AU2009273911B2 - Methods for diagnosing and treating a heart condition in a patient - Google Patents
Methods for diagnosing and treating a heart condition in a patient Download PDFInfo
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- AU2009273911B2 AU2009273911B2 AU2009273911A AU2009273911A AU2009273911B2 AU 2009273911 B2 AU2009273911 B2 AU 2009273911B2 AU 2009273911 A AU2009273911 A AU 2009273911A AU 2009273911 A AU2009273911 A AU 2009273911A AU 2009273911 B2 AU2009273911 B2 AU 2009273911B2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/04—Nitro compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8338608P | 2008-07-24 | 2008-07-24 | |
| US61/083,386 | 2008-07-24 | ||
| PCT/US2009/051695 WO2010011928A1 (en) | 2008-07-24 | 2009-07-24 | Methods for diagnosing and treating a heart condition in a patient |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2009273911A1 AU2009273911A1 (en) | 2010-01-28 |
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| WO2009120607A1 (en) * | 2008-03-27 | 2009-10-01 | Nellcor Puritan Bennett Llc | Method for controlling delivery of breathing gas to a patient using multiple ventilaton parameters |
| WO2009120639A2 (en) | 2008-03-27 | 2009-10-01 | Nellcor Puritan Bennett Llc | Breathing assistance systems with lung recruitment maneuvers |
| WO2010011928A1 (en) | 2008-07-24 | 2010-01-28 | Geno Llc | Methods for diagnosing and treating a heart condition in a patient |
| CA2763111C (en) | 2009-05-27 | 2019-09-24 | Ino Therapeutics Llc | Devices and methods for engaging indexed valve and pressurized canister assembly with collar and for linear actuation by plunger assembly into fluid communication with device for regulating drug delivery |
| JP5965845B2 (ja) * | 2010-02-01 | 2016-08-10 | ゲノ エルエルシー | 一酸化窒素送達システム |
| CA2797702C (en) * | 2010-04-26 | 2020-03-10 | VERO Biotech LLC. | Delivery of ultra pure nitric oxide (no) |
| US8638200B2 (en) | 2010-05-07 | 2014-01-28 | Covidien Lp | Ventilator-initiated prompt regarding Auto-PEEP detection during volume ventilation of non-triggering patient |
| US8607789B2 (en) | 2010-06-30 | 2013-12-17 | Covidien Lp | Ventilator-initiated prompt regarding auto-PEEP detection during volume ventilation of non-triggering patient exhibiting obstructive component |
| US8607790B2 (en) | 2010-06-30 | 2013-12-17 | Covidien Lp | Ventilator-initiated prompt regarding auto-PEEP detection during pressure ventilation of patient exhibiting obstructive component |
| US8607791B2 (en) | 2010-06-30 | 2013-12-17 | Covidien Lp | Ventilator-initiated prompt regarding auto-PEEP detection during pressure ventilation |
| US8607788B2 (en) | 2010-06-30 | 2013-12-17 | Covidien Lp | Ventilator-initiated prompt regarding auto-PEEP detection during volume ventilation of triggering patient exhibiting obstructive component |
| US8757152B2 (en) | 2010-11-29 | 2014-06-24 | Covidien Lp | Ventilator-initiated prompt regarding detection of double triggering during a volume-control breath type |
| US8757153B2 (en) | 2010-11-29 | 2014-06-24 | Covidien Lp | Ventilator-initiated prompt regarding detection of double triggering during ventilation |
| US8595639B2 (en) | 2010-11-29 | 2013-11-26 | Covidien Lp | Ventilator-initiated prompt regarding detection of fluctuations in resistance |
| CA2819854A1 (en) | 2010-12-03 | 2012-06-07 | Geno Llc | Nitric oxide treatments |
| US9038633B2 (en) | 2011-03-02 | 2015-05-26 | Covidien Lp | Ventilator-initiated prompt regarding high delivered tidal volume |
| EP2713723B1 (en) | 2011-05-27 | 2018-09-12 | Geno LLC | Method of determining vasoreactivity using inhaled nitric oxide |
| BR112014000329A2 (pt) * | 2011-07-07 | 2017-02-07 | Scripps Health | método de análise de distúrbios cardiovasculares e uso do mesmo |
| US20130145731A1 (en) * | 2011-12-07 | 2013-06-13 | Ecolab Usa Inc. | Apparatus and method for configuring and opening product packaging |
| MX368858B (es) * | 2012-03-15 | 2019-10-18 | Mallinckrodt Hospital Products Ip Ltd | Metodos para administrar altas concentraciones de oxido nitrico. |
| US9027552B2 (en) | 2012-07-31 | 2015-05-12 | Covidien Lp | Ventilator-initiated prompt or setting regarding detection of asynchrony during ventilation |
| TWI590837B (zh) * | 2014-03-25 | 2017-07-11 | 林信湧 | 一種用於治療心臟病之吸入式醫藥組成物及其備製方法 |
| BR112019016708B1 (pt) | 2017-02-27 | 2024-01-30 | Third Pole, Inc | Sistemas de geração de óxido nítrico |
| MX2020010523A (es) | 2017-02-27 | 2021-02-09 | Third Pole Inc | Sistemas y metodos para generar oxido nitrico. |
| WO2018157175A1 (en) | 2017-02-27 | 2018-08-30 | Third Pole, Inc. | Systems and methods for ambulatory generation of nitric oxide |
| US11672938B1 (en) | 2018-07-18 | 2023-06-13 | Vero Biotech LLC | Start-up protocols for nitric oxide delivery device |
| US11754538B1 (en) * | 2018-07-18 | 2023-09-12 | Vero Biotech Inc. | Method and apparatus for automatic calibration |
| CN114269685A (zh) | 2019-05-15 | 2022-04-01 | 第三极股份有限公司 | 用于一氧化氮生成的电极 |
| WO2020232414A1 (en) | 2019-05-15 | 2020-11-19 | Third Pole, Inc. | Architectures for production of nitric oxide |
| EP3969416A4 (en) | 2019-05-15 | 2023-11-01 | Third Pole, Inc. | SYSTEMS AND DEVICES FOR GENERATING NITROGEN OXIDE |
| EP4069069A4 (en) | 2020-01-11 | 2024-07-03 | Third Pole, Inc. | SYSTEMS AND METHODS FOR NITROGEN OXIDE PRODUCTION WITH HUMIDITY CONTROL |
| EP4167920A4 (en) | 2020-06-18 | 2024-06-12 | Third Pole, Inc. | Systems and methods for preventing and treating infections with nitric oxide |
| WO2022082072A1 (en) | 2020-10-16 | 2022-04-21 | Third Pole, Inc. | Nitric oxide generation process controls |
| EP4405019A4 (en) | 2021-09-23 | 2025-07-16 | Third Pole Inc | SYSTEMS AND METHODS FOR PROVIDING NITRIC OXIDE |
| WO2023201363A2 (en) | 2022-04-14 | 2023-10-19 | Third Pole, Inc. | Delivery of medicinal gas in a liquid medium |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6165435A (en) * | 1998-12-24 | 2000-12-26 | Praxair Technology, Inc. | Method and production of nitric acid |
| US20060048779A1 (en) * | 2004-08-18 | 2006-03-09 | Rounbehler David R | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US20070148260A1 (en) * | 2005-12-22 | 2007-06-28 | Andre Denault | Method for maintaining cerebral hemispheric oxygen saturation during surgery |
| US20070191478A1 (en) * | 1999-09-08 | 2007-08-16 | Duke University | Methods of treating cardio pulmonary diseases with NO group compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5427797A (en) * | 1993-04-06 | 1995-06-27 | Brigham And Women's Hospital | Systemic effects of nitric oxide inhalation |
| GB2279014B (en) * | 1993-06-02 | 1997-07-16 | Niall Keaney | Device for controlling delivery of respiratory drugs |
| GB9320978D0 (en) * | 1993-10-12 | 1993-12-01 | Higenbottam Timohy W | Nitric oxide treatment |
| US6063407A (en) * | 1995-02-16 | 2000-05-16 | The General Hospital Corporation | Treatment of vascular thrombosis and restenosis with inhaled nitric oxide |
| WO2010011928A1 (en) | 2008-07-24 | 2010-01-28 | Geno Llc | Methods for diagnosing and treating a heart condition in a patient |
-
2009
- 2009-07-24 WO PCT/US2009/051695 patent/WO2010011928A1/en not_active Ceased
- 2009-07-24 AU AU2009273911A patent/AU2009273911B2/en not_active Ceased
- 2009-07-24 JP JP2011520226A patent/JP6058888B2/ja not_active Expired - Fee Related
- 2009-07-24 CA CA3037614A patent/CA3037614A1/en not_active Abandoned
- 2009-07-24 EP EP09801072.1A patent/EP2306814B1/en not_active Not-in-force
- 2009-07-24 US US12/508,959 patent/US11000484B2/en not_active Expired - Fee Related
- 2009-07-24 CA CA2730011A patent/CA2730011C/en not_active Expired - Fee Related
- 2009-07-24 EP EP13188785.3A patent/EP2687086B1/en not_active Not-in-force
-
2015
- 2015-02-27 JP JP2015038636A patent/JP2015145376A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6165435A (en) * | 1998-12-24 | 2000-12-26 | Praxair Technology, Inc. | Method and production of nitric acid |
| US20070191478A1 (en) * | 1999-09-08 | 2007-08-16 | Duke University | Methods of treating cardio pulmonary diseases with NO group compounds |
| US20060048779A1 (en) * | 2004-08-18 | 2006-03-09 | Rounbehler David R | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US20070148260A1 (en) * | 2005-12-22 | 2007-06-28 | Andre Denault | Method for maintaining cerebral hemispheric oxygen saturation during surgery |
Non-Patent Citations (2)
| Title |
|---|
| ADATIA, I. et al. The Journal of Thoracic and Cardiovascular Surgery, 1996, vol. 112, no. 5, ;pages 1403-1405. * |
| WESSEL, D.L. et al. Circulation, 1993, vol. 88, no. 5, pages 2128-2138. * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2687086B1 (en) | 2016-09-14 |
| EP2306814A1 (en) | 2011-04-13 |
| JP6058888B2 (ja) | 2017-01-11 |
| EP2687086A1 (en) | 2014-01-22 |
| WO2010011928A1 (en) | 2010-01-28 |
| EP2306814B1 (en) | 2013-11-27 |
| JP2011529083A (ja) | 2011-12-01 |
| JP2015145376A (ja) | 2015-08-13 |
| EP2306814A4 (en) | 2011-08-31 |
| CA3037614A1 (en) | 2010-01-28 |
| US11000484B2 (en) | 2021-05-11 |
| CA2730011A1 (en) | 2010-01-28 |
| AU2009273911A1 (en) | 2010-01-28 |
| CA2730011C (en) | 2019-05-07 |
| US20100030091A1 (en) | 2010-02-04 |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| HB | Alteration of name in register |
Owner name: VERO BIOTECH LLC. Free format text: FORMER NAME(S): GENO LLC |
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| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |