AU2009240417B2 - Small-molecule inhibitors of the androgen receptor - Google Patents
Small-molecule inhibitors of the androgen receptor Download PDFInfo
- Publication number
- AU2009240417B2 AU2009240417B2 AU2009240417A AU2009240417A AU2009240417B2 AU 2009240417 B2 AU2009240417 B2 AU 2009240417B2 AU 2009240417 A AU2009240417 A AU 2009240417A AU 2009240417 A AU2009240417 A AU 2009240417A AU 2009240417 B2 AU2009240417 B2 AU 2009240417B2
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- Prior art keywords
- compound
- compounds
- group
- alkyl
- androgen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4755908P | 2008-04-24 | 2008-04-24 | |
| US61/047,559 | 2008-04-24 | ||
| PCT/US2009/041715 WO2009132307A1 (en) | 2008-04-24 | 2009-04-24 | Small-molecule inhibitors of the androgen receptor |
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| AU2009240417A1 AU2009240417A1 (en) | 2009-10-29 |
| AU2009240417B2 true AU2009240417B2 (en) | 2014-06-26 |
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| AU2009240417A Ceased AU2009240417B2 (en) | 2008-04-24 | 2009-04-24 | Small-molecule inhibitors of the androgen receptor |
Country Status (8)
| Country | Link |
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| US (2) | US8354538B2 (https=) |
| EP (1) | EP2276345A4 (https=) |
| JP (1) | JP5599385B2 (https=) |
| KR (1) | KR101640512B1 (https=) |
| AU (1) | AU2009240417B2 (https=) |
| CA (1) | CA2722340A1 (https=) |
| NZ (1) | NZ589299A (https=) |
| WO (1) | WO2009132307A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2496135B (en) * | 2011-11-01 | 2015-03-18 | Valirx Plc | Inhibitors of the interaction between a Src family kinase and an androgen receptor or estradiol receptor for treatment of endometriosis |
| CN105143463A (zh) * | 2013-02-25 | 2015-12-09 | 诺华股份有限公司 | 新的雄激素受体突变 |
| GB2513615A (en) | 2013-05-01 | 2014-11-05 | Cancer Rec Tech Ltd | Medical use |
| CN108349900A (zh) | 2015-09-04 | 2018-07-31 | 希望之城 | 雄激素受体拮抗剂 |
| US10933061B2 (en) | 2017-12-21 | 2021-03-02 | Shepherd Therapeutics, Inc. | Pyrvinium pamoate therapies and methods of use |
| WO2019152731A1 (en) * | 2018-01-31 | 2019-08-08 | Alpine Androsciences, Inc. | Androgen receptor antagonists |
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| US3821228A (en) * | 1967-06-10 | 1974-06-28 | Pfizer Ltd | 2-aminoalkyl tetrahydroquinolines |
| DE2421382A1 (de) * | 1974-05-03 | 1975-11-20 | Council Scient Ind Res | 1-substituierte 4-(beta-2-chinolylaethyl)- piperazine und deren 1,2,3,4-tetrahydrochinolinanaloge |
| WO2003031436A1 (en) * | 2001-10-05 | 2003-04-17 | Recordati S.A. | Heterocyclic compounds for use in the treatment of disorders of the urinary tract |
| EP1325914A1 (en) * | 2000-09-14 | 2003-07-09 | Kaken Pharmaceutical Co., Ltd. | Tetrahydroquinoline compounds |
| WO2006078754A1 (en) * | 2005-01-18 | 2006-07-27 | Immusol Incorporated | Novel quinolinium salts and derivatives |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3983121A (en) * | 1974-07-01 | 1976-09-28 | Council Of Scientific And Industrial Research | 1-Substituted 4-(β-2-quinolylethyl)piperazines and 1,2,3,4-tetrahydroquinolyl-ethyl analogues thereof |
| US5840500A (en) * | 1996-07-11 | 1998-11-24 | Trega Biosciences, Inc. | Quinoline derivatives and quinoline combinatorial libraries |
| KR100826485B1 (ko) * | 1999-10-14 | 2008-05-02 | 가켄 세야쿠 가부시키가이샤 | 테트라히드로퀴놀린 유도체 |
| CN1506359A (zh) | 2002-12-05 | 2004-06-23 | �й�ҽѧ��ѧԺҩ���о��� | 新的香豆素酰胺衍生物及其制法和其药物组合物与用途 |
| US8519158B2 (en) * | 2004-03-12 | 2013-08-27 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| JP2008510811A (ja) * | 2004-08-25 | 2008-04-10 | メルク エンド カムパニー インコーポレーテッド | アンドロゲン受容体モジュレーター |
| WO2007117466A2 (en) | 2006-03-31 | 2007-10-18 | Massachusetts Institute Of Technology | Celastrol, gedunin, and derivatives thereof as hsp90 inhibitors |
| WO2008128100A1 (en) | 2007-04-13 | 2008-10-23 | The Regents Of The University Of California | Small-molecule inhibitors of the androgen receptor |
-
2009
- 2009-04-24 CA CA2722340A patent/CA2722340A1/en not_active Abandoned
- 2009-04-24 NZ NZ589299A patent/NZ589299A/xx not_active IP Right Cessation
- 2009-04-24 AU AU2009240417A patent/AU2009240417B2/en not_active Ceased
- 2009-04-24 US US12/989,389 patent/US8354538B2/en not_active Expired - Fee Related
- 2009-04-24 EP EP09735196A patent/EP2276345A4/en not_active Withdrawn
- 2009-04-24 KR KR1020107026231A patent/KR101640512B1/ko not_active Expired - Fee Related
- 2009-04-24 WO PCT/US2009/041715 patent/WO2009132307A1/en not_active Ceased
- 2009-04-24 JP JP2011506486A patent/JP5599385B2/ja not_active Expired - Fee Related
-
2012
- 2012-12-06 US US13/706,647 patent/US8580773B2/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3821228A (en) * | 1967-06-10 | 1974-06-28 | Pfizer Ltd | 2-aminoalkyl tetrahydroquinolines |
| DE2421382A1 (de) * | 1974-05-03 | 1975-11-20 | Council Scient Ind Res | 1-substituierte 4-(beta-2-chinolylaethyl)- piperazine und deren 1,2,3,4-tetrahydrochinolinanaloge |
| EP1325914A1 (en) * | 2000-09-14 | 2003-07-09 | Kaken Pharmaceutical Co., Ltd. | Tetrahydroquinoline compounds |
| WO2003031436A1 (en) * | 2001-10-05 | 2003-04-17 | Recordati S.A. | Heterocyclic compounds for use in the treatment of disorders of the urinary tract |
| US20030162777A1 (en) * | 2001-10-05 | 2003-08-28 | Recordati S.A. | Novel N-acylated heterocycles |
| WO2006078754A1 (en) * | 2005-01-18 | 2006-07-27 | Immusol Incorporated | Novel quinolinium salts and derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009132307A1 (en) | 2009-10-29 |
| KR20110002872A (ko) | 2011-01-10 |
| US20130096095A1 (en) | 2013-04-18 |
| US8580773B2 (en) | 2013-11-12 |
| CA2722340A1 (en) | 2009-10-29 |
| JP2011518843A (ja) | 2011-06-30 |
| KR101640512B1 (ko) | 2016-07-18 |
| US8354538B2 (en) | 2013-01-15 |
| AU2009240417A1 (en) | 2009-10-29 |
| JP5599385B2 (ja) | 2014-10-01 |
| EP2276345A1 (en) | 2011-01-26 |
| NZ589299A (en) | 2013-01-25 |
| EP2276345A4 (en) | 2012-06-06 |
| US20110224253A1 (en) | 2011-09-15 |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |