AU2005280419B2 - Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid - Google Patents
Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid Download PDFInfo
- Publication number
- AU2005280419B2 AU2005280419B2 AU2005280419A AU2005280419A AU2005280419B2 AU 2005280419 B2 AU2005280419 B2 AU 2005280419B2 AU 2005280419 A AU2005280419 A AU 2005280419A AU 2005280419 A AU2005280419 A AU 2005280419A AU 2005280419 B2 AU2005280419 B2 AU 2005280419B2
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- Australia
- Prior art keywords
- dpb
- barbituric acid
- dosage form
- oral dosage
- diphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 claims description 6
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
- C07D239/64—Salts of organic bases; Organic double compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60032704P | 2004-08-10 | 2004-08-10 | |
| US60/600,327 | 2004-08-10 | ||
| PCT/US2005/028380 WO2006026095A2 (en) | 2004-08-10 | 2005-08-10 | Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2005280419A1 AU2005280419A1 (en) | 2006-03-09 |
| AU2005280419B2 true AU2005280419B2 (en) | 2010-09-23 |
Family
ID=34942111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005280419A Ceased AU2005280419B2 (en) | 2004-08-10 | 2005-08-10 | Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP1625848A1 (enExample) |
| JP (2) | JP2008509914A (enExample) |
| KR (2) | KR20070074549A (enExample) |
| CN (2) | CN102512422A (enExample) |
| AT (1) | ATE510541T1 (enExample) |
| AU (1) | AU2005280419B2 (enExample) |
| BR (1) | BRPI0513337A (enExample) |
| CA (1) | CA2576832C (enExample) |
| IL (1) | IL181247A (enExample) |
| MX (1) | MX2007001655A (enExample) |
| NZ (1) | NZ553653A (enExample) |
| SG (1) | SG163500A1 (enExample) |
| WO (1) | WO2006026095A2 (enExample) |
| ZA (1) | ZA201106419B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6756379B2 (en) | 2001-07-26 | 2004-06-29 | Taro Pharmaceutical Industries Ltd. | Non-sedating barbiturate compounds as neuroprotective agents |
| US7683071B2 (en) | 2000-07-26 | 2010-03-23 | Taro Pharmaceuticals Industries Ltd. | Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid |
| CN100502871C (zh) | 2002-12-11 | 2009-06-24 | 塔罗制药工业有限公司 | 巴比土酸衍生物在制备用于治疗运动障碍的药物中的应用 |
| EP1625848A1 (en) * | 2004-08-10 | 2006-02-15 | Taro Pharmaceuticals North America, Inc. | Composition and method for enhanced delivery of 5,5-diphenyl barbituric acid |
| CN102863579B (zh) * | 2012-09-14 | 2014-02-05 | 东南大学 | 一种巴比妥酸螯合树脂及其制备方法和应用 |
| KR102162003B1 (ko) | 2014-04-14 | 2020-10-06 | 삼성전자주식회사 | 무선 네트워크 연결 제어 방법 및 장치 |
| KR101822417B1 (ko) * | 2017-06-14 | 2018-01-29 | 주식회사 청도제약 | 인간의 체액에서 산화 스트레스를 측정하기 위한 방법 |
| GB202100352D0 (en) * | 2021-01-12 | 2021-02-24 | Balticgruppen Bio Ab | New methods |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030153589A1 (en) * | 2001-07-26 | 2003-08-14 | Moros Daniel A | Non-sedating barbiturate compounds as neuroprotective agents |
| WO2004052350A2 (en) * | 2002-12-11 | 2004-06-24 | Taro Pharmaceutical Industries Limited | Method of treating movement disorders using barbituric acid derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2119701A (en) * | 1934-06-29 | 1938-06-07 | Winthrop Chem Co Inc | Alkoxyalkyl mercury nitrogen compounds |
| IL69722A (en) * | 1983-09-14 | 1986-09-30 | Taro Pharma Ind | Oxopyrimidine derivatives and pharmaceutical compositions containing them |
| DE4433764A1 (de) * | 1994-09-22 | 1996-03-28 | Asta Medica Ag | Darreichungsformen enthaltend alpha-Liponsäure, feste Salze von R-Thioctsäure mit verbesserter Freisetzung und Bioverfügbarkeit |
| US6093820A (en) * | 1997-10-02 | 2000-07-25 | Taro Pharmaceutical Industries Ltd. | Method and reagents for N-alkylating ureides |
| EP1311270B1 (en) * | 2000-07-26 | 2008-01-09 | Taro Pharmaceutical Industries Limited | Non-sedating barbiturate compounds as neuroprotective agents |
| CN1896084A (zh) * | 2002-01-30 | 2007-01-17 | 塔罗制药工业有限公司 | 非镇静性巴比土酸衍生物 |
| EP1625848A1 (en) * | 2004-08-10 | 2006-02-15 | Taro Pharmaceuticals North America, Inc. | Composition and method for enhanced delivery of 5,5-diphenyl barbituric acid |
-
2005
- 2005-04-12 EP EP05290804A patent/EP1625848A1/en not_active Withdrawn
- 2005-08-10 SG SG201001644-2A patent/SG163500A1/en unknown
- 2005-08-10 EP EP05786192A patent/EP1781294B1/en not_active Expired - Lifetime
- 2005-08-10 NZ NZ553653A patent/NZ553653A/en not_active IP Right Cessation
- 2005-08-10 KR KR1020077005582A patent/KR20070074549A/ko not_active Abandoned
- 2005-08-10 BR BRPI0513337-8A patent/BRPI0513337A/pt not_active IP Right Cessation
- 2005-08-10 AU AU2005280419A patent/AU2005280419B2/en not_active Ceased
- 2005-08-10 MX MX2007001655A patent/MX2007001655A/es active IP Right Grant
- 2005-08-10 CN CN2011103358486A patent/CN102512422A/zh active Pending
- 2005-08-10 CA CA2576832A patent/CA2576832C/en not_active Expired - Fee Related
- 2005-08-10 WO PCT/US2005/028380 patent/WO2006026095A2/en not_active Ceased
- 2005-08-10 AT AT05786192T patent/ATE510541T1/de not_active IP Right Cessation
- 2005-08-10 KR KR1020127026918A patent/KR20120130256A/ko not_active Ceased
- 2005-08-10 CN CNA2005800340587A patent/CN101052403A/zh active Pending
- 2005-08-10 JP JP2007525753A patent/JP2008509914A/ja not_active Ceased
-
2007
- 2007-02-08 IL IL181247A patent/IL181247A/en not_active IP Right Cessation
-
2011
- 2011-09-01 ZA ZA2011/06419A patent/ZA201106419B/en unknown
-
2013
- 2013-06-04 JP JP2013118224A patent/JP2013177442A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030153589A1 (en) * | 2001-07-26 | 2003-08-14 | Moros Daniel A | Non-sedating barbiturate compounds as neuroprotective agents |
| WO2004052350A2 (en) * | 2002-12-11 | 2004-06-24 | Taro Pharmaceutical Industries Limited | Method of treating movement disorders using barbituric acid derivatives |
Non-Patent Citations (1)
| Title |
|---|
| Breimer D D et al., European Journal of Clinical Pharmacology, 1975, vol. 9, nos. 2-3, pp 169-178 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2576832A1 (en) | 2006-03-09 |
| WO2006026095A2 (en) | 2006-03-09 |
| EP1781294A4 (en) | 2007-12-26 |
| SG163500A1 (en) | 2010-08-30 |
| NZ553653A (en) | 2010-06-25 |
| ATE510541T1 (de) | 2011-06-15 |
| HK1108313A1 (en) | 2008-05-02 |
| CN102512422A (zh) | 2012-06-27 |
| BRPI0513337A (pt) | 2008-05-06 |
| EP1781294B1 (en) | 2011-05-25 |
| EP1625848A1 (en) | 2006-02-15 |
| JP2013177442A (ja) | 2013-09-09 |
| MX2007001655A (es) | 2007-04-23 |
| ZA201106419B (en) | 2012-05-30 |
| IL181247A0 (en) | 2007-07-04 |
| JP2008509914A (ja) | 2008-04-03 |
| CA2576832C (en) | 2013-06-11 |
| KR20120130256A (ko) | 2012-11-29 |
| IL181247A (en) | 2012-05-31 |
| AU2005280419A1 (en) | 2006-03-09 |
| WO2006026095A3 (en) | 2007-02-01 |
| EP1781294A2 (en) | 2007-05-09 |
| KR20070074549A (ko) | 2007-07-12 |
| CN101052403A (zh) | 2007-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |