AU2003274378A1 - Crystal structure of cytochrome p450 3a4 and its use - Google Patents

Crystal structure of cytochrome p450 3a4 and its use

Info

Publication number
AU2003274378A1
AU2003274378A1 AU2003274378A AU2003274378A AU2003274378A1 AU 2003274378 A1 AU2003274378 A1 AU 2003274378A1 AU 2003274378 A AU2003274378 A AU 2003274378A AU 2003274378 A AU2003274378 A AU 2003274378A AU 2003274378 A1 AU2003274378 A1 AU 2003274378A1
Authority
AU
Australia
Prior art keywords
cytochrome
crystal structure
crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003274378A
Other languages
English (en)
Inventor
Harren Jhoti
Stewart Brian Kirton
Ian James Tickle
Clemens Vonrhein
Pamela Ann Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astex Technology Ltd
Original Assignee
Astex Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astex Technology Ltd filed Critical Astex Technology Ltd
Publication of AU2003274378A1 publication Critical patent/AU2003274378A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/80—Cytochromes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2003274378A 2002-10-25 2003-10-24 Crystal structure of cytochrome p450 3a4 and its use Abandoned AU2003274378A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42106302P 2002-10-25 2002-10-25
US60/421,063 2002-10-25
US47944803P 2003-06-19 2003-06-19
US60/479,448 2003-06-19
PCT/GB2003/004598 WO2004038015A1 (en) 2002-10-25 2003-10-24 Crystal structure of cytochrome p450 3a4 and its use

Publications (1)

Publication Number Publication Date
AU2003274378A1 true AU2003274378A1 (en) 2004-05-13

Family

ID=32179837

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003274378A Abandoned AU2003274378A1 (en) 2002-10-25 2003-10-24 Crystal structure of cytochrome p450 3a4 and its use

Country Status (5)

Country Link
EP (1) EP1554380A1 (ja)
JP (1) JP2006503912A (ja)
AU (1) AU2003274378A1 (ja)
DE (1) DE03758362T1 (ja)
WO (1) WO2004038015A1 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032119A1 (en) * 2001-04-02 2005-02-10 Astex Technology Ltd. Crystal structure of cytochrome P450
US7148046B2 (en) 2001-04-02 2006-12-12 Astex Therapeutics Limited Crystal structure of cytochrome P450
WO2007052049A2 (en) * 2005-11-04 2007-05-10 Astrazeneca Ab Crystal structure of cytochrome p450 and uses thereof
JP6615525B2 (ja) * 2015-07-30 2019-12-04 シスメックス株式会社 ヘムタンパク質の生産方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19549267A1 (de) * 1995-12-28 1997-07-03 Max Delbrueck Centrum Verfahren zur Kristallisation von Proteinen
WO1999008812A1 (en) * 1997-08-20 1999-02-25 The University Of Rochester Functional bacterial/mammalian cytochrome p450 chimera
US6312917B1 (en) * 1998-12-04 2001-11-06 The University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to oxidative metabolism

Also Published As

Publication number Publication date
WO2004038015A1 (en) 2004-05-06
JP2006503912A (ja) 2006-02-02
DE03758362T1 (de) 2005-08-25
EP1554380A1 (en) 2005-07-20

Similar Documents

Publication Publication Date Title
AU2003275311A1 (en) Solid micro-perforators and methods of use
AU2003217870A1 (en) Pini-modulating compounds and methods of use thereof
AU2003225669A1 (en) Pin1-modulating compounds and methods of use thereof
AU2003225668A1 (en) Pin1-modulating compounds and methods of use thereof
AU2003262121A1 (en) Nanowire devices and methods of fabrication
AU2003213673A1 (en) Pin1-modulating compounds and methods of use thereof
AU2003235676A1 (en) Tricyclic-bis-enone derivatives and methods of use thereof
AU2003288902A1 (en) Microcapsules and methods of use
AU2003304093A1 (en) Catalytic preburner and associated methods of operation
AU2003219987A1 (en) Electroluminescent materials and methods of manufacture and use
AU2003220101A1 (en) Distribution of wireless telephony and data signals in a substantially closed environment
AU2003259735A1 (en) Small-mer compositions and methods of use
AU2003290513A1 (en) Capacitive resonators and methods of fabrication
AU2003228210A1 (en) Attenuating and amplifying user interface themes
AU2003259717A1 (en) Modulators of rabggt and methods of use thereof
AU2003219824A1 (en) Fluorinated molecules and methods of making and using same
AU2003281687A1 (en) Photopolymerizable composition and use thereof
AU2003285270A1 (en) Intermetallic material and use of said material
AU2003215244A1 (en) Complexes and methods of using same
AU2002310619A1 (en) Methods of purification of cytochrome p450 proteins and of their crystallizing
AU2003252026A1 (en) Npc1l1 (npc3) and methods of use thereof
AU2003274378A1 (en) Crystal structure of cytochrome p450 3a4 and its use
AU2003287802A1 (en) Palpometer and methods of use thereof
AU2003285686A1 (en) Glycoisoforms of adiponectin and uses thereof
AU2003216354A1 (en) Modulators of paraptosis and related methods

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase