AU2008219269B2 - Combination therapy using TNF and alfa-galactosyl ceramide - Google Patents

Combination therapy using TNF and alfa-galactosyl ceramide Download PDF

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Publication number
AU2008219269B2
AU2008219269B2 AU2008219269A AU2008219269A AU2008219269B2 AU 2008219269 B2 AU2008219269 B2 AU 2008219269B2 AU 2008219269 A AU2008219269 A AU 2008219269A AU 2008219269 A AU2008219269 A AU 2008219269A AU 2008219269 B2 AU2008219269 B2 AU 2008219269B2
Authority
AU
Australia
Prior art keywords
tnf
alfa
galcer
treatment
tumour
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
AU2008219269A
Other languages
English (en)
Other versions
AU2008219269A1 (en
Inventor
Peter Brouckaert
Dirk Elewaut
Leander Huyghe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universiteit Gent
Vlaams Instituut voor Biotechnologie VIB
Original Assignee
Universiteit Gent
Vlaams Instituut voor Biotechnologie VIB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universiteit Gent, Vlaams Instituut voor Biotechnologie VIB filed Critical Universiteit Gent
Publication of AU2008219269A1 publication Critical patent/AU2008219269A1/en
Application granted granted Critical
Publication of AU2008219269B2 publication Critical patent/AU2008219269B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2008219269A 2007-02-21 2008-02-20 Combination therapy using TNF and alfa-galactosyl ceramide Expired - Fee Related AU2008219269B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07102787.4 2007-02-21
EP07102787 2007-02-21
PCT/EP2008/052055 WO2008101951A1 (en) 2007-02-21 2008-02-20 Combination therapy using tnf and alfa-galactosyl ceramide

Publications (2)

Publication Number Publication Date
AU2008219269A1 AU2008219269A1 (en) 2008-08-28
AU2008219269B2 true AU2008219269B2 (en) 2012-10-25

Family

ID=39495301

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008219269A Expired - Fee Related AU2008219269B2 (en) 2007-02-21 2008-02-20 Combination therapy using TNF and alfa-galactosyl ceramide

Country Status (6)

Country Link
US (1) US7959907B2 (enExample)
EP (1) EP2117583B1 (enExample)
JP (1) JP2010519274A (enExample)
AU (1) AU2008219269B2 (enExample)
CA (1) CA2678088A1 (enExample)
WO (1) WO2008101951A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010519274A (ja) 2007-02-21 2010-06-03 フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー（ヴェーイーベー・ヴェーゼットウェー） ＴＮＦおよびα−ガラクトシルセラミドを使用する併用療法
WO2016065353A1 (en) * 2014-10-24 2016-04-28 University Of Miami Combination therapy with fenofibrate and 2-deoxyglucose or 2-deoxymannose

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4677063A (en) 1985-05-02 1987-06-30 Cetus Corporation Human tumor necrosis factor
US4677064A (en) 1984-11-09 1987-06-30 Cetus Corporation Human tumor necrosis factor
JPH0559081A (ja) 1991-08-29 1993-03-09 Kirin Brewery Co Ltd 新規スフインゴ糖脂質、その製造法および使用
US6001619A (en) 1995-10-04 1999-12-14 Cold Spring Harbor Laboratory Ubiquitin ligases, and uses related thereto
IL147005A0 (en) 1999-06-11 2002-08-14 Univ New York State Res Found Antagonists of bmp and tgfb signaling pathways
JP2005533057A (ja) 2002-06-13 2005-11-04 ニューヨーク・ユニバーシティ 合成ｃ−糖脂質、ならびに癌、感染性疾患および自己免疫疾患を処置するための合成ｃ−糖脂質の使用
EP1639008A1 (en) 2003-07-01 2006-03-29 VIB vzw Ubiquitinated tnf receptor 2 and its uses
KR101377116B1 (ko) 2004-08-27 2014-03-24 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 면역 및 자가면역의 조절제로서의 세라마이드 유도체
JP2010519274A (ja) 2007-02-21 2010-06-03 フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー（ヴェーイーベー・ヴェーゼットウェー） ＴＮＦおよびα−ガラクトシルセラミドを使用する併用療法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NAKUI ET AL, CLINICAL & EXPERIMENTAL METASTASIS, VOL 18, 2000, PAGES 147-153 *

Also Published As

Publication number Publication date
WO2008101951A1 (en) 2008-08-28
JP2010519274A (ja) 2010-06-03
EP2117583A1 (en) 2009-11-18
AU2008219269A1 (en) 2008-08-28
CA2678088A1 (en) 2008-08-28
US20100166697A1 (en) 2010-07-01
EP2117583B1 (en) 2013-05-22
US7959907B2 (en) 2011-06-14

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AU2008219269B2 (en) Combination therapy using TNF and alfa-galactosyl ceramide
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Legal Events

Date Code Title Description
MK25 Application lapsed reg. 22.2i(2) - failure to pay acceptance fee