AU2005304708B2 - Cardiac stem cells - Google Patents

Cardiac stem cells Download PDF

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Publication number
AU2005304708B2
AU2005304708B2 AU2005304708A AU2005304708A AU2005304708B2 AU 2005304708 B2 AU2005304708 B2 AU 2005304708B2 AU 2005304708 A AU2005304708 A AU 2005304708A AU 2005304708 A AU2005304708 A AU 2005304708A AU 2005304708 B2 AU2005304708 B2 AU 2005304708B2
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AU
Australia
Prior art keywords
cells
cdcs
mammal
heart
damaged
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Expired
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AU2005304708A
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English (en)
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AU2005304708A1 (en
Inventor
Maria Roselle Abraham
Eduardo Marban
Rachel R. Smith
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Johns Hopkins University
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Johns Hopkins University
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Application granted granted Critical
Publication of AU2005304708B2 publication Critical patent/AU2005304708B2/en
Priority to AU2012202233A priority Critical patent/AU2012202233B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/44—Thiols, e.g. mercaptoethanol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/175—Cardiotrophin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/32—Polylysine, polyornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Endoscopes (AREA)
AU2005304708A 2004-11-08 2005-11-08 Cardiac stem cells Expired AU2005304708B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012202233A AU2012202233B2 (en) 2004-11-08 2012-04-17 Cardiac stem cells

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62569504P 2004-11-08 2004-11-08
US60/625,695 2004-11-08
PCT/US2005/040359 WO2006052925A2 (en) 2004-11-08 2005-11-08 Cardiac stem cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012202233A Division AU2012202233B2 (en) 2004-11-08 2012-04-17 Cardiac stem cells

Publications (2)

Publication Number Publication Date
AU2005304708A1 AU2005304708A1 (en) 2006-05-18
AU2005304708B2 true AU2005304708B2 (en) 2012-01-19

Family

ID=36337122

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005304708A Expired AU2005304708B2 (en) 2004-11-08 2005-11-08 Cardiac stem cells

Country Status (7)

Country Link
US (3) US20080267921A1 (https=)
EP (2) EP1809740B1 (https=)
JP (3) JP5202953B2 (https=)
CN (2) CN101087563A (https=)
AU (1) AU2005304708B2 (https=)
CA (1) CA2585980C (https=)
WO (1) WO2006052925A2 (https=)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20030376A1 (it) * 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
WO2008006605A2 (en) 2006-07-13 2008-01-17 Cellartis Ab A novel population of multipotent cardiac precursor cells derived from human blastocysts derived stem cells
EP2087098A4 (en) * 2006-11-09 2010-03-31 Univ Johns Hopkins DETERMINATION OF CARDIOMYOCYTES ADULT MAMMALS IN HEART STEM CELLS
WO2009065080A1 (en) * 2007-11-16 2009-05-22 San Diego State University Research Foundation Compositions and method for manipulating pim-1 activity in circulatory system cells
US20090227469A1 (en) * 2008-03-10 2009-09-10 Conklin Bruce R Cells and assays for use in detecting long qt syndrome
AU2010233169A1 (en) 2009-04-09 2011-11-03 Arizona Board Of Regents On Behalf Of The University Of Arizona Cellular seeding and co-culture of a three dimensional fibroblast construct
WO2010141877A1 (en) * 2009-06-04 2010-12-09 Cedars-Sinai Medical Center Method of treating stem cells
DK2498796T3 (en) 2009-11-09 2018-03-05 Aal Scient Inc HEART DISEASE TREATMENT
WO2011057251A2 (en) 2009-11-09 2011-05-12 The Brigham And Women's Hospital, Inc. Treatment of heart disease
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
CN202078342U (zh) * 2011-04-02 2011-12-21 浙江海洋学院 外阴增生物活检钳
US20130142762A1 (en) 2011-11-07 2013-06-06 Hina W. Chaudhry Methods of cardiac repair
US11286463B2 (en) 2012-03-08 2022-03-29 Advanced ReGen Medical Technologies, LLC Reprogramming of aged adult stem cells
US9884076B2 (en) 2012-06-05 2018-02-06 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
ES2668307T3 (es) * 2012-06-07 2018-05-17 Medrobotics Corporation Instrumentos quirúrgicos articulados y métodos para desplegar los mismos
EP3563859B1 (en) 2012-08-13 2021-10-13 Cedars-Sinai Medical Center Cardiosphere-derived exosomes for tissue regeneration
GB201304831D0 (en) * 2013-03-15 2013-05-01 Coretherapix Slu Adult cardiac stem cell population
KR101358777B1 (ko) * 2013-04-30 2014-02-10 서울대학교병원 심장내막 유래의 성체줄기세포 및 이의 제조방법
CN103431878B (zh) * 2013-09-05 2014-12-03 山东省农业科学院畜牧兽医研究所 一种动物组织取样器
WO2015081094A1 (en) 2013-11-27 2015-06-04 University Of Louisville Research Foundation, Inc. Cardiac progenitor cells and methods of use therefor
US20150174166A1 (en) 2013-12-20 2015-06-25 Advanced ReGen Medical Technologies, LLC Compositions for Cellular Restoration and Methods of Making and Using Same
US10772911B2 (en) 2013-12-20 2020-09-15 Advanced ReGen Medical Technologies, LLC Cell free compositions for cellular restoration and methods of making and using same
US20170296595A1 (en) 2014-09-18 2017-10-19 North Carolina State University Mammalian Lung Spheroids and Lung Spheroid Cells and Uses Thereof
EP4494699A3 (en) 2014-10-03 2025-04-30 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
WO2016054569A1 (en) * 2014-10-03 2016-04-07 Cedars-Sinai Medical Center Cardiosphere-derived cells (cdcs) as therapeutic agents for pulmonary hypertension
WO2017123662A1 (en) 2016-01-11 2017-07-20 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
US11534466B2 (en) 2016-03-09 2022-12-27 Aal Scientifics, Inc. Pancreatic stem cells and uses thereof
US11203754B2 (en) 2016-04-29 2021-12-21 Advanced ReGen Medical Technologies, LLC Microrna compositions and methods of making and using same
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
CN107460165A (zh) * 2016-08-10 2017-12-12 中山大学附属第医院 一种心脏干细胞及其用途
US11541078B2 (en) 2016-09-20 2023-01-03 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
US20190365822A1 (en) * 2017-02-01 2019-12-05 Aal Scientifics, Inc. CARDIAC PROGENITOR CELLS HAVING ENHANCED p53 EXPRESSION AND USES THEREOF
WO2018186185A1 (ja) 2017-04-06 2018-10-11 日機装株式会社 細胞の培養方法、細胞支持複合体の製造方法、培養細胞及び細胞支持複合体
JP7336769B2 (ja) 2017-04-19 2023-09-01 シーダーズ―シナイ メディカル センター 骨格筋ジストロフィーを治療する方法及び組成物
KR102182513B1 (ko) * 2017-06-30 2020-11-25 인제대학교 산학협력단 인간 유래 심장 줄기세포 미세구의 제조 방법 및 용도
EP4218775A1 (en) 2017-08-04 2023-08-02 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles for treatment and prevention of cancer
WO2019126068A1 (en) 2017-12-20 2019-06-27 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
EP3740576A4 (en) 2018-01-18 2021-10-20 Advanced Regen Medical Technologies, LLC THERAPEUTIC COMPOSITIONS AND THEIR PREPARATION AND USE METHODS
EP3749344A4 (en) 2018-02-05 2022-01-26 Cedars-Sinai Medical Center METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS
CN108179133A (zh) * 2018-02-06 2018-06-19 广州大学 c-kit+心脏干细胞聚集体及分泌合成培养液在制备药物中应用
CN108379662A (zh) * 2018-02-08 2018-08-10 深圳大图科创技术开发有限公司 一种干细胞在心脏移植模型的应用
WO2019181920A1 (ja) * 2018-03-22 2019-09-26 日機装株式会社 細胞の培養方法、細胞支持複合体の製造方法、培養細胞および細胞支持複合体
CN109247958A (zh) * 2018-09-11 2019-01-22 凌宙贵 一种一次性经皮穿刺肺活检钳
WO2020227489A1 (en) * 2019-05-08 2020-11-12 Cedars-Sinai Medical Center Therapeutically active cells and exosomes
CN110226946B (zh) * 2019-06-12 2022-05-17 杭州市第三人民医院 泌尿外科手术标本收集器
CN110448731A (zh) * 2019-07-23 2019-11-15 中国人民解放军总医院 温度敏感培养皿制备人心肌球源性干细胞膜性贴片的方法
CN110680411B (zh) * 2019-10-09 2020-10-02 山东大学 一种宫颈穿刺活检钳及其使用方法
CN110882015A (zh) * 2019-10-15 2020-03-17 张茹 一种可单人操作活检钳
WO2021241524A1 (ja) * 2020-05-25 2021-12-02 国立大学法人京都大学 増殖能が高い心筋細胞を選別する方法
CN115813456B (zh) * 2022-12-09 2023-06-27 沈阳医学院附属第二医院 一种心内膜心肌活组织钳及其使用方法
WO2026035943A1 (en) 2024-08-08 2026-02-12 Cedars-Sinai Medical Center Formulations for oral delivery of nucleic acids
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999049015A2 (en) * 1998-03-23 1999-09-30 Zymogenetics, Inc. Cardiac-derived stem cells

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175004A (en) * 1988-12-27 1992-12-29 Matsumura Kenneth N Propagatable, new combinant cells for cellular replacement therapy
US6387369B1 (en) * 1997-07-14 2002-05-14 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
US6074408A (en) * 1998-10-13 2000-06-13 Freeman; Kenneth V. Modular medical instrument and method of using same
EP1254952A4 (en) * 1999-12-28 2004-09-22 Kyowa Hakko Kogyo Kk CELLS THAT ARE ABLE TO DIFFERENTIZE IN THE HEART MUSCLE CELLS
US20020061587A1 (en) * 2000-07-31 2002-05-23 Piero Anversa Methods and compositions for the repair and/or regeneration of damaged myocardium
US20030044976A1 (en) * 2001-08-27 2003-03-06 Advanced Cell Technology De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
AU2003259152A1 (en) * 2002-07-23 2004-02-09 Boston Scientific Limited Cell therapy for regeneration
CA2505251A1 (en) * 2002-11-05 2004-05-27 Brigham And Women's Hospital, Inc. Mesenchymal stem cells and methods of use thereof
US7837631B2 (en) * 2003-03-14 2010-11-23 Boston Scientific Scimed Inc. Biopsy forceps with removable jaw segments
ITRM20030376A1 (it) * 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
WO2005076743A2 (en) * 2004-02-17 2005-08-25 Yeda Research And Development Co. Ltd. Disaccharide molecules and derivatives thereof and methods of using same
ES2313805B1 (es) * 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
CN101248171B (zh) * 2005-04-12 2015-11-25 迈索布拉斯特股份有限公司 通过组织非特异性碱性磷酸酶分离成人多潜能细胞
WO2008040027A2 (en) * 2006-09-28 2008-04-03 The Regents Of The University Of California Directed differentiation and maturation of stem cell-derived cardiomyocytes
WO2008058216A2 (en) * 2006-11-07 2008-05-15 Keck Graduate Institute Enriched stem cell and progenitor cell populations, and methods of producing and using such populations
US20090081170A1 (en) * 2007-09-13 2009-03-26 Paul Riley Cardiac progenitor cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999049015A2 (en) * 1998-03-23 1999-09-30 Zymogenetics, Inc. Cardiac-derived stem cells

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BELTRAMI A.P. et al, Cell, 2003, Vo. 114, No. 6, pages 763-776 *
MESSINA E. et al, Circulation Research, 2004, Vol. 95, No. 9, pages 911-921 *
OH H ET AL: "CARDIAC MUSCLE PLASTICITY IN ADULT AND EMBRYO BY HEART-DERIVED PROGENITOR CELLS" ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, vol. 1015, 1 May 2004 (2004-05-01), pages 182-189 *
OH H ET AL: "Cardiac progenitor cells from adult myocardium: homing, differentiatin, and fusion after infarction" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 100, no. 21, 14 October 2003 (2003-10-14), pages 12313-12318 *

Also Published As

Publication number Publication date
EP1809740A2 (en) 2007-07-25
US20080267921A1 (en) 2008-10-30
AU2005304708A1 (en) 2006-05-18
EP2546333A3 (en) 2013-04-10
EP1809740A4 (en) 2009-11-25
US20100061966A1 (en) 2010-03-11
CN101437938A (zh) 2009-05-20
CA2585980A1 (en) 2006-05-18
JP5202953B2 (ja) 2013-06-05
EP2546333A2 (en) 2013-01-16
WO2006052925A3 (en) 2009-05-14
JP2013046780A (ja) 2013-03-07
US20100068811A1 (en) 2010-03-18
EP1809740B1 (en) 2018-08-29
CN101087563A (zh) 2007-12-12
CN101437938B (zh) 2015-05-13
JP2015180671A (ja) 2015-10-15
CA2585980C (en) 2017-09-26
JP2008518730A (ja) 2008-06-05
JP6076402B2 (ja) 2017-02-08
WO2006052925A2 (en) 2006-05-18

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