AU2013204850B2 - Improved process for purifying milk proteins and products thereof - Google Patents

Improved process for purifying milk proteins and products thereof Download PDF

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Publication number
AU2013204850B2
AU2013204850B2 AU2013204850A AU2013204850A AU2013204850B2 AU 2013204850 B2 AU2013204850 B2 AU 2013204850B2 AU 2013204850 A AU2013204850 A AU 2013204850A AU 2013204850 A AU2013204850 A AU 2013204850A AU 2013204850 B2 AU2013204850 B2 AU 2013204850B2
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AU
Australia
Prior art keywords
lactoferrin
milk
rnases
growth factors
filtration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013204850A
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English (en)
Other versions
AU2013204850A1 (en
Inventor
Andrew Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Murray Goulburn Co Opeartive Co Ltd
Original Assignee
Murray Goulburn Co Opeartive Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2012904391A external-priority patent/AU2012904391A0/en
Application filed by Murray Goulburn Co Opeartive Co Ltd filed Critical Murray Goulburn Co Opeartive Co Ltd
Priority to AU2013204850A priority Critical patent/AU2013204850B2/en
Priority to BR112015007675A priority patent/BR112015007675A2/pt
Priority to KR1020157010221A priority patent/KR20150079618A/ko
Priority to CA 2887003 priority patent/CA2887003A1/en
Priority to EP13844822.0A priority patent/EP2904007A4/en
Priority to PCT/AU2013/001154 priority patent/WO2014056026A1/en
Priority to JP2015534885A priority patent/JP2016500662A/ja
Priority to US14/434,272 priority patent/US20150232823A1/en
Priority to NZ631827A priority patent/NZ631827A/en
Priority to RU2015116931A priority patent/RU2015116931A/ru
Priority to CN201380055327.2A priority patent/CN104736560A/zh
Publication of AU2013204850A1 publication Critical patent/AU2013204850A1/en
Priority to IN2968DEN2015 priority patent/IN2015DN02968A/en
Publication of AU2013204850B2 publication Critical patent/AU2013204850B2/en
Application granted granted Critical
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40Transferrins, e.g. lactoferrins, ovotransferrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/34Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79Transferrins, e.g. lactoferrins, ovotransferrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Analytical Chemistry (AREA)
  • Water Supply & Treatment (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
AU2013204850A 2012-10-08 2013-04-12 Improved process for purifying milk proteins and products thereof Ceased AU2013204850B2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
AU2013204850A AU2013204850B2 (en) 2012-10-08 2013-04-12 Improved process for purifying milk proteins and products thereof
JP2015534885A JP2016500662A (ja) 2012-10-08 2013-10-08 乳汁から成長因子を精製するための改良されたプロセスおよびその製品
NZ631827A NZ631827A (en) 2012-10-08 2013-10-08 Improved process for purifying growth factors from milk and products thereof
CA 2887003 CA2887003A1 (en) 2012-10-08 2013-10-08 Improved process for purifying growth factors from milk and products thereof
EP13844822.0A EP2904007A4 (en) 2012-10-08 2013-10-08 IMPROVED METHOD FOR PURIFYING GROWTH FACTORS FROM MILK AND PRODUCTS DERIVED THEREFROM
PCT/AU2013/001154 WO2014056026A1 (en) 2012-10-08 2013-10-08 Improved process for purifying growth factors from milk and products thereof
BR112015007675A BR112015007675A2 (pt) 2012-10-08 2013-10-08 melhoria do processo de fatores de crescimento purifying a partir de leite e produtos derivados
US14/434,272 US20150232823A1 (en) 2012-10-08 2013-10-08 Process for purifying growth factors from milk and products thereof
KR1020157010221A KR20150079618A (ko) 2012-10-08 2013-10-08 우유로부터 성장 인자를 정제하기 위한 개선된 방법 및 이의 제품
RU2015116931A RU2015116931A (ru) 2012-10-08 2013-10-08 Усовершенствованный способ очистки факторов роста молока и их продукты
CN201380055327.2A CN104736560A (zh) 2012-10-08 2013-10-08 用于从乳纯化生长因子的改进方法及其产品
IN2968DEN2015 IN2015DN02968A (https=) 2012-10-08 2015-04-09

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2012904391A AU2012904391A0 (en) 2012-10-08 Improved process for purifying milk proteins and products thereof
AU2012904391 2012-10-08
AU2013204850A AU2013204850B2 (en) 2012-10-08 2013-04-12 Improved process for purifying milk proteins and products thereof

Publications (2)

Publication Number Publication Date
AU2013204850A1 AU2013204850A1 (en) 2014-04-24
AU2013204850B2 true AU2013204850B2 (en) 2015-06-25

Family

ID=50476774

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013204850A Ceased AU2013204850B2 (en) 2012-10-08 2013-04-12 Improved process for purifying milk proteins and products thereof

Country Status (12)

Country Link
US (1) US20150232823A1 (https=)
EP (1) EP2904007A4 (https=)
JP (1) JP2016500662A (https=)
KR (1) KR20150079618A (https=)
CN (1) CN104736560A (https=)
AU (1) AU2013204850B2 (https=)
BR (1) BR112015007675A2 (https=)
CA (1) CA2887003A1 (https=)
IN (1) IN2015DN02968A (https=)
NZ (1) NZ631827A (https=)
RU (1) RU2015116931A (https=)
WO (1) WO2014056026A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3636657A1 (en) 2018-10-08 2020-04-15 Ablynx N.V. Chromatography-free antibody purification method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003008447A1 (en) * 2001-07-20 2003-01-30 Campina B.V. Process for obtaining growth factor (tgf-beta and igf-1), lactoperoxidase and immunoglobulins preparations from milk products having low mutual cross-contamination
US20050208638A1 (en) * 2004-03-22 2005-09-22 Chao Wu Process for preparing bioactive protein-enriched whey products

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2584727B1 (fr) * 1985-07-11 1988-06-17 Roussel Uclaf Procede d'extraction de proteines du lait, produits, application du procede, et compositions pharmaceutiques
US5221734A (en) * 1987-10-01 1993-06-22 Ciba-Geigy Corporation Process for preparing a polypeptide growth factor for milk
GB8729031D0 (en) * 1987-12-11 1988-01-27 Express Foods Group Ltd Isolation of immunoglobulin rich fraction from whey
JPH05202098A (ja) * 1992-01-29 1993-08-10 Snow Brand Milk Prod Co Ltd 乳質原料から生理活性物質の製造法
ATE209862T1 (de) * 1994-02-16 2001-12-15 Pharming Intellectual Pty Bv Isolierung von lactoferrin aus milch
AUPM534794A0 (en) * 1994-04-28 1994-05-19 Gropep Pty Ltd Modified milk growth factor
NL1005677C2 (nl) * 1997-03-27 1998-09-29 Campina Melkunie Bv Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan.
US6875459B2 (en) * 2001-09-10 2005-04-05 Henry B. Kopf Method and apparatus for separation of milk, colostrum, and whey
CN101027080A (zh) * 2004-03-04 2007-08-29 Gtc生物治疗有限公司 用高效切向流过滤进行蛋白质分级的方法
US8252341B2 (en) * 2004-09-14 2012-08-28 Paul Brazeau Isolation of growth and differentiating factors from colostrum
FR2901796A1 (fr) * 2006-05-31 2007-12-07 Lab Francais Du Fractionnement Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
CN101724013B (zh) * 2008-10-24 2012-05-30 哈尔滨康普乳品有限公司 从牛初乳中工业化分离纯化免疫球蛋白a、免疫球蛋白g和乳铁蛋白的方法
RU2579661C2 (ru) * 2009-01-28 2016-04-10 Жан-Поль ПЕРРОДЭН Способ производства лактоферрина, фракция, содержащая лактоферрин, и ее применения
WO2011113100A1 (en) * 2010-03-17 2011-09-22 Murray Goulburn Co-Operative Co. Limited Method of treating a bone disorder

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003008447A1 (en) * 2001-07-20 2003-01-30 Campina B.V. Process for obtaining growth factor (tgf-beta and igf-1), lactoperoxidase and immunoglobulins preparations from milk products having low mutual cross-contamination
US20050208638A1 (en) * 2004-03-22 2005-09-22 Chao Wu Process for preparing bioactive protein-enriched whey products

Also Published As

Publication number Publication date
CN104736560A (zh) 2015-06-24
AU2013204850A1 (en) 2014-04-24
CA2887003A1 (en) 2014-04-17
IN2015DN02968A (https=) 2015-09-18
JP2016500662A (ja) 2016-01-14
RU2015116931A (ru) 2016-11-27
KR20150079618A (ko) 2015-07-08
BR112015007675A2 (pt) 2017-07-04
NZ631827A (en) 2017-01-27
WO2014056026A1 (en) 2014-04-17
EP2904007A4 (en) 2016-05-18
EP2904007A1 (en) 2015-08-12
US20150232823A1 (en) 2015-08-20

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired