TWI329105B
(en)
*
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
CN1678321A
(en)
|
2002-07-29 |
2005-10-05 |
里格尔药品股份有限公司 |
Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
|
PT1625121E
(en)
|
2002-12-20 |
2010-03-11 |
Pfizer Prod Inc |
Pyrimidine derivatives for the treatment of abnormal cell growth
|
UA80767C2
(en)
*
|
2002-12-20 |
2007-10-25 |
Pfizer Prod Inc |
Pyrimidine derivatives for the treatment of abnormal cell growth
|
US7109337B2
(en)
|
2002-12-20 |
2006-09-19 |
Pfizer Inc |
Pyrimidine derivatives for the treatment of abnormal cell growth
|
GB0305929D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
EP1656372B1
(en)
|
2003-07-30 |
2013-04-10 |
Rigel Pharmaceuticals, Inc. |
2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
|
MXPA06001759A
(en)
*
|
2003-08-15 |
2006-05-12 |
Novartis Ag |
2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders.
|
MXPA06013164A
(en)
|
2004-05-14 |
2007-02-13 |
Pfizer Prod Inc |
Pyrimidines derivatives for the treatment of abnormal cell growth.
|
BRPI0511132A
(en)
|
2004-05-14 |
2007-11-27 |
Pfizer Prod Inc |
pyrimidine derivatives and pharmaceutical composition comprising the same
|
BRPI0510963A
(en)
|
2004-05-14 |
2007-11-20 |
Pfizer Prod Inc |
pyrimidine derivatives for the treatment of abnormal cell growth
|
WO2006004776A1
(en)
*
|
2004-06-29 |
2006-01-12 |
Rigel Pharmaceuticals, Inc. |
4-pyrimidineamine compounds and their uses as anti-proliferative agents
|
WO2006012502A2
(en)
*
|
2004-07-23 |
2006-02-02 |
Rigel Pharmaceuticals, Inc. |
Formulation of insoluble small molecule therapeutics in lipid-based carriers
|
GB0419160D0
(en)
*
|
2004-08-27 |
2004-09-29 |
Novartis Ag |
Organic compounds
|
GB0419161D0
(en)
*
|
2004-08-27 |
2004-09-29 |
Novartis Ag |
Organic compounds
|
CA2580838A1
(en)
*
|
2004-09-27 |
2006-04-06 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
US7557207B2
(en)
|
2004-11-24 |
2009-07-07 |
Rigel Pharmaceuticals, Inc. |
Spiro 2,4-pyrimidinediamine compounds and their uses
|
PT1856135E
(en)
|
2005-01-19 |
2010-02-26 |
Rigel Pharmaceuticals Inc |
Prodrugs of 2,4-pyrimidinediamine compounds and their uses
|
US20060247263A1
(en)
*
|
2005-04-19 |
2006-11-02 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
KR100602320B1
(en)
*
|
2005-05-03 |
2006-07-18 |
주식회사 하이닉스반도체 |
Non-volatile memory device having uniform programming speed
|
SG137989A1
(en)
|
2005-06-08 |
2008-01-28 |
Rigel Pharmaceuticals Inc |
Compositions and methods for inhibition of the JAK pathway
|
US20070203161A1
(en)
*
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
US8604042B2
(en)
|
2005-11-01 |
2013-12-10 |
Targegen, Inc. |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
US8246984B2
(en)
|
2005-12-06 |
2012-08-21 |
Rigel Pharmaceuticals, Inc. |
Formulation of insoluble small molecule therapeutics in lipid-based carriers
|
KR101060051B1
(en)
|
2005-12-21 |
2011-08-29 |
화이자 프로덕츠 인크. |
Pyrimidine Derivatives to Treat Abnormal Cell Growth
|
TW200736232A
(en)
*
|
2006-01-26 |
2007-10-01 |
Astrazeneca Ab |
Pyrimidine derivatives
|
CA2642229C
(en)
|
2006-02-24 |
2015-05-12 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
GB2451594A
(en)
*
|
2006-03-15 |
2009-02-04 |
Csir |
Modulation of phosphoryl transferase activity of glutamine synthetase
|
WO2007105023A1
(en)
*
|
2006-03-15 |
2007-09-20 |
Csir |
Modulation of phosphoryl transferase activity of glutamine synthetase
|
CA2673125C
(en)
|
2006-10-19 |
2015-04-21 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
CN101535276B
(en)
|
2006-10-23 |
2013-08-28 |
赛福伦公司 |
Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-MET inhibitors
|
RS53588B1
(en)
|
2006-12-08 |
2015-02-27 |
Irm Llc |
Compounds and compositions as protein kinase inhibitors
|
EP1939185A1
(en)
*
|
2006-12-20 |
2008-07-02 |
Bayer Schering Pharma Aktiengesellschaft |
New types of hetaryl-phenylendiamin-pyrimidines as protein kinase inhibitors for the treatment of cancer
|
AU2007338115A1
(en)
|
2006-12-22 |
2008-07-03 |
F. Hoffmann-La Roche Ag |
Spiro-piperidine derivatives
|
FR2911137B1
(en)
*
|
2007-01-05 |
2009-02-20 |
Sanofi Aventis Sa |
NOVEL 2,4-DIANILINOPYRIMIDE DERIVATIVES, THEIR PREPARATION AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND IN PARTICULAR AS INHIBITORS OF IKK
|
TW200843776A
(en)
*
|
2007-03-01 |
2008-11-16 |
Supergen Inc |
Pyrimidine-2,4-diamine derivatives and their use as JAK2 kinase inhibitors
|
EP1969929A1
(en)
*
|
2007-03-12 |
2008-09-17 |
Bayer CropScience AG |
Substituted phenylamidines and their use as fungicides
|
AU2016201820B2
(en)
*
|
2007-04-18 |
2018-03-08 |
Pfizer Products Inc. |
Sulfonyl amide derivatives for the treatment of abnormal cell growth
|
AP2009005010A0
(en)
|
2007-04-18 |
2009-10-31 |
Pfizer Prod Inc |
Sulfonyl amide derivatives for the treatment of abnormal cell growth
|
AU2014201847B2
(en)
*
|
2007-04-18 |
2015-12-24 |
Pfizer Products Inc. |
Sulfonyl amide derivatives for the treatment of abnormal cell growth
|
EP2231620A1
(en)
|
2007-12-03 |
2010-09-29 |
Boehringer Ingelheim International GmbH |
Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation
|
CA2703824C
(en)
|
2008-01-11 |
2016-06-07 |
F. Hoffmann-La Roche Ag |
Modulators for amyloid beta
|
RU2010137300A
(en)
*
|
2008-02-22 |
2012-03-27 |
Ф. Хоффманн-Ля Рош Аг (Ch) |
BETA AMYLOID MODULATORS
|
NZ589315A
(en)
|
2008-04-16 |
2012-11-30 |
Portola Pharm Inc |
2,6-diamino-pyrimidin-5-yl-carboxamides as Spleen tryosine kinase (syk) or Janus kinase (JAK) inhibitors
|
JP5802127B2
(en)
|
2008-04-16 |
2015-10-28 |
ポートラ ファーマシューティカルズ, インコーポレイテッド |
2,6-Diamino-pyrimidin-5-yl-carboxamides as SYK or JAK kinase inhibitors
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
JP2011518219A
(en)
|
2008-04-22 |
2011-06-23 |
ポートラ ファーマシューティカルズ, インコーポレイテッド |
Inhibitors of protein kinases
|
EA029131B1
(en)
|
2008-05-21 |
2018-02-28 |
Ариад Фармасьютикалз, Инк. |
Phosphorous derivatives as kinase inhibitors
|
US9273077B2
(en)
|
2008-05-21 |
2016-03-01 |
Ariad Pharmaceuticals, Inc. |
Phosphorus derivatives as kinase inhibitors
|
DE102008049323A1
(en)
*
|
2008-09-29 |
2010-04-01 |
Henkel Ag & Co. Kgaa |
New developer components
|
KR101324414B1
(en)
|
2008-10-09 |
2013-11-01 |
에프. 호프만-라 로슈 아게 |
Modulators for amyloid beta
|
KR101293421B1
(en)
|
2008-11-10 |
2013-08-05 |
에프. 호프만-라 로슈 아게 |
Heterocyclic gamma secretase modulators
|
CN102292333B
(en)
*
|
2009-01-15 |
2015-05-13 |
里格尔药品股份有限公司 |
Protein kinase c inhibitors and uses thereof
|
JP5539518B2
(en)
|
2009-08-14 |
2014-07-02 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
|
US8933227B2
(en)
|
2009-08-14 |
2015-01-13 |
Boehringer Ingelheim International Gmbh |
Selective synthesis of functionalized pyrimidines
|
WO2011090738A2
(en)
|
2009-12-29 |
2011-07-28 |
Dana-Farber Cancer Institute, Inc. |
Type ii raf kinase inhibitors
|
US8486967B2
(en)
|
2010-02-17 |
2013-07-16 |
Hoffmann-La Roche Inc. |
Heteroaryl substituted piperidines
|
RU2528386C2
(en)
|
2010-05-21 |
2014-09-20 |
Кемилиа Аб |
New pyrimidine derivatives
|
US9102625B2
(en)
|
2010-11-01 |
2015-08-11 |
Portola Pharmaceuticals, Inc. |
Nicotinamides as JAK kinase modulators
|
US20130317029A1
(en)
|
2010-11-01 |
2013-11-28 |
Portola Pharmaceuticals, Inc. |
Oxypyrimidines as syk modulators
|
CN103282352B
(en)
|
2010-11-01 |
2016-08-10 |
波托拉医药品公司 |
Benzamides and nicotinamide as SYK regulator
|
CA2816957A1
(en)
|
2010-11-07 |
2012-05-10 |
Targegen, Inc. |
Compositions and methods for treating myelofibrosis
|
ES2587864T3
(en)
|
2011-03-24 |
2016-10-27 |
Noviga Research Ab |
Pyrimidine derivatives
|
US9249124B2
(en)
|
2011-03-30 |
2016-02-02 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Aurora kinase inhibitors and methods of making and using thereof
|
US9834518B2
(en)
|
2011-05-04 |
2017-12-05 |
Ariad Pharmaceuticals, Inc. |
Compounds for inhibiting cell proliferation in EGFR-driven cancers
|
EP3812387A1
(en)
|
2011-07-21 |
2021-04-28 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Heterocyclic protein kinase inhibitors
|
US9382239B2
(en)
*
|
2011-11-17 |
2016-07-05 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of c-Jun-N-terminal kinase (JNK)
|
US8877760B2
(en)
|
2011-11-23 |
2014-11-04 |
Portola Pharmaceuticals, Inc. |
Substituted pyrazine-2-carboxamide kinase inhibitors
|
EP2606884A1
(en)
*
|
2011-12-21 |
2013-06-26 |
Ecole Polytechnique Fédérale de Lausanne (EPFL) |
Inhibitors of notch signaling pathway and use thereof in treatment of cancers
|
WO2013169401A1
(en)
|
2012-05-05 |
2013-11-14 |
Ariad Pharmaceuticals, Inc. |
Compounds for inhibiting cell proliferation in egfr-driven cancers
|
KR101446742B1
(en)
*
|
2012-08-10 |
2014-10-01 |
한국화학연구원 |
N2,N4-bis(4-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine derivatives or pharmaceutically acceptable salt thereof, and pharmaceutical composition for the prevention or treatment of cancer containing the same as an active ingredient
|
US9676756B2
(en)
|
2012-10-08 |
2017-06-13 |
Portola Pharmaceuticals, Inc. |
Substituted pyrimidinyl kinase inhibitors
|
USRE48175E1
(en)
|
2012-10-19 |
2020-08-25 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
DK2970205T3
(en)
|
2013-03-14 |
2019-07-29 |
Tolero Pharmaceuticals Inc |
JAK2 and ALK2 inhibitors and methods for their use
|
US9611283B1
(en)
|
2013-04-10 |
2017-04-04 |
Ariad Pharmaceuticals, Inc. |
Methods for inhibiting cell proliferation in ALK-driven cancers
|
WO2015058140A1
(en)
|
2013-10-18 |
2015-04-23 |
Dana-Farber Cancer Institute, Inc. |
Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)
|
WO2015058126A1
(en)
|
2013-10-18 |
2015-04-23 |
Syros Pharmaceuticals, Inc. |
Heteroaromatic compounds useful for the treatment of prolferative diseases
|
US10106507B2
(en)
|
2014-08-03 |
2018-10-23 |
H. Lee Moffitt Cancer Center and Research Insitute, Inc. |
Potent dual BRD4-kinase inhibitors as cancer therapeutics
|
CA2972239A1
(en)
|
2014-12-23 |
2016-06-30 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
EP3273966B1
(en)
|
2015-03-27 |
2023-05-03 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
EP4019515A1
(en)
|
2015-09-09 |
2022-06-29 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
WO2017066428A1
(en)
|
2015-10-13 |
2017-04-20 |
H. Lee Moffitt Cancer Center & Research Institute, Inc. |
Brd4-kinase inhibitors as cancer therapeutics
|
KR102628675B1
(en)
*
|
2017-05-26 |
2024-01-25 |
캔써 리서치 테크놀로지 리미티드 |
Inhibitor of BCL6 derived from benzimidazolone
|
JP2020525525A
(en)
|
2017-06-30 |
2020-08-27 |
ベイジン タイド ファーマシューティカル カンパニー リミテッドBeijing Tide Pharmaceutical Co., Ltd. |
RHO-related protein kinase inhibitor, pharmaceutical composition containing RHO-related protein kinase inhibitor, preparation method and use of the pharmaceutical composition
|
JP7311228B2
(en)
|
2017-06-30 |
2023-07-19 |
ベイジン タイド ファーマシューティカル カンパニー リミテッド |
RHO-related protein kinase inhibitors, pharmaceutical compositions containing same and methods for preparation and use thereof
|
WO2019000683A1
(en)
|
2017-06-30 |
2019-01-03 |
北京泰德制药股份有限公司 |
Rho-associated protein kinase inhibitor, pharmaceutical composition containing rho-associated protein kinase inhibitor, preparation method and use of the pharmaceutical composition
|
CN109776522B
(en)
*
|
2017-10-30 |
2020-12-29 |
广东东阳光药业有限公司 |
Substituted heteroaryl compounds, compositions and uses thereof
|
MX2020010437A
(en)
|
2018-04-05 |
2021-01-29 |
Sumitomo Pharma Oncology Inc |
Axl kinase inhibitors and use of the same.
|
MX2020010556A
(en)
|
2018-04-13 |
2021-03-02 |
Sumitomo Pharma Oncology Inc |
Pim kinase inhibitors for treatment of myeloproliferative neoplasms and fibrosis associated with cancer.
|
WO2020006724A1
(en)
*
|
2018-07-05 |
2020-01-09 |
清华大学 |
Compound for targeted degradation of fak protein and use thereof
|
US11040038B2
(en)
|
2018-07-26 |
2021-06-22 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Methods for treating diseases associated with abnormal ACVR1 expression and ACVR1 inhibitors for use in the same
|
CN111362922A
(en)
*
|
2018-12-26 |
2020-07-03 |
上海喆邺生物科技有限公司 |
2, 4-diaminopyrimidine derivatives and their use
|
MX2021009371A
(en)
|
2019-02-12 |
2021-09-10 |
Sumitomo Pharma Oncology Inc |
Formulations comprising heterocyclic protein kinase inhibitors.
|
CN114105887B
(en)
*
|
2021-09-16 |
2023-12-01 |
沈阳药科大学 |
Aminopyrimidine derivative and preparation method and application thereof
|
WO2024097653A1
(en)
|
2022-10-31 |
2024-05-10 |
Sumitomo Pharma America, Inc. |
Pim1 inhibitor for treating myeloproliferative neoplasms
|