AU2005299473B2 - Therapeutic and delivery methods of prostaglandin EP4 agonists - Google Patents

Therapeutic and delivery methods of prostaglandin EP4 agonists Download PDF

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Publication number
AU2005299473B2
AU2005299473B2 AU2005299473A AU2005299473A AU2005299473B2 AU 2005299473 B2 AU2005299473 B2 AU 2005299473B2 AU 2005299473 A AU2005299473 A AU 2005299473A AU 2005299473 A AU2005299473 A AU 2005299473A AU 2005299473 B2 AU2005299473 B2 AU 2005299473B2
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AU
Australia
Prior art keywords
colitis
prodrug
prostaglandin
mammal
ester
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005299473A
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English (en)
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AU2005299473A1 (en
Inventor
Robert M. Burk
Yariv Donde
John E. Donello
Todd S. Gac
Daniel W. Gil
Mark Holoboski
Wha Bin Im
Karen M. Kedzie
David W. Old
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Allergan Inc
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Allergan Inc
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Publication of AU2005299473A1 publication Critical patent/AU2005299473A1/en
Application granted granted Critical
Publication of AU2005299473B2 publication Critical patent/AU2005299473B2/en
Priority to AU2012227306A priority Critical patent/AU2012227306A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2005299473A 2004-10-26 2005-10-24 Therapeutic and delivery methods of prostaglandin EP4 agonists Ceased AU2005299473B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012227306A AU2012227306A1 (en) 2004-10-26 2012-09-25 Therapeutic and delivery methods of prostaglandin EP4 agonists

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62242204P 2004-10-26 2004-10-26
US60/622,422 2004-10-26
PCT/US2005/038303 WO2006047476A2 (en) 2004-10-26 2005-10-24 Therapeutic and delivery methods of prostaglandin ep4 agonists

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012227306A Division AU2012227306A1 (en) 2004-10-26 2012-09-25 Therapeutic and delivery methods of prostaglandin EP4 agonists

Publications (2)

Publication Number Publication Date
AU2005299473A1 AU2005299473A1 (en) 2006-05-04
AU2005299473B2 true AU2005299473B2 (en) 2012-06-28

Family

ID=35840538

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005299473A Ceased AU2005299473B2 (en) 2004-10-26 2005-10-24 Therapeutic and delivery methods of prostaglandin EP4 agonists

Country Status (7)

Country Link
US (1) US20080132543A1 (https=)
EP (1) EP1805139A2 (https=)
JP (1) JP2008518013A (https=)
AU (1) AU2005299473B2 (https=)
BR (1) BRPI0518242A2 (https=)
CA (1) CA2585367A1 (https=)
WO (1) WO2006047476A2 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006052893A2 (en) * 2004-11-08 2006-05-18 Allergan, Inc. Substituted pyrrolidone compounds as ep4 agonists
US20060281818A1 (en) * 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
US20070232660A1 (en) * 2006-04-04 2007-10-04 Allergan, Inc. Therapeutic and delivery methods of prostaglandin ep4 agonists
EP2120962A1 (en) * 2006-12-18 2009-11-25 Allergan, Inc. Methods and compositions for treating gastrointestinal disorders
EP2408444A4 (en) 2009-03-19 2012-09-26 Fate Therapeutics Inc COMPOSITIONS WITH CYCLIC AMP AMPLIFIERS AND / OR EP LIGANDS, AND METHOD FOR THEIR PRODUCTION AND USE
WO2011047048A1 (en) 2009-10-14 2011-04-21 Gemmus Pharma, Inc. Combination therapy treatment for viral infections
EP2603227B1 (en) 2010-08-12 2017-10-04 Fate Therapeutics, Inc. Improved hematopoietic stem and progenitor cell therapy
AU2011364973A1 (en) * 2011-04-07 2013-11-07 Allergan, Inc. Devices, compositions and methods utilizing EP4 and EP2 receptor agonists for preventing, reducing or treating capsular contracture
PT2760994T (pt) 2011-09-30 2017-08-24 Bluebird Bio Inc Compostos para melhor transdução viral
US10111907B2 (en) 2011-12-02 2018-10-30 Fate Therapeutics, Inc. Methods of treating ischemia
EP3785767A1 (en) 2011-12-02 2021-03-03 Fate Therapeutics, Inc. Enhanced stem cell composition
US10851412B2 (en) 2013-03-15 2020-12-01 Fate Therapeutics, Inc. Cell potency assay for therapeutic potential
US9943545B2 (en) 2013-03-15 2018-04-17 Fate Therapeutics, Inc. Stem cell culture media and methods of enhancing cell survival
KR102456567B1 (ko) 2013-08-09 2022-10-19 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
WO2017139561A1 (en) 2016-02-12 2017-08-17 Bluebird Bio, Inc. Vcn enhancer compositions and methods of using the same
WO2017139576A1 (en) 2016-02-12 2017-08-17 Bluebird Bio, Inc. Vcn enhancer compositions and methods of using the same
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
GB202211232D0 (en) 2022-08-02 2022-09-14 Heptares Therapeutics Ltd Prostaglandin EP4 receptor agonist compounds

Citations (10)

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Publication number Priority date Publication date Assignee Title
JPS5052047A (https=) * 1973-07-12 1975-05-09
EP0287036A2 (en) * 1987-04-13 1988-10-19 Ono Pharmaceutical Co., Ltd. New pharmaceutical compositions comprising esters or amides as active ingredients
EP0985663A1 (en) * 1998-04-16 2000-03-15 Ono Pharmaceutical Co., Ltd. A 3.7-dithiaprostanoic acid derivative
EP1097922A1 (en) * 1998-07-15 2001-05-09 Ono Pharmaceutical Co., Ltd. 5-thia-omega-substituted phenyl-prostaglandin e derivatives, process for producing the same and drugs containing the same as the active ingredient
US20020002140A1 (en) * 2000-01-14 2002-01-03 Holick Michael F. Novel bisphosphonates and uses thereof
US6586468B1 (en) * 1998-09-14 2003-07-01 Ono Pharmaceutical Co., Ltd. ω-substituted phenyl-prostaglandin E derivatives and drugs containing the same as the active ingredient
EP1417975A1 (en) * 2001-07-23 2004-05-12 Ono Pharmaceutical Co., Ltd. REMEDIES FOR DISEASES WITH BONE MASS LOSS HAVING EP sb 4 /sb AGONIST AS THE ACTIVE INGREDIENT
US20040102499A1 (en) * 2001-06-14 2004-05-27 Allergan, Inc. EP4 agonists as agents for lowering intraocular pressure
US20040157901A1 (en) * 2003-02-11 2004-08-12 Allergan, Inc. 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure
US20050222094A1 (en) * 2001-06-14 2005-10-06 Burk Robert M Treatment of inflammatory bowel disease

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
OA12533A (en) * 2000-11-27 2006-06-05 Pfizer Prod Inc Ep4 receptor selective agonists in the treatment of osteoporosis.
CA2451392A1 (en) * 2001-07-16 2003-01-30 F. Hoffmann-La Roche Ag Prostaglandin analogues as ep4 receptor agonists
WO2003077910A1 (en) * 2002-03-18 2003-09-25 Pfizer Products Inc. Methods of treatment with selective ep4 receptor agonists
US7053085B2 (en) * 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
CA2511255C (en) * 2003-01-10 2009-04-07 F. Hoffmann-La Roche Ag 2-piperidone derivatives as prostaglandin agonists
AU2004211936B2 (en) * 2003-02-11 2008-09-11 Allergan, Inc. 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5052047A (https=) * 1973-07-12 1975-05-09
EP0287036A2 (en) * 1987-04-13 1988-10-19 Ono Pharmaceutical Co., Ltd. New pharmaceutical compositions comprising esters or amides as active ingredients
EP0985663A1 (en) * 1998-04-16 2000-03-15 Ono Pharmaceutical Co., Ltd. A 3.7-dithiaprostanoic acid derivative
EP1097922A1 (en) * 1998-07-15 2001-05-09 Ono Pharmaceutical Co., Ltd. 5-thia-omega-substituted phenyl-prostaglandin e derivatives, process for producing the same and drugs containing the same as the active ingredient
US6586468B1 (en) * 1998-09-14 2003-07-01 Ono Pharmaceutical Co., Ltd. ω-substituted phenyl-prostaglandin E derivatives and drugs containing the same as the active ingredient
US20020002140A1 (en) * 2000-01-14 2002-01-03 Holick Michael F. Novel bisphosphonates and uses thereof
US20040102499A1 (en) * 2001-06-14 2004-05-27 Allergan, Inc. EP4 agonists as agents for lowering intraocular pressure
US20050222094A1 (en) * 2001-06-14 2005-10-06 Burk Robert M Treatment of inflammatory bowel disease
EP1417975A1 (en) * 2001-07-23 2004-05-12 Ono Pharmaceutical Co., Ltd. REMEDIES FOR DISEASES WITH BONE MASS LOSS HAVING EP sb 4 /sb AGONIST AS THE ACTIVE INGREDIENT
US20040157901A1 (en) * 2003-02-11 2004-08-12 Allergan, Inc. 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure

Non-Patent Citations (8)

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Title
AKAMATSU K et al. Int. J of Pharmaceutics, vol. 155 (1), 1997, pp. 65-74. *
ANDERSON, BRADLEY D. et al. J. Pharmaceutical Sci. vol. 69 (4), pp. 424-430. *
CHOURASIA M. K. et al. J. of Delivery & Targeting of Therapeutic Agents, vol. 11 (2), 2004, pp. 129-148. *
FRIEND D. R. et al. J. of Controlled Release, vol. 15 (1), 1991, pp. 47-54. *
KABASHIMA K et al. J. of Clinical Investigation, vol. 109 (7), 2002, pp. 883-893. *
KAJINO HIROKI et al. Pediatric Research, vol. 56 (4), pp. 586-590. *
MARUYAMA T et al. Bioorganic & Medicinal Chemistry, vol. 10, 2002, pp. 2103-2110. *
YOSHIDA K et al. Proceedings of the National Academy of Sciences of the United States of America, vol. 99 (7), pp. 4580-4585. *

Also Published As

Publication number Publication date
WO2006047476A2 (en) 2006-05-04
AU2005299473A1 (en) 2006-05-04
WO2006047476A3 (en) 2006-09-28
CA2585367A1 (en) 2006-05-04
US20080132543A1 (en) 2008-06-05
BRPI0518242A2 (pt) 2008-11-11
JP2008518013A (ja) 2008-05-29
EP1805139A2 (en) 2007-07-11

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired