AU2006100580A4

AU2006100580A4 - Pesticide composition

Info

Publication number: AU2006100580A4
Application number: AU2006100580A
Authority: AU
Inventors: Kai Kin Lau
Original assignee: Jurox Pty Ltd
Current assignee: Jurox Pty Ltd
Priority date: 2006-07-12
Filing date: 2006-07-12
Publication date: 2006-09-07
Anticipated expiration: 2014-07-12
Also published as: AU2006100580C4; AU2006100580B4

Description

AUSTRALIA

Patents Act 1990 JUROX PTY LTD COMPLETE SPECIFICATION INNOVATION PATENT Invention Title: Pesticide composition The following statement is a full description of this invention including the best method of performing it known to us:- EN Technical Field This invention relates to insect growth regulator (IGR) compositions for external use in the prevention and control of insect and acarid infestations of animals and in particular to cyromazine compositions.

C0 Background art The IGR cyromazine has a solubility in water of 1.1% and only slight solubility O in methanol. Cyromazine is generally provided as a wettable powder, a suspension \0 concentrate or an aqueous solution. The wettable powder has the disadvantage that it is dusty and therefore poses a hazard to persons handling the product at the time of manufacture or at the time of application. The suspension concentrate suffers from sedementation and caking during storage and requires vigorous shaking of the product before use. The wettable powder and suspension concentrate are generally diluted with water prior to use. The aqueous solution is generally used without further dilution.

This ready-to-use aqueous formulation has a low active content and contains a large amount of water to solubilise the active. As a result, transportation of the product to an end user may be cumbersome and costly.

Disclosure of invention It is desirable to provide a formulation that can support a high concentration of cyromazine in solution, a formulation which may be diluted with water as required and may be applied topically.

Accordingly, in a first aspect, the present invention provides a composition comprising an effective amount of cyromazine, one or more organic solvents selected from the group consisting of polyols, glycol ethers, glycerol ether acetates, Ci-Cs alkyl pyrrolidones, acetal and mixtures thereof; one or more organic acids selected group consisting of Ci-C 6 carboxylic acids, C 2

-C

6 dicarboxylic acids and mixtures thereof; and optionally one or more surfactants.

In a second aspect, the invention provides a method of preventing or controlling insect and acarid infestations of a warm blooded non human animal, the method comprising topically administering to the animal a composition comprising an effective amount of cyromazine, one or more organic solvents selected from the group consisting of polyols, glycol ethers, glycerol ether acetates, CI-C 8 alkyl pyrrolidones, acetal and mixtures thereof; one or more organic acids selected group consisting of C 1

-C

6 carboxylic acids, C 2

-C

m:\speci\120000\128-129\128430specificationgrb.doc In a third aspect, the present invention is directed to use of an effective amount Sof cyromazine which is solubilised in a composition which comprises: one or more organic solvents selected from the group consisting of polyols, glycol ethers, glycerol ether acetates, CI-C 8 alkyl pyrrolidones, acetal and mixtures thereof; one or more organic acids selected group consisting of CI-C 6 carboxylic acids, C 2

-C

6 00 dicarboxylic acids and mixtures thereof; and optionally, one or more surfactants, in the preparation of a composition for preventing or controlling insect and acarid infestations of a warm blooded non human animal.

I Throughout this specification the word "comprise", or variations such as 010 "comprises" or "comprising", will be understood to imply the inclusion of a stated element, integer or step, or group of elements, integers or steps, but not the exclusion of any other element, integer or step, or group of elements, integers or steps.

Cyromazine may be included in the composition of the present invention in a concentration of up to 400g/L. The composition is suitable for topical administration to an animal, for example as a dip, a pour-on, a spray-on or a jetting formulation. The composition may be diluted with water prior to use and the level of dilution will vary with the initial concentration of cyromazine and the selected method of application.

The cyromazine may be included in the composition of the invention in an amount of from 10g/L to 400g/L, preferably an amount of from 100g/L to 300g/L.

The one or more organic solvents included in the composition are selected from the group consisting of polyols, glycol ethers, glycerol ether acetates, Ci-C 8 alkyl pyrrolidones, acetal and mixtures thereof. Suitable polyols include but are not limited to propylene glycol, glycerol and polyethylene glycol. Suitable glycol ethers include but are not limited to dipropylene glycol monomethylether, butyl icanol and butyl di icanol. Suitable glycerol ether acetates include but are not limited to ethylene glycol monobutylether acetate and propylene glycol monoethyl ether acetate. Suitable CI-C 8 alkyl pyrrolidones include but are not limited to N-methyl pyrrolidone, 1-octyl-2 pyrrolidinone and lauryl pyrrolidone. Suitable acetal include but are not limited to glycerol formal and tetraglycol. Preferably the organic solvents are selected from one or more of glycerol formal, tetraglycol and propylene glycol. More preferably, the solvent is a mixture of propylene glycol with glycerol formal or tetraglycol.

The total concentration of the solvent may be in the range of from 200 to 900g/L, preferably from 300 to 600g/L.

One or more organic acids are included in the composition of the invention selected from the group consisting of CI-C 6 carboxylic acids, C 2

-C

6 dicarboxylic acids and mixtures thereof. Suitable organic acids include but are not limited to formic acid, m:\speci\120000\128-129\128430specificationgrb.doc acetic acid, lactic acid, propionic acid, caproic acid ethandioic acid, hexanedioic acid Sand mixtures thereof. Preferred are lactic acid and acetic acid and most preferred is c lactic acid.

The acid may be included in a concentration in the range of from 10 to 300g/L, preferably 100 to 200g/L.

00 The composition optionally contains one or more surfactants. The one or more surfactants may be selected from nonionic surfactants such as C 8 -Clo alkylphenyl Sethoxylates such as ethoxylated nonylphenyl and ethoxylated octylphenyl, sorbitan I fatty acid ester ethoxylates such as polyoxyethylene sorbitan fatty acid esters.

The C 8 -Cio alkyl phenyl ethoxylates preferably contain from 2 to 100 moles of ethylene oxide and may be selected from the commercially available Teric series products such as those identified as Teric N9 and Teric X8. The sorbitan fatty acid ester ethoxylates preferably contain from 4 to 20 moles of ethylene oxide and may be selected from polysorbate 60 and polysorbate Preferably the surfactant is present in the composition at a concentration in the range of from 10 to 200g/L, more preferably in the range of from 30 to 100g/L.

Veterinarily acceptable excipients and adjuvants may be included in the composition such as colour, thickening agent and preservative.

Modes for carrying out the invention In order to better understand the nature of this invention a number of examples will be described.

Example 1 Quantity Supplier Cyromazine 260 g/L Pacific Resource Teric N9 45 g/L ICI Acetic Acid 118 g/L Sigma Chemicals Tetraglycol 500 g/L Tiger Chemicals Propylene glycol q.s. to 1 L Pacific Resource Example 2 Quantity Supplier Cyromazine 300 g/L Pacific Resource Teric N9 50 g/L ICI Acetic Acid 10 g/L Sigma Chemicals Glycerol Formal 500 g/L Tiger Chemicals m:\speci\120000\128-129\128430specificationgrb.doc cLactic Acid 100 g/L Sigma Chemicals Propylene glycol q.s. to 1 L Pacific Resource The formulations of Example 1 and 2 were prepared by dissolving cyromazine in a mixture of the surfactant, organic solvent and acid followed by high speed mixing until uniform.

OO

00 It will be appreciated by persons skilled in the art that numerous variations and/or modifications may be made to the invention as shown in the specific Sembodiments without departing from the spirit or scope of the invention as broadly (N described. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive.

m:\speci\120000\1 28-129\128430specificationgrb.doc

Claims

2. A composition according to claim 1 wherein the one or more organic solvents is Sselected from the group consisting of propylene glycol, glycerol, polyethylene glycol, O dipropylene glycol monomethylether, butyl icanol, butyl di icanol, ethylene glycol monobutylether acetate, propylene glycol monoethyl ether acetate, N-methyl pyrrolidone, 1-octyl-2 pyrrolidinone, lauryl pyrrolidone, glycerol formal, tetraglycol. and mixtures thereof and wherein the one or more organic acids is selected from the group consisting of formic acid, acetic acid, lactic acid, propionic acid, caproic acid ethandioic acid, hexandioic acid and mixtures thereof.
3. A composition according to claim 1 or claim 2 wherein the at least one organic solvent is included in an amount of from 200 to 900g/L, preferably from 300 to 600g/L and is selected from one or more of glycerol formal, tetraglycol and propylene glycol.
4. A composition according to any one of claims 1 to 3 wherein the at least one organic acid is included in an amount of from 10 to 300g/L, preferably from 100 to 200g/L and is selected from lactic acid, acetic acid and mixtures thereof. A method of preventing or controlling insect and acarid infestations of a warm blooded animal, the method comprising topically administering to the animal a composition comprising: an effective amount of cyromazine; one or more organic solvents selected from the group consisting of polyols, glycol ethers, glycerol ether acetates, Ci-C 8 alkyl pyrrolidones, acetal and mixtures thereof; one or more organic acids selected group consisting of CI-C 6 carboxylic acids, C 2 -C 6 dicarboxylic acids and mixtures thereof; and optionally one or more surfactants. Dated this twelfth day of July 2006 Jurox Pty Ltd Patent Attorneys for the Applicant: F B RICE CO m:\speci\120000\128-129\128430specificationgrb.doc