AU2011242139A1 - Compositions containing anti-acne agents and the use thereof - Google Patents
Compositions containing anti-acne agents and the use thereof Download PDFInfo
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Abstract
The invention features a composition including an anti-acne agent, an antimicrobial agent, and a lactate, and the use thereof
Description
- 1 AUSTRALIA PATENTS ACT 1990 COMPLETE SPECIFICATION FOR A STANDARD PATENT ORIGINAL Name of Applicant: Johnson & Johnson Consumer Companies, Inc. Actual Inventors: Jeffrey M. Wu and Jue-Chen Liu and Jeannette Chantalat and Ying Sun and Stefanie A. Johnsen and Hanuman B. Jampani Address for Service is: SHELSTON IP 60 Margaret Street Telephone No: (02) 9777 1111 SYDNEY NSW 2000 Facsimile No. (02) 9241 4666 CCN: 3710000352 Attorney Code: SW Invention Title: Compositions containing anti-acne agents and the use thereof Details of Original Application No. 2005202771 dated 24 Jun 2005 The following statement is a full description of this invention, including the best method of performing it known to me/us: File: 46421AUP01 - la Compositions Containing Anti-acne agents and the Use Thereof BACKGROUND OF THE INVENTION Acne is a skin disorder that is often accompanied by pimples that sometimes 5 cause acne sufferers embarrassment. Consumers have utilized topical anti-acne agents, such as salicylic acid and benzoyl peroxide to treat acne for many years. Topical anti acne agents typically function by exfoliating skin and/or killing bacteria on the surface of the skin. Although such anti-acne agents are often effective at treating acne pimples, they tend to take a long time, typically days or weeks, to abate acne symptoms. They are 10 also often ineffective at treating pre-emergent pimples. Pigment abnormalities such as post-inflammatory hyperpigmentation (PIH) and scars are often caused by acne, pseudofolliculitis barbae (PFB), and other follicular diseases. It is more common in darker skin types, but all skin types can suffer from these post-inflammatory marks. The presence of PIH and dark marks results in skin that 15 does not appear smooth, clear, nor even. SUMMARY OF THE INVENTION The present invention features a composition including an anti-acne agent, an antimicrobial agent, and a lactate. The present invention also features a method of 20 treating a follicular disease, such as acne, by applying a composition to an area of skin in need of such treatment. The present invention also features a method of reducing the appearance of pores or oil on the skin by applying a composition to an area of skin in need of such treatment. The present invention also features a method of evening skin tone or smoothing skin by applying a composition to an area of skin in need of such 25 treatment. Other features and advantages of the present invention will be apparent from the detailed description of the invention and from the claims. DETAILED DESCRIPTION OF THE INVENTION 30 It is believed that one skilled in the art can, based upon the description herein, utilize the present invention to its fullest extent. The following specific embodiments are to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever.
-2 Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention belongs. Also, all publications, patent applications, patents, and other references mentioned herein are incorporated by reference. Whenever used, any 5 percentage is weight by weight (w/w) unless otherwise indicated. As used herein, "topically applying" means directly laying on or spreading on outer skin, e.g., by use of the hands or an applicator such as a wipe, puff, roller, or spray. As used herein, "cosmetically-acceptable" means that the compound(s) or composition(s) which the term describes are suitable for use in contact with tissues (e.g., 10 the skin) without undue toxicity, incompatibility, instability, irritation, allergic response, and the like. This term is not intended to limit the compound/composition to which it describes for use solely as a cosmetic (e.g., the ingredient/product may be used as a pharmaceutical). As used herein, "safe and effective amount" means an amount of compound(s) or 15 composition(s) sufficient to treat acne, but low enough to avoid serious side effects. What is meant by "promoting" is promoting, advertising, or marketing. Examples of promoting include, but are not limited to, written, visual, or verbal statements made on the product containing the composition or in stores, magazines, newspaper, radio, television, internet, and the like. 20 The compositions of the present invention are useful for treating follicular diseases, such as acne, rosacea, hyperlipidemia, seborrhea, sebacious hyperplasia, follicular rash, demodex folliculorum follicular infections such as folliculitis, staphylcoccal impetigoacne necrotica, and psudofolliculitis barbe, follicular ketarosis, keratosis pilaris, phrynoderma, ichthyosis follicularis, alopecia, follicular dysplasia, 25 hirsutism, oily skin, and hypertrichosis. As used herein, the term "treating" or "treatment" means the treatment (e.g., alleviation or elimination of symptoms and/or cure) and/or prevention or inhibition of the condition (e.g., a skin condition). The compositions of the present invention are also useful for evening skin tone (such as lightening dark areas of skin) in need of