AU2007297754B2 - Heterocyclic inhibitors of c-MET and uses thereof - Google Patents
Heterocyclic inhibitors of c-MET and uses thereof Download PDFInfo
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- AU2007297754B2 AU2007297754B2 AU2007297754A AU2007297754A AU2007297754B2 AU 2007297754 B2 AU2007297754 B2 AU 2007297754B2 AU 2007297754 A AU2007297754 A AU 2007297754A AU 2007297754 A AU2007297754 A AU 2007297754A AU 2007297754 B2 AU2007297754 B2 AU 2007297754B2
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- aliphatic
- optionally substituted
- ring
- pct
- cancer
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US84535606P | 2006-09-18 | 2006-09-18 | |
| US60/845,356 | 2006-09-18 | ||
| PCT/US2007/020222 WO2008036272A1 (en) | 2006-09-18 | 2007-09-18 | HETEROCYCLIC INHIBITORS OF c-MET AND USES THEREOF |
Publications (2)
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| AU2007297754A1 AU2007297754A1 (en) | 2008-03-27 |
| AU2007297754B2 true AU2007297754B2 (en) | 2012-05-17 |
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| AU2007297754A Ceased AU2007297754B2 (en) | 2006-09-18 | 2007-09-18 | Heterocyclic inhibitors of c-MET and uses thereof |
Country Status (9)
| Country | Link |
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| US (1) | US8481538B2 (show.php) |
| EP (1) | EP2066676A1 (show.php) |
| JP (1) | JP2010519174A (show.php) |
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| CA (1) | CA2663528A1 (show.php) |
| MX (1) | MX2009002842A (show.php) |
| NZ (1) | NZ575548A (show.php) |
| WO (1) | WO2008036272A1 (show.php) |
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| BRPI0912882A2 (pt) * | 2008-05-21 | 2017-05-16 | Incyte Corp | sais de 2-flúor-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamida e processos relacionados à preparação dos mesmos |
| EP2438041A4 (en) * | 2009-06-01 | 2012-11-21 | Merck Sharp & Dohme | PYRAZINE-carboxamide-orexin receptor Antagonist |
| RS63612B1 (sr) | 2009-12-31 | 2022-10-31 | Hutchison Medipharma Ltd | Neki triazolopirazini, njihove kompozicije i postupci njihovog korišćenja |
| EA025281B9 (ru) | 2010-05-17 | 2017-08-31 | Инкозен Терапьютикс Пвт. Лтд. | СОЕДИНЕНИЯ 3,5-ДИЗАМЕЩЕННОГО-3H-ИМИДАЗО[4,5-b]ПИРИДИНА И 3,5-ДИЗАМЕЩЕННОГО-3H-[1,2,3]ТРИАЗОЛО[4,5-b]ПИРИДИНА КАК МОДУЛЯТОРЫ ПРОТЕИНКИНАЗ |
| NZ629499A (en) | 2012-03-30 | 2016-05-27 | Rhizen Pharmaceuticals Sa | Novel 3,5-disubstituted-3h-imidazo[4,5-b]pyridine and 3,5- disubstituted -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of c-met protein kinases |
| AR101106A1 (es) | 2014-07-02 | 2016-11-23 | Pharmacyclics Llc | Inhibidores de tirosina quinasa de bruton |
| US10421756B2 (en) | 2015-07-06 | 2019-09-24 | Rodin Therapeutics, Inc. | Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase |
| PT3319959T (pt) | 2015-07-06 | 2021-12-06 | Alkermes Inc | Inibidores hetero-halo de histona desacetilase |
| KR102526032B1 (ko) | 2017-01-11 | 2023-04-25 | 로딘 테라퓨틱스, 인크. | 히스톤 데아세틸라제의 바이시클릭 억제제 |
| DK3664802T3 (en) | 2017-08-07 | 2022-05-30 | Alkermes Inc | Bicyclic inhibitors of histone deacetylase |
| WO2020118683A1 (en) * | 2018-12-14 | 2020-06-18 | Lynk Pharmaceuticals Co. Ltd. | Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof |
| TR202010296A1 (tr) * | 2020-06-30 | 2022-01-21 | Anadolu Ueniversitesi | Akt inhibisyonu aracılığıyla a549 hücrelerinde sitotoksik ve apoptotik etki gösteren yeni triazol ve triazolotiyadiazin türevleri |
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| WO2007064797A2 (en) * | 2005-11-30 | 2007-06-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-met and uses thereof |
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| KR100830859B1 (ko) * | 2000-04-27 | 2008-05-21 | 아스텔라스세이야쿠 가부시키가이샤 | 이미다조피리딘 유도체 및 이를 함유하는 의약 조성물 |
| RU2005122484A (ru) * | 2002-12-18 | 2006-01-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Композиции, используемые в качестве ингибиторов протеинкиназ |
| US7122548B2 (en) | 2003-07-02 | 2006-10-17 | Sugen, Inc. | Triazolotriazine compounds and uses thereof |
| US7732468B2 (en) * | 2006-11-15 | 2010-06-08 | Cytovia, Inc. | 3-aryl-6-aryl-[ 1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles and related compounds as activators of caspases and inducers of apoptosis and the use thereof |
| EP2178877A1 (en) * | 2007-07-13 | 2010-04-28 | GlaxoSmithKline LLC | Anti-viral compounds, compositions, and methods of use |
| PL2240487T3 (pl) * | 2008-02-05 | 2012-05-31 | Sanofi Sa | Triazolopirydazyny jako inhibitory PAR1, ich otrzymywanie i zastosowanie jako leków |
| AU2010226490A1 (en) * | 2009-03-20 | 2011-10-06 | Amgen Inc. | Inhibitors of PI3 kinase |
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- 2007-09-18 JP JP2009528341A patent/JP2010519174A/ja active Pending
- 2007-09-18 MX MX2009002842A patent/MX2009002842A/es unknown
- 2007-09-18 CA CA002663528A patent/CA2663528A1/en not_active Abandoned
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| WO2007064797A2 (en) * | 2005-11-30 | 2007-06-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-met and uses thereof |
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| CA2663528A1 (en) | 2008-03-27 |
| AU2007297754A1 (en) | 2008-03-27 |
| CN101796056A (zh) | 2010-08-04 |
| JP2010519174A (ja) | 2010-06-03 |
| US20100144739A1 (en) | 2010-06-10 |
| NZ575548A (en) | 2011-09-30 |
| WO2008036272A1 (en) | 2008-03-27 |
| EP2066676A1 (en) | 2009-06-10 |
| MX2009002842A (es) | 2009-05-27 |
| US8481538B2 (en) | 2013-07-09 |
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