AU2005275023B2 - Compositions and methods for treatment of colitis - Google Patents
Compositions and methods for treatment of colitis Download PDFInfo
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- AU2005275023B2 AU2005275023B2 AU2005275023A AU2005275023A AU2005275023B2 AU 2005275023 B2 AU2005275023 B2 AU 2005275023B2 AU 2005275023 A AU2005275023 A AU 2005275023A AU 2005275023 A AU2005275023 A AU 2005275023A AU 2005275023 B2 AU2005275023 B2 AU 2005275023B2
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| US10/912,948 US7928132B2 (en) | 2004-08-06 | 2004-08-06 | Methods for the amelioration of episodes of acute or chronic ulcerative colitis |
| PCT/US2005/025067 WO2006019962A1 (en) | 2004-08-06 | 2005-07-14 | Compositions and methods for treatment of colitis |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9326972B2 (en) | 2004-03-16 | 2016-05-03 | Ohio University | Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression |
| US9750723B2 (en) | 2013-10-31 | 2017-09-05 | Ohio University | Prevention and treatment of non-alcoholic fatty liver disease |
| US10392381B2 (en) | 2014-07-18 | 2019-08-27 | Ohio University | Prevention and treatment of non-alcoholic fatty liver disease |
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| DE602004030586D1 (de) * | 2003-09-15 | 2011-01-27 | Oklahoma Med Res Found | Verfahren zur verwendung von cytokintests zur diagnose, behandlung und beurteilung von ankyloider spondylitis |
| US7943328B1 (en) | 2006-03-03 | 2011-05-17 | Prometheus Laboratories Inc. | Method and system for assisting in diagnosing irritable bowel syndrome |
| US20080085524A1 (en) * | 2006-08-15 | 2008-04-10 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
| FR2917087B1 (fr) | 2007-06-05 | 2012-09-21 | Galderma Res & Dev | Nouveaux 4-phenyl-imidazole-2-thiones comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique. |
| US20090215908A1 (en) * | 2007-09-24 | 2009-08-27 | Reliance Life Sciences Pvt. Ltd. | Toll like receptor (tlr) signaling antagonist |
| BRPI0911195A2 (pt) | 2008-04-09 | 2017-06-20 | The Univ Of North Caroline At Chapel Hill | métodos de regulação de arranjo de citoesqueleto de actina e formação de gap intracelular |
| SG175133A1 (en) * | 2009-04-09 | 2011-12-29 | Univ North Carolina | Methods of treating edema related to ischemia-reperfusion |
| US8367316B2 (en) | 2009-05-01 | 2013-02-05 | Alfagene Bioscience, Inc. | Human gastrointestinal stem cell-derived primary intestinal epithelial cell system and methods of use thereof |
| US10668092B2 (en) | 2010-09-24 | 2020-06-02 | The John Hopkins University | Compositions and methods for treatment of inflammatory disorders |
| WO2012040636A2 (en) * | 2010-09-24 | 2012-03-29 | The Broad Institute, Inc. | Compounds and methods for treating diseases mediated by protease activated receptors |
| KR101213070B1 (ko) | 2010-11-09 | 2012-12-18 | 부산대학교 산학협력단 | 포스포리파아제 ｄ１억제제를 유효성분으로 포함하는 류마티스 관절염 예방 또는 치료용 조성물 |
| JP6144288B2 (ja) * | 2012-03-13 | 2017-06-07 | ジェームス・クック・ユニバーシティー | 炎症を治療する方法 |
| US8865723B2 (en) | 2012-10-25 | 2014-10-21 | Tetra Discovery Partners Llc | Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury |
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| CN105745223A (zh) | 2013-09-18 | 2016-07-06 | 詹姆斯库克大学 | 修饰的抗炎蛋白及使用方法 |
| CN105486869A (zh) * | 2014-10-08 | 2016-04-13 | 江苏维赛科技生物发展有限公司 | 一种检测动物源食品中甲巯咪唑残留的酶联免疫试剂盒及其应用 |
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| EP3753557B1 (en) | 2018-02-15 | 2025-11-05 | National University Corporation Chiba University | Preventive or therapeutic agent and pharmaceutical composition for inflammatory diseases or bone diseases |
| JP2023508365A (ja) * | 2019-12-24 | 2023-03-02 | アードバーク・セラピューティクス・インコーポレイテッド | 多様な炎症性障害を処置または予防するための医薬組成物 |
| CN113730444A (zh) * | 2021-07-27 | 2021-12-03 | 自然资源部第一海洋研究所 | 一种海带中可溶性膳食纤维在制备用于改善溃疡性结肠炎的药物和功能性食品中的应用 |
| CN114288388B (zh) * | 2022-01-25 | 2023-11-03 | 华中科技大学同济医学院附属协和医院 | 网膜素在制备炎症性肠病治疗药物中的应用 |
