AU2008284271B2 - Matriptase protein and uses thereof - Google Patents

Matriptase protein and uses thereof Download PDF

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Publication number
AU2008284271B2
AU2008284271B2 AU2008284271A AU2008284271A AU2008284271B2 AU 2008284271 B2 AU2008284271 B2 AU 2008284271B2 AU 2008284271 A AU2008284271 A AU 2008284271A AU 2008284271 A AU2008284271 A AU 2008284271A AU 2008284271 B2 AU2008284271 B2 AU 2008284271B2
Authority
AU
Australia
Prior art keywords
cancer
matriptase
matriptase stem
stem
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008284271A
Other languages
English (en)
Other versions
AU2008284271A1 (en
Inventor
Christian Rohlff
Jonathan Alexander Terrett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Biotherapeutics Ltd
ER Squibb and Sons LLC
Original Assignee
Oxford Biotherapeutics Ltd
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Biotherapeutics Ltd, ER Squibb and Sons LLC filed Critical Oxford Biotherapeutics Ltd
Publication of AU2008284271A1 publication Critical patent/AU2008284271A1/en
Assigned to MEDAREX, L.L.C., OXFORD GENOME SCIENCES (UK) LTD. reassignment MEDAREX, L.L.C. Amend patent request/document other than specification (104) Assignors: MEDAREX, INC., OXFORD GENOME SCIENCES (UK) LTD.
Assigned to MEDAREX, L.L.C., OXFORD BIO THERAPEUTICS LTD reassignment MEDAREX, L.L.C. Alteration of Name(s) of Applicant(s) under S113 Assignors: MEDAREX, L.L.C., OXFORD GENOME SCIENCES (UK) LTD.
Assigned to OXFORD BIOTHERAPEUTICS LTD, MEDAREX, L.L.C. reassignment OXFORD BIOTHERAPEUTICS LTD Alteration of Name(s) of Applicant(s) under S113 Assignors: MEDAREX, L.L.C., OXFORD BIO THERAPEUTICS LTD
Application granted granted Critical
Publication of AU2008284271B2 publication Critical patent/AU2008284271B2/en
Assigned to OXFORD BIOTHERAPEUTICS LTD, E. R. SQUIBB & SONS, L.L.C. reassignment OXFORD BIOTHERAPEUTICS LTD Request to Amend Deed and Register Assignors: MEDAREX, L.L.C., OXFORD BIOTHERAPEUTICS LTD
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2008284271A 2007-08-07 2008-08-07 Matriptase protein and uses thereof Ceased AU2008284271B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96383707P 2007-08-07 2007-08-07
US60/963,837 2007-08-07
PCT/US2008/009512 WO2009020645A2 (en) 2007-08-07 2008-08-07 Matriptase protein and uses thereof

Publications (2)

Publication Number Publication Date
AU2008284271A1 AU2008284271A1 (en) 2009-02-12
AU2008284271B2 true AU2008284271B2 (en) 2014-03-13

Family

ID=40239716

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008284271A Ceased AU2008284271B2 (en) 2007-08-07 2008-08-07 Matriptase protein and uses thereof

Country Status (7)

Country Link
US (1) US8420091B2 (enExample)
EP (1) EP2185933B1 (enExample)
JP (2) JP5864856B2 (enExample)
AU (1) AU2008284271B2 (enExample)
DK (1) DK2185933T3 (enExample)
ES (1) ES2550754T3 (enExample)
WO (1) WO2009020645A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120294800A1 (en) * 2009-01-07 2012-11-22 University Of Medicine And Dentistry Of New Jersey Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies
WO2011063127A1 (en) 2009-11-18 2011-05-26 University Of Medicine And Dentistry Of New Jersey Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies
JP5816558B2 (ja) * 2009-03-05 2015-11-18 メダレックス・リミテッド・ライアビリティ・カンパニーＭｅｄａｒｅｘ， Ｌ．Ｌ．Ｃ． Ｃａｄｍ１に特異的な完全ヒト抗体
US9849192B2 (en) 2009-11-18 2017-12-26 Rutgers, The State University Of New Jersey Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies
EP2904015A4 (en) 2012-10-02 2016-10-05 Univ Rutgers TARGETED RELEASE OF ANTIBODIES TO ACTIVATED MATRIPTASE-CONJUGATED TOXINS
MX2016006486A (es) 2013-11-25 2016-08-05 Oxford Biotherapeutics Ltd Anticuerpos.
CN111579784B (zh) * 2014-11-07 2023-12-22 藤仓化成株式会社 以dhps基因作为指标使用的动脉硬化及癌的检测方法
IL261757B2 (en) 2016-03-18 2023-09-01 Univ Rutgers Treatment of stem cells with chemotherapeutic agents conjugated to anti-matriptase antibodies using connecting parts that can be broken down in the living body

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007047796A2 (en) * 2005-10-17 2007-04-26 Institute For Systems Biology Tissue-and serum-derived glycoproteins and methods of their use

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US7022821B1 (en) * 1998-02-20 2006-04-04 O'brien Timothy J Antibody kit for the detection of TADG-15 protein
US5972616A (en) 1998-02-20 1999-10-26 The Board Of Trustees Of The University Of Arkansas TADG-15: an extracellular serine protease overexpressed in breast and ovarian carcinomas
EP1161266A4 (en) 1999-03-12 2007-09-19 Univ Georgetown Matriptase, a serine protease and its applications
US7030231B1 (en) * 1999-09-30 2006-04-18 Catalyst Biosciences, Inc. Membrane type serine protease 1 (MT-SP1) and uses thereof
JP2003512036A (ja) * 1999-10-20 2003-04-02 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ アーカンソー Ｔａｄｇ−１５：癌において過剰発現されている細胞外セリンプロテアーゼ
US6447978B1 (en) 1999-12-03 2002-09-10 Kodak Polychrome Graphics Llc Imaging member containing heat switchable polymer and method of use
AU2001233262A1 (en) 2000-02-03 2001-08-14 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
US6903201B2 (en) 2001-01-05 2005-06-07 Curagen Corporation Proteins and nucleic acids encoding same
US7125703B2 (en) 2001-03-13 2006-10-24 Dendreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
US7172892B2 (en) 2001-03-22 2007-02-06 Dendreon Corporation Nucleic acid molecules encoding serine protease CVSP14, the encoded polypeptides and methods based thereon
JP2005506047A (ja) 2001-03-27 2005-03-03 デンドレオン・サンディエゴ・リミテッド・ライアビリティ・カンパニー 膜貫通型セリンプロテアーゼ９をコード化する核酸分子、コード化されたポリペプチドおよびそれらに基づく方法
US7112430B2 (en) 2001-05-14 2006-09-26 Dendreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon
US7019019B2 (en) 2002-12-23 2006-03-28 Dendreon Corporation Matriptase inhibitors and methods of use
JP5026964B2 (ja) 2004-07-09 2012-09-19 テレフオンアクチーボラゲット エル エム エリクソン（パブル） マルチメディア通信システムにおいて異なったサービスを提供する方法および装置
US7572444B2 (en) 2004-12-20 2009-08-11 Amgen Fremont Inc. Binding proteins specific for human matriptase
EP1851543A2 (en) 2005-02-24 2007-11-07 Compugen Ltd. Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007047796A2 (en) * 2005-10-17 2007-04-26 Institute For Systems Biology Tissue-and serum-derived glycoproteins and methods of their use

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
abcam® 'Anti-ST14 antibody (ab28267)' [retrieved on 7 February 2013]. Retrieved from the Internet <URL: http://www.abcam.com/ST14-antibody-ab28267.html?refer404=catalogue%2028267 *
abcam® Scientific Support and Customer Services response to an inquiry, 'Anti-ST14 antibody (ab28267)' [retrieved on 7 February 2013]. Retrieved from the Internet <URL: http://www.abcam.com/ST14-antibody-ab28267-support.html *
abcam® 'ST14 peptide (Stem region) (ab41263)' [retrieved on 7 February 2013]. Retrieved from the Internet <URL: http://www.abcam.com/ab41263.html *
CHO, E. G., et al., The Journal of Biological Chemistry, 2001, vol. 276, pages 44581-44589 *
TSUZUKI, S., et al., Biochemical Journal, 2005, vol. 388, pages 679-687 *

Also Published As

Publication number Publication date
JP5864856B2 (ja) 2016-02-17
EP2185933A2 (en) 2010-05-19
DK2185933T3 (en) 2015-10-26
JP2014223083A (ja) 2014-12-04
ES2550754T3 (es) 2015-11-12
US8420091B2 (en) 2013-04-16
WO2009020645A2 (en) 2009-02-12
US20100285017A1 (en) 2010-11-11
JP2010535506A (ja) 2010-11-25
AU2008284271A1 (en) 2009-02-12
WO2009020645A3 (en) 2009-05-07
EP2185933B1 (en) 2015-10-07

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired