AU2003283096A1 - Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors - Google Patents

Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors

Info

Publication number
AU2003283096A1
AU2003283096A1 AU2003283096A AU2003283096A AU2003283096A1 AU 2003283096 A1 AU2003283096 A1 AU 2003283096A1 AU 2003283096 A AU2003283096 A AU 2003283096A AU 2003283096 A AU2003283096 A AU 2003283096A AU 2003283096 A1 AU2003283096 A1 AU 2003283096A1
Authority
AU
Australia
Prior art keywords
furanones
cyclooxygenase
diaryl
inhibitors
nitric oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003283096A
Inventor
Zhaoyin Wang
Robert N. Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Publication of AU2003283096A1 publication Critical patent/AU2003283096A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003283096A 2002-11-05 2003-11-03 Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors Abandoned AU2003283096A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42386602P 2002-11-05 2002-11-05
US60/423,866 2002-11-05
PCT/CA2003/001691 WO2004041803A1 (en) 2002-11-05 2003-11-03 Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors

Publications (1)

Publication Number Publication Date
AU2003283096A1 true AU2003283096A1 (en) 2004-06-07

Family

ID=32312720

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003283096A Abandoned AU2003283096A1 (en) 2002-11-05 2003-11-03 Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors

Country Status (2)

Country Link
AU (1) AU2003283096A1 (en)
WO (1) WO2004041803A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004021238D1 (en) 2003-03-05 2009-07-09 Merck Frosst Company NITROGEN MONOXIDE RELEASING PRODRUGS OF DIARYL-2- (5H) FURANOES AS INHIBITORS OF CYCLOOXYGENASE-2
WO2006040676A1 (en) * 2004-10-12 2006-04-20 Pharmacia & Upjohn Company Llc Nitrosated benzopyran compounds as novel cyclooxygenase-2 selective inhibitors
EP1828155A4 (en) * 2004-11-15 2011-04-20 Nicox Sa Diuretic compounds comprising heterocyclic nitric oxide donor groups,compositions and methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
TWI243672B (en) * 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents

Also Published As

Publication number Publication date
WO2004041803A1 (en) 2004-05-21

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase