AU2007314076B2 - Organo-arsenoxide compounds and use thereof - Google Patents

Organo-arsenoxide compounds and use thereof Download PDF

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Publication number
AU2007314076B2
AU2007314076B2 AU2007314076A AU2007314076A AU2007314076B2 AU 2007314076 B2 AU2007314076 B2 AU 2007314076B2 AU 2007314076 A AU2007314076 A AU 2007314076A AU 2007314076 A AU2007314076 A AU 2007314076A AU 2007314076 B2 AU2007314076 B2 AU 2007314076B2
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AU
Australia
Prior art keywords
compound
formula
vertebrate
cells
arsenoxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
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AU2007314076A
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English (en)
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AU2007314076A1 (en
Inventor
Pierre Dilda
Philip John Hogg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NewSouth Innovations Pty Ltd
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NewSouth Innovations Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2006906220A external-priority patent/AU2006906220A0/en
Application filed by NewSouth Innovations Pty Ltd filed Critical NewSouth Innovations Pty Ltd
Priority to AU2007314076A priority Critical patent/AU2007314076B2/en
Publication of AU2007314076A1 publication Critical patent/AU2007314076A1/en
Application granted granted Critical
Publication of AU2007314076B2 publication Critical patent/AU2007314076B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/74—Aromatic compounds
    • C07F9/76—Aromatic compounds containing hydroxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2007314076A 2006-11-01 2007-11-01 Organo-arsenoxide compounds and use thereof Active AU2007314076B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2007314076A AU2007314076B2 (en) 2006-11-01 2007-11-01 Organo-arsenoxide compounds and use thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AU2006906220A AU2006906220A0 (en) 2006-11-01 Arsenoxide compounds and use thereof
AU2006906220 2006-11-01
PCT/AU2007/001676 WO2008052279A1 (en) 2006-11-01 2007-11-01 Organo-arsenoxide compounds and use thereof
AU2007314076A AU2007314076B2 (en) 2006-11-01 2007-11-01 Organo-arsenoxide compounds and use thereof

Publications (2)

Publication Number Publication Date
AU2007314076A1 AU2007314076A1 (en) 2008-05-08
AU2007314076B2 true AU2007314076B2 (en) 2012-07-19

Family

ID=39343707

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007314076A Active AU2007314076B2 (en) 2006-11-01 2007-11-01 Organo-arsenoxide compounds and use thereof

Country Status (8)

Country Link
US (2) US8268883B2 (enExample)
EP (1) EP2069371B1 (enExample)
JP (1) JP5301449B2 (enExample)
CN (1) CN101595115B (enExample)
AU (1) AU2007314076B2 (enExample)
CA (1) CA2668010C (enExample)
ES (1) ES2411094T3 (enExample)
WO (1) WO2008052279A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4571408B2 (ja) 2002-01-07 2010-10-27 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン
JP4426456B2 (ja) 2002-11-07 2010-03-03 ニューサウス イノベイションズ ピーティーワイ リミテッド ミトコンドリア膜透過性遷移の誘導
WO2009043114A1 (en) * 2007-10-04 2009-04-09 Newsouth Innovations Pty Limited Arsenoxide compound and method of use
TWI539493B (zh) 2010-03-08 2016-06-21 黛納羅伊有限責任公司 用於摻雜具有分子單層之矽基材之方法及組合物
US8853438B2 (en) * 2012-11-05 2014-10-07 Dynaloy, Llc Formulations of solutions and processes for forming a substrate including an arsenic dopant
EP3307263A4 (en) 2015-06-15 2019-02-13 NewSouth Innovations Pty Limited PHARMACEUTICAL COMBINATIONS OF ORGANO ARSENOXIDE COMPOUNDS AND MTOR HAZARDS
US20220152229A1 (en) 2019-04-12 2022-05-19 Centenary Institute Of Cancer Medicine And Cell Biology Conjugates and their use as imaging agents

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021628A1 (en) * 1999-09-20 2001-03-29 Unisearch Limited A substantially cell membrane impermeable compound and use thereof
WO2002074305A1 (en) * 2001-03-19 2002-09-26 Unisearch Limited Use of a substantially cell membrane impermeable compound for treating arthritis
WO2003003011A1 (en) * 2001-06-28 2003-01-09 Unisearch Limited Modification of angiogenesis by targeting protein tyrosine phosphatases
WO2003039564A1 (en) * 2001-11-08 2003-05-15 Unisearch Limited Selective targeting of apoptotic cells
WO2004042079A1 (en) * 2002-11-07 2004-05-21 Unisearch Limited Induction of the mitochondrial permeability transition

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2370092A (en) 1942-05-04 1945-02-20 Parke Davis & Co Organic amine derivatives and method of obtaining same
US2409291A (en) 1942-05-19 1946-10-15 Squibb & Sons Inc Chemotherapeutic sulfanilamide derivatives
US2465308A (en) 1946-11-27 1949-03-22 Hoffmann La Roche Arsenoso compounds and method of preparation
US2664432A (en) 1947-01-28 1953-12-29 Ernst A H Friedheim Heterocyclic metal and sulfur organic compounds
US2553515A (en) 1948-12-11 1951-05-15 Hoffmann La Roche N-(p-arsenoso-benzyl)-urea
US2951766A (en) 1957-07-15 1960-09-06 Le Roy A White Antiseptic plastic
BE786573A (fr) 1971-07-20 1973-01-22 Hoechst Ag Medicament a base de composes arsenicaux organiques et de derives du benzimidazole
FR2640269B1 (fr) 1988-12-13 1991-03-15 Maes Ludo Composes organometalliques, leurs modes de preparation et compositions pharmaceutiques les contenant
US5270196A (en) 1989-10-20 1993-12-14 Bristol-Myers Squibb Company Arylsulfatase from streptomyces
FR2684382B1 (fr) 1991-12-02 1994-10-21 Rhone Merieux Medicaments et preparations pures de dichlorhydrate de melarsomine, leur procede d'obtention et produits intermediaires obtenus.
EP0981344A1 (en) 1997-05-14 2000-03-01 The University of New Mexico Inhibition of cell surface protein disulfide isomerase
EP1391206B1 (en) 1997-10-15 2008-07-02 Polarx Biopharmaceuticals, Inc. Pharmaceutical compositions comprising arsenic trioxide for the treatment of non-Hodgkin's lymphoma
CN1233476A (zh) 1998-04-24 1999-11-03 陆道培 治疗急性白血病的药物及其制备方法
EP1049780A1 (en) 1998-11-03 2000-11-08 Mitokor Adenine nucleotide translocator (ant) fusion proteins and uses thereof
US6191123B1 (en) 1999-03-19 2001-02-20 Parker Hughes Institute Organic-arsenic compounds
WO2000079274A2 (en) 1999-06-22 2000-12-28 Mitokor Methods for assaying subcellular conditions using energy transfer
JP4571408B2 (ja) * 2002-01-07 2010-10-27 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン
AU2002952526A0 (en) * 2002-11-07 2002-11-21 Unisearch Limited Induction of the mitochondrial permeability transition
WO2009043114A1 (en) * 2007-10-04 2009-04-09 Newsouth Innovations Pty Limited Arsenoxide compound and method of use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021628A1 (en) * 1999-09-20 2001-03-29 Unisearch Limited A substantially cell membrane impermeable compound and use thereof
WO2002074305A1 (en) * 2001-03-19 2002-09-26 Unisearch Limited Use of a substantially cell membrane impermeable compound for treating arthritis
WO2003003011A1 (en) * 2001-06-28 2003-01-09 Unisearch Limited Modification of angiogenesis by targeting protein tyrosine phosphatases
WO2003039564A1 (en) * 2001-11-08 2003-05-15 Unisearch Limited Selective targeting of apoptotic cells
WO2004042079A1 (en) * 2002-11-07 2004-05-21 Unisearch Limited Induction of the mitochondrial permeability transition

Also Published As

Publication number Publication date
WO2008052279A1 (en) 2008-05-08
US20100041749A1 (en) 2010-02-18
US8268883B2 (en) 2012-09-18
US9765101B2 (en) 2017-09-19
US20130041027A1 (en) 2013-02-14
JP2010508245A (ja) 2010-03-18
JP5301449B2 (ja) 2013-09-25
CA2668010A1 (en) 2008-05-08
CN101595115B (zh) 2012-07-18
ES2411094T3 (es) 2013-07-04
CN101595115A (zh) 2009-12-02
EP2069371B1 (en) 2013-03-13
EP2069371A1 (en) 2009-06-17
EP2069371A4 (en) 2010-02-10
CA2668010C (en) 2015-03-24
AU2007314076A1 (en) 2008-05-08

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