such treatment, smoothing the skin 30 (such as reducing texture on the skin), reducing the production of sebum, and reducing the appearance of oil, shine, and/or pores on skin in need of such treatment. Examples of such skin in need of such treatment include, but are not limited to, skin having -3 excessive pigmentation (such as freckles, post-inflammatory hyperpigmentation (PIH), or pigmented scars), rough skin, oily skin, or skin having large, visible pores. In one embodiment, the composition is for the treatment of acne, including but not limited to the treatment or prevention of acne blemishes, acne pimples, pre-emergent 5 pimples, blackheads, and/or whiteheads. What is meant by a "pre-emergent pimple" is an inflamed follicle that are not visually apparent on the surface of the skin with the naked eye (e.g., as a lesion). In one embodiment, the appearance of acne (e.g., the size and/or appearance of the acne lesion and/or blackhead) is reduced within about eight hours, such as within about four hours. 10 In one embodiment, the present invention relates to topical compositions including an anti-acne agent. What is meant by an anti-acne agent is an compound that has been approved by the U.S. Food and Drug Administration for the topical treatment of acne. Examples of anti-acne agents include, but are not limited to, salicylic acid, benzoyl peroxide, sulphur, retinoic acid, candida bombicola/glucose/methyl rapeseedate ferment, 15 peat water, resorcinol, silt, peat, permethin, azelaic acid, clindamycin, adapalene, erythromycin, sodium sulfacetamide, and combinations thereof. In one embodiment, the amount of anti-acne agent in the composition is from about 0.01% to about 10%, for example from about 0.1% to about 5%, or from about 0.5% to about 2% by weight, based on the total weight of the composition. 20 In one embodiment, the compositions of the present invention include a hair growth agent. What is meant by a hair growth agent is a compound that induces hair growth. Examples of hair growth agents include, but are not limited to, minoxadil, spironolactone, cyproterone acetate, azelaic acid, buserelin, bicalutamide, cromakalim, cyclosporin, aminoglutethimide, cyproterone acetate, diazoxide, phenytoin, estradiols, 25 flutamide, prezatide copper, inocoterone, leuprolide acetate, ketoconazole, pinacidil, progesterone, finasteride, retinoic acid, turosteride, vitamins and minerals such as vitamin E, niacin (vitamin B3), pantothenic acid (vitamin B5), pyridoxine (vitamin B6), vitamin B12, vitamin C, vitamin K, biotin, inositol, zinc, copper, cysteine, methionine, coenzyme QI0, essential fatty acids such as flaxseed oil, primrose oil, and fish oil, 30 herbal extracts such as ginko biloba, and combinations thereof In one embodiment, the compositions of the present invention include a hair retardation agent. What is meant by a hair retardation agent is a compound that reduces the appearance and/or growth of hair. Examples of hair retardation agents include, but -4 are not limited to eflornithine hydrochloride, soy extracts, antiandrogenic sterols from serenoa (Serenoa repens) and/or from Cucurbita seeds (Cucurbita pepo), dipeptide N (Carboxymethyl)phenylalanyl-p-alanine compounds, 3-deazaneplanocin, inhibitors of nitric oxide synthetase such as NG-methyl-L-arginine, inhibitors of glutamine 5 metabolism such as 6-diazo-5-oxonorleucine (I), and combinations thereof In one embodiment, the compositions of the present invention include an antimicrobial agent. What is meant by an antimicrobial agent is a compound that kills microorganisms or prevents or inhibits their growth or reproduction. Examples of antimicrobial agents include, but are not limited to: ethanol, propanol, betains, 10 benzalkonium chloride, benzethonium chloride, lauric arginayte, sugarquat, methyl benzethonium chloride, cetypyridiunium chloride, 2,4,4',-trichloro-2- hydroxy diphenyl ether (Triclosan), parachlorometa xylenol (PCMX), lodopropynyl butylcarbamate, diazolidinyl urea, chlorhexidene digluconate, chlorhexidene acetate, chlorhexidene isethionate, chlorhexidene hydrochloride, hexetidine, Quaternium 15, triclocarbon, 15 polyhexamethylene biguanide, cetylpyridium chloride, imidazolidinyl urea, diazolidinyl urea, 3-iodo-2-propynyl-N-butylcarbamate, 2-methyl-4- isothiazo lin-3 -one, dimethyl dimethyl hydantoin,(5-chloro-2-(2,4-dichlorophenoxy)phenol, monolaurin glyceryl laurate, camellia sinensis, candida bombicola/glucose/methyl rapeseedate ferment, hydrogen peroxide, phenol, poloxamer 188, PVP-iodine, thiourea, natural antimicrobial 20 agents, such as cinnamon oil, cinnamaldehyde, lemongrass oil, clove oil, saw palmetto extract, thyme oil white, thyme oil red, thymol, tea tree oil, pinus pinaster bark extract, rosemary leaf extract, grape seed extract, and betel oil, silver containing compounds, such as silver nitrate, silver lactate, silver citrate, and silver zeolite, antimicrobial fatty acid ester of a polyhydric alcohol, a fatty ether of a polyhydric alcohol and alkoxylated 25 derivatives thereof, and combinations thereof In one embodiment, the amount of antimicrobial agent in the compositions is from about 0.001% to about 10%, such as from about 0.01% to about 5% such as from about 0.05% to about 2% by weight, based on the total weight of the composition. In one embodiment the antimicrobial agent is an anti-fungal agent such as an 30 azole. Examples include, but are not limited to, miconazole, ketoconazole, econazole, itraconazole, sertaconazole, fluconazole, voriconazole, clioquinol, bifoconazole, terconazole, butoconazole, tioconazole, oxiconazole, sulconazole, saperconazole, clotrimazole, undecylenic acid, haloprogin, butenafine, tolnafiate, nystatin, ciclopirox -5 olamine, terbinafine, amorolfine, naftifine, elubiol, griseofulvin, their cosmetically acceptable salts, and combinations thereof In one embodiment the antimicrobial agent is an antibiotic or an antiseptic. Examples include, but are not limited to, mupirocin, neomycin sulfate bacitracin, 5 polymyxin B, 1-ofloxacin, tetracyclines such as chlortetracycline hydrochloride, oxytetracycline - 10 hydrochloride and tetrachcycline hydrochoride, clindamycin phosphate, gentamicin sulfate, metronidazole, hexylresorcinol, methylbenzethonium chloride, phenol, quaternary ammonium compounds, tea tree oil, and combinations thereof 10 In one embodiment, the compositions of the present invention include an antipsoriatic agent. Examples of antipsoriatic agents include, but are not limited to, corticosteroids (e.g., betamethasone dipropionate, betamethasone valerate, clobetasol propionate, diflorasone diacetate, halobetasol propionate, triamcinonide, dexamethasone, fluocinonide, fluocinolone acetonide, halcinonide, triamcinolone acetate, 15 hydrocortisone, hydrocortisone verlerate, hydrocortisone butyrate, aclometasone dipropionte, flurandrenolide, mometasone furoate, and methylpredniso lone acetate), methotrexate, cyclosporine, calcipotriene, anthraline, shale oil, elubiol, ketoconazole, coal tar, salicylic acid, zinc pyrithione, selenium sulfide, hydrocortisone, sulfur, menthol, and pramoxine hydrochloride, and combinations thereof 20 In one embodiment, the compositions of the present invention include an anti viral agent. Examples of anti-viral agents include, but are not limited to, imiquimod, podofilox, podophyllin, interferon alpha, acyclovir, famcyclovir, valcyclovir, reticulos and cidofovir. In one embodiment, the compositions of the present invention include an anti 25 inflammatory agent. Examples of anti-inflammatory agents, include, but are not limited to, non-steroidal and steroidal anti-inflammatory agents such as corticosteroids such as hydrocortisone, hydroxyltriamcino lone alphamethyl dexamethasone, dexamethasone phosphate, beclomethasone dipropionate, clobetasol valerate, desonide, desoxymethasone, desoxycorticosterone acetate, dexamethasone, dichlorisone, 30 diflorasone diacetate, diflucortolone valerate, fluadrenolone, fluclarolone acetonide, fludrocortisone, flumethasone pivalate, fluosinolone acetonide, fluocinonide, flucortine butylester, fluocortolone, fluprednidene (fluprednyl idene)acetate, flurandrenolone, halcinonide, hydrocortisone acetate, hydrocortisone butyrate, methylprednisolone, -6 triamcinolone acetonide, cortisone, cortodoxone, flucetonide, fludrocortisone, difluorosone diacetate, fluradrenalone acetonide, medrysone, amciafel, amcinafide, betamethasone, chlorprednisone, chlorprednisone acetate, clocortelone, clescinolone, dichlorisone, difluprednate, flucloronide, flunisolide, fluoromethalone, fluperolone, 5 flupredniso lone, hydrocortisone valerate, hydrocortisone cyclopentylproprionate, hydrocortamate, meprednisone, paramethasone, prednisolone, prednisone, beclomethasone dipropionate, betamethasone dipropionate, and triamcinolone, and combinations thereof Examples ofnon-steroidal anti-inflammatory agents include but not limited to COX inhibitors, LOX inhibitors, and p38 kinase inhibitors, 10 immunosuppresant agents such as cyclosporin, and cytokine synthesis inhibitors. Other natural anti-inflammatories include, but are not limited to, extracts of feverfew, soy, or oats, beta-glucan, and totarol. Other active agents include, but are not limited to, wound healing enhancing agents such as calcium alginate, collagen, recombinant human platelet-derived growth 15 factor (PDGF) and other growth factors, ketanserin, iloprost, prostaglandin E, and hyaluronic acid; scar reducing agents such as mannose-6-phosphate; analgesic agents; debriding agents such as papain, and enzymatic debriding agents; and anesthetics such as lidocaine and benzocaine. In one embodiment, the composition comprises one or more of menthol, camphor, an antihistamine, or a local anesthetic such as tetracaine, 20 lidocaine, prilocaine, benzocaine, bupivacaine, mepivacaine, dibucaine, etidocaine, butacaine, cyclomethycaine, hexylcaine, proparacaine, and lopivacaine, capsaicin, or oatmeal. In one embodiment, the amount of anti-inflammatory agent, anti-viral agent, antipsoroiatic agent and/or other active agent in the compositions is from about 0.001% to 25 about 10%, such as from about 0.01% to about 5% such as from about 0.05% to about 2% by weight, based on the total weight of the composition. The compositions of the present invention further includes a lactate. Examples of lactates include, but are not limited to, C2-C35 lactates such as C2-C22 lactates such as cetyl lactate and C12-C15 lactates. The amount of lactates in the composition of the 30 present invention may vary from about 0.1% to about 50%, for example from about 0.5% to about 20%, or from about 1% to about 10% by weight, based on the total weight of the composition.
-7 In one embodiment, the composition of the present invention further comprises a phospholipid. Examples of phospolipids include, but are not limited to synthetic phospholipids and natural phospholipids such as phospholipids composed of diester and triester phosphatides such as Cocamidopropyl PG-Dimonium Chloride (Colalipid CTM, 5 Colonial Chemical, Inc., South Pittsburgh, TN, USA), Stearamidopropyl PG-Dimonium Chloride (Colalipid STTM), Sunfloweramidopropyl phosphate PG-dimonium chloride (Colalipid SUJNTM), Sodium Olivamidopropyl PG-Dimonium Chloride Phosphate(Colalipid OLTM), Sodiumgrapeseedamindopropyl PG-Dimonium Chloride Phosphate (Colalipid GSTM), Linoleamidopropyl PG-Dimonium Chloride Phophate 10 (Colalipid SAFEL
TM
), PEG-8 dimethicone sunfloweramidopropyl PG-dimonium complex (Colalipid SIL T M ), ricinoleamidopropyl PG-dimonium chloride phosphate (Colalipid RCTM), sodium coco PG-dimonium chloride phosphate (ArlasilkTM phospholipids CDM, Uniqema, ICI Group of Companies, Wilton, UK), Cocamidopropyl PG-Dimonium Chloride (Arlasilk M phospholipids PTC), stearamidipropyl PG 15 dimonium chloride phosphate (Arlasilk T M phospholipids SV), linoleamidopropyl PG dimonium chloride phosphate (Arlasilkm phospholipids EFA), linoleamidopropyl PG dimonium chloride phosphate dimethicone(Arlasilk TM phospholipids PLN), Myristamidopropyl PG-Dimonium Chloride Phosphate (Arlasilk' TM phospholipids PTM), and sodium borageamidopropyl PG-dimonium chloride phosphate (Arlasilk T 20 phospholipids GLA), and combinations thereof In one embodiment, the composition includes a sebum miscible agent. What is meant by a sebum miscible agent is an agent that is miscible with sebum as set forth in the following assay. Artificial sebum is prepared as set forth on page 79 (Table 5.4) of a book chapter entitled "The Influence of Skin Surface Lipids on Topical Formulations" 25 by Obsorne and Hatzenbuhler (in "Topical Drug Delivery Formulations", edited by D. Osborne and A. Amann, Marcel Dekker, Inc., New York, 1990, pages 69-85). At room temperature this sebum is a white waxy substance. 50 pl of the sebum is deposited into a 200 pl clear vial using a precision micropipette. 100 pl of the test agent is then added to the vial. The vial was warmed at 32"C and visually inspected at the baseline and at 30 eight hours. If the agent is miscible with the sebum, the sebum will become transparent. The following is a non-limiting example of sebum miscible agents: aromatic alcohols such as phenyl alcohols with chemical structures of C6H5-R(OH) where R is an aliphatic radical, such as benzyl alcohol and phenethyl alcohol; aromatic glycol ethers - 8 such as ethylene glycol phenyl ether; propylene or butylene oxide-based glycol ethers such as propylene glycol methyl ether and those disclosed in U.S. Patent No. 5,133,967; fatty acids, polyunsaturated fatty acids such as linoleic acid, linolenic acid, stearidonic acid, plant, fruit, or marine derived extracts rich in essential fatty acid or polyunsaturated 5 fatty acids such as but not limited to vaccinium myrtillus (bilberry) seed oil, vaccinium macrocarpon (cranberry) seed oil, vaccinium vitis-idaea (lingonberry) seed oil, rubus idaeus (raspberry) seed oil, rubus chamaemorus (cloudberry) seed oil, ribes nigrum (black currant) seed oil, hippophae rhamnoides (sea buckthorn) seed oil, echium plantagineum (echium) seed oil, hordeum vulgare (barley) seed oil, betula alba bud 10 extract, saw palmetto extract, borage oil, evening primrose oil, witch hazel extract and soy oil; cetyl ocenate; isostearyl benzoate; pentaerythiol teraoctenate; isostearyl benzoate; methyl gluceth; tocopherol acetate; benzalkonium chloride; and benzethonium chloride, and combinations thereof The compositions of the present invention may further include an alcohol. 15 Examples of suitable alcohols include, but are not limited to, ethyl alcohol. In one embodiment, the composition includes less than 40%, such as from about 0.01% to about 40%, for example from about 0.1% to about 30%, or from about 1% to about 20% by weight, of alcohol based on the total weight of the composition. In one embodiment, the composition includes a nonionic surfactant. Examples of 20 nonionic surfactants are disclosed on pages 2955-2976 of the International Cosmetic Ingredient Dictionary and Handbook, eds. Wenninger and McEwen, (The Cosmetic, Toiletry, and Fragrance Assoc., Washington, D.C., 9h Edition, 2002) (hereinafter "CTFA Handbook"). In one embodiment, the composition includes a skin lightening agent. Examples of 25 skin lightening agents include, but are not limited to, retinoids such as retinol, extracts of soy or licorice, and tyrosine inhibitors such as hydroquinone, ascorbyl glucoside, kojic acid, calcium D-pantetheine-S-sulfonate, arbutin, magnesium ascorbyl phosphate, pantothiol, dihydrolipoic acid, and arlatone. In one embodiment, the composition of the present invention has a pH greater that 30 about 2 and a pH less than about 10 such as less than about 7, such as less than about 4.5. The topical compositions useful in the present invention involve formulations suitable for topical application to skin. The composition may further include a cosmetically-acceptable topical carrier. The cosmetically-acceptable topical carrier may -9 comprise from about 50% to about 99%, by weight, of the composition (e.g., from about 80% to about 95%, by weight, of the composition). The compositions may be made into a wide variety of product types that include but are not limited to solid and liquid compositions such as lotions, creams, gels, sticks, 5 sprays, shaving creams, ointments, cleansing liquid washes and solid bars, pastes, powders, mousses, masks, peels, make-ups, and wipes. These product types may comprise several types of cosmetically acceptable topical carriers including, but not limited to solutions, emulsions (e.g., microemulsions and nanoemulsions), gels, solids and liposomes). The compositions may be used in conjunction with other devices such 10 as skin abrading, skin messaging, electro-stimulation devices, light-therapy devices, ultrasound devices, radio frequency devices, thermal/cooling devices, and micro penetration devices. The following are non-limitative examples of such carriers. Other carriers can be formulated by those of ordinary skill in the art. The topical compositions useful in the present invention can be formulated as 15 solutions. Solutions typically include an aqueous solvent (e.g., from about 50% to about 99% or from about 90% to about 95% of a cosmetically acceptable aqueous solvent). Topical compositions useful in the subject invention may be formulated as a solution comprising an emollient. Such compositions preferably contain from about 2% to about 50% of an emollient(s). As used herein, "emollients" refer to materials used for 20 the prevention or relief of dryness, as well as for the protection of the skin. A wide variety of suitable emollients are known and may be used herein. See International Cosmetic Ingredient Dictionary and Handbook, eds. Wenninger and McEwen, pp. 1656 61, 1626, and 1654-55 (The Cosmetic, Toiletry, and Fragrance Assoc., Washington, D.C., 7" Edition, 1997) (hereinafter "CTFA Handbook") contains numerous examples 25 of suitable materials. A lotion can be made from such a solution. Lotions typically comprise from about 1% to about 20% (e.g., from about 5% to about 10%) of an emollient(s) and from about 50% to about 90% (e.g., from about 60% to about 80%) of water. Another type of product that may be formulated from a solution is a cream. A 30 cream typically comprises from about 5% to about 50% (e.g., from about 10% to about 20%) of an emollient(s) and from about 45% to about 85% (e.g., from about 50% to about 75%) of water.
- 10 Yet another type of product that may be formulated from a solution is an ointment. An ointment may comprise a simple base of animal or vegetable oils or semi solid hydrocarbons. An ointment may comprise from about 2% to about 10% of an emollient(s) plus from about 0.1% to about 2% of a thickening agent(s). A more 5 complete disclosure of thickening agents or viscosity increasing agents useful herein can be found in the CTFA Handbook pp. 1693-1697. The topical compositions useful in the present invention may be formulated as emulsions. If the carrier is an emulsion, from about 1% to about 10% (e.g., from about 2% to about 5%) of the carrier comprises an emulsifier(s). Emulsifiers may be nonionic, 10 anionic or cationic. Suitable emulsifiers are disclosed in, for example, CTFA Handbook, pp.
1 673-1686. Lotions and creams can be formulated as emulsions. Typically such lotions comprise from 0.5% to about 5% of an emulsifier(s). Such creams would typically comprise from about I% to about 20% (e.g., from about 5% to about 10%) of an 15 emollient(s); from about 20% to about 80% (e.g., from 30% to about 70%) of water; and from about 1% to about 10% (e.g., from about 2% to about 5%) of an emulsifier(s). Single emulsion skin care preparations, such as lotions and creams, of the oil-in water type and water-in-oil type are well-known in the cosmetic art and are useful in the subject invention. Multiphase emulsion compositions, such as the water-in-oil-in-water 20 type are also useful in the subject invention. In general, such single or multiphase emulsions contain water, emollients, and emulsifiers as essential ingredients. The topical compositions of this invention can also be formulated as a gel (e.g., an aqueous gel using a suitable gelling agent(s)). Suitable gelling agents for aqueous gels include, but are not limited to, natural gums, acrylic acid and acrylate polymers and 25 copolymers, and cellulose derivatives (e.g., hydroxymethyl cellulose and hydroxypropyl cellulose). Suitable gelling agents for oils (such as mineral oil) include, but are not limited to, hydrogenated butylene/ethylene/styrene copolymer and hydrogenated ethylene/propylene/styrene copolymer. Such gels typically comprise between about 0.1% and 5%, by weight, of such gelling agents. 30 In one embodiment, the composition is anhydrous. In one embodiment, such anhydrous composition is exothermic upon application.
- 11 The topical compositions of the present invention can also be formulated into a solid formulation (e.g., a wax-based stick, soap bar composition, powder, a wipe containing powder, or a dressing). The topical compositions useful in the subject invention may contain, in addition 5 to the aforementioned components, a wide variety of additional oil-soluble materials and/or water-soluble materials conventionally used in compositions for use on the skin at their art-established levels. The topical compositions may be applied as needed and/or as part of a regular regimen ranging from application once a week up to one or more times a day (e.g., twice a 10 day). The amount used will vary with the age and physical condition of the end user, the duration of the treatment, the specific compound, product, or composition employed, the particular cosmetically-acceptable carrier utilized, and like factors. Several examples are described below. The invention should not be construed to be limited to the details thereof 15 Example I A composition ofthe present invention (pH = 3.7) was prepared by first solubilizing salicylic acid and ethanol and then adding the remaining materials listed in Table I and mixing the materials in a homogenizer until homogenous. 20 Table 1 Ingredient %W/W Ethanol 40 Salicylic Acid 2 Cl 2-C 15 alkyl lactate 2 Fragrance 0.1 Benzalkonium Chloride, 50% Solution USP 0.2 Aminomethyl Propanol 0.19 DI Water Qs to 100% Example 2 25 A composition of the present invention (pH = 3.7) was prepared in a similar manner as Example 1.
- 12 Table 2 Ingredient %W/W Ethanol 40 Salicylic Acid 2
C
12
-C
15 alkyl lactate 2 Fragrance 0.1 Benzalkonium Chloride, 50% Solution, USP 0.2 Glycerin, 1 Sodium Coco PG-Dimonium Chloride Phosphate 0.06 Aminomethyl Propanol 0.19 DI Water Qs to 100% 5 Example 3 A composition (pH = 3.7) of the present invention was prepared by combining the materials listed in Table 3 as follows. First, the First Pre-mix ingredients were mixed and then the mixture was mixed with the Phase B ingredients until homogenous. The ingredients of phase A were also mixed until homogenous. Then, the phase B mixture was 10 added and mixed into the phase B until uniform. The post addition ingredients and the second Pre-mix were then added to the resulting emulsion until uniform.
- 13 Table 3 Ingredient %W/W First Pre-mix Phenethyl Dimethicone 0.222 Stearoxytrimethylsilane and Stearyl Alcohol 0.028 Ethanol 4 Second Pre-mix Feverfew Extract I DI water 5 Phase A Ethanol 36 Salicylic Acid 2 DI Water 42.739 Hydroxypropylcellulose 1.5 Glycerin 3 Phase B Cyclomethicone 1.665
C
12
-
15 alkyl lactate Cetyl lactate 0.5 Propylene Glycol 0.1 Fragrance 0.1 Diazolidinyl Urea and Iodopropynyl Butylcarbamate 0.1 Ethylene Glycol Phenyl Ether 0.5 Post Addition Benzalkonium Chloride, 50% Solution, USP 0.2 Sodium Coco PG-Dimonium Chloride Phosphate 0.056 Propylene Glycol and Diazolidinyl Urea and Methylparaben and Propylparaben 0.1 Aminomethyl Propanol 0.19 Example 4 5 A composition (pH = 3.7) of the present invention was prepared by combining the materials listed in Table 4 in the same manner as described in Example 3.
-14 Table 4 Ingredient %W/W Pre-mix Ethanol 4 Phenethyl Dimethicone 0.2 Stearoxytrimethylsilane and Stearyl Alcohol 0.028 Phase A Ethanol 36 Salicylic Acid 2 DI Water 39.736 Hydroxypropylcellulose 1.5 Glycerin 3 Phase B Cyclomethicone 1.66
C
12 15 alkyl lactate I Cetyl lactate 0.5 Propylene Glycol 0.1 Fragrance 0.13 DI Water 9 Diazolidinyl Urea and lodopropynyl Butylcarbamate 0.1 Ethylene Glycol Phenyl Ether 0.5 Post Addition Benzalkonium Chloride, 50% Solution, USP 0.2 Sodium Coco PG-Dimonium Chloride Phosphate 0.056 Propylene Glycol and Diazolidinyl Urea and Methylparaben and Propylparaben 0.1 Aminomethyl Propanol 0.19 Example 5 5 A composition (pH = 3.7) of the present invention was prepared by combining the materials listed in Table 5. For phase B, the water was heated to -40'C and all other ingredients were added and mixed until dissolved. Phase A ingredients were mixed until homogenous. Phase A was added to phase B and mixed until uniform. Post addition ingredients were then added.
- 15 Table 5 Ingredient %W/W Phase A C 1 2 is alkyl lactate I Salicylic Acid 0.5 PEG-32 12 Phase B DI water 60 glycerin 2 Methylethylcellulose 0.75 Isohexadecane and Ammonium Polyacryloylldimethyl Taurate and Polysorbate 80 Post Addition Benzalkonium Chloride, 50% Solution, USP 0.2 Sodium Coco PG-Dimonium Chloride Phosphate DI water Qs to 100 Example 6 5 A clinical study was conducted using the composition of Example 4 to treat mild to moderate acne. The study demonstrated the ability of the compositions of the present invention to quickly treat acne (twice a day product applications on the affected acne areas). A control composition of Clearasil@ Acne Treatment Cream (Boots International Inc., London UK) containing 10% benzoyl peroxide ("10% BPO") and an untreated acne 10 population receiving no treatment ("Untreated") were also used in the study. The acne severity was graded according to the following scale (as recommended by American academy of dermatology): very no lesion slight Slight Mild moderate severe 0.0 1.0 2.0 3.0 4.0 5.0 15 -16 The results of the clinical study for mild to severe patients (baseline grade 3-5) are shown below in Table 6. Table 6 48 hours Sample OVERALL SIZEREDNESS ELEVATION PEELING Average 10% BPO(n=5) -0.2 0 -0.4 -0.6 1 %improv 10% BPO 20 20 60 60 0 %NC 10% BPO 80 60 20 40 40 %worse 10% BPO 0 20 20 0 60 Average Example 4 (n=10) -0.8 -0.5 -0.5 -0.6 0.3 %improv Example 4 40 50 40 50 10 %NC Example 4 40 30 40 30 60 %worse Example 4 20 20 20 20 30 Average Untreated (n=2) -0.5 0.5 0.5 1 0 %improve Untreated 50 0 0 0 0 %NC Untreated 50 50 50 50 100 %worse Untreated 0 50 50 50 0 5 NC = no change The relative improvement to baseline in pimple size, redness and elevation for the mild acne lesions was superior for the formulation of Example 4 versus the 10% BPO treatment. There was also less peeling associated with the formulation of the present invention. 10 The results of the clinical study for moderate to severe acne patients whose pimples are more deeply rooted (baseline grade 4-5) are shown below in Table 7. Example 4 displayed surprising superior efficacy to treat all of the measured symptoms of moderate to severe acne as compared to untreated control and the 10% BPO cream. 15 Table 7 48 HRS Sample OVERALLSIZE REDNESS ELEVATION PEELING Average 10% BPO n=3 -0.3 0 0 -0.3 1.3 %improve 10% BPO 33.3 33.3 33.3 33.3 0 %NC 10% BPO 66.7 33.3 33.3 66.7 33.3 %worse 10% BPO 0 33.3 33.3 0 66.7 Average Example 4 (n=4) -1.8 -1.8 -1.5 -1.8 -0.3 %improv Example 4 50 100 75 75 25 %NC Example 4 50 0 25 25 75 %worse Example 4 0 0 0 0 0 Average Untreated (n=2) -0.5 0.5 0.5 1 0 %improv Untreated 50 0 0 0 0 %NC Untreated 50 50 50 50 100 %worse Untreated 0 50 50 50 0 - 17 For moderate to severe acne, where pimples are often normally more deeply rooted, the composition of the present invention showed dramatic improvement in size, redness, elevation and peeling without irritating the skin, dryness, and forming noticeable scars and postmarks afterwards. 5 Example 7 A clinical study was also conducted to evaluate the fast-acting efficacy of the formula of Example 4 versus Clearasil@ Acne Treatment Cream in the treatment of mild to moderate acne vulgaris over a I week period. This study was a double blind study 10 involving twice a day full-face application. Subjects were males and females between the ages of 12-30 with a Fitzpatrick Skin Type of I - IV. Subjects exhibited mild to moderate acne vulgaris at the baseline visit, with 1-3 target inflammatory lesions in the active phase. Dermatologist clinical evaluations of the target lesion surprisingly showed that 15 there was a statistically significant reduction in the erythema of the acne target lesions treated with the formulation of Example 4 as early as the four hour time point, with significant reductions in the diameter of the target lesions starting at eight hours, and a significant reduction in lesion height/elevation at Day 2, which were all maintained over time. BPO 10% had no significant effect at 4 hours, and there was a statistically 20 significant difference between Example 4 and 10% BPO treatment cream in target lesion erythema at the 8-hour time point and in diameter at the week I time point, in favor of the current invention. Subjects using Example 4 also did not exhibit an increase in any of the skin irritation parameters (peeling, edema, erythema, burning, stinging, itching), as graded by the dermatologist or by the subjects. There was a statistically significant 25 decrease in peeling and oiliness as evaluated by the dermatologist, and a significant decrease in itching and tightness as evaluated by the subjects at various time points versus baseline. Subjects using Example 4 experienced significantly less peeling beginning at 4 hours and significantly less oiliness and dryness beginning at Day 1 versus those 30 subjects using the 10% BPO treatment, which continued through the study. In contrast, subjects using the 10% BPO product experienced a statistically significant increase in oiliness at the Day 2 time point.
- 18 Example 8 Two formulations containing 0.10% histamine were prepared according to the following tables: 5 Table 8a Ingredient % (wt/wt) Ethanol 40 Salicylic acid 2 DI water 40 Benzalkonium Chloride 0.1 Sodium Hydroxide 0.27 Histamine 0.1 DI water 17.53 Table 8b 10 Ingredient % (wt/wt) Ethanol 40 Salicylic acid 2
C
1 2- 15 Alkyl lactate 5 DI water 40 Benzalkonium Chloride 0.1 Sodium Hydroxide 0.27 Histamine 0.1 DI water 12.53 A male subject was recruited to evaluate the in-vivo delivery of histamine by these two formulations. Both formulations were shook and 0.05 ml of the solutions were withdrawn and spread onto pre-marked areas of equal size on different sides of the 15 subject nose. The sensation and appearance were recorded. Typical histamine effects of erythema, itching, slight burning was observed for both formulas. The formula of Table - 19 8b (containing the C 1 2- 15 alkyl lactate) had such visible response in less than 2 minutes and peaked at around 5 minutes. The formula of Table 8a (not containing the C 1 2
-
15 alkyl lactate) started to experience such visible histamine effect only after about 5 minutes and peaked at around 10-15 minutes. The formula of Table 8b induced and itching sensation 5 that lasted for than one hour, much longer than the formula of Table 8a's response of less than 35-40 minutes. Example 9 A composition was prepared using the following components in Table 9a: 10 Table 9a Chemical Name % wt Ethyl Alcohol 39.3 Salicylic Acid 2 Witch Hazel (Hamamelis Virginiana) & Ethanol 5 Hydroxyethylcellulose 0.1 Deionized Water 35.804 Glycerin 3 Phenoxyethanol 0.555 Benzalkonium Chloride, 50% Solution, USP 0.2 Propylene Glycol 0.111 Dipropylene Glycol Isocetheth-20 Acetate 0.5 Cyclopentasiloxane 1.665 Poly Sorbate 20 0.367 Fragrance 0.13 Phenethyl Dimethicone 0.222 C12-15 Alkyl Lactate 1.111 Cetyl Lactate 0.555 Sodium Coco PG-Dimonium Chloride Phosphate I Polyacrylamide and C13-14 Isoparafin and Laureth 7 7.5 Sodium Hydroxide (20% solution) 0.88 15 The composition was prepared as follows: First, beaker A was charged with Dipropylene Glycol lsocetheth-20 Acetate and heated to 40'C until it melted. In beaker B, the ethyl alcohol and salicylic acid were added and mixed. In beaker C, the deionized water and hydroxyethylcellulose were added, and the resultant mixture was stirred and heated to 35-40*C until uniform. The composition was then allowed to cool to room 20 temperature. Once cooled, the contents from beaker B were added to beaker C and stirred until homogeneous. While continuing to mix, the following ingredients were - 20 added in order: witch hazel, glycerin, phenoxyethanol, benzalkonium chloride, and propylene glycol. The Cyclopentasiloxane, Poly Sorbate 20, Phenethyl Dimethicone, fragrance, C12-15 alkyl lactate, cetyl lactate, and Sodium Coco PG-Dimonium Chloride Phosphate 5 were then added to beaker A. The contents of beaker A were then added to beaker C, and the resulting composition was mixed until uniform. The pH of the uniform composition was then adjusted to be between 3.5-4.0 with the solution of 20% sodium hydroxide. The polyacrylamide and Cl 3-14 Isoparaffin and Laureth 7 mixture was then added, with the batch mixed until homogeneous. The finished product was then 10 packaged into 1-ounce tubes. The 1 -ounce tubes were distributed to males and females ages 12 to 30 years with Fitzpatrick Skin Types of I - IV. Subjects were instructed to every morning and evening to wash his/her face with the PURPOSE@ Gentle Cleansing Wash (Johnson & Johnson Consumer Products Company, Skillman, NJ). They were instructed to squeeze 15 approximately a nickel-sized amount of finished product onto their fingertips and apply it to their entire facial area, avoiding the eye, lip, and mouth areas. After each product application, they were instructed to not wash their face for at least three (3) hours after applying the test product. A self-assessment questionnaire was prepared for the subjects to complete at the 20 beginning of the study, weeks 1, 2, 5 and 6. Table 9b includes the condition and subjects perception of the condition at such time point. The grading scale was from 1-10, where 1 indicated the worst and 10 indicated the best. All results were normalized to Week 0, so that each number below indicates the change from baseline. A positive number indicates improvement. 25 Table lOb Indication Week 0 Week I Week 2 Week 5 Week 6 Pain/soreness associated with 0 0.67 0.78 0.30 0.40 pimples Pain/soreness associated with new 0 0.89 0.78 1.10 1.00 pimples coming up but that can't be seen Oiliness of skin 0 0.72 2.50 2.25 2.20 Shininess of skin 0 0.06 1.67 1.15 0.45 Pore size 0 1.11 2.39 1.95 2.85 Visibility of marks/scars from 0 0.89 1.61 1.75 2.05 - 21 previous pimples Skin smoothness 0 0.89 2.11 1.95 2.25 Dryness of skin 0 0.67 0.94 1.20 1.25 Flakiness of skin 0 1.28 1.94 1.85 2.00 A benefit assessment questionnaire was also prepared for the subjects to be completed simultaneously with the self-assessment questionnaire. Table 1 Oc includes the benefit and the subject's perception of the condition at the time point listed. The 5 grading scale was from 1-5, where 1 indicates that the subject completely disagreed while 5 indicates that the subject completely agreed. The percentage of subjects rating the benefit statement as 4 (agree somewhat) or a 5 (agree completely) is shown in Table I Oc below. 10 Table IOc Benefit Week 1 Week 2 Week 5 Week 6 1 felt new pimples starting to appear but they 70 66.7 72.7 80 never appeared My pimples are less sore/painful/irritated 88.9 71.4 66.7 77.8 My pores look less noticeable 55.6 54.5 78.6 75 My skin feels less oily 66.7 75 100 83.3 My skin feels less shiny 54.5 63.6 100 69.2 My skin feels smoother 69.2 57.1 92.9 71.4 My dark marks look less visible 33.3 66.7 57.1 69.2 This product stops pimples before they 76.9 71.4 93.3 76.5 become visible Expert grading of global acne parameters were also completed at the beginning and at 2, 5, and 6 weeks. Expert grading took place in single room where lighting conditions were consistent throughout the study. The study was double-blind, so neither 15 the grader nor the subject knew what treatment he/she was applying. Severity was graded from 0-4, with 0 indicating no acne or least severe and 4 indicating most severe. A decrease in score over time indicates improvement. The results are shown in Table I Od.
- 22 Table IOd Week 0 Week 2 Week 5 Week 6 Severity 2.23 1.94 1.73 1.70 It is understood that while the invention has been described in conjunction with 5 the detailed description thereof, that the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. Other aspects, advantages, and modifications are within the claims. 10
Claims (20)
1. A composition comprising an anti-acne agent, an antimicrobial agent, and a lactate. 5
2. The composition according to claim I wherein said anti-acne agent is selected from the group consisting of salicylic acid, benzoyl peroxide, sulphur, retinoic acid, azelaic acid, clindamycin, adapalene, erythromycin, sodium sulfacetamide, and combinations thereof 10
3. The composition according to claim I or claim 2 wherein said antimicrobial agent is selected from the group consisting of benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, 3-iodo-2-propynyl-N-butylcarbamate, hexetidine (5 amino-1, 3-bis-(2-ethylhexyl)-5-methyl-hexahydropyrimidine), Quaternium 15 triclosan, 15 chlorhexidine digluconate, and combinations thereof
4. The composition according to any one of claims 1-3 wherein said lactate is selected from the group consisting of C 12 - C 16 alkyl lactates and combinations thereof 20
5. The composition according to any one of claim 1-4 wherein said composition further comprises a phospholipid.
6. The composition according to claim 5 wherein said phospholipid is 25 sodium coco PG-Dimonium Chloride phosphate, cocamidopropyl PG-Dimonium Chloride Phosphate or myristamidopropyl PG-Dimonium Chloride phosphate.
7. A method of treating a follicular disease comprising applying to an area of skin in need of such treatment a composition comprising an anti-acne agent, an 30 antimicrobial agent, and a lactate.
8. A method according to claim 7, wherein said follicular disease is acne, rosacea, or seborrhea. - 24
9. A method according to claim 8, wherein said method of treating acne comprises treating pre-emergent pimples. 5
10. A method according to claim 9, wherein said method of treating acne comprises treating blackheads.
11. A method according to claim 10, wherein the appearance of said acne is reduced within about eight hours. 10
12. A method of reducing the appearance of pores or oil on the skin comprising applying to an area of skin in need of such treatment a composition comprising an anti-acne agent, an antimicrobial agent, and a lactate. 15
13. A method of evening skin tone or smoothing skin comprising applying to an area of skin in need of such treatment a composition comprising an anti-acne agent, an antimicrobial agent, and a lactate.
14. A method according to claim 12, wherein said skin has freckles, post 20 inflammatory hyperpigmentation (PIH), or scars.
15. The method according to any one of claims 7-14 wherein said antimicrobial agent is selected from the group consisting of benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, 3-iodo-2-propynyl-N-butylcarbamate, hexetidine (5 25 amino-1, 3-bis-(2-ethylhexyl)-5-methyl-hexahydropyrimidine), Quaternium 15 triclosan, chlorhexidine digluconate, and combinations thereof.
16. The method according to any one of claims 7-15 wherein said lactate is selected from the group consisting of C 1 2 - C 1 6 alkyl lactates and combinations thereof 30
17. The method according to any one of claims 7-16 wherein said composition further comprises a phospholipid. - 25
18. The method according to claim 17 wherein said phospholipid is sodium coco PG-Dimonium Chloride phosphate, cocamidopropyl PG-Dimonium Chloride Phosphate or myristamidopropyl PG-Dimonium Chloride phosphate. 5
19. A composition substantially as herein described with reference to any one of the embodiments of the invention illustrated in the accompanying drawings and/or examples.
20. A method substantially as herein described with reference to any one of 10 the embodiments of the invention illustrated in the accompanying drawings and/or examples.
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