AU2003259237B2 - Human G protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure - Google Patents

Human G protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure Download PDF

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Publication number
AU2003259237B2
AU2003259237B2 AU2003259237A AU2003259237A AU2003259237B2 AU 2003259237 B2 AU2003259237 B2 AU 2003259237B2 AU 2003259237 A AU2003259237 A AU 2003259237A AU 2003259237 A AU2003259237 A AU 2003259237A AU 2003259237 B2 AU2003259237 B2 AU 2003259237B2
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AU
Australia
Prior art keywords
seq
sequence
receptor
rup41
set forth
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Ceased
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AU2003259237A
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English (en)
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AU2003259237A1 (en
Inventor
John W. Adams
Daniel T. Connolly
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Arena Pharmaceuticals Inc
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Arena Pharmaceuticals Inc
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Application filed by Arena Pharmaceuticals Inc filed Critical Arena Pharmaceuticals Inc
Publication of AU2003259237A1 publication Critical patent/AU2003259237A1/en
Application granted granted Critical
Publication of AU2003259237B2 publication Critical patent/AU2003259237B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
AU2003259237A 2002-08-01 2003-07-25 Human G protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure Ceased AU2003259237B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40077402P 2002-08-01 2002-08-01
US60/400,774 2002-08-01
PCT/US2003/023296 WO2004013285A2 (en) 2002-08-01 2003-07-25 Human g protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure

Publications (2)

Publication Number Publication Date
AU2003259237A1 AU2003259237A1 (en) 2004-02-23
AU2003259237B2 true AU2003259237B2 (en) 2011-01-06

Family

ID=31495875

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003259237A Ceased AU2003259237B2 (en) 2002-08-01 2003-07-25 Human G protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure

Country Status (8)

Country Link
US (2) US7611832B2 (enExample)
EP (1) EP1543025A4 (enExample)
JP (1) JP2005534319A (enExample)
CN (1) CN100473662C (enExample)
AU (1) AU2003259237B2 (enExample)
CA (1) CA2494607A1 (enExample)
TW (3) TWI291555B (enExample)
WO (1) WO2004013285A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004013285A2 (en) 2002-08-01 2004-02-12 Arena Pharmaceuticals, Inc. Human g protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure
CA2586542A1 (en) * 2004-11-08 2006-05-11 University Of Rochester Transgenic non-human animal models of ischemia-reperfusion injury and uses thereof
WO2015131099A1 (en) * 2014-02-28 2015-09-03 The General Hospital Corporation Diagnosis of multiple myeloma and lymphoma
EP3134433A4 (en) * 2014-04-25 2017-10-04 Libramen Naturals Inc. G-protein coupled receptor 22 transformed cell lines and uses therefor
CN107362365B (zh) * 2017-08-21 2020-01-07 武汉大风生物科技有限公司 Gpr31抑制剂在制药中的应用
CN114642668B (zh) * 2020-12-21 2024-04-05 忻佑康医药科技(南京)有限公司 拉坦前列素的药物新用途
CN119351340B (zh) * 2024-10-31 2025-07-08 中国食品药品检定研究院(国家药品监督管理局医疗器械标准管理中心、中国药品检验总所) 一种测定rhTSH药物生物学活性的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010491A1 (en) * 1997-08-28 1999-03-04 Incyte Pharmaceuticals, Inc. New human g-protein coupled receptor
US6555339B1 (en) * 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997024436A2 (en) * 1995-12-28 1997-07-10 Takeda Chemical Industries, Ltd. Ligand polypeptides for the g-protein-coupled receptor protein, their production and use
JP2003531637A (ja) * 2000-05-03 2003-10-28 アストラゼネカ アクチボラグ 方 法
AU2001282894A1 (en) 2000-07-19 2002-01-30 Deltagen, Inc. Transgenic mice containing targeted gene disruptions
WO2002061432A2 (en) 2001-02-01 2002-08-08 Lifespan Biosciences, Inc. Gpr22, a g protein-coupled receptor (gpcr) and compositions and methods related thereto
EP1470240A4 (en) 2002-02-01 2006-08-30 Millennium Pharm Inc METHOD AND COMPOSITIONS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES USING 1682, 6169, 6193, 7771, 14395, 29002, 33216, 43726, 69292, 21656, 32427, 2402, 7747, 1720, 9151, 60491, 1371, 7077, 33207, 1419 , 18036, 16105, 38650, 14245, 58848, 1870, 25856, 32394, 3484, 345, 9252, 9135, 10532, 18610, 8165, 2
WO2004013285A2 (en) 2002-08-01 2004-02-12 Arena Pharmaceuticals, Inc. Human g protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure
AU2006304329A1 (en) 2005-10-14 2007-04-26 Arena Pharmaceuticals, Inc. GPR22 and methods relating thereto

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555339B1 (en) * 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
WO1999010491A1 (en) * 1997-08-28 1999-03-04 Incyte Pharmaceuticals, Inc. New human g-protein coupled receptor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Accession number AC096185, Database EMBL, 19 September 2001 *

Also Published As

Publication number Publication date
US7611832B2 (en) 2009-11-03
US20050238579A1 (en) 2005-10-27
CN1684975A (zh) 2005-10-19
TW200410985A (en) 2004-07-01
TW200815603A (en) 2008-04-01
CA2494607A1 (en) 2004-02-12
US20070224127A1 (en) 2007-09-27
TW200800009A (en) 2008-01-01
WO2004013285A3 (en) 2004-06-10
TWI291555B (en) 2007-12-21
WO2004013285A2 (en) 2004-02-12
CN100473662C (zh) 2009-04-01
JP2005534319A (ja) 2005-11-17
AU2003259237A1 (en) 2004-02-23
EP1543025A4 (en) 2006-03-15
EP1543025A2 (en) 2005-06-22

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired