AU2006315274B2 - Platelet aggregation assays - Google Patents
Platelet aggregation assays Download PDFInfo
- Publication number
- AU2006315274B2 AU2006315274B2 AU2006315274A AU2006315274A AU2006315274B2 AU 2006315274 B2 AU2006315274 B2 AU 2006315274B2 AU 2006315274 A AU2006315274 A AU 2006315274A AU 2006315274 A AU2006315274 A AU 2006315274A AU 2006315274 B2 AU2006315274 B2 AU 2006315274B2
- Authority
- AU
- Australia
- Prior art keywords
- cd40l
- antibody
- platelets
- cross
- binding moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 208000010110 spontaneous platelet aggregation Diseases 0.000 title claims abstract description 56
- 238000003556 assay Methods 0.000 title claims description 15
- 108010029697 CD40 Ligand Proteins 0.000 claims abstract description 111
- 102100032937 CD40 ligand Human genes 0.000 claims abstract description 111
- 230000027455 binding Effects 0.000 claims abstract description 61
- 238000000034 method Methods 0.000 claims abstract description 45
- 206010053567 Coagulopathies Diseases 0.000 claims abstract description 20
- 230000035602 clotting Effects 0.000 claims abstract description 20
- 238000004220 aggregation Methods 0.000 claims description 52
- 230000002776 aggregation Effects 0.000 claims description 52
- 239000003431 cross linking reagent Substances 0.000 claims description 43
- 230000003213 activating effect Effects 0.000 claims description 35
- 210000004623 platelet-rich plasma Anatomy 0.000 claims description 32
- 239000003795 chemical substances by application Substances 0.000 claims description 29
- 102000009109 Fc receptors Human genes 0.000 claims description 15
- 108010087819 Fc receptors Proteins 0.000 claims description 15
- 108090000623 proteins and genes Proteins 0.000 claims description 13
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 210000004369 blood Anatomy 0.000 claims description 11
- 239000008280 blood Substances 0.000 claims description 11
- 102000008186 Collagen Human genes 0.000 claims description 8
- 108010035532 Collagen Proteins 0.000 claims description 8
- 108090000190 Thrombin Proteins 0.000 claims description 8
- 210000004027 cell Anatomy 0.000 claims description 8
- 229920001436 collagen Polymers 0.000 claims description 8
- 108010089485 convulxin Proteins 0.000 claims description 8
- 229960004072 thrombin Drugs 0.000 claims description 8
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 claims description 8
- 108010028275 Leukocyte Elastase Proteins 0.000 claims description 7
- 102000016799 Leukocyte elastase Human genes 0.000 claims description 7
- 102400000432 CD40 ligand, soluble form Human genes 0.000 claims 10
- 101800000267 CD40 ligand, soluble form Proteins 0.000 claims 10
- 101000621371 Homo sapiens WD and tetratricopeptide repeats protein 1 Proteins 0.000 claims 3
- 101000892274 Human adenovirus C serotype 2 Adenovirus death protein Proteins 0.000 claims 3
- 101000820656 Rattus norvegicus Seminal vesicle secretory protein 4 Proteins 0.000 claims 3
- -1 p-selectin Proteins 0.000 claims 3
- XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical group C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 description 43
- XTWYTFMLZFPYCI-UHFFFAOYSA-N Adenosine diphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(O)=O)C(O)C1O XTWYTFMLZFPYCI-UHFFFAOYSA-N 0.000 description 43
- 239000000523 sample Substances 0.000 description 21
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 14
- 230000000694 effects Effects 0.000 description 11
- 230000000284 resting effect Effects 0.000 description 8
- 229960002685 biotin Drugs 0.000 description 7
- 235000020958 biotin Nutrition 0.000 description 7
- 239000011616 biotin Substances 0.000 description 7
- 230000004913 activation Effects 0.000 description 6
- 102000005962 receptors Human genes 0.000 description 6
- 108020003175 receptors Proteins 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000001262 western blot Methods 0.000 description 6
- 238000004132 cross linking Methods 0.000 description 5
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- 238000004062 sedimentation Methods 0.000 description 4
- 238000004448 titration Methods 0.000 description 4
- 101150013553 CD40 gene Proteins 0.000 description 3
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 3
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 210000002889 endothelial cell Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 229920002684 Sepharose Polymers 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 102000052502 human ELANE Human genes 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000011664 signaling Effects 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 230000009424 thromboembolic effect Effects 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 102100025222 CD63 antigen Human genes 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 108091006020 Fc-tagged proteins Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101100059511 Homo sapiens CD40LG gene Proteins 0.000 description 1
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 description 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 description 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 239000012741 Laemmli sample buffer Substances 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 102000008212 P-Selectin Human genes 0.000 description 1
- 108010035766 P-Selectin Proteins 0.000 description 1
- 241000219061 Rheum Species 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000020411 cell activation Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008614 cellular interaction Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000001 effect on platelet aggregation Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 230000010118 platelet activation Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 230000002947 procoagulating effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- XXUZFRDUEGQHOV-UHFFFAOYSA-J strontium ranelate Chemical compound [Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N XXUZFRDUEGQHOV-UHFFFAOYSA-J 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73748805P | 2005-11-17 | 2005-11-17 | |
| US60/737,488 | 2005-11-17 | ||
| US80484306P | 2006-06-15 | 2006-06-15 | |
| US60/804,843 | 2006-06-15 | ||
| PCT/US2006/044840 WO2007059332A2 (en) | 2005-11-17 | 2006-11-17 | Platelet aggregation assays |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2006315274A1 AU2006315274A1 (en) | 2007-05-24 |
| AU2006315274B2 true AU2006315274B2 (en) | 2012-07-05 |
Family
ID=38049325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2006315274A Ceased AU2006315274B2 (en) | 2005-11-17 | 2006-11-17 | Platelet aggregation assays |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8409810B2 (https=) |
| EP (2) | EP2431746A1 (https=) |
| JP (3) | JP5396083B2 (https=) |
| AU (1) | AU2006315274B2 (https=) |
| CA (1) | CA2629647C (https=) |
| DK (1) | DK1955078T3 (https=) |
| ES (1) | ES2425571T3 (https=) |
| NZ (1) | NZ568992A (https=) |
| WO (1) | WO2007059332A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1871259A (zh) | 2003-08-22 | 2006-11-29 | 比奥根艾迪克Ma公司 | 具有改变的效应物功能的经改进的抗体和制备它的方法 |
| EA014226B1 (ru) | 2004-07-26 | 2010-10-29 | Байоджен Айдек Ма Инк. | Антитела к cd154, их фрагменты и способы применения антител и фрагментов |
| PT2125894T (pt) | 2007-03-22 | 2019-02-27 | Biogen Ma Inc | Proteínas de ligação incluindo anticorpos, derivados de anticorpos e fragmentos de anticorpos que se ligam especificamente ao cd154 e as suas utilizações |
| EP2708892B1 (de) * | 2012-09-18 | 2015-04-15 | Siemens Healthcare Diagnostics Products GmbH | Verfahren zur Bestimmung Plättchen-assoziierter Analyten |
| PT2971039T (pt) | 2013-03-14 | 2020-05-06 | Immusoft Corp | Métodos para diferenciação e transdução in vitro de células b de memória com vetores virais pseudotipados vsv-g |
| JP5847140B2 (ja) * | 2013-08-29 | 2016-01-20 | 国立大学法人東北大学 | 慢性血栓塞栓性肺高血圧症の検査方法 |
| WO2015065986A1 (en) * | 2013-10-29 | 2015-05-07 | Bloodcenter Research Foundation | Method of detecting platelet activating antibodies that cause heparin-induced thrombocytopenia/thrombosis |
| DK3234107T3 (da) * | 2014-12-19 | 2022-10-17 | Immusoft Corp | B-celler til in vivo-levering af terapeutiske midler |
| MA41459A (fr) | 2015-02-03 | 2017-12-12 | Als Therapy Development Inst | Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l |
| WO2016208948A1 (ko) * | 2015-06-23 | 2016-12-29 | 서울대학교산학협력단 | Cd154 결합 폴리펩타이드 및 그 용도 |
| CN110662768B (zh) | 2017-05-24 | 2024-01-30 | Als治疗发展学会 | 治疗性抗cd40配体抗体 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3694161A (en) * | 1971-04-14 | 1972-09-26 | Armour Pharma | Method for measuring platelet aggregation |
| WO2003040691A2 (en) * | 2001-11-05 | 2003-05-15 | The Brigham And Women's Hospital, Inc. | Soluble cd40l(cd154) as a prognostic marker of atherosclerotic diseases |
| WO2003055516A1 (en) * | 2001-12-22 | 2003-07-10 | The University Of Reading | Pecam-1 modulation |
| EP1530047A1 (en) * | 2003-11-07 | 2005-05-11 | Roche Diagnostics GmbH | Proximal markers of arterial thrombosis and inflammation for risk stratification of coronary heart disease |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4344919A1 (de) * | 1993-12-30 | 1995-07-06 | Behringwerke Ag | Verfahren zur Bestimmung der Thrombozytenaggregation |
| US5951951A (en) * | 1997-04-30 | 1999-09-14 | Medtronic, Inc. | Platelet function evaluation technique for citrated whole blood |
| AU8867501A (en) | 2000-09-01 | 2002-03-13 | Biogen Inc | Co-crystal structure of monoclonal antibody 5c8 and cd154, and use thereof in drug design |
| US6500630B2 (en) | 2001-01-12 | 2002-12-31 | Mayo Foundation For Medical Education And Research | Marker for inflammatory conditions |
| WO2002078743A1 (en) | 2001-02-16 | 2002-10-10 | University Of Rochester | Compositions and methods for reducing tranfusion reactions |
| US6861504B2 (en) | 2001-05-03 | 2005-03-01 | Cbr, Inc. | Compounds and methods for the modulation of CD154 |
| ATE458199T1 (de) | 2001-05-04 | 2010-03-15 | Biosite Inc | Diagnostische marker der akuten koronaren syndrome und ihre verwendungen |
| EP1587838B1 (en) * | 2003-01-10 | 2015-04-15 | Ablynx N.V. | Therapeutic polypeptides, homologues thereof, fragments thereof and their use in modulating platelet-mediated aggregation |
| US7550532B2 (en) | 2005-07-11 | 2009-06-23 | Illinois Tool Works Inc. | Polyester resin composition |
-
2006
- 2006-11-17 EP EP11188112A patent/EP2431746A1/en not_active Withdrawn
- 2006-11-17 DK DK06838022.9T patent/DK1955078T3/da active
- 2006-11-17 WO PCT/US2006/044840 patent/WO2007059332A2/en not_active Ceased
- 2006-11-17 ES ES06838022T patent/ES2425571T3/es active Active
- 2006-11-17 US US12/093,658 patent/US8409810B2/en not_active Expired - Fee Related
- 2006-11-17 CA CA2629647A patent/CA2629647C/en not_active Expired - Fee Related
- 2006-11-17 JP JP2008541395A patent/JP5396083B2/ja not_active Expired - Fee Related
- 2006-11-17 AU AU2006315274A patent/AU2006315274B2/en not_active Ceased
- 2006-11-17 NZ NZ568992A patent/NZ568992A/en not_active IP Right Cessation
- 2006-11-17 EP EP06838022.9A patent/EP1955078B1/en active Active
-
2011
- 2011-12-29 JP JP2011290232A patent/JP5639993B2/ja not_active Expired - Fee Related
-
2013
- 2013-02-25 US US13/776,098 patent/US9297810B2/en not_active Expired - Fee Related
-
2014
- 2014-03-25 JP JP2014061273A patent/JP2014112114A/ja not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3694161A (en) * | 1971-04-14 | 1972-09-26 | Armour Pharma | Method for measuring platelet aggregation |
| WO2003040691A2 (en) * | 2001-11-05 | 2003-05-15 | The Brigham And Women's Hospital, Inc. | Soluble cd40l(cd154) as a prognostic marker of atherosclerotic diseases |
| WO2003055516A1 (en) * | 2001-12-22 | 2003-07-10 | The University Of Reading | Pecam-1 modulation |
| EP1530047A1 (en) * | 2003-11-07 | 2005-05-11 | Roche Diagnostics GmbH | Proximal markers of arterial thrombosis and inflammation for risk stratification of coronary heart disease |
Non-Patent Citations (4)
| Title |
|---|
| Henn V. et aI, The inflammatory action ofCD40 ligand (CDI54) expressed on activated human platelets is temporally limited by coexpressed CD40, Blood (2001 Aug 15) Vol 98 No 4 pp1047-1054. * |
| Langer F. et aI.: 'The role ofCD40 in CD40L-and antibody-mediated platelet activation', Thromb Haemost (2005 June) Vol 93 No 61137-46. * |
| Medline On-line abstract Accession Number 2004077257 of, Koyoma I. et al., Thombophilia associated with anti-CD154 monoclonal antibody treatment and its prophylaxis in non-human primates, Transplantation (2004 Feb 15) Vol 77 No 3 pp. 460-62 * |
| Xu H. et aI: 'Human Platelets activate porcine endothelial cells through a CD154 dependant pathway', Transplantation (2001 Dec 15) Vol 72 No 11, pp. 1858-1861. * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012073273A (ja) | 2012-04-12 |
| EP2431746A1 (en) | 2012-03-21 |
| ES2425571T3 (es) | 2013-10-16 |
| US9297810B2 (en) | 2016-03-29 |
| EP1955078A4 (en) | 2009-09-02 |
| US20130189713A1 (en) | 2013-07-25 |
| EP1955078A2 (en) | 2008-08-13 |
| JP2009516201A (ja) | 2009-04-16 |
| JP2014112114A (ja) | 2014-06-19 |
| JP5639993B2 (ja) | 2014-12-10 |
| NZ568992A (en) | 2012-01-12 |
| JP5396083B2 (ja) | 2014-01-22 |
| US8409810B2 (en) | 2013-04-02 |
| DK1955078T3 (da) | 2013-09-23 |
| CA2629647C (en) | 2013-05-21 |
| EP1955078B1 (en) | 2013-07-17 |
| US20090220998A1 (en) | 2009-09-03 |
| CA2629647A1 (en) | 2007-05-24 |
| WO2007059332A2 (en) | 2007-05-24 |
| AU2006315274A1 (en) | 2007-05-24 |
| WO2007059332A3 (en) | 2008-01-24 |
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