AU2005230241A1 - Medical plaster for application on the skin - Google Patents
Medical plaster for application on the skin Download PDFInfo
- Publication number
- AU2005230241A1 AU2005230241A1 AU2005230241A AU2005230241A AU2005230241A1 AU 2005230241 A1 AU2005230241 A1 AU 2005230241A1 AU 2005230241 A AU2005230241 A AU 2005230241A AU 2005230241 A AU2005230241 A AU 2005230241A AU 2005230241 A1 AU2005230241 A1 AU 2005230241A1
- Authority
- AU
- Australia
- Prior art keywords
- film
- protective film
- layer
- patch according
- medical patch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011505 plaster Substances 0.000 title description 5
- 239000010410 layer Substances 0.000 claims description 62
- 230000001681 protective effect Effects 0.000 claims description 57
- 239000000853 adhesive Substances 0.000 claims description 40
- 230000001070 adhesive effect Effects 0.000 claims description 40
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 28
- 239000013543 active substance Substances 0.000 claims description 27
- 238000000576 coating method Methods 0.000 claims description 22
- 239000011159 matrix material Substances 0.000 claims description 21
- 239000011248 coating agent Substances 0.000 claims description 20
- 238000004519 manufacturing process Methods 0.000 claims description 13
- 239000012790 adhesive layer Substances 0.000 claims description 12
- 230000002940 repellent Effects 0.000 claims description 11
- 239000005871 repellent Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 229930195733 hydrocarbon Natural products 0.000 claims description 6
- 150000002430 hydrocarbons Chemical class 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 229920006267 polyester film Polymers 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- 238000004891 communication Methods 0.000 claims description 4
- 239000000262 estrogen Substances 0.000 claims description 4
- 239000004215 Carbon black (E152) Substances 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- SIGSPDASOTUPFS-XUDSTZEESA-N gestodene Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](C=C4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 SIGSPDASOTUPFS-XUDSTZEESA-N 0.000 claims description 3
- 229960005352 gestodene Drugs 0.000 claims description 3
- 239000000583 progesterone congener Substances 0.000 claims description 3
- 230000002787 reinforcement Effects 0.000 claims description 3
- 230000008021 deposition Effects 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 2
- 238000010276 construction Methods 0.000 claims 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229920006254 polymer film Polymers 0.000 claims 1
- 238000009256 replacement therapy Methods 0.000 claims 1
- 239000010408 film Substances 0.000 description 97
- 239000000463 material Substances 0.000 description 10
- 239000000203 mixture Substances 0.000 description 7
- 229920000139 polyethylene terephthalate Polymers 0.000 description 7
- 239000005020 polyethylene terephthalate Substances 0.000 description 7
- -1 polyethylene terephthalate Polymers 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 230000007774 longterm Effects 0.000 description 3
- 229920000058 polyacrylate Polymers 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 2
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 229920002367 Polyisobutene Polymers 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 229960002568 ethinylestradiol Drugs 0.000 description 2
- 229920002313 fluoropolymer Polymers 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 239000005033 polyvinylidene chloride Substances 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004753 textile Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- 229920001824 Barex® Polymers 0.000 description 1
- 239000004821 Contact adhesive Substances 0.000 description 1
- 229920005987 OPPANOL® Polymers 0.000 description 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 1
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000004811 fluoropolymer Substances 0.000 description 1
- 239000003517 fume Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 238000002657 hormone replacement therapy Methods 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000010327 methods by industry Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Manufacturing & Machinery (AREA)
- Botany (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Description
RWS Group Ltd, of Europa House, Marsham Way, Gerrards Cross, Buckinghamshire, England, hereby solemnly and sincerely declares that, to the best of its knowledge and belief, the following document, prepared by one of its translators competent in the art and conversant with the English and German languages, is a true and correct translation of the PCT Application filed under No. PCT/EP2005/002970. Date: 11 September 2006 C. E. SITCH Acting Managing Director For and on behalf of RWS Group Ltd WO 2005/097021 PCT/EP2005/002970 Medical plaster for application on the skin (Description) Technical field 5 The invention relates to a medical patch for use on the skin and to a process for preparing it. This system consists of an adhesive interior, an exterior surrounding the interior, said exterior being designed 10 to be non-adhesive. Prior Art It is known that, after they have been worn, medical 15 patches tend to leave a distinct dark ring on the skin. This phenomenon increases with the period of application and takes on particularly problematic forms if patches are worn for longer than 3 and up to 7 days. This is the case in particular with transdermal active 20 substance patches, which in the field of hormone replacement or hormonal contraception are frequently applied for 7 days at a time. The dirt ring forms essentially as a result of textile 25 fibres and particles of dirt and skin adhering to the adhesive layer's cut edge, which is open at the margin. Depending on surface energies and the nature of the adhesive, it is even possible for particles to be taken up into the adhesive layer as a result of adhesive 30 flow. A further, particularly intensifying factor is that, during prolonged wear on the skin, patches may be displaced by mechanical stress, this displacement being accompanied additionally by the emergence at the margin of adhesive, which increases the dirt ring through 35 particle adhesion. The detachment of the patches, which likewise begins from the margin, offers a further area for dirt to deposit following a prolonged time of application.
- 2 When the patches are removed, more or less large portions of the dirt ring formed remain on the skin. They are usually difficult to rub off mechanically and 5 do not disappear until after several days, as a result of customary body care. Although it has been possible to obtain certain improvements by increasing the cohesion of the medical 10 pressure-sensitive adhesives (PSAs) - for example, by admixing long-chain polymers or by chemical crosslinking - the increased cohesion and reduced plasticity frequently also result in a reduction in long-term adhesiveness. Only a partially flowable PSA 15 with aggressive adhesion can ensure sticking to the skin for up to a week. In this area of mutually contradictory requirements imposed on the medical PSA, it has to date been impossible to avoid the formation of aesthetically unappealing dirt rings in the course 20 of long-term application. The patent literature has disclosed medical patch systems having different kinds of adhesive regions. 25 The U.S. patent US 4,664,106 describes a wound plaster which is protected by a detachable protective film and possesses an adhesive-free marginal region which is removed on use. 30 The U.S. patent US 5,690,610 describes an adhesive compression material for checking bleeding, the body being an adhesive-free pressure plate. This pressure plate is mounted between pad and skin-contact adhesive layer and corresponds in its dimensions to said 35 adhesive layer. A non-adhesive region in use is not disclosed. The U.S. patent US 5,599,289 discloses a medical patch system which possesses a support web, an adhesive - 3 material lying above this support web, and a release ply lying above the adhesive. A non-adhesive outer region in use is not disclosed. 5 The DE patent DE 743 775 describes a wound plaster with a plaster base made of sterile material and with an adhesive layer. Up until the time of use, gauze strips are arranged in such a way that adhesive layer and sterile layer are protected simultaneously. The patent 10 considers incomplete attachment of the patch, and hence marginal regions which are indirectly non-adhering, to constitute an insecurity and disadvantage. Description of the invention 15 It is an object of the invention, therefore, to overcome the aforementioned disadvantages of conventional medical patches, particularly the problem of dirt ring formation. 20 According to the invention the object is achieved by means of a medical patch for use on the skin, wherein the contact area to the skin has a pressure-sensitive adhesive interior and also an exterior surrounding the 25 interior. Said exterior has been designed so as to be non-adhesive on its skin-facing surface. For patches, this is most appropriately realizable by the introduction of an additional layer in the patch's 30 marginal zone, preferably by means of a narrow film integrated at the margin and referred to below as marginal film. In application, this marginal film is situated between 35 the pressure-sensitive adhesive layer of the patch, on the skin side, and the skin, thereby preventing contact of the adhesive with the skin in this zone.
- 4 In the case of active substance patches the marginal film should preferably be composed of a material which is virtually impermeable to the active substance or substances present. Otherwise active substance is 5 delivered from the patch to the skin via the marginal zone as well; such delivery, owing to the contact of the marginal zone with the skin's surface, which for constructional reasons is not very reproducible, and additionally owing to the delivery of active substance 10 taking place unavoidably with divergent kinetics via the marginal film in relation to the central adhesive layer, is undesirable. For these reasons, particularly suitable materials for the marginal film are polyethylene terephthalate (PET), polyvinyl chloride 15 (PVC), polyvinylidene chloride (PVDC) or polyvinyl chloride-polyvinylidene chloride copolymers (e.g. Saran") and polyacrylonitrile (e.g. Barex") . PET (e.g. Hostaphan") is particularly preferred on account of the multiplicity of grades available commercially, in 20 particular in the region of very thin films. Any remanent delivery of active substance through the marginal zone that there may be, depending on the barrier action of the marginal film, is preferably 25 lower by a factor of at least 10, more preferably lower by a factor of at least 100, than the delivery of active substance per unit area over the pressure sensitive adhesive region of the patch. 30 An optimum range for the width of the marginal zone to be provided has been determined: excessive widths lead to a margin which is very easily bent around and pulled along by mechanical contact with the clothing or other foreign bodies, as a result of which there may be 35 premature detachment of the patch. Too narrow a margin, by contrast, is on the one hand difficult to realize technically with sufficient symmetry and reproducibility and on the other hand offers inadequate protection of the interior area of adhesive against -5 particle contamination from outside, in relation to the production complexity. It has been found that the margin width ought to be in 5 the range from 0.5 to 5 mm, preferably in the range from 0.75 to 3 mm and with particular preference in the range from 1 to 1.5 mm. The optimum figure, however, is also dependent on the size of the patch and on the radii of curvature of its contour line: in the case of 10 relatively large patches with relatively wide radii, it is also possible to provide wider margins. The ideal figure of 1-1.5 mm width applies in particular to patches in a size of from 5 to 25 cm 2 with a circular, oval or rectangularly rounded-off form. 15 In certain cases it may be sensible to vary the width of the marginal zone along the contour line of the patch - for example, broader in the region of low radii of curvature, narrower in the case of narrow radii 20 since at narrow curvatures there is a particularly great risk of mechanical foldover of the margin on contact with clothing. With regard to the thickness of the marginal film, too, 25 an optimum has been found between excessively thin and excessively thick material: too thick a film, depending on material, reduces the wear comfort of the patch by mechanical stresses on the skin, as a result of its rigidity even when its width is low. 30 Too thin a film, on the other hand, does not provide sufficient reinforcement of the margin, so that the marginal zone readily loses its positive contact with the skin and stands up at the margin of the patch as. a 35 result of bending over or rolling up, for example. A material of appropriate thickness provides the marginal zone with the required shape retention while not perceptively impairing the mechanical wear comfort -6 on the skin. According to the invention, the non-adhesive exterior constitutes a border composed of a polymeric film or a 5 polymeric sheet and applied to the adhesive layer of the patch. In the case of polyester films (PET) a thickness of from 6 to 150 pim, preferably 9 to 75 pm and with 10 particular preference about 36 ptm has been determined to be suitable. Where the layer is a polymer sheet based on a hydrocarbon polymer or silicone polymer, it may possess 15 a layer thickness of from 6 to 150 ym, preferably 15 to 75 pm. It is also possible for the applied border to protrude, in terms of its area, partly or completely beyond the 20 contour lines of the rest of the patch. In accordance with the invention the non-adhesive exterior may have a width along the contour line of the patch of from 0.5 to 5.0 mm, preferably 1 to 3 mm and 25 with particular preference 1.0 to 1.5 mm. It has additionally been found that a repellent coating of the marginal film on the skin-facing surface has advantageous effects, by suppressing the inward flow or 30 undercreeping of the pressure-sensitive adhesive during storage and during application on the skin. The marginal zone remains free from adhesive for longer, as a result, and the formation of dirt rings is further reduced. 35 In the case of PSAs based on polyacrylates or hydrocarbons (e.g. polyisobutylene) siliconization is suitable as a form of repellent coating, whereas in the case of silicone-based PSAs the coating ought to be on - 7 the basis of specific, fluorinated polymers. In the case of patches for a long application period of 3 to 7 days, this repellent coating ought to exhibit 5 low mechanical rub-off, so as to ensure long durability. The problem of rub-off is known to the skilled person in the field of siliconization, and various techniques and products are available for reducing it. 10 In order to make the inventive technology of a dirt minimizing marginal zone more readily recognizable for the user, it can be advantageous to give the marginal zone a different design, in terms of colour or 15 transparency, from the remaining area of the patch. This can be done by applying a surface coating material to the marginal film or by metallizing it, preferably by vapour deposition of aluminium to the non-skin facing surface of the marginal film. Alternatively a 20 visual emphasis may be given to the marginal zone by means of partial printing of the backing layer of the patch. In the medical patch of the invention it is possible 25 for there to be at least one active pharmaceutical substance present. The rate of active substance delivery per unit area in the exterior can be lower by a factor of at least 10 30 than the rate of delivery in the active substance interior, preferably by a factor of at least 100. It is also possible for the medical patch to comprise active substances for hormone replacement therapy or 35 for transdermal contraception. Advantageous embodiments of active substances are gestagens and oestrogens, preferably gestodene in combination with an oestrogen.
- 8 It is also possible for the application period of the medical patch to be 3 to 7 days. 5 The backing layer of the medical patch of the invention is not subject to any necessities which go beyond the requirements that are customary in this field. Preferred use is made of polyester films (PET, e.g. Hostaphan'), polyethylene films (e.g. CoTran 9720) or 10 multilayer laminates comprising these materials. The adhesive layer may be composed of one or more layers, which may be identical of different in composition. Preference is given to one- or two-layer 15 systems which in one or both layers comprise at least one active pharmaceutical substance. The invention, however, expressly relates additionally to non-active substance medical patches from the areas, for example, of wound care, catheter fixing or promotion of wound 20 healing. Suitable PSA formulations include pressure-sensitive adhesives based on polyacrylates, hydrocarbons or silicones, and also blends thereof, such as are known 25 to the skilled person in the field of medical patches and transdermal therapeutic systems. Owing to the inventively suppressed formation of dirt rings, however, it is also possible to employ 30 formulations with low cohesion and strongly adhesive formulations, which are otherwise unacceptable owing to the emergence of adhesive mass at the patch margin in the course of storage and/or application. Such formulations are based, for example, on non-crosslinked 35 polyacrylate PSAs (e.g. Durotak 387-2051, Durotak 387 2287), non-crosslinked silicone PSAs with high spontaneous adhesiveness/tack (e.g. Dow Corning Bio PSA 430X or 460X with X = 1, 2, 3) or hydrocarbon adhesives with a high fraction of low molecular mass hydrocarbons - 9 (e.g. more than 20% Oppanol B10). The active substance portion of the patch may also be implemented in the manner of a reservoir system, with a 5 semi-solid or liquid active substance reservoir. Suitability as redetachable protective film is possessed by all coated papers and films that are customary for medical patches and transdermal 10 therapeutic systems. This protective film can be made in the same size and contour as the patch lying on it or else may be designed so as to overhang at the sides. To facilitate 15 application it is possible for an application aid to be punched in the protective film. It has been found that the formation of dirt rings can be avoided to a very high extent, and in some cases 20 even completely, if the marginal zone of the medical patch is made non-adhesive. An adhesive-free margin provided at the margin on all sides very substantially protects the more inward margin of the adhesive area against dirt and textile contact. 25 It is noted that this protection of the margin of the adhesive layer, in conjunction with mechanical reinforcement of this marginal zone, surprisingly results in an improvement in the long-term adhesiveness 30 of the patch, by preventing or retarding the mechanical detachment of the patch from the margin, caused by edge lifting and frictional contact with clothing. The original expectation here was that a patch which is 35 not adhesive at the margin would be rubbed off quickly, even particularly quickly, by contact with clothing or other mechanical stress.
- 10 Description of the Figures: Figures Fig. 1-Al (cross-section) and A2 (plan view) show a medical patch of the invention in the simplest 5 arrangement of all the components, which for the purposes of this invention is referred to as type A. A backing layer (1) is followed by at least one matrix layer (2), which may contain active substance and is followed at the margin by a marginal film (3); to 10 finish off, a redetachable protective film (protective film) is provided. This protective film (4) does not overhang at the margin; the system is a fully punched through system. 15 Figures Fig. 2-B1 (cross-section) and A2 (plan view) show a medical patch referred to in accordance with the invention as type B, for which in contradistinction to type A the protective film (4) overhangs at the margin. 20 Figures Fig. 3-Cl (cross-section) and C2 (plan view) show a medical patch referred to in accordance with the invention as type C, where the outer contour line of the marginal film (3) extends outside the contour line of the inner region, composed of backing layer (1) and 25 matrix layer (2). Figure Fig. 4-D depicts further, optional design features of the medical patches of the invention, illustrated for type B by way of example: 30 For greater ease of application an incision (5) is provided in the protective film, and along that incision initially only part of the protective film (4) can be removed before the patch is partially adhered, 35 and then the second half of the protective film (4) is removed and, finally, the patch is adhered fully. To make it easier to remove the patch subsequently, a tab like enlargement (6) is provided on the non-adhesive marginal region. At the end of the time of application, - 11 the patch can be gripped more easily and pulled off by this end. Figure Fig. 5-E shows details of a preferred version of 5 the patch of type A: The surface of the marginal film (3) that faces the protective film (4) has a coating (7) which is repellent to the adhesive matrix (2). The patch-facing surface of the protective film (4) necessarily likewise 10 has a repellent coating, it being possible for this coating (8) to be identical to or different from the coating (7) of the marginal film (3). Figure Fig. 6-F shows details of a further preferred 15 version of the patch of type A: The surface of the marginal film (3) that faces the protective film (4) has a coating (7) which is repellent to the adhesive matrix (2). Additionally the surface of the marginal film (3) facing the matrix 20 layer (2) has been aluminized (9) for the purpose of ease of visual differentiation on the marginal zone of the remaining patch. Figure Fig. 7-G shows details of a preferred version of 25 the patch of type C: The surface of the marginal film (3) that faces the protective film (4) has a coating (7) which is repellent to the adhesive matrix (2) . Additionally the surface of the marginal film (3) that faces the matrix 30 layer (2) also has a repellent coating (10). The patch facing surface of the protective film (4) is necessarily repellently coated (8) in turn, it being possible for this coating (8) to be implemented identical to or different from the coatings (7 and 10) 35 of the marginal film (3) . The coatings (7 and 10) of the marginal film (3) can be implemented in the same way or differently. The release force of the adhesive matrix layer (2) from the coating (8) of the protective film (4) is preferably greater than the release force - 12 of the adhesive matrix layer (2) from the coating (10) of the marginal film (3), so that in the production process the adhesive matrix layer (2) can be removed from the coating (10) of the marginal film (3) without 5 also detaching from the coating (8) of the protective film (4) . Figures Fig. 8-H1 (cross-section) and H2 (plan view) illustrate the transfer of the inventive principle to 10 active substance patches of the reservoir system type. Between the backing layer (1) and a heat-sealable interlayer (11), which may also be implemented in the form of a control membrane for the delivery of active substance, there is a liquid or semi-solid active 15 substance reservoir (12) which is enclosed on all sides. This system otherwise corresponds to inventive type A. An overhanging protective film can be provided in the same way as for type B. 20 For producing patches with a zone which is not adhesive at the margin it is preferred from a process engineering standpoint to introduce a marginal film along the margin of the patch. A description is given below of the key production steps for the basic types 25 A, B and C, from which types D to G can be derived by varying the starting materials and/or process steps. A process for producing the medical patch of type A of the invention, comprising the production of a laminate 30 for the interior, composed of a backing layer, at least one active substance layer of pressure-sensitive adhesive and, for the exterior, preferably, a removable protective film, and also the use of a film repellently coated preferably on one side comprises the following 35 steps: a) in one step diecuts corresponding to the contours of the subsequent interior are made in the film provided for the marginal region, and the diecut areas are discarded, - 13 b) in a further step the film diecut under step a) is brought together one atop the other with the protective film of the patches that are to be produced; in the case of a repellently coated 5 surface this repellent surface of the punched film comes to lie on the likewise repellently coated surface of the protective film, c) in a further step the laminate of the interior, composed of at least one pressure-sensitive 10 adhesive matrix layer and also the backing layer, from which any protective film envisaged in the production operation has been removed, is laminated by its pressure-sensitive adhesive side onto the assembly consisting of the punched film 15 of the marginal region and the protective film, the pressure-sensitive adhesive side of the laminate being brought into two-dimensional communication with the uncoated surface of the film of the marginal region and, via the diecuts 20 therein, directly with the repellently coated surface of the protective film as well, d) in a last step the outer contour line of the patch is punched through all of the layers of the resultant laminate, this outer contour line 25 extending at the distance intended for the width of the marginal zone round the diecuts, made under step a), in the film of the marginal region. A process for producing the medical patch of type B of 30 the invention, comprising the process steps as indicated above, is distinguished in that in step d), differently, the laminate is not punched through all of the layers but instead the contour line of the patch is punched through all of the layers with the exception of 35 the protective film. Thereafter, the excess laminate mesh is removed from the protective film and discarded, before in a further step a protective film contour protruding beyond the margin of the patch is punched or cut.
- 14 A process for producing the medical patch of type C of the invention, comprising the production of a laminate for the interior, composed of a backing layer, at least 5 one active substance layer of pressure-sensitive adhesive and, preferably, a removable protective film, and also the use of a film repellently coated on at least one side for the exterior, is characterized in that it comprises the following steps: 10 a) in one step diecuts corresponding to the contours of the subsequent interior are made in the film provided for the marginal region and coated repellently on at least one side, and the diecut areas are discarded, 15 b) in a further step the film diecut under step a) is brought together one atop the other with the protective film of the patches that are to be produced; where the at least one repellently coated surface of the punched film comes to lie on 20 the side facing the protective film, c) in a further step the laminate of the interior, composed of the backing layer and also at least one pressure-sensitive adhesive matrix layer, from which any protective film envisaged in the 25 production operation has been removed, is laminated by its pressure-sensitive adhesive side onto the assembly consisting of the punched film of the marginal region and the protective film, the pressure-sensitive adhesive side of the 30 laminate being brought into two-dimensional communication with the uncoated surface of the film of the marginal region and, via the diecuts therein, directly with the repellently coated surface of the protective film as well, 35 d) in a further step the contour line of the interior of the patch is punched through the backing layer and the at least one matrix layer, this inner contour line extending at the distance intended round the diecuts, made under step a), in the film - 15 of the marginal region, e) In a further step, the excess laminate mesh composed of backing layer and at least one matrix layer is removed and discarded, 5 f) in a last step the outer contour line of the patch is punched through the exterior and the protective film, this outer contour line extending at the distance intended for the width of the overhanging marginal zone round the diecuts, made under step 10 d), in the film of the marginal region. Exemplary Embodiments Patch composition: 15 Patch backing layer Polyethylene film CoTran 9720 (3M) PSA matrix; layer thickness 100 g/m 2 Parts (dried) 20 Ethinylestradiol 0.6 Gestodene 1.9 MA73A 97.5 Total 100.0 25 Marginal Film Polyethylene terephthalate (PET) 36 ptm (Hostaphan RN 36) siliconized on one side (Laufenberg). Protective film 30 ScotchPak 9742 (3M) = 117 im polyester film, fluoropolymer-coated on one side The production of the exemplary system begins with the PSA matrix comprising active substance. For that 35 purpose the two active substances, ethinylestradiol and progestogen, are dissolved in pressure sensitive adhesive solution MA73A (Adhesives Research, - 16 polyisobutylene-based PSA with added tackifier resin based on hydrogenated rosin esters). This solution is coated in a layer thickness of 500 ptm 5 using a manual film applicator frame onto a siliconized polyester film (protective film) and after 10 minutes of drying in a laboratory fume cupboard at room temperature is dried in a drying cabinet at 60 0 C for a further 30 minutes. 10 The dried film has a layer thickness of approximately 100 g/m 2 ; it may be necessary to adapt the slot height during coating until the target coat-weight is obtained. 15 The dried film is lined with the CoTran 9720 backing layer. Circular diecuts with an area of 10 cm 2 are made in the 20 marginal film. The marginal film is subsequently placed with its siliconized side downwards onto the protective film film, with the siliconized side of the protective film 25 facing upwards. The protective film is then removed from the adhesive matrix produced and the exposed adhesive area is laminated onto the marginal film. The adhesive layer 30 enters into a permanent bond with the non-siliconized surface of the marginal film; as a result of the diecuts in the marginal film, moreover, the adhesive layer enters into a readily releasable bond with the siliconized surface of the protective film. 35 Finally an 11.5 cm 2 circular TTS is diecut from the assembly, the punching of this outer contour being placed symmetrically around the circular diecut of 10 cm2 in the marginal film.
- 17 This produces a marginal zone with a width of approximately 1 mm.
Claims (18)
1. Medical patch for use on the skin, wherein the contact area to the skin has a pressure-sensitive 5 adhesive interior and also an exterior surrounding the interior, characterized in that the said exterior has been designed so as to be non adhesive on its skin-facing surface. 10
2. Medical patch according to Claim 1, characterized in that the exterior has a mechanical reinforcement in the form of an additional layer in the construction of the patch. 15
3. Medical patch according to Claim 2, characterized in that the layer referred to comprises a polyester film in a layer thickness of from 6 to 150 pLm, preferably 15 to 75 pm. 20
4. Medical patch according to Claim 2, characterized in that the layer referred to comprises a polymer film based on a hydrocarbon polymer or silicone polymer in a layer thickness of from 6 to 150 pm, preferably 15 to 75 pm. 25
5. Medical patch according to one or more of the preceding claims, characterized in that the non adhesive exterior has a width along the contour line of the patch of from 0.5 to 5 mm, preferably 30 1.0 to 3.0 mm.
6. Medical patch according to one or more of the preceding claims, characterized in that the non adhesive exterior constitutes a border composed of 35 a polymeric film or a polymeric sheet and applied to the adhesive layer of the patch. 19
7. Medical patch according to Claim 6, characterized in that the applied border protrudes partly or completely in the area beyond the contour lines of the rest of the patch. 5
8. Medical patch according to one or more of the preceding claims, characterized in that the skin facing surface of the exterior has a coating which is repellent to the pressure-sensitive adhesive, 10 preferably a siliconization or a coating with a fluorine-containing polymer.
9. Medical patch according to one or more of the preceding claims, characterized in that the non 15 adhesive exterior is implemented differently in colour or transparency from the remaining area, preferably by means of vapour deposition of metal on one of the films forming part of the layer construction of the marginal zone. 20
10. Medical patch according to one or more of the preceding claims, characterized in that at least one active pharmaceutical substance is present. 25
11. Medical patch according to Claim 10, characterized in that the rate of active substance delivery per unit area in the exterior is lower by a factor of at least 10 than the rate of delivery in the active substance interior, with particular 30 preference by a factor of at least 100.
12. Medical patch according to one or more of the preceding claims, characterized in that the period of application is from 3 to 7 days. 35
13. Medical patch according to one or more of the preceding claims, characterized in that it comprises active substances for hormone - 20 replacement therapy or for transdermal contraception.
14. Medical patch according to one or more of the 5 preceding claims, characterized in that the active substance is a progestogen and/or an estrogen.
15. Medical patch according to Claim 14, characterized in that it comprises gestodene in combination with 10 an oestrogen.
16. Process for producing the medical patch according to Claim 1, comprising the production of a laminate for the interior, composed of a backing 15 layer, at least one active substance layer of pressure-sensitive adhesive and, preferably, a removable protective film, and also the use of a film repellently coated preferably on one side for the exterior, characterized in that it comprises 20 the following steps: a) in one step diecuts corresponding to the contours of the subsequent interior are made in the film provided for the marginal region, and the diecut areas are discarded, 25 b) in a further step the film diecut under step a) is brought together one atop the other with the protective film of the patches that are to be produced; in the case of a repellently coated surface this repellent surface of the punched 30 film comes to lie on the likewise repellently coated surface of the protective film, c) in a further step the laminate of the interior, composed of at least one pressure-sensitive adhesive matrix layer and also the backing 35 layer, from which any protective film envisaged in the production operation has been removed, is laminated by its pressure-sensitive adhesive side onto the assembly consisting of the REPLACEMENT SHEET (RULE 26) - 21 punched film of the marginal region and the protective film, the pressure-sensitive adhesive side of the laminate being brought into two-dimensional communication with the 5 uncoated surface of the film of the marginal region and, via the diecuts therein, directly with the repellently coated surface of the protective film as well, d) in a last step the outer contour line of the 10 patch is punched through all of the layers of the resultant laminate, this outer contour line extending at the distance intended for the width of the marginal zone round the diecuts, made under step a), in the film of the marginal 15 region.
17. Process for producing the medical patch according to Claim 15, comprising the process steps according to Claim 15, characterized in that in 20 step d), differently, the laminate is not punched through all of the layers but instead the contour line of the patch is punched through all of the layers with the exception of the protective film, whereafter the excess laminate mesh is removed 25 from the protective film and discarded, before in a further step a protective film contour protruding beyond the margin of the patch is punched or cut. 30
18. Process for producing the medical patch according to Claim 1, comprising the production of a laminate for the interior, composed of a backing layer, at least one active substance layer of pressure-sensitive adhesive and, for the exterior, 35 preferably, a removable protective film, and also the use of a film repellently coated on at least one side, characterized in that it comprises the following steps: REPLACEMENT SHEET (RULE 26) - 22 a) in one step diecuts corresponding to the contours of the subsequent interior are made in the film provided for the marginal region and coated repellently on at least one side, and 5 the diecut areas are discarded, b) in a further step the film diecut under step a) is brought together one atop the other with the protective film of the patches that are to be produced; where the at least one repellently 10 coated surface of the punched film comes to lie on the side facing the protective film, c) in a further step the laminate of the interior, composed of the backing layer and also at least one pressure- sensitive adhesive matrix layer, 15 from which any protective film envisaged in the production operation has been removed, is laminated by its pressure-sensitive adhesive side onto the assembly consisting of the punched film of the marginal region and the 20 protective film, the pressure-sensitive adhesive side of the laminate being brought into two-dimensional communication with the uncoated surface of the film of the marginal region and, via the diecuts therein, directly 25 with the repellently coated surface of the protective film as well, d) in a further step the contour line of the interior of the patch is punched through the backing layer and the at least one matrix 30 layer, this inner contour line extending at the distance intended round the diecuts, made under step a), in the film of the marginal region, e) in a further step, the excess, laminate mesh composed of backing layer and at least one 35 matrix layer is removed and discarded, f) in a last step the outer contour line of the patch is punched through the exterior and the protective film, this outer contour .line - 23 extending at the distance intended for the width of the overhanging marginal zone round the diecuts, made under step d), in the film of the marginal region. 5
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004016591.2 | 2004-03-31 | ||
DE102004016591A DE102004016591A1 (en) | 2004-03-31 | 2004-03-31 | Medical plasters with reduced adhesive residue |
PCT/EP2005/002970 WO2005097021A1 (en) | 2004-03-31 | 2005-03-19 | Medical plaster for application on the skin |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2005230241A1 true AU2005230241A1 (en) | 2005-10-20 |
AU2005230241B2 AU2005230241B2 (en) | 2009-02-05 |
Family
ID=34961647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2005230241A Ceased AU2005230241B2 (en) | 2004-03-31 | 2005-03-19 | Medical plaster for application on the skin |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1732487B1 (en) |
JP (1) | JP4638480B2 (en) |
KR (1) | KR100790703B1 (en) |
CN (1) | CN1960689B (en) |
AR (1) | AR048453A1 (en) |
AT (1) | ATE375135T1 (en) |
AU (1) | AU2005230241B2 (en) |
BR (1) | BRPI0509567A (en) |
CA (1) | CA2561196C (en) |
CR (1) | CR8660A (en) |
CU (1) | CU20060186A7 (en) |
DE (2) | DE102004016591A1 (en) |
DK (1) | DK1732487T3 (en) |
EA (1) | EA010078B1 (en) |
EC (1) | ECSP066949A (en) |
ES (1) | ES2294686T3 (en) |
HK (1) | HK1103006A1 (en) |
IL (1) | IL178190A0 (en) |
NO (1) | NO20064960L (en) |
PL (1) | PL1732487T3 (en) |
PT (1) | PT1732487E (en) |
UA (1) | UA84063C2 (en) |
WO (1) | WO2005097021A1 (en) |
ZA (1) | ZA200609007B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY165336A (en) | 2011-04-22 | 2018-03-21 | Hisamitsu Pharmaceutical Co | Pressure-Sensitive Adhesive Tape Package |
RU2573104C2 (en) * | 2011-09-01 | 2016-01-20 | Нитто Денко Корпорейшн | Adhesive bandage and adhesive preparation |
SE540253C2 (en) | 2016-07-01 | 2018-05-15 | Expertus Kemiteknik Ab | Device for surface sampling with removal device |
CN109125913A (en) * | 2018-11-05 | 2019-01-04 | 王云鹏 | A kind of medical scar plaster of drug containing and preparation method thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE743775C (en) * | 1940-10-20 | 1944-03-31 | Celluloid Fabrik Ag Deutsche | Adhesive plaster |
JPS57173716U (en) * | 1981-04-25 | 1982-11-02 | ||
US4664106A (en) * | 1985-12-20 | 1987-05-12 | Labeltape Meditect Inc. | Wound dressing |
GB2193637B (en) * | 1986-07-05 | 1990-03-14 | Aso Pharmaceutical | First-aid adhesive bandage |
DE69427716T2 (en) * | 1993-03-10 | 2002-06-13 | Nichiban Kk | Adhesive bandage for hemostasis |
FI941336A (en) * | 1993-03-23 | 1994-09-24 | Diomedes Oy | A patch that acts as a dispenser |
JPH0910256A (en) * | 1995-06-30 | 1997-01-14 | Eisaku Sato | Tape for wound without dirt on edge |
JP3754744B2 (en) * | 1996-03-01 | 2006-03-15 | 株式会社共和 | Adhesive film |
CN2370868Y (en) * | 1999-04-21 | 2000-03-29 | 杨福海 | Multi-layer structure plaster |
DE29911111U1 (en) * | 1999-06-25 | 1999-09-23 | Novosis Pharma Ag | Pavement with reduced cold flow |
US20030180493A1 (en) * | 2000-06-30 | 2003-09-25 | Nobuchika Hirashima | Auxiallary implement for patch application |
-
2004
- 2004-03-31 DE DE102004016591A patent/DE102004016591A1/en not_active Withdrawn
-
2005
- 2005-03-19 EA EA200601635A patent/EA010078B1/en not_active IP Right Cessation
- 2005-03-19 AT AT05716249T patent/ATE375135T1/en not_active IP Right Cessation
- 2005-03-19 PL PL05716249T patent/PL1732487T3/en unknown
- 2005-03-19 DK DK05716249T patent/DK1732487T3/en active
- 2005-03-19 JP JP2007505440A patent/JP4638480B2/en not_active Expired - Fee Related
- 2005-03-19 DE DE502005001682T patent/DE502005001682D1/en active Active
- 2005-03-19 UA UAA200611428A patent/UA84063C2/en unknown
- 2005-03-19 CN CN2005800176050A patent/CN1960689B/en not_active Expired - Fee Related
- 2005-03-19 WO PCT/EP2005/002970 patent/WO2005097021A1/en active IP Right Grant
- 2005-03-19 BR BRPI0509567-0A patent/BRPI0509567A/en not_active IP Right Cessation
- 2005-03-19 ES ES05716249T patent/ES2294686T3/en active Active
- 2005-03-19 AU AU2005230241A patent/AU2005230241B2/en not_active Ceased
- 2005-03-19 CA CA002561196A patent/CA2561196C/en not_active Expired - Fee Related
- 2005-03-19 KR KR1020067020401A patent/KR100790703B1/en not_active IP Right Cessation
- 2005-03-19 PT PT05716249T patent/PT1732487E/en unknown
- 2005-03-19 EP EP05716249A patent/EP1732487B1/en active Active
- 2005-03-30 AR ARP050101245A patent/AR048453A1/en active IP Right Grant
-
2006
- 2006-09-19 IL IL178190A patent/IL178190A0/en unknown
- 2006-09-26 CU CU20060186A patent/CU20060186A7/en unknown
- 2006-09-27 CR CR8660A patent/CR8660A/en unknown
- 2006-10-23 EC EC2006006949A patent/ECSP066949A/en unknown
- 2006-10-30 NO NO20064960A patent/NO20064960L/en not_active Application Discontinuation
- 2006-10-30 ZA ZA200609007A patent/ZA200609007B/en unknown
-
2007
- 2007-10-25 HK HK07111513.8A patent/HK1103006A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1732487B1 (en) | 2007-10-10 |
DK1732487T3 (en) | 2008-01-21 |
EA200601635A1 (en) | 2007-04-27 |
AU2005230241B2 (en) | 2009-02-05 |
JP4638480B2 (en) | 2011-02-23 |
PL1732487T3 (en) | 2008-02-29 |
DE502005001682D1 (en) | 2007-11-22 |
KR20070002035A (en) | 2007-01-04 |
CU20060186A7 (en) | 2011-01-27 |
CA2561196C (en) | 2009-09-01 |
HK1103006A1 (en) | 2007-12-14 |
CN1960689A (en) | 2007-05-09 |
KR100790703B1 (en) | 2008-01-02 |
CA2561196A1 (en) | 2005-10-20 |
NO20064960L (en) | 2006-10-30 |
ATE375135T1 (en) | 2007-10-15 |
ZA200609007B (en) | 2008-07-30 |
UA84063C2 (en) | 2008-09-10 |
IL178190A0 (en) | 2006-12-31 |
JP2007530190A (en) | 2007-11-01 |
EA010078B1 (en) | 2008-06-30 |
PT1732487E (en) | 2007-12-18 |
WO2005097021A1 (en) | 2005-10-20 |
CR8660A (en) | 2007-08-28 |
AR048453A1 (en) | 2006-04-26 |
DE102004016591A1 (en) | 2005-10-27 |
ECSP066949A (en) | 2006-12-20 |
CN1960689B (en) | 2011-04-27 |
BRPI0509567A (en) | 2007-09-25 |
EP1732487A1 (en) | 2006-12-20 |
ES2294686T3 (en) | 2008-04-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2011299629B2 (en) | Fixation device | |
JP2013237691A (en) | Composition and method for controlling drug loss and delivery in transdermal drug delivery system | |
NO303262B1 (en) | Process for preparing a solid state matrix system for transdermal drug delivery | |
CA2208132A1 (en) | Transdermal delivery system with adhesive overlay and peel seal disc | |
JPH10511966A (en) | Estradiol containing patch | |
WO2005009371A2 (en) | Ultra thin film transdermal/dermal or transmucosal/mucosal delivery system | |
JP4199485B2 (en) | Patch | |
US11583505B2 (en) | Over-patch having improved compatibility and a long adhesion duration and method for producing said over-patch | |
CA2561196C (en) | Medical plaster for application on the skin | |
WO2012092165A1 (en) | Transdermal drug delivery system comprising levonorgestrel acetate | |
JP2002521427A (en) | Estradiol-containing patch for transdermal administration of hormones | |
KR20010080321A (en) | Therapeutic system containing an active substance for the application on the skin which contains at least two polymerous layers | |
Czech et al. | Acrylic pressure‐sensitive adhesive for transdermal drug delivery systems | |
CA2338987A1 (en) | Adhesive agent composition, and permeable adhesive tape, adhesive drug composition and adhesive tape preparation containing the adhesive agent composition | |
US7468470B2 (en) | Medicinal patch that leaves less adhesive residue when removed | |
WO2009084611A1 (en) | Antipruritic sheet | |
TWI286928B (en) | Medical patches with reduced adhesive residue | |
CN113874409A (en) | Acrylic polymer and adhesive composition | |
MXPA06011266A (en) | Medical plaster for application on the skin | |
US20220079887A1 (en) | Transdermal therapeutic system with diffusion barrier | |
Pfister | Silicone PSA's offer flexibility for medical, pharmaceutical use | |
JP2003073263A (en) | Cataplasm with improved stability | |
JP2002521426A (en) | Estradiol-containing patch for transdermal administration of hormones | |
JPH08104622A (en) | Support and application agent for external use using the same | |
JPH08295623A (en) | External preparation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FGA | Letters patent sealed or granted (standard patent) | ||
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |