AU2011285890B2 - Combinations of Hepatitis C virus inhibitors - Google Patents

Combinations of Hepatitis C virus inhibitors Download PDF

Info

Publication number
AU2011285890B2
AU2011285890B2 AU2011285890A AU2011285890A AU2011285890B2 AU 2011285890 B2 AU2011285890 B2 AU 2011285890B2 AU 2011285890 A AU2011285890 A AU 2011285890A AU 2011285890 A AU2011285890 A AU 2011285890A AU 2011285890 B2 AU2011285890 B2 AU 2011285890B2
Authority
AU
Australia
Prior art keywords
compound
hcv
acceptable salt
pharmaceutically acceptable
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011285890A
Other languages
English (en)
Other versions
AU2011285890A1 (en
Inventor
Min Gao
David F. Gardiner
Julie A. Lemm
Fiona Mcphee
Stacey A. Voss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Holdings Ireland ULC
Original Assignee
Bristol Myers Squibb Holdings Ireland ULC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Holdings Ireland ULC filed Critical Bristol Myers Squibb Holdings Ireland ULC
Publication of AU2011285890A1 publication Critical patent/AU2011285890A1/en
Application granted granted Critical
Publication of AU2011285890B2 publication Critical patent/AU2011285890B2/en
Assigned to BRISTOL-MYERS SQUIBB HOLDINGS IRELAND reassignment BRISTOL-MYERS SQUIBB HOLDINGS IRELAND Request for Assignment Assignors: BRISTOL-MYERS SQUIBB COMPANY
Assigned to BRISTOL-MYERS SQUIBB HOLDINGS IRELAND UNLIMITED COMPANY reassignment BRISTOL-MYERS SQUIBB HOLDINGS IRELAND UNLIMITED COMPANY Request to Amend Deed and Register Assignors: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41681,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2011285890A 2010-08-06 2011-08-02 Combinations of Hepatitis C virus inhibitors Ceased AU2011285890B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37139910P 2010-08-06 2010-08-06
US61/371,399 2010-08-06
PCT/US2011/046285 WO2012018829A1 (en) 2010-08-06 2011-08-02 Combinations of hepatitis c virus inhibitors

Publications (2)

Publication Number Publication Date
AU2011285890A1 AU2011285890A1 (en) 2013-03-21
AU2011285890B2 true AU2011285890B2 (en) 2014-12-18

Family

ID=45559795

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011285890A Ceased AU2011285890B2 (en) 2010-08-06 2011-08-02 Combinations of Hepatitis C virus inhibitors

Country Status (14)

Country Link
US (3) US20120196794A1 (cg-RX-API-DMAC7.html)
EP (1) EP2600835B1 (cg-RX-API-DMAC7.html)
JP (2) JP6196154B2 (cg-RX-API-DMAC7.html)
KR (1) KR101846596B1 (cg-RX-API-DMAC7.html)
CN (2) CN105148275A (cg-RX-API-DMAC7.html)
AU (1) AU2011285890B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013002922A2 (cg-RX-API-DMAC7.html)
CA (1) CA2807589C (cg-RX-API-DMAC7.html)
EA (1) EA022303B1 (cg-RX-API-DMAC7.html)
ES (1) ES2685174T3 (cg-RX-API-DMAC7.html)
IL (1) IL224369B (cg-RX-API-DMAC7.html)
MX (1) MX2013001170A (cg-RX-API-DMAC7.html)
SG (2) SG187193A1 (cg-RX-API-DMAC7.html)
WO (1) WO2012018829A1 (cg-RX-API-DMAC7.html)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8329159B2 (en) 2006-08-11 2012-12-11 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US20110274648A1 (en) 2009-11-11 2011-11-10 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US20110269956A1 (en) 2009-11-11 2011-11-03 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US20110281910A1 (en) 2009-11-12 2011-11-17 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US8362020B2 (en) 2009-12-30 2013-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US20120196794A1 (en) * 2010-08-06 2012-08-02 Bristol-Myers Squibb Company Combinations of Hepatitis C Virus Inhibitors
EP2963034A1 (en) 2010-08-26 2016-01-06 RFS Pharma, LLC. Potent and selective inhibitors of hepatitis c virus
US8552047B2 (en) 2011-02-07 2013-10-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9243025B2 (en) * 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9546160B2 (en) 2011-05-12 2017-01-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8691757B2 (en) 2011-06-15 2014-04-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
AU2013201406B2 (en) 2011-10-21 2014-10-02 Abbvie Ireland Unlimited Company Methods for treating HCV
AR088408A1 (es) 2011-10-21 2014-05-28 Abbvie Inc Metodos para el tratamiento de hcv
US9326973B2 (en) 2012-01-13 2016-05-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
DK2909205T3 (en) 2012-10-19 2017-03-06 Bristol Myers Squibb Co 9-METHYL-SUBSTITUTED HEXADECAHYDROCYCLOPROPA (E) PYRROL (1,2-A) (1,4) DIAZOCYCLOPENTADECINYLCARBAMATE DERIVATIVES AS NON-STRUCTURAL 3 (NS3) PROTEASE INHIBITORS FOR TREATMENT
US9334279B2 (en) 2012-11-02 2016-05-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014070964A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014070974A1 (en) 2012-11-05 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2964664B1 (en) 2013-03-07 2017-01-11 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US20150023913A1 (en) 2013-07-02 2015-01-22 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US9717712B2 (en) 2013-07-02 2017-08-01 Bristol-Myers Squibb Company Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus
CN105530933B (zh) 2013-07-17 2018-12-11 百时美施贵宝公司 用于治疗hcv的包含联苯衍生物的组合产品
US10617675B2 (en) 2015-08-06 2020-04-14 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EA201892448A1 (ru) 2016-04-28 2019-06-28 Эмори Юниверсити Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011046811A1 (en) * 2009-10-12 2011-04-21 Bristol-Myers Squibb Company Combinations of a specific hcv ns5a inhibitor and an hcv ns3 protease inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY140680A (en) * 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
US7456166B2 (en) * 2006-05-17 2008-11-25 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US8329159B2 (en) * 2006-08-11 2012-12-11 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2346329B1 (en) * 2008-10-09 2013-08-21 Anadys Pharmaceuticals, Inc. A method of inhibiting hepatitis c virus by combination of a 5,6-dihydro-1h-pyridin-2-one and one or more additional antiviral compounds
US20120196794A1 (en) * 2010-08-06 2012-08-02 Bristol-Myers Squibb Company Combinations of Hepatitis C Virus Inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011046811A1 (en) * 2009-10-12 2011-04-21 Bristol-Myers Squibb Company Combinations of a specific hcv ns5a inhibitor and an hcv ns3 protease inhibitor

Also Published As

Publication number Publication date
AU2011285890A1 (en) 2013-03-21
KR101846596B1 (ko) 2018-04-06
EA201390155A1 (ru) 2013-05-30
CA2807589A1 (en) 2012-02-09
JP2016155844A (ja) 2016-09-01
JP6196154B2 (ja) 2017-09-13
EA022303B1 (ru) 2015-12-30
BR112013002922A2 (pt) 2016-06-07
EP2600835A1 (en) 2013-06-12
KR20140002611A (ko) 2014-01-08
CN103153280A (zh) 2013-06-12
MX2013001170A (es) 2013-02-15
CN105148275A (zh) 2015-12-16
WO2012018829A1 (en) 2012-02-09
US20140235617A1 (en) 2014-08-21
EP2600835B1 (en) 2018-05-30
IL224369B (en) 2019-08-29
CA2807589C (en) 2016-08-30
ES2685174T3 (es) 2018-10-05
US20120196794A1 (en) 2012-08-02
SG2014008346A (en) 2014-05-29
US20150335655A1 (en) 2015-11-26
SG187193A1 (en) 2013-03-28
CN103153280B (zh) 2015-09-09
EP2600835A4 (en) 2013-11-20
JP2013535487A (ja) 2013-09-12

Similar Documents

Publication Publication Date Title
AU2011285890B2 (en) Combinations of Hepatitis C virus inhibitors
US8415374B2 (en) Combinations of hepatitis C virus inhibitors
US9060971B2 (en) Combination pharmaceutical agents as inhibitors of HCV replication
HK1180211B (en) Combinations of hepatitis c virus inhibitors
HK1180211A (en) Combinations of hepatitis c virus inhibitors
HK1172237B (en) Combinations of a specific hcv ns5a inhibitor and an hcv ns3 protease inhibitor
HK1172237A (en) Combinations of a specific hcv ns5a inhibitor and an hcv ns3 protease inhibitor
EP3437643A1 (en) Methods for treating hcv
HK40004326A (en) Methods for treating hcv
HK1259694A1 (en) Methods for treating hcv

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND

Free format text: FORMER APPLICANT(S): BRISTOL-MYERS SQUIBB COMPANY

FGA Letters patent sealed or granted (standard patent)
HB Alteration of name in register

Owner name: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND UNLIMITED CO

Free format text: FORMER NAME(S): BRISTOL-MYERS SQUIBB HOLDINGS IRELAND

MK14 Patent ceased section 143(a) (annual fees not paid) or expired