AU2005274926B2 - Compounds and methods for treatment of cancer - Google Patents

Compounds and methods for treatment of cancer Download PDF

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Publication number
AU2005274926B2
AU2005274926B2 AU2005274926A AU2005274926A AU2005274926B2 AU 2005274926 B2 AU2005274926 B2 AU 2005274926B2 AU 2005274926 A AU2005274926 A AU 2005274926A AU 2005274926 A AU2005274926 A AU 2005274926A AU 2005274926 B2 AU2005274926 B2 AU 2005274926B2
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AU
Australia
Prior art keywords
cells
cancer
crystalline form
compound
leukemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005274926A
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English (en)
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AU2005274926A1 (en
Inventor
Hatice Duzkale
Emil J. Freireich
Mingzhang Gao
Hagop Kantarjian
Merida Sotelo-Lerma
Srdan Verstovsek
Ralph A. Zingaro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texas A&M University System
University of Texas System
Original Assignee
Texas A&M University System
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas A&M University System, University of Texas System filed Critical Texas A&M University System
Publication of AU2005274926A1 publication Critical patent/AU2005274926A1/en
Application granted granted Critical
Publication of AU2005274926B2 publication Critical patent/AU2005274926B2/en
Priority to AU2011204901A priority Critical patent/AU2011204901B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66Arsenic compounds
    • C07F9/70Organo-arsenic compounds
    • C07F9/72Aliphatic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66Arsenic compounds
    • C07F9/70Organo-arsenic compounds
    • C07F9/74Aromatic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66Arsenic compounds
    • C07F9/70Organo-arsenic compounds
    • C07F9/80Heterocyclic compounds
    • C07F9/82Arsenic compounds containing one or more pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
AU2005274926A 2004-07-16 2005-07-15 Compounds and methods for treatment of cancer Ceased AU2005274926B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2011204901A AU2011204901B2 (en) 2004-07-16 2011-07-21 Compounds and methods for treatment of cancer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58859604P 2004-07-16 2004-07-16
US60/588,596 2004-07-16
PCT/US2005/025192 WO2006020048A2 (en) 2004-07-16 2005-07-15 Compounds and methods for treatment of cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2011204901A Division AU2011204901B2 (en) 2004-07-16 2011-07-21 Compounds and methods for treatment of cancer

Publications (2)

Publication Number Publication Date
AU2005274926A1 AU2005274926A1 (en) 2006-02-23
AU2005274926B2 true AU2005274926B2 (en) 2011-04-28

Family

ID=35414967

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005274926A Ceased AU2005274926B2 (en) 2004-07-16 2005-07-15 Compounds and methods for treatment of cancer

Country Status (11)

Country Link
US (2) US7405314B2 (US20040106767A1-20040603-C00005.png)
EP (1) EP1771459A2 (US20040106767A1-20040603-C00005.png)
JP (3) JP5618461B2 (US20040106767A1-20040603-C00005.png)
KR (5) KR20130095857A (US20040106767A1-20040603-C00005.png)
CN (3) CN101076533B (US20040106767A1-20040603-C00005.png)
AU (1) AU2005274926B2 (US20040106767A1-20040603-C00005.png)
CA (2) CA2574032C (US20040106767A1-20040603-C00005.png)
HK (1) HK1204476A1 (US20040106767A1-20040603-C00005.png)
IL (2) IL180729A (US20040106767A1-20040603-C00005.png)
TW (3) TW201440760A (US20040106767A1-20040603-C00005.png)
WO (1) WO2006020048A2 (US20040106767A1-20040603-C00005.png)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057012A2 (en) 2002-01-07 2003-07-17 Board Of Regents, The University Of Texas System S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer
US7628810B2 (en) 2003-05-28 2009-12-08 Acufocus, Inc. Mask configured to maintain nutrient transport without producing visible diffraction patterns
TW201440760A (zh) 2004-07-16 2014-11-01 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
US7968738B2 (en) 2005-07-29 2011-06-28 Ziopharm Oncology, Inc. Compounds and methods for the treatment of cancer
WO2007082104A2 (en) 2006-01-13 2007-07-19 The Texas A & M University System Compounds and methods for the treatment of cancer
TW200829261A (en) * 2006-09-29 2008-07-16 Ziopharm Oncology Inc Method for controlling angiogenesis in animals
ES2392737T3 (es) 2007-11-02 2012-12-13 Ziopharm Oncology, Inc. Terapia combinada con compuestos arsenicales orgánicos
BRPI0821002A2 (pt) * 2007-12-12 2015-06-16 Ziopharm Oncology Inc Compostos e métodos para o tratamento de câncer
DK3388111T3 (da) * 2008-08-20 2021-12-06 Solasia Pharma K K Organoarsenforbindelse til behandlingen af kræft
CN102060722B (zh) * 2009-05-01 2014-06-11 常州高新技术产业开发区三维工业技术研究所有限公司 一种含砷化合物及其制备方法和用途
US10004593B2 (en) 2009-08-13 2018-06-26 Acufocus, Inc. Intraocular lens with elastic mask
KR101796801B1 (ko) 2009-08-13 2017-11-10 아큐포커스, 인크. 마스크형 안구 내 임플란트 및 렌즈
EP2717884A1 (en) 2011-06-06 2014-04-16 Chevron Phillips Chemical Company LP Use of metallocene compounds for cancer treatment
WO2013082545A1 (en) 2011-12-02 2013-06-06 Acufocus, Inc. Ocular mask having selective spectral transmission
US9427922B2 (en) 2013-03-14 2016-08-30 Acufocus, Inc. Process for manufacturing an intraocular lens with an embedded mask
KR20160086960A (ko) * 2013-12-05 2016-07-20 솔레이지아 파마 가부시키가이샤 암 치료를 위한 화합물 및 방법
GB201418491D0 (en) * 2014-10-17 2014-12-03 Monfort University De Compounds
WO2016081493A1 (en) 2014-11-19 2016-05-26 Acufocus, Inc. Fracturable mask for treating presbyopia
EP3359987B1 (en) 2015-10-05 2024-02-28 AcuFocus, Inc. Methods of molding intraocular lenses
JP7055747B2 (ja) 2015-11-24 2022-04-18 アキュフォーカス・インコーポレーテッド 焦点深度の拡張を伴うトーリック小開口眼内レンズ
CN105330701B (zh) * 2015-11-27 2017-05-31 昆明医科大学 一种含砷化合物及其制备方法和应用
EP3790508A4 (en) 2018-05-09 2022-02-09 AcuFocus, Inc. INTRAOCULAR IMPLANT WITH REMOVABLE OPTICS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057012A2 (en) * 2002-01-07 2003-07-17 Board Of Regents, The University Of Texas System S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Family Cites Families (7)

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AU751932B2 (en) * 1997-10-15 2002-08-29 Polarx Biopharmaceuticals, Inc. Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
EP1964557B1 (en) 1997-11-10 2013-01-02 Memorial Sloan-Kettering Cancer Center Process for producing arsenic trioxide formulations
CN1233476A (zh) * 1998-04-24 1999-11-03 陆道培 治疗急性白血病的药物及其制备方法
EP1002537A1 (en) 1998-10-30 2000-05-24 Assistance Publique, Hopitaux De Paris Use of melarsoprol for the manufacture of a medicament for treating B-cell lymphoproliferative diseases, such as multiple myeloma
US6191123B1 (en) * 1999-03-19 2001-02-20 Parker Hughes Institute Organic-arsenic compounds
JP5242877B2 (ja) * 2000-04-26 2013-07-24 オレゴン ヘルス アンド サイエンス ユニバーシティー チオールをベースとする化学保護剤の投与
TW201440760A (zh) * 2004-07-16 2014-11-01 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057012A2 (en) * 2002-01-07 2003-07-17 Board Of Regents, The University Of Texas System S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

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Journal of Chemical Society, 1932, 1365-1369 *
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Journal of Medicinal Chemistry, 1979, 22(5): 571-575 *

Also Published As

Publication number Publication date
JP5745660B2 (ja) 2015-07-08
KR20070046120A (ko) 2007-05-02
CN104163833A (zh) 2014-11-26
TW200616615A (en) 2006-06-01
CN101076533B (zh) 2013-11-06
TW201440760A (zh) 2014-11-01
HK1204476A1 (en) 2015-11-20
KR20130001323A (ko) 2013-01-03
IL180729A (en) 2012-03-29
WO2006020048A2 (en) 2006-02-23
CA2777473C (en) 2013-08-27
KR20140013110A (ko) 2014-02-04
CN105777811A (zh) 2016-07-20
TWI411431B (zh) 2013-10-11
CA2574032C (en) 2015-02-24
JP2014122233A (ja) 2014-07-03
EP1771459A2 (en) 2007-04-11
KR101252866B1 (ko) 2013-04-10
JP2012051919A (ja) 2012-03-15
IL215896A0 (en) 2011-12-29
US7405314B2 (en) 2008-07-29
WO2006020048B1 (en) 2006-10-19
US20080090793A1 (en) 2008-04-17
CN101076533A (zh) 2007-11-21
WO2006020048A3 (en) 2006-08-24
IL180729A0 (en) 2007-06-03
TW201350113A (zh) 2013-12-16
AU2005274926A1 (en) 2006-02-23
CA2777473A1 (en) 2006-02-23
JP2008506710A (ja) 2008-03-06
US20060128682A1 (en) 2006-06-15
CA2574032A1 (en) 2006-02-23
JP5618461B2 (ja) 2014-11-05
KR20140136525A (ko) 2014-11-28
KR20130095857A (ko) 2013-08-28

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Legal Events

Date Code Title Description
MK25 Application lapsed reg. 22.2i(2) - failure to pay acceptance fee
TH Corrigenda

Free format text: IN VOL 25, NO 40, PAGE(S) 5003 UNDER THE HEADING APPLICATIONS LAPSED, REFUSED OR WITHDRAWN, PATENTSCEASED OR EXPIRED - 2005 DELETE ALL REFERENCE TO 2005274926.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired