EP1828155A4 - Diuretic compounds comprising heterocyclic nitric oxide donor groups,compositions and methods of use - Google Patents

Diuretic compounds comprising heterocyclic nitric oxide donor groups,compositions and methods of use

Info

Publication number
EP1828155A4
EP1828155A4 EP05851657A EP05851657A EP1828155A4 EP 1828155 A4 EP1828155 A4 EP 1828155A4 EP 05851657 A EP05851657 A EP 05851657A EP 05851657 A EP05851657 A EP 05851657A EP 1828155 A4 EP1828155 A4 EP 1828155A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
nitric oxide
oxide donor
donor groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05851657A
Other languages
German (de)
French (fr)
Other versions
EP1828155A2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicox SA
Original Assignee
Nicox SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox SA filed Critical Nicox SA
Priority claimed from PCT/US2005/041321 external-priority patent/WO2006055542A2/en
Publication of EP1828155A2 publication Critical patent/EP1828155A2/en
Publication of EP1828155A4 publication Critical patent/EP1828155A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
EP05851657A 2004-11-15 2005-11-15 Diuretic compounds comprising heterocyclic nitric oxide donor groups,compositions and methods of use Withdrawn EP1828155A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62717704P 2004-11-15 2004-11-15
PCT/US2005/041321 WO2006055542A2 (en) 2004-11-15 2005-11-15 Diuretic compounds comprising heterocyclic nitric oxide donor groups, compositions and methods of use

Publications (2)

Publication Number Publication Date
EP1828155A2 EP1828155A2 (en) 2007-09-05
EP1828155A4 true EP1828155A4 (en) 2011-04-20

Family

ID=38325889

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05851657A Withdrawn EP1828155A4 (en) 2004-11-15 2005-11-15 Diuretic compounds comprising heterocyclic nitric oxide donor groups,compositions and methods of use

Country Status (1)

Country Link
EP (1) EP1828155A4 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004041803A1 (en) * 2002-11-05 2004-05-21 Merck Frosst Canada & Co. Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
WO2005023183A2 (en) * 2003-08-28 2005-03-17 Nitromed, Inc. Nitrosated ad nitrosylated diuretic compouds, compositions and methods of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004041803A1 (en) * 2002-11-05 2004-05-21 Merck Frosst Canada & Co. Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
WO2005023183A2 (en) * 2003-08-28 2005-03-17 Nitromed, Inc. Nitrosated ad nitrosylated diuretic compouds, compositions and methods of use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BURGAUD J L ET AL: "NITRIC-OXIDE RELEASING MOLECULES: A NEW CLASS OF DRUGS WITH SEVERAL MAJOR INDICATIONS", CURRENT PHARMACEUTICAL DESIGN, BENTHAM SCIENCE PUBLISHERS, NL, vol. 8, no. 3, 1 January 2002 (2002-01-01), pages 201 - 213, XP001122072, ISSN: 1381-6128, DOI: 10.2174/1381612023396357 *
PRANDI C ET AL: "Development of Absorption Furosemide Prodrugs: Synthesis, In Vitro and in Vivo Evaluation", FARMACO, SOCIETA CHIMICA ITALIANA, PAVIA, IT, vol. 47, no. 2, 1 January 1992 (1992-01-01), pages 249 - 263, XP007917297, ISSN: 0014-827X *

Also Published As

Publication number Publication date
EP1828155A2 (en) 2007-09-05

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20070615

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: NICOX S.A.

A4 Supplementary search report drawn up and despatched

Effective date: 20110323

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/41 20060101ALI20110317BHEP

Ipc: C07D 285/16 20060101AFI20070704BHEP

Ipc: A61K 31/54 20060101ALI20110317BHEP

Ipc: C07D 411/12 20060101ALI20110317BHEP

Ipc: A61K 31/4245 20060101ALI20110317BHEP

Ipc: C07D 295/00 20060101ALI20110317BHEP

Ipc: C07D 269/00 20060101ALI20110317BHEP

Ipc: A61K 31/5375 20060101ALI20110317BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20110601