AU2004229256A1 - Use of L-carnitine for the treatment of cardiovascular diseases - Google Patents
Use of L-carnitine for the treatment of cardiovascular diseases Download PDFInfo
- Publication number
- AU2004229256A1 AU2004229256A1 AU2004229256A AU2004229256A AU2004229256A1 AU 2004229256 A1 AU2004229256 A1 AU 2004229256A1 AU 2004229256 A AU2004229256 A AU 2004229256A AU 2004229256 A AU2004229256 A AU 2004229256A AU 2004229256 A1 AU2004229256 A1 AU 2004229256A1
- Authority
- AU
- Australia
- Prior art keywords
- carnitine
- use according
- acid
- acute myocardial
- myocardial infarction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title claims description 68
- 238000011282 treatment Methods 0.000 title claims description 23
- 208000024172 Cardiovascular disease Diseases 0.000 title description 2
- 206010000891 acute myocardial infarction Diseases 0.000 claims description 33
- 206010061216 Infarction Diseases 0.000 claims description 31
- 230000034994 death Effects 0.000 claims description 30
- 231100000517 death Toxicity 0.000 claims description 30
- 239000003814 drug Substances 0.000 claims description 30
- 230000007574 infarction Effects 0.000 claims description 30
- 239000002253 acid Substances 0.000 claims description 20
- 229940079593 drug Drugs 0.000 claims description 20
- 208000024891 symptom Diseases 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 15
- 238000004393 prognosis Methods 0.000 claims description 11
- 230000007774 longterm Effects 0.000 claims description 10
- 230000002107 myocardial effect Effects 0.000 claims description 9
- -1 pamoate Substances 0.000 claims description 8
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 8
- 239000005541 ACE inhibitor Substances 0.000 claims description 7
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 6
- 238000001356 surgical procedure Methods 0.000 claims description 6
- 229940127291 Calcium channel antagonist Drugs 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 4
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 4
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- NDVRKEKNSBMTAX-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O NDVRKEKNSBMTAX-BTVCFUMJSA-N 0.000 claims description 2
- NVXFXLSOGLFXKQ-JMSVASOKSA-N (2s)-1-[(2r,4r)-5-ethoxy-2,4-dimethyl-5-oxopentanoyl]-2,3-dihydroindole-2-carboxylic acid Chemical compound C1=CC=C2N(C(=O)[C@H](C)C[C@@H](C)C(=O)OCC)[C@H](C(O)=O)CC2=C1 NVXFXLSOGLFXKQ-JMSVASOKSA-N 0.000 claims description 2
- QIJLJZOGPPQCOG-NFAWXSAZSA-N (2s)-1-[(2s)-3-[(2r)-2-(cyclohexanecarbonylamino)propanoyl]sulfanyl-2-methylpropanoyl]pyrrolidine-2-carboxylic acid Chemical compound N([C@H](C)C(=O)SC[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)C(=O)C1CCCCC1 QIJLJZOGPPQCOG-NFAWXSAZSA-N 0.000 claims description 2
- BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 claims description 2
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 2
- XRKXJJYSKUIIEN-UHFFFAOYSA-N 2-[cyclopentyl-[3-(2,2-dimethylpropanoylsulfanyl)-2-methylpropanoyl]amino]acetic acid Chemical compound CC(C)(C)C(=O)SCC(C)C(=O)N(CC(O)=O)C1CCCC1 XRKXJJYSKUIIEN-UHFFFAOYSA-N 0.000 claims description 2
- QWJSAWXRUVVRLH-LREBCSMRSA-M 2-hydroxyethyl(trimethyl)azanium;(2r,3r)-2,3,4-trihydroxy-4-oxobutanoate Chemical compound C[N+](C)(C)CCO.OC(=O)[C@H](O)[C@@H](O)C([O-])=O QWJSAWXRUVVRLH-LREBCSMRSA-M 0.000 claims description 2
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- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 2
- XPCFTKFZXHTYIP-PMACEKPBSA-N Benazepril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-PMACEKPBSA-N 0.000 claims description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 2
- IFYLTXNCFVRALQ-OALUTQOASA-N Ceronapril Chemical compound O([C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)P(O)(=O)CCCCC1=CC=CC=C1 IFYLTXNCFVRALQ-OALUTQOASA-N 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
- 108010061435 Enalapril Proteins 0.000 claims description 2
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
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- ZBBHBTPTTSWHBA-UHFFFAOYSA-N Nicardipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)CC=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZBBHBTPTTSWHBA-UHFFFAOYSA-N 0.000 claims description 2
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- 239000011780 sodium chloride Substances 0.000 description 1
- 208000016505 systemic primary carnitine deficiency disease Diseases 0.000 description 1
- BQMKAHQKDSZAIQ-UHFFFAOYSA-N tetrasodium;iron(3+);nitroxyl anion;pentacyanide Chemical compound [Na+].[Na+].[Na+].[Na+].[Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].O=[N-] BQMKAHQKDSZAIQ-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 229960000103 thrombolytic agent Drugs 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 208000021331 vascular occlusion disease Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2010202396A AU2010202396A1 (en) | 2003-04-17 | 2010-06-14 | Use of L-carnitine for the treatment of cardiovascular diseases |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM2003A000178 | 2003-04-17 | ||
| IT000178A ITRM20030178A1 (it) | 2003-04-17 | 2003-04-17 | Uso della l-carnitina per il trattamento di patologie cardiovascolari. |
| PCT/IT2004/000107 WO2004091602A1 (en) | 2003-04-17 | 2004-03-03 | Use of l-carnitine for the treatment of cardiovascular diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2010202396A Division AU2010202396A1 (en) | 2003-04-17 | 2010-06-14 | Use of L-carnitine for the treatment of cardiovascular diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2004229256A1 true AU2004229256A1 (en) | 2004-10-28 |
Family
ID=29765768
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2004229256A Withdrawn AU2004229256A1 (en) | 2003-04-17 | 2004-03-03 | Use of L-carnitine for the treatment of cardiovascular diseases |
| AU2010202396A Abandoned AU2010202396A1 (en) | 2003-04-17 | 2010-06-14 | Use of L-carnitine for the treatment of cardiovascular diseases |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2010202396A Abandoned AU2010202396A1 (en) | 2003-04-17 | 2010-06-14 | Use of L-carnitine for the treatment of cardiovascular diseases |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20060052450A1 (enExample) |
| EP (1) | EP1613301A1 (enExample) |
| JP (1) | JP2006523685A (enExample) |
| KR (1) | KR20050121196A (enExample) |
| CN (2) | CN101467992A (enExample) |
| AU (2) | AU2004229256A1 (enExample) |
| BR (1) | BRPI0406552A (enExample) |
| CA (1) | CA2508636A1 (enExample) |
| IT (1) | ITRM20030178A1 (enExample) |
| MX (1) | MXPA05007612A (enExample) |
| WO (1) | WO2004091602A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20040346A1 (it) * | 2004-07-13 | 2004-10-13 | Sigma Tau Ind Farmaceuti | Uso della l-carnitina per il trattamento di patologie cardiovascolari. |
| US20070260674A1 (en) * | 2006-05-02 | 2007-11-08 | Research In Motion Limited | Push framework for delivery of dynamic mobile content |
| EP2268304A2 (en) * | 2008-03-26 | 2011-01-05 | Orthologic Corp. | Methods for treating acute myocardial infarction |
| EP2353596A1 (en) | 2010-02-02 | 2011-08-10 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Combination composition, comprising as active ingredients L-carnitine or propionyl L-carnitine, for the prevention or treatment of chronic venous insufficiency |
| WO2012150146A1 (en) | 2011-05-03 | 2012-11-08 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Composition useful for the treatment of lipid metabolism disorders |
| CN114073705A (zh) * | 2020-08-14 | 2022-02-22 | 常州高新技术产业开发区三维工业技术研究所有限公司 | 一种降尿酸药物组合物及其应用 |
| CN112180013B (zh) * | 2020-09-29 | 2022-11-15 | 上海脉示生物技术有限公司 | 用于心肌梗死诊断的肠道微生物代谢标志物组合物及其检测方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS531812B2 (enExample) * | 1972-12-07 | 1978-01-23 | ||
| WO2000030637A1 (en) * | 1998-11-26 | 2000-06-02 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of fumarate salt of l-carnitine or its alkanoyl derivatives in ischaemia |
-
2003
- 2003-04-17 IT IT000178A patent/ITRM20030178A1/it unknown
-
2004
- 2004-03-03 CN CNA2008101490996A patent/CN101467992A/zh active Pending
- 2004-03-03 BR BR0406552-2A patent/BRPI0406552A/pt not_active IP Right Cessation
- 2004-03-03 CN CNA2004800015143A patent/CN1717232A/zh active Pending
- 2004-03-03 EP EP04716692A patent/EP1613301A1/en not_active Ceased
- 2004-03-03 AU AU2004229256A patent/AU2004229256A1/en not_active Withdrawn
- 2004-03-03 US US10/538,868 patent/US20060052450A1/en not_active Abandoned
- 2004-03-03 CA CA002508636A patent/CA2508636A1/en not_active Abandoned
- 2004-03-03 WO PCT/IT2004/000107 patent/WO2004091602A1/en not_active Ceased
- 2004-03-03 MX MXPA05007612A patent/MXPA05007612A/es active IP Right Grant
- 2004-03-03 JP JP2006507635A patent/JP2006523685A/ja active Pending
- 2004-03-03 KR KR1020057013711A patent/KR20050121196A/ko not_active Ceased
-
2010
- 2010-06-14 AU AU2010202396A patent/AU2010202396A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2508636A1 (en) | 2004-10-28 |
| EP1613301A1 (en) | 2006-01-11 |
| ITRM20030178A0 (it) | 2003-04-17 |
| AU2010202396A1 (en) | 2010-07-01 |
| KR20050121196A (ko) | 2005-12-26 |
| ITRM20030178A1 (it) | 2004-10-18 |
| MXPA05007612A (es) | 2005-09-30 |
| US20060052450A1 (en) | 2006-03-09 |
| CN1717232A (zh) | 2006-01-04 |
| WO2004091602A1 (en) | 2004-10-28 |
| JP2006523685A (ja) | 2006-10-19 |
| BRPI0406552A (pt) | 2005-12-20 |
| CN101467992A (zh) | 2009-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK12 | Application lapsed section 141(1)/reg 8.3(2) - applicant filed a written notice of withdrawal |