AU2005336513B2 - Thiazolyl mGluR5 antagonists and methods for their use - Google Patents

Thiazolyl mGluR5 antagonists and methods for their use Download PDF

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Publication number
AU2005336513B2
AU2005336513B2 AU2005336513A AU2005336513A AU2005336513B2 AU 2005336513 B2 AU2005336513 B2 AU 2005336513B2 AU 2005336513 A AU2005336513 A AU 2005336513A AU 2005336513 A AU2005336513 A AU 2005336513A AU 2005336513 B2 AU2005336513 B2 AU 2005336513B2
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AU
Australia
Prior art keywords
disorders
thiazol
methyl
mmol
ethynyl
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Ceased
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AU2005336513A
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AU2005336513A1 (en
AU2005336513A8 (en
Inventor
Jeannie M. Arruda
Nicholas D. Cosford
Brian W. Eastman
Dehua Huang
Chris King
Joseph Payne
Steve F. Poon
Jeffrey R. Roppe
Thomas J. Seiders
Nicholas D. Smith
Jean-Michel Vernier
Bowei Wang
Xiumin Zhao
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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Publication of AU2005336513A1 publication Critical patent/AU2005336513A1/en
Publication of AU2005336513A8 publication Critical patent/AU2005336513A8/en
Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. Alteration of Name(s) of Applicant(s) under S113 Assignors: MERCK & CO., INC.
Priority to AU2012208981A priority Critical patent/AU2012208981A1/en
Application granted granted Critical
Publication of AU2005336513B2 publication Critical patent/AU2005336513B2/en
Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. Request to Amend Deed and Register Assignors: MERCK SHARP & DOHME CORP.
Assigned to MERCK SHARP & DOHME LLC reassignment MERCK SHARP & DOHME LLC Request to Amend Deed and Register Assignors: MERCK SHARP & DOHME CORP.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
AU2005336513A 2004-10-07 2005-10-06 Thiazolyl mGluR5 antagonists and methods for their use Ceased AU2005336513B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012208981A AU2012208981A1 (en) 2004-10-07 2012-07-27 Thiazolyl mGluR5 antagonists and methods for their use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61680504P 2004-10-07 2004-10-07
US60/616,805 2004-10-07
PCT/US2005/035921 WO2007050050A2 (en) 2004-10-07 2005-10-06 Thiazolyl mglur5 antagonists and methods for their use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012208981A Division AU2012208981A1 (en) 2004-10-07 2012-07-27 Thiazolyl mGluR5 antagonists and methods for their use

Publications (3)

Publication Number Publication Date
AU2005336513A1 AU2005336513A1 (en) 2007-05-17
AU2005336513A8 AU2005336513A8 (en) 2009-01-08
AU2005336513B2 true AU2005336513B2 (en) 2012-08-09

Family

ID=37968242

Family Applications (1)

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AU2005336513A Ceased AU2005336513B2 (en) 2004-10-07 2005-10-06 Thiazolyl mGluR5 antagonists and methods for their use

Country Status (9)

Country Link
US (3) US7879882B2 (OSRAM)
EP (2) EP1893608B1 (OSRAM)
JP (2) JP5635727B2 (OSRAM)
CN (1) CN101223166B (OSRAM)
AT (1) ATE520692T1 (OSRAM)
AU (1) AU2005336513B2 (OSRAM)
CA (1) CA2583572C (OSRAM)
ES (1) ES2369783T3 (OSRAM)
WO (1) WO2007050050A2 (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101223166B (zh) * 2004-10-07 2011-10-19 默沙东公司 噻唑基mglur5拮抗剂及其应用方法
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
TW201124391A (en) * 2009-10-20 2011-07-16 Lundbeck & Co As H 2-substituted-ethynylthiazole derivatives and uses of same
CN102762572A (zh) 2010-02-01 2012-10-31 诺瓦提斯公司 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
CN102753527B (zh) 2010-02-02 2014-12-24 诺华股份有限公司 用作crf受体拮抗剂的环己基酰胺衍生物
US8420661B2 (en) 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
US8772300B2 (en) * 2011-04-19 2014-07-08 Hoffmann-La Roche Inc. Phenyl or pyridinyl-ethynyl derivatives
PH12013501895A1 (en) * 2011-04-26 2013-10-14 Hoffmann La Roche Ethynyl derivatives as positive allosteric modulators of the mglur5
MY165141A (en) * 2011-04-26 2018-02-28 Hoffmann La Roche Pyrazolidin-3-one derivatives
WO2014121883A1 (en) 2013-02-07 2014-08-14 Merck Patent Gmbh Substituted acetylene derivatives and their use as positive allosteric modulators of mglur4
UA116023C2 (uk) * 2013-07-08 2018-01-25 Ф. Хоффманн-Ля Рош Аг Етинільні похідні як антагоністи метаботропного глутаматного рецептора
WO2015188368A1 (en) * 2014-06-13 2015-12-17 Merck Sharp & Dohme Corp. Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles
ES2786673T3 (es) 2015-06-03 2020-10-13 Hoffmann La Roche Derivados de etinilo
MY201938A (en) 2017-08-04 2024-03-25 Skyhawk Therapeutics Inc Methods and compositions for modulating splicing
CN114007613A (zh) 2019-02-05 2022-02-01 斯基霍克疗法公司 用于调节剪接的方法和组合物
JP7603595B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016121A1 (en) * 1999-08-31 2001-03-08 Merck & Co., Inc. Heterocyclic compounds and methods of use thereof
WO2004038374A2 (en) * 2002-10-24 2004-05-06 Merck & Co., Inc. Alkyne derivatives as tracers for metabotropic glutamate receptor binding

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6956049B1 (en) * 1999-08-31 2005-10-18 Merck & Co., Inc. Methods of modulating processes mediated by excitatory amino acid receptors
US7365074B2 (en) * 1999-08-31 2008-04-29 Merck & Co., Inc. Pyridazine, pyrimidine and pyrazine ethyne compounds
US7462619B2 (en) * 1999-08-31 2008-12-09 Merck & Co., Inc. Pyridazine, pyrimidine and pyrazine ethyne compounds
US6774138B2 (en) 1999-08-31 2004-08-10 Merck & Co., Inc. Thiazolyl(pyridyl)ethyne compounds
US6551270B1 (en) 2000-08-30 2003-04-22 Snowden Pencer, Inc. Dual lumen access port
US6903005B1 (en) 2000-08-30 2005-06-07 Micron Technology, Inc. Method for the formation of RuSixOy-containing barrier layers for high-k dielectrics
CN101223166B (zh) * 2004-10-07 2011-10-19 默沙东公司 噻唑基mglur5拮抗剂及其应用方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016121A1 (en) * 1999-08-31 2001-03-08 Merck & Co., Inc. Heterocyclic compounds and methods of use thereof
WO2004038374A2 (en) * 2002-10-24 2004-05-06 Merck & Co., Inc. Alkyne derivatives as tracers for metabotropic glutamate receptor binding

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Cosford, N. D. P. et al (2003) Bioorg. Med. Chem. Lett., 13:351-354 *

Also Published As

Publication number Publication date
JP2008516004A (ja) 2008-05-15
CA2583572A1 (en) 2006-04-07
EP2380889A2 (en) 2011-10-26
US20090203903A1 (en) 2009-08-13
ES2369783T3 (es) 2011-12-05
US20120289696A1 (en) 2012-11-15
ATE520692T1 (de) 2011-09-15
EP1893608A4 (en) 2009-04-22
WO2007050050A3 (en) 2008-02-07
US20110230526A1 (en) 2011-09-22
CN101223166A (zh) 2008-07-16
EP2380889A3 (en) 2012-01-18
WO2007050050A2 (en) 2007-05-03
AU2005336513A1 (en) 2007-05-17
CN101223166B (zh) 2011-10-19
EP1893608A2 (en) 2008-03-05
EP1893608B1 (en) 2011-08-17
US8609852B2 (en) 2013-12-17
JP5635727B2 (ja) 2014-12-03
US7879882B2 (en) 2011-02-01
AU2005336513A8 (en) 2009-01-08
EP2380889B1 (en) 2013-06-26
US8242143B2 (en) 2012-08-14
JP2015013885A (ja) 2015-01-22
CA2583572C (en) 2016-07-12

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