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| CN119174731B (zh) * | 2024-11-15 | 2025-03-14 | 温州医科大学附属口腔医院 | 一种pmc纳米酶及其制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000025756A2 (de) * | 1998-11-02 | 2000-05-11 | Dr. Falk Pharma Gmbh | Arzneimittel zur topischen behandlung entzündlicher darmerkrankungen |
| US6365616B1 (en) * | 1998-08-31 | 2002-04-02 | Sentron Medical, Inc. | Methimazole derivatives and tautomeric cyclic thiones to treat autoimmune diseases |
| WO2004017962A2 (en) * | 2002-08-26 | 2004-03-04 | S.L.A. Pharma Ag | Tropical formulation comprising at least 5% of metronidazole in white petrolatum and its use in the anal and rectal region |
| AU2004317993A1 (en) * | 2004-03-16 | 2005-10-13 | Interthyr Corporation | Methimazole derivatives and tautomeric cyclic thiones to inhibit cell adhesion |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) * | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3630200A (en) * | 1969-06-09 | 1971-12-28 | Alza Corp | Ocular insert |
| US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) * | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4734421A (en) * | 1986-10-29 | 1988-03-29 | Merck & Co., Inc. | Anti-inflammatory substituted 2-benzyl-mercapto-imidazole and pyrimidine derivatives compositions and method of use therefor |
| US5480583A (en) * | 1991-12-02 | 1996-01-02 | Intevep, S.A. | Emulsion of viscous hydrocarbon in aqueous buffer solution and method for preparing same |
| US20050209295A1 (en) * | 2004-03-16 | 2005-09-22 | Kohn Leonard D | Methimazole derivatives and tautomeric cyclic thiones to inhibit cell adhesion |
-
2004
- 2004-08-06 US US10/912,948 patent/US7928132B2/en not_active Expired - Fee Related
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2005
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- 2005-07-14 WO PCT/US2005/025067 patent/WO2006019962A1/en not_active Ceased
- 2005-07-14 CA CA2575777A patent/CA2575777C/en not_active Expired - Fee Related
- 2005-07-14 AU AU2005275023A patent/AU2005275023B2/en not_active Ceased
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6365616B1 (en) * | 1998-08-31 | 2002-04-02 | Sentron Medical, Inc. | Methimazole derivatives and tautomeric cyclic thiones to treat autoimmune diseases |
| WO2000025756A2 (de) * | 1998-11-02 | 2000-05-11 | Dr. Falk Pharma Gmbh | Arzneimittel zur topischen behandlung entzündlicher darmerkrankungen |
| WO2004017962A2 (en) * | 2002-08-26 | 2004-03-04 | S.L.A. Pharma Ag | Tropical formulation comprising at least 5% of metronidazole in white petrolatum and its use in the anal and rectal region |
| AU2004317993A1 (en) * | 2004-03-16 | 2005-10-13 | Interthyr Corporation | Methimazole derivatives and tautomeric cyclic thiones to inhibit cell adhesion |
Non-Patent Citations (5)
| Title |
|---|
| Al Moutaery et al. Experimental and Toxicologic Pathology (2003) vol. 55, no. 4 pages 277-285 * |
| Dagia Nilesh et al. J. Immunology (2004) vol. 173, no. 3 pages 2041-2049* * |
| Isman et al. J.Endocrinology (2003) vol. 177, no. 3 pages 471-476 * |
| Oren et al. Alimentary Pharmacology and Therapeutics (1997) vol. 11, no. 2, pages 341-345 * |
| Singer Dinah et al. J. Immunology (1994) vol. 153, no. 2, pages 873-880 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9326972B2 (en) | 2004-03-16 | 2016-05-03 | Ohio University | Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression |
| US9750723B2 (en) | 2013-10-31 | 2017-09-05 | Ohio University | Prevention and treatment of non-alcoholic fatty liver disease |
| US10392381B2 (en) | 2014-07-18 | 2019-08-27 | Ohio University | Prevention and treatment of non-alcoholic fatty liver disease |
Also Published As
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| CA2575777A1 (en) | 2006-02-23 |
| WO2006019962B1 (en) | 2006-04-20 |
| EP1773329A1 (en) | 2007-04-18 |
| JP2008509137A (ja) | 2008-03-27 |
| JP5039550B2 (ja) | 2012-10-03 |
| US20060058365A1 (en) | 2006-03-16 |
| WO2006019962A1 (en) | 2006-02-23 |
| CA2575777C (en) | 2011-01-11 |
| AU2005275023A1 (en) | 2006-02-23 |
| US7928132B2 (en) | 2011-04-19 |
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