AU2003259359A1 - 2,4-diaminoquinazoline, 2-amino-4-hydroxypteridine and 2,4-diaminopyrimidine ester derivatives as dihydrofolate reductase inhibitors - Google Patents

2,4-diaminoquinazoline, 2-amino-4-hydroxypteridine and 2,4-diaminopyrimidine ester derivatives as dihydrofolate reductase inhibitors

Info

Publication number
AU2003259359A1
AU2003259359A1 AU2003259359A AU2003259359A AU2003259359A1 AU 2003259359 A1 AU2003259359 A1 AU 2003259359A1 AU 2003259359 A AU2003259359 A AU 2003259359A AU 2003259359 A AU2003259359 A AU 2003259359A AU 2003259359 A1 AU2003259359 A1 AU 2003259359A1
Authority
AU
Australia
Prior art keywords
hydroxypteridine
diaminoquinazoline
diaminopyrimidine
amino
reductase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003259359A
Inventor
Per Andersson
Arne Boman
Torbjorn Lundstedt
Elisabeth Seifert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Melacure Therapeutics AB
Original Assignee
Melacure Therapeutics AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melacure Therapeutics AB filed Critical Melacure Therapeutics AB
Publication of AU2003259359A1 publication Critical patent/AU2003259359A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
AU2003259359A 2002-08-27 2003-08-27 2,4-diaminoquinazoline, 2-amino-4-hydroxypteridine and 2,4-diaminopyrimidine ester derivatives as dihydrofolate reductase inhibitors Abandoned AU2003259359A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0219893A GB0219893D0 (en) 2002-08-27 2002-08-27 Pharmaceutically active compounds
GB0219893.5 2002-08-27
PCT/GB2003/003704 WO2004020417A1 (en) 2002-08-27 2003-08-27 2,4-diaminoquinazoline, 2-amino-4-hydroxypteridine and 2,4-diaminopyrimidine ester derivatives as dihydrofolate reductase inhibitors

Publications (1)

Publication Number Publication Date
AU2003259359A1 true AU2003259359A1 (en) 2004-03-19

Family

ID=9943019

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003259359A Abandoned AU2003259359A1 (en) 2002-08-27 2003-08-27 2,4-diaminoquinazoline, 2-amino-4-hydroxypteridine and 2,4-diaminopyrimidine ester derivatives as dihydrofolate reductase inhibitors

Country Status (3)

Country Link
AU (1) AU2003259359A1 (en)
GB (1) GB0219893D0 (en)
WO (1) WO2004020417A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0700061A2 (en) 2001-06-28 2007-05-02 Pliva D D Pyridopyrimidine and pyrimidinopyrimidine derivatives, process for their preparation and pharmaceutical compositions therof as antibacterials having dhfr inhibitor activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992017478A1 (en) * 1991-04-08 1992-10-15 Duquesne University Of The Holy Ghost 5-ALKYL-6-[[AMINO]METHYL]PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AND METHODS OF PREPARING AND USING THESE DERIVATIVES

Also Published As

Publication number Publication date
GB0219893D0 (en) 2002-10-02
WO2004020417A1 (en) 2004-03-11
WO2004020417A8 (en) 2004-04-15

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase