl, or an amino, alkyl, alkoxy, acyl, sulfonyl, sulfinyl, 20 phosphinate, carbocycle or heterocycle that is optionally substituted with hydroxyl, carboxyl, carbonyl, amino, halogen, haloalkyl, alkyl, alkoxy, alkylthio, sulfonyl, sulfinyl, acyl, a carbocycle or a heterocycle; R 2 is halogen, hydroxyl, alkyl, acyl or alkoxy, wherein each alkyl, acyl and alkoxy is optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, 25 alkylsulfonyl or alkoxy; R 3 is halogen, hydroxyl, carboxyl, alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, sulfinyl, sulfonyl, a carbocycle or a heterocycle wherein each alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, sulfinyl, sulfonyl, carbocycle and heterocycle is optionally substituted with hydroxyl, halogen, 30 amino, nitro, alkyl, acyl, sulfonyl or alkoxy; R 4 is H or alkyl; m is 0-3; n is 0-3; 247 and salts and solvates thereof.

2. The compound of claim 1, wherein A is a ring selected from the group consisting of A 1 , A2 A',A A , A 6 and A 7 : Z2ZNN Z1 Z2 ) N R2' (R2), R2' 5 A' A 2 A 3 A 4 NN A 5 A 6 A 7 wherein Z 1 is 0, S or NR 5 wherein R 5 is H or alkyl; Z 2 is CH, CR 2 or N; R 2 is halogen, 10 hydroxyl, alkyl or alkoxy; R 2 ' is H, halogen, hydroxyl, alkyl or alkoxy; and n is 0-3.

3. The compound of claim 2, wherein A is ring A' wherein Z 1 is S and Z 2 is CH or N. 2

4. The compound of claim 2, wherein A is the ring A. 15

5. The compound of claim 2, wherein R 2 or R 2 ' is Cl.

6. The compound of claim 1, wherein A is Ai, A A2a A3a A 3, A4a Asa, A a, A a,: SI SD/ C' 20 Ala Aib A2a ~N S _-N CI CI AVa A 3 b A4a 248 N ..- N C, CN C' A 5a A 6a A 7a

7. The compound of claim 1, wherein X is NR 4 C(O). 5

8. The compound of claim 1, wherein X is NR 4 SO 2 .

9. The compound of claim 7, wherein R 4 is H or Me.

10 10. The compound of claim 9, wherein R 4 is H.

11. The compound of claim 1, wherein R 3 is Me or F.

12. The compound of claim 1, wherein R 3 is Me and m is 1 or 2. 15

13. The compound of claim 1, wherein R 3 is F and m is 1 or 2.

14. The compound of claim 1, wherein m is 0. 20

15. The compound claim 1, wherein R 1 is selected from the group consisting of formula Ila Iho: (RO) (ReOO (R)O N Ila Ilb IIc 25 (R)O (R)O (R 6 )o 0 Ild Ile hIf 249 (ReOO (ReOO (ReOO N H H IIg Ih Ili (R 6 )o (R6)o (RO ro N w 5 IIj Ilk III (RO)O N (RsOO (RsOO NN N NR7 C N Irm Iln Io 10 wherein W is 0, S or NR 7 wherein R 7 is H, alkyl, acyl, a carbocycle or a heterocycle wherein said alkyl carbocycle and heterocycle are each optionally substituted with 1-3 amino, halogen, hydroxyl and haloalkyl; R 6 in each instance is independently hydroxyl, halogen, amino, carbonyl, nitro, cyano, 15 acyl, alkyl, sulfonyl, alkylsulfonyl, alkylsulfinyl, alkoxy, alkylcarbamoyl, alkanoylamine, alkylsulfamoyl, alkylsulfonamide, a carbocycle or a heterocycle; wherein said amino, alkyl, carbonyl, acyl, sulfonyl, alkylsulfonyl, alkylsulfinyl, alkoxy, alkylcarbamoyl, alkanoylamine, alkylsulfamoyl, alkylsulfonamide, carbocycle and heterocycle substituent is optionally substituted with amino, 20 halogen, hydroxyl, carbonyl, or a carbocycle or heterocycle that is optionally substituted with hydroxyl, amino, halogen, haloalkyl, alkyl, alkoxy or acyl; and o is 0-3.

16. The compound of claim 15, wherein R 1 is the group of formula Ila. 25

17. The compound of claim 16, wherein R 6 is alkoxy and o is 1 or 2.

18. The compound of claim 16, wherein R 1 is selected from the group of formula Ila' - Ila 28 : 250 OMe OMe OMe OMe ,, ome OMe OMe XOMe m Me~ Ila 1 Ila 2 Ila 3 Ila 4 Ila 5 O~e O~tOPr 5 Ila 6 Ila 7 Ila 8 Ila 9 Halo OPr CI Hal'I Ila1 2 Ila'1 3 Ila'1 4 Ila'1 5 10 C a NHAc Ila 16 Ila 1 7 Ila 1 8 Ila

19 Ila 20 NH(CH 2 ) 5 NH 2 CF 3 OEt NO 2 -NO 2 - CF 3 NO 2 15 Ila 2 1 Ila 22 Ila 23 Ila 2 4 Ila 25 251 );CI C OMe Ila 2 6 Ila 27 Ila 2 8 w A 2 5 19. The compound of claim 16, wherein A is ring A or A. 2,

20. The compound of claim 16, wherein A is ring A a

21. The compound of claim 16, wherein R 3 is Me or F. 10

22. The compound of claim 3, wherein m is 0.

23. The compound of claim 3, wherein X is NR 4 C(O). 15

24. The compound of claim 15, wherein R 1 is the group of formula Ilb.

25. The compound of claim 24, wherein R 6 is alkyl or haloalkyl.

26. The compound of claim 24, wherein R 1 is the group of formula I1b' 20 CF 3 - N I1b' 1 2

27. The compound of claim 24, wherein A is ring A' or A. 25

28. The compound of claim 24, wherein A is ring A 2 .

29. The compound of claim 24, wherein R 3 is H, Me or F.

30 30. The compound of claim 24, wherein R 3 is H. 252

31. The compound of claim 24, wherein X is NR 4 C(O).

32. A composition comprising a compound of claim 1 and a pharmaceutically acceptable 5 carrier.

33. A method of treating cancer in a mammal, comprising administering to said mammal an effective amount of a compound of claim 1. 10

34. The method of claim 33, wherein said cancer is basal cell carcinoma, medullablastoma, pancreatic adenocarcinoma, small-cell lung carcinoma, breast carcinoma, rhabdomyosarcoma, oesophageal cancer, stomach cancer, biliary tract cancer.

35. A method of inhibiting angiogenesis in a mammal, comprising administering to said 15 mammal an effective amount of a compound of claim 1.

36. A method of inhibiting hedgehog pathway signalling in a cell comprising contacting said cell with an effective amount of a compound of claim 1. 20

37. A process for preparing a compound of formula Ib" CI (R 3 )m I N H N B (R)o Ib" whererin 25 ring B is a carbocycle or heterocycle; R 3 is halogen, hydroxyl, carboxyl, alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, alkylsulfinyl, alkylsulfonyl, a carbocycle or a heterocycle wherein each alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, alkylsulfinyl, alkylsulfonyl, carbocycle and heterocycle is optionally substituted with hydroxyl, 30 halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; 253 R 6 in each instance is independently hydroxyl, halogen, amino, carbonyl, nitro, cyano, acyl, alkyl, sulfonyl, alkylsulfonyl, alkylsulfinyl, alkoxy, alkylcarbamoyl, alkanoylamine, alkylsulfamoyl, alkylsulfonamide, a carbocycle or a heterocycle; wherein said amino, alkyl, carbonyl, acyl, sulfonyl, alkylsulfonyl, alkylsulfinyl, 5 alkoxy, alkylcarbamoyl, alkanoylamine, alkylsulfamoyl, alkylsulfonamide, carbocycle and heterocycle substituent is optionally substituted with amino, halogen, hydroxyl, carbonyl, or a carbocycle or heterocycle that is optionally substituted with hydroxyl, amino, halogen, haloalkyl, alkyl, alkoxy or acyl; o is 0-3; and 10 m is 0-3; said process comprising -reacting a compound of formula (a) (R3)mK , 15 N Zn-Q (a) wherein Q is Cl, Br or I; with a compound of formula (b) CI L NO 2 (b) 20 wherein L is Br, I or OTf; to yield a compound of formula (c); (R 3 )m CI N NO 2 (c) - reducing said compound of formula (c) to give a compound of formula (d) CI (R 3 )m I N NH 2 25 (d) - and reacting said compound of formula (d) with a compound of formula (e) 254 (e) wherein Q' is halogen, OH, OR wherein R is an activating group; to yield said compound of formula Ib". Dated: 22 August 2013 255