AU2010253834B2 - Inhibition 0f inflammation using antagonists of MUC1 - Google Patents

Inhibition 0f inflammation using antagonists of MUC1 Download PDF

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Publication number
AU2010253834B2
AU2010253834B2 AU2010253834A AU2010253834A AU2010253834B2 AU 2010253834 B2 AU2010253834 B2 AU 2010253834B2 AU 2010253834 A AU2010253834 A AU 2010253834A AU 2010253834 A AU2010253834 A AU 2010253834A AU 2010253834 B2 AU2010253834 B2 AU 2010253834B2
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AU
Australia
Prior art keywords
muc1
cell
cells
peptide
accordance
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010253834A
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English (en)
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AU2010253834A1 (en
Inventor
Surender Kharbanda
Donald W. Kufe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Genus Oncology LLC
Original Assignee
Dana Farber Cancer Institute Inc
Genus Oncology LLC
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Application filed by Dana Farber Cancer Institute Inc, Genus Oncology LLC filed Critical Dana Farber Cancer Institute Inc
Publication of AU2010253834A1 publication Critical patent/AU2010253834A1/en
Application granted granted Critical
Publication of AU2010253834B2 publication Critical patent/AU2010253834B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1735—Mucins, e.g. human intestinal mucin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2010253834A 2009-05-27 2010-05-27 Inhibition 0f inflammation using antagonists of MUC1 Ceased AU2010253834B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US18153009P 2009-05-27 2009-05-27
US61/181,530 2009-05-27
US25373009P 2009-10-21 2009-10-21
US61/253,730 2009-10-21
US30399710P 2010-02-12 2010-02-12
US61/303,997 2010-02-12
PCT/US2010/036436 WO2010138740A1 (en) 2009-05-27 2010-05-27 Inhibition 0f inflammation using antagonists of muc1

Publications (2)

Publication Number Publication Date
AU2010253834A1 AU2010253834A1 (en) 2011-12-08
AU2010253834B2 true AU2010253834B2 (en) 2013-12-19

Family

ID=43223089

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010253834A Ceased AU2010253834B2 (en) 2009-05-27 2010-05-27 Inhibition 0f inflammation using antagonists of MUC1

Country Status (9)

Country Link
US (2) US8614186B2 (https=)
EP (1) EP2435062A4 (https=)
JP (1) JP5702371B2 (https=)
CN (1) CN102665748A (https=)
AU (1) AU2010253834B2 (https=)
CA (1) CA2763327C (https=)
IL (1) IL216612A0 (https=)
MX (1) MX2011012625A (https=)
WO (1) WO2010138740A1 (https=)

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US8524669B2 (en) 2008-10-17 2013-09-03 Dana-Farber Cancer Institute, Inc. MUC-1 cytoplasmic domain peptides as inhibitors of cancer
WO2011100688A1 (en) * 2010-02-12 2011-08-18 Dana-Farber Cancer Institute, Inc. Improved antagonists of muc1
WO2013026015A1 (en) 2011-08-18 2013-02-21 Dana-Farber Cancer Institute, Inc. Muc1 ligand traps for use in treating cancers
US9044421B2 (en) 2012-03-28 2015-06-02 Genus Oncology, Llc Treating MUC1-expressing cancers with combination therapies
WO2013170257A1 (en) * 2012-05-11 2013-11-14 Dana-Farber Cancer Institute, Inc. Treating muc1-expressing cancers with helicase inhibitors
CN103848890B (zh) * 2012-11-30 2015-09-09 北京市结核病胸部肿瘤研究所 Muc1自身抗体识别的抗原多肽
WO2014164395A1 (en) 2013-03-11 2014-10-09 Dana-Farber Cancer Institute, Inc. Combination anti-estrogen receptor cancer therapy using muc1 peptides and chemotherapeutics
US10507227B2 (en) 2014-04-15 2019-12-17 The Hospital For Sick Children Cationic antimicrobial peptides
RU2712452C2 (ru) * 2014-07-02 2020-01-29 Инфлектис Байосайенс Новое терапевтическое применение производных бензилиденгуанидина для лечения протеинопатий
EP3197474B1 (en) 2014-09-26 2023-06-07 Rajendra Sahai Bhatnagar Inhibitors of nf kappa-b activity for treatment of diseases and disorders
CA3075440A1 (en) * 2017-09-13 2019-03-21 B.R.A.H.M.S Gmbh Pro-adm as a therapy monitoring marker for critcally ill patients
CN107952069A (zh) * 2017-11-24 2018-04-24 长春百克生物科技股份公司 重组疫苗及其应用
WO2020243787A1 (en) * 2019-06-06 2020-12-10 The University Of Sydney Anti-inflammatory agents
CN117929754B (zh) * 2024-01-25 2025-02-11 广州医科大学附属第一医院（广州呼吸中心） Muc1-c段在肺动脉高压预防或治疗药物制备中的应用
WO2025217515A2 (en) * 2024-04-12 2025-10-16 Dana-Farber Cancer Institute, Inc. Identification of muc1-c as a target for the treatment of squamous cell carcinomas
WO2025231266A1 (en) * 2024-05-01 2025-11-06 Emory University Use of muc1 mimetic peptide inhibitors for inhibition of mucus secretion
CN119236051B (zh) * 2024-09-29 2025-12-19 北京大学 Muc1抑制剂在制备预防、治疗细菌感染药物中的应用

Citations (1)

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EP1538164A1 (en) * 2003-12-04 2005-06-08 Vectron Therapeutics AG RGD targeting moiety its production and use

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Also Published As

Publication number Publication date
WO2010138740A1 (en) 2010-12-02
US9096687B2 (en) 2015-08-04
JP2012528191A (ja) 2012-11-12
JP5702371B2 (ja) 2015-04-15
CA2763327A1 (en) 2010-12-02
CN102665748A (zh) 2012-09-12
IL216612A0 (en) 2012-02-29
MX2011012625A (es) 2012-04-20
CA2763327C (en) 2019-04-02
AU2010253834A1 (en) 2011-12-08
US20140187494A1 (en) 2014-07-03
EP2435062A4 (en) 2013-01-02
US8614186B2 (en) 2013-12-24
EP2435062A1 (en) 2012-04-04
US20110015138A1 (en) 2011-01-20

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired