AU2003276514A1 - 4-imidazol-1-ylmethyl-pyrimidine derivatives_as ligands for gabaa receptors - Google Patents
4-imidazol-1-ylmethyl-pyrimidine derivatives_as ligands for gabaa receptorsInfo
- Publication number
- AU2003276514A1 AU2003276514A1 AU2003276514A AU2003276514A AU2003276514A1 AU 2003276514 A1 AU2003276514 A1 AU 2003276514A1 AU 2003276514 A AU2003276514 A AU 2003276514A AU 2003276514 A AU2003276514 A AU 2003276514A AU 2003276514 A1 AU2003276514 A1 AU 2003276514A1
- Authority
- AU
- Australia
- Prior art keywords
- sub
- receptors
- imidazol
- ligands
- gaba
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003446 ligand Substances 0.000 title abstract 3
- MIQCQUJDYOHTOK-UHFFFAOYSA-N 4-(imidazol-1-ylmethyl)pyrimidine Chemical class C1=CN=CN1CC1=CC=NC=N1 MIQCQUJDYOHTOK-UHFFFAOYSA-N 0.000 title abstract 2
- 102000027484 GABAA receptors Human genes 0.000 title 1
- 108091008681 GABAA receptors Proteins 0.000 title 1
- 210000003169 central nervous system Anatomy 0.000 abstract 4
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 3
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 230000004807 localization Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42494502P | 2002-11-08 | 2002-11-08 | |
| US60/424,945 | 2002-11-08 | ||
| PCT/IB2003/004978 WO2004041808A1 (en) | 2002-11-08 | 2003-11-04 | 4-imidazol-1-ylmethyl-pyrimidine derivatives_as ligands for gabaa receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2003276514A1 true AU2003276514A1 (en) | 2004-06-07 |
Family
ID=32312901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003276514A Abandoned AU2003276514A1 (en) | 2002-11-08 | 2003-11-04 | 4-imidazol-1-ylmethyl-pyrimidine derivatives_as ligands for gabaa receptors |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6951864B2 (https=) |
| EP (1) | EP1560822B1 (https=) |
| JP (1) | JP2006508102A (https=) |
| AT (1) | ATE335732T1 (https=) |
| AU (1) | AU2003276514A1 (https=) |
| CA (1) | CA2495708A1 (https=) |
| DE (1) | DE60307499T2 (https=) |
| ES (1) | ES2268488T3 (https=) |
| WO (1) | WO2004041808A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100579579C (zh) | 2002-10-01 | 2010-01-13 | 诺华疫苗和诊断公司 | 抗癌及抗感染性疾病组合物及其使用方法 |
| EP1594848A1 (en) | 2003-02-19 | 2005-11-16 | Neurogen Corporation | Aryl acid pyrimidinyl methyl amides, pyridazinyl methyl amides and related compounds |
| CA2524376A1 (en) * | 2003-05-05 | 2004-12-16 | Neurogen Corporation | Substituted imidazolopyrazine and triazolopyrazyne derivatives: gabaa receptor ligands |
| WO2005012306A2 (en) | 2003-07-25 | 2005-02-10 | Neurogen Corporation | Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands |
| KR101170925B1 (ko) * | 2004-06-18 | 2012-08-07 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 암 치료용 키네신 방추 단백질 (ｋｓｐ) 억제제로서의ｎ-(1-(1-벤질-4-페닐-1ｈ-이미다졸-2-일)-2,2-디메틸프로필)벤자미드 유도체 및 관련 화합물 |
| AU2008205169B2 (en) | 2007-01-05 | 2012-02-02 | Novartis Ag | Imidazole derivatives as kinesin spindle protein inhibitors (Eg-5) |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8535601A1 (es) * | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
| ATE338758T1 (de) * | 2001-03-23 | 2006-09-15 | Merck Sharp & Dohme | Imidazopyrimidin-derivate als liganden für gaba- rezeptoren |
| CN100579579C (zh) * | 2002-10-01 | 2010-01-13 | 诺华疫苗和诊断公司 | 抗癌及抗感染性疾病组合物及其使用方法 |
-
2003
- 2003-11-04 AT AT03810562T patent/ATE335732T1/de not_active IP Right Cessation
- 2003-11-04 DE DE60307499T patent/DE60307499T2/de not_active Expired - Fee Related
- 2003-11-04 JP JP2004549490A patent/JP2006508102A/ja active Pending
- 2003-11-04 EP EP03810562A patent/EP1560822B1/en not_active Expired - Lifetime
- 2003-11-04 CA CA002495708A patent/CA2495708A1/en not_active Abandoned
- 2003-11-04 ES ES03810562T patent/ES2268488T3/es not_active Expired - Lifetime
- 2003-11-04 WO PCT/IB2003/004978 patent/WO2004041808A1/en not_active Ceased
- 2003-11-04 AU AU2003276514A patent/AU2003276514A1/en not_active Abandoned
- 2003-11-06 US US10/702,629 patent/US6951864B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2495708A1 (en) | 2004-05-21 |
| WO2004041808A1 (en) | 2004-05-21 |
| EP1560822B1 (en) | 2006-08-09 |
| ES2268488T3 (es) | 2007-03-16 |
| ATE335732T1 (de) | 2006-09-15 |
| DE60307499D1 (de) | 2006-09-21 |
| DE60307499T2 (de) | 2007-02-01 |
| US6951864B2 (en) | 2005-10-04 |
| EP1560822A1 (en) | 2005-08-10 |
| JP2006508102A (ja) | 2006-03-09 |
| US20040102457A1 (en) | 2004-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |