AU2011291110B2 - Pyrimidine derivatives as FAK inhibitors - Google Patents

Pyrimidine derivatives as FAK inhibitors Download PDF

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Publication number
AU2011291110B2
AU2011291110B2 AU2011291110A AU2011291110A AU2011291110B2 AU 2011291110 B2 AU2011291110 B2 AU 2011291110B2 AU 2011291110 A AU2011291110 A AU 2011291110A AU 2011291110 A AU2011291110 A AU 2011291110A AU 2011291110 B2 AU2011291110 B2 AU 2011291110B2
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Australia
Prior art keywords
dihydro
oxo
ylamino
pyrimidin
phenyl
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Ceased
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AU2011291110A
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AU2011291110A1 (en
Inventor
Christina Esdar
Hartmut Greiner
Timo Heinrich
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
AU2011291110A 2010-08-18 2011-07-19 Pyrimidine derivatives as FAK inhibitors Ceased AU2011291110B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102010034699.3 2010-08-18
DE102010034699A DE102010034699A1 (de) 2010-08-18 2010-08-18 Pyrimidinderivate
PCT/EP2011/003597 WO2012022408A1 (de) 2010-08-18 2011-07-19 Pyrimidinderivate als fak inhibitoren

Publications (2)

Publication Number Publication Date
AU2011291110A1 AU2011291110A1 (en) 2013-04-04
AU2011291110B2 true AU2011291110B2 (en) 2015-01-22

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Application Number Title Priority Date Filing Date
AU2011291110A Ceased AU2011291110B2 (en) 2010-08-18 2011-07-19 Pyrimidine derivatives as FAK inhibitors

Country Status (17)

Country Link
US (1) US8906916B2 (enExample)
EP (1) EP2606034B1 (enExample)
JP (2) JP6049617B2 (enExample)
CN (1) CN103052627B (enExample)
AR (1) AR082722A1 (enExample)
AU (1) AU2011291110B2 (enExample)
CA (1) CA2808540C (enExample)
DE (1) DE102010034699A1 (enExample)
DK (1) DK2606034T3 (enExample)
ES (1) ES2572740T3 (enExample)
HR (1) HRP20160562T1 (enExample)
HU (1) HUE027846T2 (enExample)
IL (1) IL224751A (enExample)
PL (1) PL2606034T3 (enExample)
RS (1) RS54882B1 (enExample)
SI (1) SI2606034T1 (enExample)
WO (1) WO2012022408A1 (enExample)

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DE102010034699A1 (de) * 2010-08-18 2012-02-23 Merck Patent Gmbh Pyrimidinderivate
WO2012110773A1 (en) 2011-02-17 2012-08-23 Cancer Therapeutics Crc Pty Limited Fak inhibitors
DK2675794T3 (da) * 2011-02-17 2019-05-06 Cancer Therapeutics Crc Pty Ltd Selektive fak-inhibitorer
US9013997B2 (en) * 2012-06-01 2015-04-21 Broadcom Corporation System for performing distributed data cut-through
WO2014027199A1 (en) * 2012-08-14 2014-02-20 Cancer Therapeutics Crc Pty Ltd Fak and flt3 inhibitors
CA2882270A1 (en) * 2012-08-17 2014-02-20 Cancer Therapeutics Crc Pty Limited Vegfr3 inhibitors
HK1209105A1 (en) * 2012-08-17 2016-03-24 Cancer Therapeutics Crc Pty Limited Vegfr3 inhibitors
TW201412740A (zh) * 2012-09-20 2014-04-01 Bayer Pharma AG 經取代之吡咯并嘧啶胺基苯并噻唑酮
WO2014174745A1 (ja) * 2013-04-26 2014-10-30 国立大学法人京都大学 Ｅｇ５阻害剤
US10106834B2 (en) 2013-10-09 2018-10-23 The General Hospital Corporation Methods of diagnosing and treating B cell acute lymphoblastic leukemia
WO2015123722A1 (en) * 2014-02-19 2015-08-27 Bionomics Limited Inhibitors
ES2914099T3 (es) * 2014-08-25 2022-06-07 Salk Inst For Biological Studi Inhibidores novedosos de ULK1 y métodos de uso de los mismos
US12702667B2 (en) * 2017-02-13 2026-08-11 University of Pittsburgh—of the Commonwealth System of Higher Education Focal adhesion kinase inhibitor as a therapeutic agent in diabetes
WO2019117813A1 (en) * 2017-12-15 2019-06-20 National University Of Singapore Focal adhesion kinase targeted therapeutics for the treatment of glaucoma and fibrosis
KR20260019479A (ko) 2023-05-04 2026-02-10 레볼루션 메디슨즈, 인크. Ras 관련 질환 또는 장애를 위한 병용 요법
CN121889155A (zh) 2023-08-07 2026-04-17 锐新医药公司 用于治疗ras蛋白相关疾病或病症的rmc-6291
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WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
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US20130158005A1 (en) 2013-06-20
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